UniProtKB - Q96IT1 (ZN496_HUMAN)
Protein
Zinc finger protein 496
Gene
ZNF496
Organism
Homo sapiens (Human)
Status
Functioni
DNA-binding transcription factor that can both act as an activator and a repressor.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 406 – 428 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 435 – 457 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 463 – 485 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 522 – 545 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 553 – 575 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96IT1 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 496Alternative name(s): Zinc finger protein with KRAB and SCAN domains 17 |
Gene namesi | Name:ZNF496 Synonyms:ZKSCAN17 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23713, ZNF496 |
MIMi | 613911, gene |
neXtProti | NX_Q96IT1 |
VEuPathDBi | HostDB:ENSG00000162714.12 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 84838 |
OpenTargetsi | ENSG00000162714 |
PharmGKBi | PA134888470 |
Miscellaneous databases
Pharosi | Q96IT1, Tdark |
Genetic variation databases
BioMutai | ZNF496 |
DMDMi | 55976755 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047617 | 1 – 587 | Zinc finger protein 496Add BLAST | 587 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 13 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 185 | PhosphoserineCombined sources | 1 | |
Modified residuei | 299 | PhosphoserineCombined sources | 1 | |
Cross-linki | 403 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 496 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q96IT1 |
MassIVEi | Q96IT1 |
MaxQBi | Q96IT1 |
PaxDbi | Q96IT1 |
PeptideAtlasi | Q96IT1 |
PRIDEi | Q96IT1 |
ProteomicsDBi | 76850 [Q96IT1-1] 76851 [Q96IT1-2] |
PTM databases
iPTMneti | Q96IT1 |
PhosphoSitePlusi | Q96IT1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000162714, Expressed in stomach and 203 other tissues |
ExpressionAtlasi | Q96IT1, baseline and differential |
Genevisiblei | Q96IT1, HS |
Organism-specific databases
HPAi | ENSG00000162714, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via zinc-fingers) with JARID2.
Interacts with NSD1 (By similarity).
By similarityBinary interactionsi
Hide detailsQ96IT1
Protein-protein interaction databases
BioGRIDi | 124291, 43 interactors |
IntActi | Q96IT1, 29 interactors |
MINTi | Q96IT1 |
STRINGi | 9606.ENSP00000294753 |
Miscellaneous databases
RNActi | Q96IT1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 124 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 | |
Domaini | 221 – 291 | KRABPROSITE-ProRule annotationAdd BLAST | 71 |
Domaini
The C2H2-type zinc finger 1, also named C2HR, mediates the interaction with NSD1.By similarity
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 406 – 428 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 435 – 457 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 463 – 485 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 522 – 545 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 553 – 575 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161967 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | Q96IT1 |
OMAi | DMIFCFS |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96IT1 |
TreeFami | TF350829 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR027767, Zfp496 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23226:SF180, PTHR23226:SF180, 1 hit |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF02023, SCAN, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96IT1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPTALCPRVL APKESEEPRK MRSPPGENPS PQGELPSPES SRRLFRRFRY
60 70 80 90 100
QEAAGPREAL QRLWDLCGGW LRPERHTKEQ ILELLVLEQF LAILPREIQS
110 120 130 140 150
WVRAQEPESG EQAVAAVEAL EREPGRPWQW LKHCEDPVVI DDGDSPLDQE
160 170 180 190 200
QEQLPVEPHS DLAKNQDAQP ITLAQCLGLP SRPPSQLSGD PVLQDAFLLQ
210 220 230 240 250
EENVRDTQQV TTLQLPPSRV SPFKDMILCF SEEDWSLLDP AQTGFYGEFI
260 270 280 290 300
IGEDYGVSMP PNDLAAQPDL SQGEENEPRV PELQDLQGKE VPQVSYLDSP
310 320 330 340 350
SLQPFQVEER RKREELQVPE FQACPQTVVP QNTYPAGGNP RSLENSLDEE
360 370 380 390 400
VTIEIVLSSS GDEDSQHGPY CTEELGSPTE KQRSLPASHR SSTEAGGEVQ
410 420 430 440 450
TSKKSYVCPN CGKIFRWRVN FIRHLRSRRE QEKPHECSVC GELFSDSEDL
460 470 480 490 500
DGHLESHEAQ KPYRCGACGK SFRLNSHLLS HRRIHLQPDR LQPVEKREQA
510 520 530 540 550
ASEDADKGPK EPLENGKAKL SFQCCECGKA FQRHDHLARH RSHFHLKDKA
560 570 580
RPFQCRYCVK SFTQNYDLLR HERLHMKRRS KQALNSY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DGR5 | A0A0C4DGR5_HUMAN | Zinc finger protein 496 | ZNF496 | 512 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038755 | 217 | P → PRIFQFNNHRSNGYILEMLG SGGKKAQIISVLSQIYV in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC104335 Genomic DNA No translation available. BC007263 mRNA Translation: AAH07263.1 BC025794 mRNA Translation: AAH25794.1 |
CCDSi | CCDS1631.1 [Q96IT1-1] |
RefSeqi | NP_116141.1, NM_032752.2 [Q96IT1-1] XP_005273385.1, XM_005273328.3 |
Genome annotation databases
Ensembli | ENST00000294753; ENSP00000294753; ENSG00000162714 [Q96IT1-1] |
GeneIDi | 84838 |
KEGGi | hsa:84838 |
UCSCi | uc001ico.4, human [Q96IT1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC104335 Genomic DNA No translation available. BC007263 mRNA Translation: AAH07263.1 BC025794 mRNA Translation: AAH25794.1 |
CCDSi | CCDS1631.1 [Q96IT1-1] |
RefSeqi | NP_116141.1, NM_032752.2 [Q96IT1-1] XP_005273385.1, XM_005273328.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 124291, 43 interactors |
IntActi | Q96IT1, 29 interactors |
MINTi | Q96IT1 |
STRINGi | 9606.ENSP00000294753 |
PTM databases
iPTMneti | Q96IT1 |
PhosphoSitePlusi | Q96IT1 |
Genetic variation databases
BioMutai | ZNF496 |
DMDMi | 55976755 |
Proteomic databases
jPOSTi | Q96IT1 |
MassIVEi | Q96IT1 |
MaxQBi | Q96IT1 |
PaxDbi | Q96IT1 |
PeptideAtlasi | Q96IT1 |
PRIDEi | Q96IT1 |
ProteomicsDBi | 76850 [Q96IT1-1] 76851 [Q96IT1-2] |
Protocols and materials databases
Antibodypediai | 20839, 156 antibodies |
DNASUi | 84838 |
Genome annotation databases
Ensembli | ENST00000294753; ENSP00000294753; ENSG00000162714 [Q96IT1-1] |
GeneIDi | 84838 |
KEGGi | hsa:84838 |
UCSCi | uc001ico.4, human [Q96IT1-1] |
Organism-specific databases
CTDi | 84838 |
DisGeNETi | 84838 |
GeneCardsi | ZNF496 |
HGNCi | HGNC:23713, ZNF496 |
HPAi | ENSG00000162714, Low tissue specificity |
MIMi | 613911, gene |
neXtProti | NX_Q96IT1 |
OpenTargetsi | ENSG00000162714 |
PharmGKBi | PA134888470 |
VEuPathDBi | HostDB:ENSG00000162714.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161967 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | Q96IT1 |
OMAi | DMIFCFS |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96IT1 |
TreeFami | TF350829 |
Enzyme and pathway databases
PathwayCommonsi | Q96IT1 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 84838, 3 hits in 896 CRISPR screens |
ChiTaRSi | ZNF496, human |
GenomeRNAii | 84838 |
Pharosi | Q96IT1, Tdark |
PROi | PR:Q96IT1 |
RNActi | Q96IT1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162714, Expressed in stomach and 203 other tissues |
ExpressionAtlasi | Q96IT1, baseline and differential |
Genevisiblei | Q96IT1, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR027767, Zfp496 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23226:SF180, PTHR23226:SF180, 1 hit |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF02023, SCAN, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN496_HUMAN | |
Accessioni | Q96IT1Primary (citable) accession number: Q96IT1 Secondary accession number(s): Q8TBS2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families