Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vesicle-trafficking protein SEC22a

Gene

SEC22A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in vesicle transport between the ER and the Golgi complex.By similarity

GO - Molecular functioni

  • transporter activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-trafficking protein SEC22a
Alternative name(s):
SEC22 vesicle-trafficking protein homolog A
SEC22 vesicle-trafficking protein-like 2
Gene namesi
Name:SEC22A
Synonyms:SEC22L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000121542.11
HGNCiHGNC:20260 SEC22A
MIMi612442 gene
neXtProtiNX_Q96IW7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 187CytoplasmicSequence analysisAdd BLAST186
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 226LumenalSequence analysisAdd BLAST18
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 253CytoplasmicSequence analysis6
Transmembranei254 – 271HelicalSequence analysisAdd BLAST18
Topological domaini272 – 274LumenalSequence analysis3
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Topological domaini296 – 307CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26984
OpenTargetsiENSG00000121542
PharmGKBiPA134921956

Polymorphism and mutation databases

BioMutaiSEC22A
DMDMi74732111

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002530432 – 307Vesicle-trafficking protein SEC22aAdd BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei8PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96IW7
MaxQBiQ96IW7
PaxDbiQ96IW7
PeptideAtlasiQ96IW7
PRIDEiQ96IW7
ProteomicsDBi76864

PTM databases

iPTMnetiQ96IW7
PhosphoSitePlusiQ96IW7

Expressioni

Gene expression databases

BgeeiENSG00000121542 Expressed in 196 organ(s), highest expression level in kidney
CleanExiHS_SEC22A
ExpressionAtlasiQ96IW7 baseline and differential
GenevisibleiQ96IW7 HS

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi117937, 19 interactors
IntActiQ96IW7, 101 interactors
MINTiQ96IW7
STRINGi9606.ENSP00000310521

Structurei

3D structure databases

ProteinModelPortaliQ96IW7
SMRiQ96IW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 119LonginPROSITE-ProRule annotationAdd BLAST112

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0862 Eukaryota
COG5143 LUCA
GeneTreeiENSGT00510000046833
HOGENOMiHOG000007733
HOVERGENiHBG053258
InParanoidiQ96IW7
KOiK08520
OMAiVQECRKY
OrthoDBiEOG091G0MPE
PhylomeDBiQ96IW7
TreeFamiTF105933

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR010908 Longin_dom
IPR027152 Sec22a
PANTHERiPTHR21136:SF68 PTHR21136:SF68, 1 hit
PfamiView protein in Pfam
PF13774 Longin, 1 hit
SMARTiView protein in SMART
SM01270 Longin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS50859 LONGIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q96IW7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMILSASVI RVRDGLPLSA STDYEQSTGM QECRKYFKML SRKLAQLPDR
60 70 80 90 100
CTLKTGHYNI NFISSLGVSY MMLCTENYPN VLAFSFLDEL QKEFITTYNM
110 120 130 140 150
MKTNTAVRPY CFIEFDNFIQ RTKQRYNNPR SLSTKINLSD MQTEIKLRPP
160 170 180 190 200
YQISMCELGS ANGVTSAFSV DCKGAGKISS AHQRLEPATL SGIVGFILSL
210 220 230 240 250
LCGALNLIRG FHAIESLLQS DGDDFNYIIA FFLGTAACLY QCYLLVYYTG
260 270 280 290 300
WRNVKSFLTF GLICLCNMYL YELRNLWQLF FHVTVGAFVT LQIWLRQAQG

KAPDYDV
Length:307
Mass (Da):34,948
Last modified:December 1, 2001 - v1
Checksum:i227A7F6944EC621F
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JNZ0C9JNZ0_HUMAN
Vesicle-trafficking protein SEC22a
SEC22A
288Annotation score:
C9JRY4C9JRY4_HUMAN
Vesicle-trafficking protein SEC22a
SEC22A
218Annotation score:
C9JDJ8C9JDJ8_HUMAN
Vesicle-trafficking protein SEC22a
SEC22A
138Annotation score:
C9J463C9J463_HUMAN
Vesicle-trafficking protein SEC22a
SEC22A
101Annotation score:
C9JZ27C9JZ27_HUMAN
Vesicle-trafficking protein SEC22a
SEC22A
108Annotation score:
F8WAU7F8WAU7_HUMAN
Vesicle-trafficking protein SEC22a
SEC22A
71Annotation score:
C9JR77C9JR77_HUMAN
Vesicle-trafficking protein SEC22a
SEC22A
99Annotation score:

Sequence cautioni

The sequence AAD43013 differs from that shown. Reason: Frameshift at positions 265 and 288.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61N → K in AAD43013 (PubMed:11042152).Curated1
Sequence conflicti116D → N in AAD43013 (PubMed:11042152).Curated1
Sequence conflicti295L → V (PubMed:11042152).Curated1
Sequence conflicti303 – 304PD → SR (PubMed:11042152).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100749 mRNA Translation: AAD43013.1 Frameshift.
AK315771 mRNA Translation: BAG38123.1
CH471052 Genomic DNA Translation: EAW79451.1
BC007122 mRNA Translation: AAH07122.1
CCDSiCCDS3021.1
RefSeqiNP_036562.2, NM_012430.4
XP_011510975.1, XM_011512673.2
XP_011510977.1, XM_011512675.2
XP_011510978.1, XM_011512676.2
UniGeneiHs.477361

Genome annotation databases

EnsembliENST00000309934; ENSP00000310521; ENSG00000121542
ENST00000492595; ENSP00000417972; ENSG00000121542
GeneIDi26984
KEGGihsa:26984
UCSCiuc003ege.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100749 mRNA Translation: AAD43013.1 Frameshift.
AK315771 mRNA Translation: BAG38123.1
CH471052 Genomic DNA Translation: EAW79451.1
BC007122 mRNA Translation: AAH07122.1
CCDSiCCDS3021.1
RefSeqiNP_036562.2, NM_012430.4
XP_011510975.1, XM_011512673.2
XP_011510977.1, XM_011512675.2
XP_011510978.1, XM_011512676.2
UniGeneiHs.477361

3D structure databases

ProteinModelPortaliQ96IW7
SMRiQ96IW7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117937, 19 interactors
IntActiQ96IW7, 101 interactors
MINTiQ96IW7
STRINGi9606.ENSP00000310521

PTM databases

iPTMnetiQ96IW7
PhosphoSitePlusiQ96IW7

Polymorphism and mutation databases

BioMutaiSEC22A
DMDMi74732111

Proteomic databases

EPDiQ96IW7
MaxQBiQ96IW7
PaxDbiQ96IW7
PeptideAtlasiQ96IW7
PRIDEiQ96IW7
ProteomicsDBi76864

Protocols and materials databases

DNASUi26984
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309934; ENSP00000310521; ENSG00000121542
ENST00000492595; ENSP00000417972; ENSG00000121542
GeneIDi26984
KEGGihsa:26984
UCSCiuc003ege.4 human

Organism-specific databases

CTDi26984
DisGeNETi26984
EuPathDBiHostDB:ENSG00000121542.11
GeneCardsiSEC22A
HGNCiHGNC:20260 SEC22A
MIMi612442 gene
neXtProtiNX_Q96IW7
OpenTargetsiENSG00000121542
PharmGKBiPA134921956
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0862 Eukaryota
COG5143 LUCA
GeneTreeiENSGT00510000046833
HOGENOMiHOG000007733
HOVERGENiHBG053258
InParanoidiQ96IW7
KOiK08520
OMAiVQECRKY
OrthoDBiEOG091G0MPE
PhylomeDBiQ96IW7
TreeFamiTF105933

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport

Miscellaneous databases

ChiTaRSiSEC22A human
GeneWikiiSEC22A
GenomeRNAii26984
PROiPR:Q96IW7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121542 Expressed in 196 organ(s), highest expression level in kidney
CleanExiHS_SEC22A
ExpressionAtlasiQ96IW7 baseline and differential
GenevisibleiQ96IW7 HS

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR010908 Longin_dom
IPR027152 Sec22a
PANTHERiPTHR21136:SF68 PTHR21136:SF68, 1 hit
PfamiView protein in Pfam
PF13774 Longin, 1 hit
SMARTiView protein in SMART
SM01270 Longin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS50859 LONGIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSC22A_HUMAN
AccessioniPrimary (citable) accession number: Q96IW7
Secondary accession number(s): B2RE26, Q9Y682
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again