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UniProtKB - Q96IY4 (CBPB2_HUMAN)

Entry version 164 (02 Dec 2020)
Sequence version 2 (11 Jan 2011)
Previous versions | rss
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Protein

Carboxypeptidase B2

Gene

CPB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+2 PublicationsNote: Binds 1 zinc ion per subunit.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

TAFI/CPB2 is unique among carboxypeptidases in that it spontaneously inactivates with a short half-life, a property that is crucial for its role in controlling blood clot lysis. The zymogen is stabilized by interactions with the activation peptide. Release of the activation peptide increases a dynamic flap mobility and in time this leads to conformational changes that disrupt the catalytic site and expose a cryptic thrombin-cleavage site present at Arg-324.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi181Zinc; catalytic2 Publications1
Metal bindingi184Zinc; catalytic2 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei239SubstrateBy similarity1
Metal bindingi310Zinc; catalytic2 Publications1
Binding sitei363SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei385Proton donor/acceptorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
Biological processBlood coagulation, Fibrinolysis, Hemostasis
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.4.17.20, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96IY4

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2022377, Metabolism of Angiotensinogen to Angiotensins
R-HSA-977606, Regulation of Complement cascade

Protein family/group databases

MEROPS protease database

More...MEROPSi		M14.009

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Carboxypeptidase B2 (EC:3.4.17.201 Publication)
Alternative name(s):
Carboxypeptidase U
Short name:
CPU
Plasma carboxypeptidase B
Short name:
pCPB
Thrombin-activable fibrinolysis inhibitor
Short name:
TAFI
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CPB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000080618.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:2300, CPB2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603101, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96IY4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1361

Open Targets

More...OpenTargetsi		ENSG00000080618

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26822

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96IY4, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3419

Drug and drug target database

More...DrugBanki		DB05712, AZD-9684
DB11311, Prothrombin

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1594

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CPB2

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373332

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000437723 – 114Activation peptideAdd BLAST92
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000004378115 – 423Carboxypeptidase B2Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi44N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi73N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi85N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi108N-linked (GlcNAc...) (complex) asparagine5 Publications1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi178 ↔ 1912 Publications
Glycosylationi241N-linked (GlcNAc...) asparagine; partial1 Publication1
Disulfide bondi250 ↔ 2742 Publications
Disulfide bondi265 ↔ 2792 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated. N-glycan at Asn-108: Hex5HexNAc4.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei324 – 325Cleavage; by thrombin2

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-657
non-CPTAC-2639

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96IY4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96IY4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96IY4

PeptideAtlas

More...PeptideAtlasi		Q96IY4

PRoteomics IDEntifications database

More...PRIDEi		Q96IY4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76868 [Q96IY4-1]
76869 [Q96IY4-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		699, 16 N-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q96IY4, 5 sites, 3 N-linked glycans (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96IY4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96IY4

UniCarbKB; an annotated and curated database of glycan structures

More...UniCarbKBi		Q96IY4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Plasma; synthesized in the liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000080618, Expressed in liver and 84 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96IY4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96IY4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000080618, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107753, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q96IY4, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000181383

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q96IY4

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96IY4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1423
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96IY4

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q96IY4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni181 – 184Substrate bindingBy similarity4
Regioni256 – 257Substrate bindingBy similarity2
Regioni311 – 312Substrate bindingBy similarity2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2650, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159160

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_019326_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96IY4

Identification of Orthologs from Complete Genome Data

More...OMAi		NQPAHIR

Database of Orthologous Groups

More...OrthoDBi		524270at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96IY4

TreeFam database of animal gene trees

More...TreeFami		TF317197

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.340, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036990, M14A-like_propep
IPR003146, M14A_act_pep
IPR000834, Peptidase_M14

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00246, Peptidase_M14, 1 hit
PF02244, Propep_M14, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00765, CRBOXYPTASEA

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00631, Zn_pept, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96IY4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLCSLAVLV PIVLFCEQHV FAFQSGQVLA ALPRTSRQVQ VLQNLTTTYE 
        60         70         80         90        100
IVLWQPVTAD LIVKKKQVHF FVNASDVDNV KAHLNVSGIP CSVLLADVED 
       110        120        130        140        150
LIQQQISNDT VSPRASASYY EQYHSLNEIY SWIEFITERH PDMLTKIHIG 
       160        170        180        190        200
SSFEKYPLYV LKVSGKEQAA KNAIWIDCGI HAREWISPAF CLWFIGHITQ 
       210        220        230        240        250
FYGIIGQYTN LLRLVDFYVM PVVNVDGYDY SWKKNRMWRK NRSFYANNHC 
       260        270        280        290        300
IGTDLNRNFA SKHWCEEGAS SSSCSETYCG LYPESEPEVK AVASFLRRNI 
       310        320        330        340        350
NQIKAYISMH SYSQHIVFPY SYTRSKSKDH EELSLVASEA VRAIEKISKN 
       360        370        380        390        400
TRYTHGHGSE TLYLAPGGGD DWIYDLGIKY SFTIELRDTG TYGFLLPERY 
       410        420 
IKPTCREAFA AVSKIAWHVI RNV
Length:423
Mass (Da):48,424
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB4D20E03ECDD55EF
GO
Isoform 2 (identifier: Q96IY4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-234: Missing.
     384-423: IELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV → SNPPVEKLLPLSLK

Show »
Length:360
Mass (Da):40,922
Checksum:i2C011F6D4265F4B8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WSY5A0A087WSY5_HUMAN
Carboxypeptidase B2
CPB2
386Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PG06A0A6Q8PG06_HUMAN
Carboxypeptidase B2
CPB2
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PHS9A0A6Q8PHS9_HUMAN
Carboxypeptidase B2
CPB2
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25S → T in BAA90475 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032565169A → T2 PublicationsCorresponds to variant dbSNP:rs3742264Ensembl.1
Natural variantiVAR_022258347I → T5 PublicationsCorresponds to variant dbSNP:rs1926447Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013446198 – 234Missing in isoform 2. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_013447384 – 423IELRD…VIRNV → SNPPVEKLLPLSLK in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M75106 mRNA Translation: AAA60042.1
AB011969 mRNA Translation: BAA90475.1
BT006936 mRNA Translation: AAP35582.1
AK290829 mRNA Translation: BAF83518.1
AY714780 Genomic DNA Translation: AAT97987.1
AL137141 Genomic DNA No translation available.
AL157758 Genomic DNA No translation available.
BC007057 mRNA Translation: AAH07057.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9401.1 [Q96IY4-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A41204

NCBI Reference Sequences

More...RefSeqi		NP_001265470.1, NM_001278541.1
NP_001863.3, NM_001872.4 [Q96IY4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000181383; ENSP00000181383; ENSG00000080618 [Q96IY4-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1361

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1361

UCSC genome browser

More...UCSCi		uc001vaw.4, human [Q96IY4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75106 mRNA Translation: AAA60042.1
AB011969 mRNA Translation: BAA90475.1
BT006936 mRNA Translation: AAP35582.1
AK290829 mRNA Translation: BAF83518.1
AY714780 Genomic DNA Translation: AAT97987.1
AL137141 Genomic DNA No translation available.
AL157758 Genomic DNA No translation available.
BC007057 mRNA Translation: AAH07057.1
CCDSiCCDS9401.1 [Q96IY4-1]
PIRiA41204
RefSeqiNP_001265470.1, NM_001278541.1
NP_001863.3, NM_001872.4 [Q96IY4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D66X-ray3.10A/B/C24-423[»]
3D67X-ray3.40A/B/C24-423[»]
3D68X-ray2.80A/B/C24-423[»]
3LMSX-ray2.50A115-423[»]
4P10X-ray2.00A23-423[»]
5HVFX-ray2.85A23-423[»]
5HVGX-ray3.05A/C23-423[»]
5HVHX-ray3.00A23-423[»]
SMRiQ96IY4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107753, 6 interactors
IntActiQ96IY4, 1 interactor
STRINGi9606.ENSP00000181383

Chemistry databases

BindingDBiQ96IY4
ChEMBLiCHEMBL3419
DrugBankiDB05712, AZD-9684
DB11311, Prothrombin
GuidetoPHARMACOLOGYi1594

Protein family/group databases

MEROPSiM14.009

PTM databases

GlyConnecti699, 16 N-Linked glycans (3 sites)
GlyGeniQ96IY4, 5 sites, 3 N-linked glycans (3 sites)
iPTMnetiQ96IY4
PhosphoSitePlusiQ96IY4
UniCarbKBiQ96IY4

Polymorphism and mutation databases

BioMutaiCPB2
DMDMi317373332

Proteomic databases

CPTACiCPTAC-657
non-CPTAC-2639
jPOSTiQ96IY4
MassIVEiQ96IY4
PaxDbiQ96IY4
PeptideAtlasiQ96IY4
PRIDEiQ96IY4
ProteomicsDBi76868 [Q96IY4-1]
76869 [Q96IY4-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q96IY4, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1324, 586 antibodies

The DNASU plasmid repository

More...DNASUi		1361

Genome annotation databases

EnsembliENST00000181383; ENSP00000181383; ENSG00000080618 [Q96IY4-1]
GeneIDi1361
KEGGihsa:1361
UCSCiuc001vaw.4, human [Q96IY4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1361
DisGeNETi1361
EuPathDBiHostDB:ENSG00000080618.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		CPB2
HGNCiHGNC:2300, CPB2
HPAiENSG00000080618, Tissue enriched (liver)
MIMi603101, gene
neXtProtiNX_Q96IY4
OpenTargetsiENSG00000080618
PharmGKBiPA26822

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2650, Eukaryota
GeneTreeiENSGT00940000159160
HOGENOMiCLU_019326_0_0_1
InParanoidiQ96IY4
OMAiNQPAHIR
OrthoDBi524270at2759
PhylomeDBiQ96IY4
TreeFamiTF317197

Enzyme and pathway databases

BRENDAi3.4.17.20, 2681
PathwayCommonsiQ96IY4
ReactomeiR-HSA-2022377, Metabolism of Angiotensinogen to Angiotensins
R-HSA-977606, Regulation of Complement cascade

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1361, 1 hit in 840 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CPB2, human
EvolutionaryTraceiQ96IY4

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Carboxypeptidase_B2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1361
PharosiQ96IY4, Tchem

Protein Ontology

More...PROi		PR:Q96IY4
RNActiQ96IY4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000080618, Expressed in liver and 84 other tissues
ExpressionAtlasiQ96IY4, baseline and differential
GenevisibleiQ96IY4, HS

Family and domain databases

Gene3Di3.30.70.340, 1 hit
InterProiView protein in InterPro
IPR036990, M14A-like_propep
IPR003146, M14A_act_pep
IPR000834, Peptidase_M14
PfamiView protein in Pfam
PF00246, Peptidase_M14, 1 hit
PF02244, Propep_M14, 1 hit
PRINTSiPR00765, CRBOXYPTASEA
SMARTiView protein in SMART
SM00631, Zn_pept, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCBPB2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96IY4
Secondary accession number(s): A8K464
, Q15114, Q5T9K1, Q5T9K2, Q9P2Y6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: January 11, 2011
Last modified: December 2, 2020
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. Peptidase families
    Classification of peptidase families and list of entries
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