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Protein

Up-regulated during skeletal muscle growth protein 5

Gene

USMG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a critical role in maintaining the ATP synthase population in mitochondria.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Up-regulated during skeletal muscle growth protein 5
Alternative name(s):
Diabetes-associated protein in insulin-sensitive tissues
HCV F-transactivated protein 2
Gene namesi
Name:USMG5
Synonyms:DAPIT, HCVFTP2
ORF Names:PD04912
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000173915.12
HGNCiHGNC:30889 USMG5
MIMi615204 gene
neXtProtiNX_Q96IX5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 45HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi84833
OpenTargetsiENSG00000173915
PharmGKBiPA134968209

Polymorphism and mutation databases

BioMutaiUSMG5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002315782 – 58Up-regulated during skeletal muscle growth protein 5Add BLAST57

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16N6-acetyllysineBy similarity1
Modified residuei17N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96IX5
MaxQBiQ96IX5
PaxDbiQ96IX5
PeptideAtlasiQ96IX5
PRIDEiQ96IX5
ProteomicsDBi76865
TopDownProteomicsiQ96IX5

PTM databases

iPTMnetiQ96IX5
PhosphoSitePlusiQ96IX5
SwissPalmiQ96IX5

Expressioni

Inductioni

Transactivated by SBP1.1 Publication

Gene expression databases

BgeeiENSG00000173915
CleanExiHS_USMG5
GenevisibleiQ96IX5 HS

Organism-specific databases

HPAiHPA044798

Interactioni

Subunit structurei

Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5ME, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68.By similarity

Protein-protein interaction databases

BioGridi124287, 38 interactors
IntActiQ96IX5, 45 interactors
MINTiQ96IX5
STRINGi9606.ENSP00000311245

Structurei

3D structure databases

ProteinModelPortaliQ96IX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2ST Eukaryota
ENOG410XXHD LUCA
GeneTreeiENSGT00390000015489
HOGENOMiHOG000008547
HOVERGENiHBG094140
InParanoidiQ96IX5
KOiK18194
OMAiPETDAQF
OrthoDBiEOG091G1870
PhylomeDBiQ96IX5
TreeFamiTF324671

Family and domain databases

InterProiView protein in InterPro
IPR009125 DAPIT
PRINTSiPR01821 DAPIT

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96IX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPESDAQY QFTGIKKYFN SYTLTGRMNC VLATYGSIAL IVLYFKLRSK

KTPAVKAT
Length:58
Mass (Da):6,458
Last modified:December 1, 2001 - v1
Checksum:i3BFC4C9E2920B126
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY740522 mRNA Translation: AAU89079.1
AJ272056 mRNA Translation: CAC81243.1
AK311888 mRNA Translation: BAG34829.1
AL591408 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49642.1
CH471066 Genomic DNA Translation: EAW49643.1
CH471066 Genomic DNA Translation: EAW49644.1
BC007087 mRNA Translation: AAH07087.1
BC072683 mRNA Translation: AAH72683.1
BC091507 mRNA Translation: AAH91507.1
CCDSiCCDS7548.1
RefSeqiNP_001193355.1, NM_001206426.1
NP_001193356.1, NM_001206427.1
NP_116136.1, NM_032747.3
UniGeneiHs.500921
Hs.732499

Genome annotation databases

EnsembliENST00000309579; ENSP00000311245; ENSG00000173915
ENST00000337003; ENSP00000337705; ENSG00000173915
ENST00000369811; ENSP00000358826; ENSG00000173915
ENST00000369815; ENSP00000358830; ENSG00000173915
ENST00000369825; ENSP00000358840; ENSG00000173915
GeneIDi84833
KEGGihsa:84833
UCSCiuc001kww.4 human

Similar proteinsi

Entry informationi

Entry nameiUSMG5_HUMAN
AccessioniPrimary (citable) accession number: Q96IX5
Secondary accession number(s): B2R4N2, D3DR92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 1, 2001
Last modified: July 18, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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