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Protein

Zinc finger protein 414

Gene

ZNF414

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri109 – 133C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri145 – 169C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri176 – 201C2H2-type 3PROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 414
Gene namesi
Name:ZNF414
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000133250.13
HGNCiHGNC:20630 ZNF414
neXtProtiNX_Q96IQ9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133250
PharmGKBiPA142670521

Polymorphism and mutation databases

BioMutaiZNF414
DMDMi125987870

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002421631 – 312Zinc finger protein 414Add BLAST312

Proteomic databases

MaxQBiQ96IQ9
PaxDbiQ96IQ9
PeptideAtlasiQ96IQ9
PRIDEiQ96IQ9
ProteomicsDBi76845

PTM databases

iPTMnetiQ96IQ9
PhosphoSitePlusiQ96IQ9

Expressioni

Gene expression databases

BgeeiENSG00000133250
CleanExiHS_ZNF414
ExpressionAtlasiQ96IQ9 baseline and differential
GenevisibleiQ96IQ9 HS

Organism-specific databases

HPAiHPA053769

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124054, 41 interactors
IntActiQ96IQ9, 47 interactors
STRINGi9606.ENSP00000377504

Structurei

3D structure databases

ProteinModelPortaliQ96IQ9
SMRiQ96IQ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri109 – 133C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri145 – 169C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri176 – 201C2H2-type 3PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00390000006876
HOGENOMiHOG000015387
HOVERGENiHBG083015
InParanoidiQ96IQ9
OMAiEGECPVF
OrthoDBiEOG091G0DB2
PhylomeDBiQ96IQ9
TreeFamiTF337512

Family and domain databases

InterProiView protein in InterPro
IPR031799 Znf-C2H2_ribbon
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF15909 zf-C2H2_8, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96IQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEKPSGPIP DMLATAEPSS SETDKEVLSP AVPAAAPSSS MSEEPGPEQA
60 70 80 90 100
ATPPVWERGG AGGMQQGSSP APDSCQPGPG PSPGLTSIVS GTSEDLRPPR
110 120 130 140 150
RRPPPGKQIP CSSPGCCLSF PSVRDLAQHL RTHCPPTQSL EGKLFRCSAL
160 170 180 190 200
SCTETFPSMQ ELVAHSKLHY KPNRYFKCEN CLLRFRTHRS LFKHLHVCAE
210 220 230 240 250
HAQSPAPPPP PALDREPPAP ERPPEVDPAS APGLPFPLLE PFTTPAPAPT
260 270 280 290 300
GPFLPYLNPA PFGLSPPRLR PFLAAAPGPP ASSAAVWKKS QGAGSSPRRP
310
QGGSDAPSGA CR
Length:312
Mass (Da):32,782
Last modified:February 6, 2007 - v2
Checksum:iB3DFB0C66CD09796
GO
Isoform 2 (identifier: Q96IQ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     310-312: ACR → HAAPSRIVWE...EGELPVFSQL

Note: No experimental confirmation available.Curated
Show »
Length:390
Mass (Da):40,994
Checksum:i63433534FF314166
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q96IQ9-2)
Sequence conflicti357A → P in AK074191 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02684765Q → R1 PublicationCorresponds to variant dbSNP:rs8100431Ensembl.1
Natural variantiVAR_02684877P → S1 PublicationCorresponds to variant dbSNP:rs1064010Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045351310 – 312ACR → HAAPSRIVWEHTRGRYSCMQ CAFSTASRPAMTLHLEDHRP GAPAAPAAGPPRPDAPADPA PLAPKVSPLLSEGELPVFSQ L in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074191 mRNA No translation available.
AC092298 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW68915.1
BC007310 mRNA Translation: AAH07310.1
BC071937 mRNA Translation: AAH71937.1
CCDSiCCDS12205.1 [Q96IQ9-1]
CCDS54211.1 [Q96IQ9-2]
RefSeqiNP_001139647.1, NM_001146175.1 [Q96IQ9-2]
NP_115746.2, NM_032370.2 [Q96IQ9-1]
UniGeneiHs.515114

Genome annotation databases

EnsembliENST00000255616; ENSP00000255616; ENSG00000133250 [Q96IQ9-1]
ENST00000393927; ENSP00000377504; ENSG00000133250 [Q96IQ9-2]
GeneIDi84330
KEGGihsa:84330
UCSCiuc002mke.5 human [Q96IQ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN414_HUMAN
AccessioniPrimary (citable) accession number: Q96IQ9
Secondary accession number(s): A8MY94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: February 6, 2007
Last modified: June 20, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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