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Entry version 143 (12 Aug 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Germ cell-less protein-like 1

Gene

GMCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96IK5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Germ cell-less protein-like 1
Alternative name(s):
Spermatogenesis-associated protein 29
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GMCL1
Synonyms:BTBD13, GCL, SPATA29
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000087338.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23843, GMCL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618627, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96IK5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64395

Open Targets

More...
OpenTargetsi
ENSG00000087338

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485477

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96IK5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GMCL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47605732

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000875201 – 515Germ cell-less protein-like 1Add BLAST515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei66PhosphoserineBy similarity1
Modified residuei68PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96IK5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96IK5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96IK5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96IK5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96IK5

PeptideAtlas

More...
PeptideAtlasi
Q96IK5

PRoteomics IDEntifications database

More...
PRIDEi
Q96IK5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76838

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96IK5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96IK5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000087338, Expressed in testis and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96IK5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96IK5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000087338, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TMPO-beta, TSG101 and TFDP2 (By similarity).

Interacts with EMD.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q96IK5
With#Exp.IntAct
APOL6 [Q9BWW8]3EBI-2548508,EBI-11574440
AXIN1 [A0A0S2Z4M1]3EBI-2548508,EBI-16429430
BEGAIN [Q9BUH8]5EBI-2548508,EBI-742722
BSCL2 [J3KQ12]3EBI-2548508,EBI-11532900
BYSL [Q13895]5EBI-2548508,EBI-358049
CCDC13 [Q8IYE1]5EBI-2548508,EBI-10961312
CDC37 [Q16543]3EBI-2548508,EBI-295634
CFAP410 - isoform 4 [O43822-4]3EBI-2548508,EBI-11943144
CHIC2 [Q9UKJ5]3EBI-2548508,EBI-741528
CIB3 [Q96Q77]3EBI-2548508,EBI-10292696
CUL3 [Q13618]5EBI-2548508,EBI-456129
DAXX [Q9UER7]3EBI-2548508,EBI-77321
EHHADH [Q08426]3EBI-2548508,EBI-2339219
ELOA [Q14241]3EBI-2548508,EBI-742350
EXOC3 [O60645]3EBI-2548508,EBI-1052278
FAM167A [Q96KS9]6EBI-2548508,EBI-10290462
FAM50B [Q9Y247]3EBI-2548508,EBI-742802
FLYWCH1 [Q4VC44]3EBI-2548508,EBI-719415
FOXR1 [Q6PIV2]3EBI-2548508,EBI-10253815
GAGE10 [A6NGK3]4EBI-2548508,EBI-12281306
GAGE2C [Q13066]6EBI-2548508,EBI-12329121
GAGE5 [Q13069]6EBI-2548508,EBI-745702
itself6EBI-2548508,EBI-2548508
HYKK [A0A0C4DGM4]5EBI-2548508,EBI-10236738
KANK2 [Q63ZY3]3EBI-2548508,EBI-2556193
KAT5 [Q92993]5EBI-2548508,EBI-399080
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-2548508,EBI-14069005
KRT75 [O95678]3EBI-2548508,EBI-2949715
LNX1 [Q8TBB1]3EBI-2548508,EBI-739832
MFAP1 [P55081]3EBI-2548508,EBI-1048159
MID1 [O15344]10EBI-2548508,EBI-2340316
MID2 - isoform 2 [Q9UJV3-2]5EBI-2548508,EBI-10172526
MINDY1 - isoform 3 [Q8N5J2-3]3EBI-2548508,EBI-12382151
MORF4L1 - isoform 2 [Q9UBU8-2]3EBI-2548508,EBI-10288852
MYLIP [Q8WY64]3EBI-2548508,EBI-6952711
MYO5B - isoform 2 [Q9ULV0-2]3EBI-2548508,EBI-14093244
NFIL3 [Q16649]3EBI-2548508,EBI-3951858
PARD6B [Q9BYG5]3EBI-2548508,EBI-295391
PAX4 [Q3KNR5]6EBI-2548508,EBI-10240813
PBXIP1 [Q96AQ6]5EBI-2548508,EBI-740845
PIBF1 [Q4G0R1]3EBI-2548508,EBI-14066006
PIH1D2 [Q8WWB5]3EBI-2548508,EBI-10232538
PPP1R18 [Q6NYC8]3EBI-2548508,EBI-2557469
PRPF18 [Q99633]3EBI-2548508,EBI-2798416
PTPN7 - isoform 2 [P35236-2]3EBI-2548508,EBI-12281408
QRICH1 [Q2TAL8]5EBI-2548508,EBI-2798044
RASA1 [P20936]3EBI-2548508,EBI-1026476
RNF4 [P78317]5EBI-2548508,EBI-2340927
RNMT [O43148]3EBI-2548508,EBI-877832
SHQ1 [Q6PI26]3EBI-2548508,EBI-2515568
SYT6 - isoform 2 [Q5T7P8-2]3EBI-2548508,EBI-10246152
TBC1D1 [Q86TI0]3EBI-2548508,EBI-1644036
TLK2 [Q86UE8]3EBI-2548508,EBI-1047967
TRIM21 [P19474]3EBI-2548508,EBI-81290
UBE2I [P63279]4EBI-2548508,EBI-80168
UBE2I [Q7KZS0]3EBI-2548508,EBI-10180829
XAGE2 [Q96GT9]5EBI-2548508,EBI-750167
XAGE3 [Q8WTP9]6EBI-2548508,EBI-6448284
YY1 [P25490]5EBI-2548508,EBI-765538
ZBTB24 [O43167]3EBI-2548508,EBI-744471
ZIM2 [Q9NZV7]3EBI-2548508,EBI-11962760
ZMYM2 [Q9UBW7]3EBI-2548508,EBI-2797576
ZNF23 [P17027]3EBI-2548508,EBI-5657766
ZSWIM3 [Q96MP5]3EBI-2548508,EBI-5235554
A0A384ME253EBI-2548508,EBI-10211777

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122152, 118 interactors

Protein interaction database and analysis system

More...
IntActi
Q96IK5, 107 interactors

Molecular INTeraction database

More...
MINTi
Q96IK5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000282570

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96IK5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96IK5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini108 – 178BTBPROSITE-ProRule annotationAdd BLAST71

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi49 – 55Nuclear localization signalSequence analysis7
Motifi85 – 91Nuclear localization signalSequence analysis7

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4682, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156185

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_025961_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96IK5

KEGG Orthology (KO)

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KOi
K10485

Identification of Orthologs from Complete Genome Data

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OMAi
YACASIY

Database of Orthologous Groups

More...
OrthoDBi
1111791at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96IK5

TreeFam database of animal gene trees

More...
TreeFami
TF316048

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011705, BACK
IPR000210, BTB/POZ_dom
IPR043380, Gcl-like
IPR011333, SKP1/BTB/POZ_sf

The PANTHER Classification System

More...
PANTHERi
PTHR23231, PTHR23231, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF07707, BACK, 1 hit
PF00651, BTB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00875, BACK, 1 hit
SM00225, BTB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54695, SSF54695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097, BTB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96IK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSLSSRVLR QPRPALAQQA QGARAGGSAR RPDTGDDAAG HGFCYCAGSH
60 70 80 90 100
KRKRSSGSFC YCHPDSETDE DEEEGDEQQR LLNTPRRKKL KSTSKYIYQT
110 120 130 140 150
LFLNGENSDI KICALGEEWS LHKIYLCQSG YFSSMFSGSW KESSMNIIEL
160 170 180 190 200
EIPDQNIDVE ALQVAFGSLY RDDVLIKPSR VVAILAAACL LQLDGLIQQC
210 220 230 240 250
GETMKETVNV KTVCGYYTSA GTYGLDSVKK KCLEWLLNNL MTHQNVELFK
260 270 280 290 300
ELSINVMKQL IGSSNLFVMQ VEMDIYTALK KWMFLQLVPS WNGSLKQLLT
310 320 330 340 350
ETDVWFSKQR KDFEGMAFLE TEQGKPFVSV FRHLRLQYII SDLASARIIE
360 370 380 390 400
QDAVVPSEWL SSVYKQQWFA MLRAEQDSEV GPQEINKEEL EGNSMRCGRK
410 420 430 440 450
LAKDGEYCWR WTGFNFGFDL LVTYTNRYII FKRNTLNQPC SGSVSLQPRR
460 470 480 490 500
SIAFRLRLAS FDSSGKLICS RTTGYQILTL EKDQEQVVMN LDSRLLIFPL
510
YICCNFLYIS PEKKN
Length:515
Mass (Da):58,685
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA310AEE9CE1AEEE
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14494 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti157I → M in BAB14416 (PubMed:14702039).Curated1
Sequence conflicti160E → G in BAB14796 (PubMed:14702039).Curated1
Sequence conflicti160E → V in BAB14494 (PubMed:14702039).Curated1
Sequence conflicti207T → A in BAB14796 (PubMed:14702039).Curated1
Sequence conflicti325K → N in BAB14494 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK023119 mRNA Translation: BAB14416.1
AK023261 mRNA Translation: BAB14494.1 Different initiation.
AK024042 mRNA Translation: BAB14796.1
BC007420 mRNA Translation: AAH07420.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1895.1

NCBI Reference Sequences

More...
RefSeqi
NP_848526.1, NM_178439.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000282570; ENSP00000282570; ENSG00000087338

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64395

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64395

UCSC genome browser

More...
UCSCi
uc002sfu.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023119 mRNA Translation: BAB14416.1
AK023261 mRNA Translation: BAB14494.1 Different initiation.
AK024042 mRNA Translation: BAB14796.1
BC007420 mRNA Translation: AAH07420.1
CCDSiCCDS1895.1
RefSeqiNP_848526.1, NM_178439.4

3D structure databases

SMRiQ96IK5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122152, 118 interactors
IntActiQ96IK5, 107 interactors
MINTiQ96IK5
STRINGi9606.ENSP00000282570

PTM databases

iPTMnetiQ96IK5
PhosphoSitePlusiQ96IK5

Polymorphism and mutation databases

BioMutaiGMCL1
DMDMi47605732

Proteomic databases

EPDiQ96IK5
jPOSTiQ96IK5
MassIVEiQ96IK5
MaxQBiQ96IK5
PaxDbiQ96IK5
PeptideAtlasiQ96IK5
PRIDEiQ96IK5
ProteomicsDBi76838

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
48205, 64 antibodies

The DNASU plasmid repository

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DNASUi
64395

Genome annotation databases

EnsembliENST00000282570; ENSP00000282570; ENSG00000087338
GeneIDi64395
KEGGihsa:64395
UCSCiuc002sfu.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64395
DisGeNETi64395
EuPathDBiHostDB:ENSG00000087338.4

GeneCards: human genes, protein and diseases

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GeneCardsi
GMCL1
HGNCiHGNC:23843, GMCL1
HPAiENSG00000087338, Low tissue specificity
MIMi618627, gene
neXtProtiNX_Q96IK5
OpenTargetsiENSG00000087338
PharmGKBiPA143485477

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4682, Eukaryota
GeneTreeiENSGT00940000156185
HOGENOMiCLU_025961_2_0_1
InParanoidiQ96IK5
KOiK10485
OMAiYACASIY
OrthoDBi1111791at2759
PhylomeDBiQ96IK5
TreeFamiTF316048

Enzyme and pathway databases

PathwayCommonsiQ96IK5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
64395, 3 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GMCL1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64395
PharosiQ96IK5, Tbio

Protein Ontology

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PROi
PR:Q96IK5
RNActiQ96IK5, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000087338, Expressed in testis and 222 other tissues
ExpressionAtlasiQ96IK5, baseline and differential
GenevisibleiQ96IK5, HS

Family and domain databases

InterProiView protein in InterPro
IPR011705, BACK
IPR000210, BTB/POZ_dom
IPR043380, Gcl-like
IPR011333, SKP1/BTB/POZ_sf
PANTHERiPTHR23231, PTHR23231, 1 hit
PfamiView protein in Pfam
PF07707, BACK, 1 hit
PF00651, BTB, 1 hit
SMARTiView protein in SMART
SM00875, BACK, 1 hit
SM00225, BTB, 1 hit
SUPFAMiSSF54695, SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097, BTB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGMCL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96IK5
Secondary accession number(s): Q9H826, Q9H8V7, Q9H927
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: August 12, 2020
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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