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Entry version 148 (02 Jun 2021)
Sequence version 1 (01 Dec 2001)
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Protein

Vesicle-trafficking protein SEC22a

Gene

SEC22A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in vesicle transport between the ER and the Golgi complex.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transporter activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96IW7

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-204005, COPII-mediated vesicle transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vesicle-trafficking protein SEC22a
Alternative name(s):
SEC22 vesicle-trafficking protein homolog A
SEC22 vesicle-trafficking protein-like 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC22A
Synonyms:SEC22L2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:20260, SEC22A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612442, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q96IW7

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000121542.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 187CytoplasmicSequence analysisAdd BLAST186
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 226LumenalSequence analysisAdd BLAST18
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 253CytoplasmicSequence analysis6
Transmembranei254 – 271HelicalSequence analysisAdd BLAST18
Topological domaini272 – 274LumenalSequence analysis3
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Topological domaini296 – 307CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26984

Open Targets

More...
OpenTargetsi
ENSG00000121542

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134921956

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96IW7, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SEC22A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74732111

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002530432 – 307Vesicle-trafficking protein SEC22aAdd BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei8PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96IW7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96IW7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96IW7

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96IW7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96IW7

PeptideAtlas

More...
PeptideAtlasi
Q96IW7

PRoteomics IDEntifications database

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PRIDEi
Q96IW7

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
76864

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96IW7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96IW7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q96IW7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000121542, Expressed in calcaneal tendon and 211 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96IW7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96IW7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000121542, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q96IW7
With#Exp.IntAct
ADGRG3 [Q86Y34]3EBI-8652744,EBI-17979264
AQP6 [Q13520]3EBI-8652744,EBI-13059134
ASGR2 - isoform 3 [P07307-3]3EBI-8652744,EBI-12808270
ATP6AP2 [O75787]3EBI-8652744,EBI-2512037
BIK [Q13323]3EBI-8652744,EBI-700794
BNIP3 [Q12983]3EBI-8652744,EBI-749464
C10orf67 - isoform 2 [Q8IYJ2-2]3EBI-8652744,EBI-13381098
C16orf54 [Q6UWD8]3EBI-8652744,EBI-18041102
CALN1 [Q9BXU9]3EBI-8652744,EBI-12187137
CD207 [Q9UJ71]3EBI-8652744,EBI-2873235
CD300A [Q9UGN4]3EBI-8652744,EBI-10320732
CD7 [P09564]3EBI-8652744,EBI-2836587
CD74 - isoform p35 [P04233-2]3EBI-8652744,EBI-12222807
CISD2 [Q8N5K1]3EBI-8652744,EBI-1045797
CLEC10A [Q8IUN9]3EBI-8652744,EBI-2873246
CLEC12B - isoform 2 [Q2HXU8-2]3EBI-8652744,EBI-12811991
CLEC2D - isoform 2 [Q9UHP7-3]3EBI-8652744,EBI-11749983
CLEC7A - isoform 6 [Q9BXN2-6]3EBI-8652744,EBI-11989440
CREB3L1 [Q96BA8]3EBI-8652744,EBI-6942903
CYB561 [P49447]3EBI-8652744,EBI-8646596
CYBRD1 [Q53TN4]3EBI-8652744,EBI-8637742
DDIT4L [Q96D03]3EBI-8652744,EBI-742054
DIABLO [Q9NR28]3EBI-8652744,EBI-517508
DTX2 [Q86UW9]10EBI-8652744,EBI-740376
EDA [Q92838]7EBI-8652744,EBI-529425
ELOVL4 [Q9GZR5]3EBI-8652744,EBI-18535450
ERLIN1 [O75477]6EBI-8652744,EBI-359299
ERVFRD-1 [P60508]3EBI-8652744,EBI-17973325
FAM174A [Q8TBP5]3EBI-8652744,EBI-18636064
FAM209A [Q5JX71]3EBI-8652744,EBI-18304435
FATE1 [Q969F0]6EBI-8652744,EBI-743099
FIMP [Q96LL3]3EBI-8652744,EBI-12887376
FUT3 [P21217]3EBI-8652744,EBI-12839380
GAD2 [Q05329]3EBI-8652744,EBI-9304251
GGT6 [Q6P531]3EBI-8652744,EBI-2868927
GJB5 [O95377]3EBI-8652744,EBI-3909454
GJB6 [O95452]3EBI-8652744,EBI-13345609
GPR37L1 [O60883]3EBI-8652744,EBI-2927498
GRAMD2B [Q96HH9]3EBI-8652744,EBI-2832937
HAVCR2 [Q8TDQ0]3EBI-8652744,EBI-11472922
HCST [Q9UBK5]3EBI-8652744,EBI-2801937
HSD17B11 [Q8NBQ5]3EBI-8652744,EBI-1052304
ICAM3 [P32942]3EBI-8652744,EBI-725421
KCNJ2 [P63252]3EBI-8652744,EBI-703457
LDLRAD1 [Q5T700]3EBI-8652744,EBI-10173166
LHFPL5 [Q8TAF8]3EBI-8652744,EBI-2820517
LPAR6 [P43657]3EBI-8652744,EBI-2876949
LRRC25 [Q8N386]3EBI-8652744,EBI-11304917
LSMEM2 [Q8N112]3EBI-8652744,EBI-10264855
MCOLN1 [Q9GZU1]3EBI-8652744,EBI-721209
MFF - isoform 5 [Q9GZY8-5]3EBI-8652744,EBI-11956541
MGST2 [Q99735]3EBI-8652744,EBI-11324706
MINAR1 [Q9UPX6]3EBI-8652744,EBI-11977115
MS4A14 [Q96JA4]3EBI-8652744,EBI-12839612
MS4A3 [Q96HJ5]3EBI-8652744,EBI-12806656
MS4A4A [Q96JQ5]5EBI-8652744,EBI-12820341
MSR1 [P21757]7EBI-8652744,EBI-1776976
OPRM1 - isoform 10 [P35372-10]3EBI-8652744,EBI-12807478
PACC1 [Q9H813]3EBI-8652744,EBI-4319734
PEX12 [O00623]3EBI-8652744,EBI-594836
PHB [P35232]3EBI-8652744,EBI-354213
PTGES [O14684]3EBI-8652744,EBI-11161398
RASGRP4 - isoform 2 [Q8TDF6-2]3EBI-8652744,EBI-12816371
RETREG3 [Q86VR2]5EBI-8652744,EBI-10192441
RILPL1 - isoform 3 [Q5EBL4-3]3EBI-8652744,EBI-12072024
RNASEK [Q6P5S7]3EBI-8652744,EBI-18397230
RNF144A [P50876]3EBI-8652744,EBI-2340657
RNF19B [Q6ZMZ0]3EBI-8652744,EBI-2466594
RNF5 [Q99942]3EBI-8652744,EBI-348482
SAR1A [Q9NR31]3EBI-8652744,EBI-3920694
SCN3B [Q9NY72]3EBI-8652744,EBI-17247926
SDHAF2 [Q9NX18]3EBI-8652744,EBI-713250
SFTPC [P11686]6EBI-8652744,EBI-10197617
SLC14A2 [Q15849]3EBI-8652744,EBI-1573290
SLC30A2 [Q9BRI3]3EBI-8652744,EBI-8644112
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-8652744,EBI-17295964
SLC39A2 [Q9NP94]3EBI-8652744,EBI-12898013
SMIM3 [Q9BZL3]3EBI-8652744,EBI-741850
SPAG4 [Q9NPE6]3EBI-8652744,EBI-10819434
STMN4 - isoform 2 [Q9H169-2]3EBI-8652744,EBI-20117546
STOML3 [Q8TAV4]3EBI-8652744,EBI-12900395
STX1A [Q16623]3EBI-8652744,EBI-712466
STX2 - isoform 1 [P32856-2]3EBI-8652744,EBI-11956649
STX4 [Q12846]6EBI-8652744,EBI-744942
SUSD3 [Q96L08]3EBI-8652744,EBI-18194029
SYNE4 [Q8N205]3EBI-8652744,EBI-7131783
TFR2 [Q9UP52]3EBI-8652744,EBI-3934135
TLCD4 [Q96MV1]3EBI-8652744,EBI-12947623
TMED9 [Q9BVK6]3EBI-8652744,EBI-1056827
TMEM106C [Q9BVX2]3EBI-8652744,EBI-2821497
TMEM159 [Q96B96]3EBI-8652744,EBI-7055862
TMEM174 [Q8WUU8]3EBI-8652744,EBI-10276729
TMEM237 - isoform 2 [Q96Q45-2]3EBI-8652744,EBI-10982110
TMEM45B [Q96B21]3EBI-8652744,EBI-3923061
TMEM52B [Q4KMG9]3EBI-8652744,EBI-18178701
TMEM71 - isoform 2 [Q6P5X7-2]3EBI-8652744,EBI-12886878
TMEM79 [Q9BSE2]7EBI-8652744,EBI-8649725
TMPRSS2 - isoform 2 [O15393-2]3EBI-8652744,EBI-12345267
TNFSF14 [O43557]3EBI-8652744,EBI-524131
TP53INP1 [Q96A56]3EBI-8652744,EBI-9986117
TRAT1 [Q6PIZ9]3EBI-8652744,EBI-17710254
TRIM59 [Q8IWR1]5EBI-8652744,EBI-10262539
TYRP1 [P17643]3EBI-8652744,EBI-7900408
ZFYVE27 [Q5T4F4]3EBI-8652744,EBI-3892947

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
117937, 117 interactors

Protein interaction database and analysis system

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IntActi
Q96IW7, 104 interactors

Molecular INTeraction database

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MINTi
Q96IW7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000310521

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96IW7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96IW7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 119LonginPROSITE-ProRule annotationAdd BLAST112

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0862, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158470

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96IW7

Identification of Orthologs from Complete Genome Data

More...
OMAi
QCYLFVY

Database of Orthologous Groups

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OrthoDBi
903466at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96IW7

TreeFam database of animal gene trees

More...
TreeFami
TF105933

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14824, Longin, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011012, Longin-like_dom_sf
IPR010908, Longin_dom
IPR027152, Sec22a
IPR043546, Sec22a/c

The PANTHER Classification System

More...
PANTHERi
PTHR46258, PTHR46258, 1 hit
PTHR46258:SF3, PTHR46258:SF3, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF13774, Longin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01270, Longin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF64356, SSF64356, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50859, LONGIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q96IW7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMILSASVI RVRDGLPLSA STDYEQSTGM QECRKYFKML SRKLAQLPDR
60 70 80 90 100
CTLKTGHYNI NFISSLGVSY MMLCTENYPN VLAFSFLDEL QKEFITTYNM
110 120 130 140 150
MKTNTAVRPY CFIEFDNFIQ RTKQRYNNPR SLSTKINLSD MQTEIKLRPP
160 170 180 190 200
YQISMCELGS ANGVTSAFSV DCKGAGKISS AHQRLEPATL SGIVGFILSL
210 220 230 240 250
LCGALNLIRG FHAIESLLQS DGDDFNYIIA FFLGTAACLY QCYLLVYYTG
260 270 280 290 300
WRNVKSFLTF GLICLCNMYL YELRNLWQLF FHVTVGAFVT LQIWLRQAQG

KAPDYDV
Length:307
Mass (Da):34,948
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i227A7F6944EC621F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JNZ0C9JNZ0_HUMAN
Vesicle-trafficking protein SEC22a
SEC22A
288Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JRY4C9JRY4_HUMAN
Vesicle-trafficking protein SEC22a
SEC22A
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J463C9J463_HUMAN
Vesicle-trafficking protein SEC22a
SEC22A
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDJ8C9JDJ8_HUMAN
Vesicle-trafficking protein SEC22a
SEC22A
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZ27C9JZ27_HUMAN
Vesicle-trafficking protein SEC22a
SEC22A
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JR77C9JR77_HUMAN
Vesicle-trafficking protein SEC22a
SEC22A
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAU7F8WAU7_HUMAN
Vesicle-trafficking protein SEC22a
SEC22A
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD43013 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti61N → K in AAD43013 (PubMed:11042152).Curated1
Sequence conflicti116D → N in AAD43013 (PubMed:11042152).Curated1
Sequence conflicti295L → V (PubMed:11042152).Curated1
Sequence conflicti303 – 304PD → SR (PubMed:11042152).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF100749 mRNA Translation: AAD43013.1 Frameshift.
AK315771 mRNA Translation: BAG38123.1
CH471052 Genomic DNA Translation: EAW79451.1
BC007122 mRNA Translation: AAH07122.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3021.1

NCBI Reference Sequences

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RefSeqi
NP_036562.2, NM_012430.4
XP_011510975.1, XM_011512673.2
XP_011510977.1, XM_011512675.2
XP_011510978.1, XM_011512676.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000309934; ENSP00000310521; ENSG00000121542
ENST00000492595; ENSP00000417972; ENSG00000121542

Database of genes from NCBI RefSeq genomes

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GeneIDi
26984

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:26984

UCSC genome browser

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UCSCi
uc003ege.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100749 mRNA Translation: AAD43013.1 Frameshift.
AK315771 mRNA Translation: BAG38123.1
CH471052 Genomic DNA Translation: EAW79451.1
BC007122 mRNA Translation: AAH07122.1
CCDSiCCDS3021.1
RefSeqiNP_036562.2, NM_012430.4
XP_011510975.1, XM_011512673.2
XP_011510977.1, XM_011512675.2
XP_011510978.1, XM_011512676.2

3D structure databases

SMRiQ96IW7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117937, 117 interactors
IntActiQ96IW7, 104 interactors
MINTiQ96IW7
STRINGi9606.ENSP00000310521

PTM databases

iPTMnetiQ96IW7
PhosphoSitePlusiQ96IW7
SwissPalmiQ96IW7

Genetic variation databases

BioMutaiSEC22A
DMDMi74732111

Proteomic databases

EPDiQ96IW7
jPOSTiQ96IW7
MassIVEiQ96IW7
MaxQBiQ96IW7
PaxDbiQ96IW7
PeptideAtlasiQ96IW7
PRIDEiQ96IW7
ProteomicsDBi76864

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
32946, 32 antibodies

The DNASU plasmid repository

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DNASUi
26984

Genome annotation databases

EnsembliENST00000309934; ENSP00000310521; ENSG00000121542
ENST00000492595; ENSP00000417972; ENSG00000121542
GeneIDi26984
KEGGihsa:26984
UCSCiuc003ege.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26984
DisGeNETi26984

GeneCards: human genes, protein and diseases

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GeneCardsi
SEC22A
HGNCiHGNC:20260, SEC22A
HPAiENSG00000121542, Low tissue specificity
MIMi612442, gene
neXtProtiNX_Q96IW7
OpenTargetsiENSG00000121542
PharmGKBiPA134921956
VEuPathDBiHostDB:ENSG00000121542.11

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0862, Eukaryota
GeneTreeiENSGT00940000158470
InParanoidiQ96IW7
OMAiQCYLFVY
OrthoDBi903466at2759
PhylomeDBiQ96IW7
TreeFamiTF105933

Enzyme and pathway databases

PathwayCommonsiQ96IW7
ReactomeiR-HSA-204005, COPII-mediated vesicle transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
26984, 12 hits in 998 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SEC22A, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SEC22A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26984
PharosiQ96IW7, Tdark

Protein Ontology

More...
PROi
PR:Q96IW7
RNActiQ96IW7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000121542, Expressed in calcaneal tendon and 211 other tissues
ExpressionAtlasiQ96IW7, baseline and differential
GenevisibleiQ96IW7, HS

Family and domain databases

CDDicd14824, Longin, 1 hit
InterProiView protein in InterPro
IPR011012, Longin-like_dom_sf
IPR010908, Longin_dom
IPR027152, Sec22a
IPR043546, Sec22a/c
PANTHERiPTHR46258, PTHR46258, 1 hit
PTHR46258:SF3, PTHR46258:SF3, 1 hit
PfamiView protein in Pfam
PF13774, Longin, 1 hit
SMARTiView protein in SMART
SM01270, Longin, 1 hit
SUPFAMiSSF64356, SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS50859, LONGIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC22A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96IW7
Secondary accession number(s): B2RE26, Q9Y682
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 1, 2001
Last modified: June 2, 2021
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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