UniProtKB - Q96IR2 (ZN845_HUMAN)
Protein
Zinc finger protein 845
Gene
ZNF845
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 215 – 237 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 243 – 265 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 271 – 293 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 299 – 321 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 327 – 349 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 355 – 377 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 383 – 405 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 411 – 433 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 439 – 461 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 467 – 489 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 495 – 517 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 523 – 545 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 551 – 573 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 579 – 601 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 607 – 629 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 635 – 657 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 663 – 685 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 691 – 713 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 719 – 741 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 747 – 769 | C2H2-type 20PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 775 – 797 | C2H2-type 21PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 803 – 825 | C2H2-type 22PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 831 – 853 | C2H2-type 23PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 859 – 881 | C2H2-type 24PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 887 – 909 | C2H2-type 25PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 915 – 937 | C2H2-type 26PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 943 – 965 | C2H2-type 27PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96IR2 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 845 |
Gene namesi | Name:ZNF845 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25112, ZNF845 |
neXtProti | NX_Q96IR2 |
VEuPathDBi | HostDB:ENSG00000213799.10 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000213799 |
PharmGKBi | PA162410863 |
Miscellaneous databases
Pharosi | Q96IR2, Tdark |
Genetic variation databases
BioMutai | ZNF845 |
DMDMi | 296453067 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000349878 | 1 – 970 | Zinc finger protein 845Add BLAST | 970 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 205 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q96IR2 |
jPOSTi | Q96IR2 |
MassIVEi | Q96IR2 |
MaxQBi | Q96IR2 |
PaxDbi | Q96IR2 |
PeptideAtlasi | Q96IR2 |
PRIDEi | Q96IR2 |
ProteomicsDBi | 76846 |
PTM databases
iPTMneti | Q96IR2 |
PhosphoSitePlusi | Q96IR2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000213799, Expressed in calcaneal tendon and 123 other tissues |
Organism-specific databases
HPAi | ENSG00000213799, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124863, 9 interactors |
IntActi | Q96IR2, 5 interactors |
STRINGi | 9606.ENSP00000388311 |
Miscellaneous databases
RNActi | Q96IR2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 81 | KRABPROSITE-ProRule annotationAdd BLAST | 74 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 215 – 237 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 243 – 265 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 271 – 293 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 299 – 321 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 327 – 349 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 355 – 377 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 383 – 405 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 411 – 433 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 439 – 461 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 467 – 489 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 495 – 517 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 523 – 545 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 551 – 573 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 579 – 601 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 607 – 629 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 635 – 657 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 663 – 685 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 691 – 713 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 719 – 741 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 747 – 769 | C2H2-type 20PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 775 – 797 | C2H2-type 21PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 803 – 825 | C2H2-type 22PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 831 – 853 | C2H2-type 23PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 859 – 881 | C2H2-type 24PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 887 – 909 | C2H2-type 25PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 915 – 937 | C2H2-type 26PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 943 – 965 | C2H2-type 27PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000155274 |
HOGENOMi | CLU_002678_17_0_1 |
InParanoidi | Q96IR2 |
OMAi | IIHLGAK |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96IR2 |
TreeFami | TF343410 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 24 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 27 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 16 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 26 hits PS50157, ZINC_FINGER_C2H2_2, 27 hits |
i Sequence
Sequence statusi: Complete.
Q96IR2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALSQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS
60 70 80 90 100
SKCMMKEFSS TAQGNTEVIH TGTLQRHERH HIGDFCFQEM EKDIHDFEFQ
110 120 130 140 150
WKEDERNSHE APMTEIKQLT GSTNRHDQRH AGNKPIKDQL GSSFHSHLPE
160 170 180 190 200
LHMFQTEGKI GNQVEKSINS ASLVSTSQRI SCRPKTHISK NYGNNFLNSS
210 220 230 240 250
LLTQKQEVHM REKSFQCNES GKAFNYSSVL RKHQIIHLGA KQYKCDVCGK
260 270 280 290 300
VFNQKRYLAC HRRCHTGKKP YKCNDCGKTF SQELTLTCHH RLHTGEKHYK
310 320 330 340 350
CSECGKTFSR NSALVIHKAI HTGEKSYKCN ECGKTFSQTS YLVYHRRLHT
360 370 380 390 400
GEKPYKCEEC DKAFSFKSNL ERHRKIHTGE KPYKCNECSR TFSRKSSLTR
410 420 430 440 450
HRRLHTGEKP YKCNDCGKTF SQMSSLVYHR RLHTGEKPYK CEECDEAFSF
460 470 480 490 500
KSNLERHRRI HTGEKPYKCN DCGKTFSQTS SLVYHRRLHT GEKPYKCEEC
510 520 530 540 550
DEAFSFKSNL ERHRIIHTGE KLYKCNECGK TFSRKSSLTR HCRLHTGEKP
560 570 580 590 600
YQCNECGKAF RGQSALIYHQ AIHGIGKLYK CNDCHQVFSN ATTIANHWRI
610 620 630 640 650
HNEERSYKCN RCGKFFRHRS YLAVHWRTHS GEKPYKCEEC DEAFSFKSNL
660 670 680 690 700
QRHRRIHTGE KPYRCNECGK TFSRKSYLTC HRRLHTGEKP YKCNECGKTF
710 720 730 740 750
GRNSALIIHK AIHTGEKPYK CNECGKAFSQ KSSLTCHLRL HTGEKPYKCE
760 770 780 790 800
ECDKVFSRKS SLEKHRRIHT GEKPYKCKVC DKAFGRDSHL AQHTRIHTGE
810 820 830 840 850
KPYKCNECGK NFRHNSALVI HKAIHSGEKP YKCNECGKTF RHNSALEIHK
860 870 880 890 900
AIHTGEKPYK CSECGKVFNR KANLSRHHRL HTGEKPYKCN KCGKVFNQQA
910 920 930 940 950
HLACHHRIHT GEKPYKCNEC GKTFRHNSVL VIHKTIHTGE KPYKCNECGK
960 970
VFNRKAKLAR HHRIHTGKKH
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 348 | L → F in AAH07307 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 537 | S → F in BAG58121 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 662 – 745 | Missing in BAG58121 (PubMed:14702039).CuratedAdd BLAST | 84 | |
Sequence conflicti | 807 | E → D in AAH07307 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK295079 mRNA Translation: BAG58121.1 AC010467 Genomic DNA No translation available. BC007307 mRNA Translation: AAH07307.1 |
CCDSi | CCDS46170.1 |
RefSeqi | NP_001308451.1, NM_001321522.1 NP_001308452.1, NM_001321523.1 NP_001308453.1, NM_001321524.1 NP_612383.1, NM_138374.2 |
Genome annotation databases
Ensembli | ENST00000458035; ENSP00000388311; ENSG00000213799 ENST00000595091; ENSP00000470005; ENSG00000213799 |
GeneIDi | 91664 |
KEGGi | hsa:91664 |
UCSCi | uc010ydv.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK295079 mRNA Translation: BAG58121.1 AC010467 Genomic DNA No translation available. BC007307 mRNA Translation: AAH07307.1 |
CCDSi | CCDS46170.1 |
RefSeqi | NP_001308451.1, NM_001321522.1 NP_001308452.1, NM_001321523.1 NP_001308453.1, NM_001321524.1 NP_612383.1, NM_138374.2 |
3D structure databases
SMRi | Q96IR2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124863, 9 interactors |
IntActi | Q96IR2, 5 interactors |
STRINGi | 9606.ENSP00000388311 |
PTM databases
iPTMneti | Q96IR2 |
PhosphoSitePlusi | Q96IR2 |
Genetic variation databases
BioMutai | ZNF845 |
DMDMi | 296453067 |
Proteomic databases
EPDi | Q96IR2 |
jPOSTi | Q96IR2 |
MassIVEi | Q96IR2 |
MaxQBi | Q96IR2 |
PaxDbi | Q96IR2 |
PeptideAtlasi | Q96IR2 |
PRIDEi | Q96IR2 |
ProteomicsDBi | 76846 |
Protocols and materials databases
Antibodypediai | 32690, 73 antibodies |
Genome annotation databases
Ensembli | ENST00000458035; ENSP00000388311; ENSG00000213799 ENST00000595091; ENSP00000470005; ENSG00000213799 |
GeneIDi | 91664 |
KEGGi | hsa:91664 |
UCSCi | uc010ydv.1, human |
Organism-specific databases
CTDi | 91664 |
GeneCardsi | ZNF845 |
HGNCi | HGNC:25112, ZNF845 |
HPAi | ENSG00000213799, Low tissue specificity |
neXtProti | NX_Q96IR2 |
OpenTargetsi | ENSG00000213799 |
PharmGKBi | PA162410863 |
VEuPathDBi | HostDB:ENSG00000213799.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000155274 |
HOGENOMi | CLU_002678_17_0_1 |
InParanoidi | Q96IR2 |
OMAi | IIHLGAK |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q96IR2 |
TreeFami | TF343410 |
Enzyme and pathway databases
PathwayCommonsi | Q96IR2 |
Miscellaneous databases
BioGRID-ORCSi | 91664, 10 hits in 872 CRISPR screens |
ChiTaRSi | ZNF845, human |
GenomeRNAii | 91664 |
Pharosi | Q96IR2, Tdark |
PROi | PR:Q96IR2 |
RNActi | Q96IR2, protein |
Gene expression databases
Bgeei | ENSG00000213799, Expressed in calcaneal tendon and 123 other tissues |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 24 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 27 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 16 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 26 hits PS50157, ZINC_FINGER_C2H2_2, 27 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN845_HUMAN | |
Accessioni | Q96IR2Primary (citable) accession number: Q96IR2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 10, 2021 | |
This is version 155 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM