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Entry version 118 (11 Dec 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Transmembrane protein 101

Gene

TMEM101

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May activate NF-kappa-B signaling pathways.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 101
Alternative name(s):
Putative NF-kappa-B-activating protein 130
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM101
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000091947.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28653 TMEM101

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96IK0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei21 – 40HelicalSequence analysisAdd BLAST20
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000091947

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670750

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96IK0 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM101

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74732068

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002408641 – 257Transmembrane protein 101Add BLAST257

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96IK0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96IK0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96IK0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96IK0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96IK0

PeptideAtlas

More...
PeptideAtlasi
Q96IK0

PRoteomics IDEntifications database

More...
PRIDEi
Q96IK0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76835

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000091947 Expressed in 185 organ(s), highest expression level in vagina

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96IK0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96IK0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039739

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124060, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q96IK0, 11 interactors

Molecular INTeraction database

More...
MINTi
Q96IK0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000468025

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96IK0 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96IK0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG43 Eukaryota
ENOG410XR0V LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011938

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232137

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96IK0

Identification of Orthologs from Complete Genome Data

More...
OMAi
CMVYSLQ

Database of Orthologous Groups

More...
OrthoDBi
1351524at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96IK0

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029371 TMEM101

The PANTHER Classification System

More...
PANTHERi
PTHR31034 PTHR31034, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15111 TMEM101, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q96IK0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASKIGSRRW MLQLIMQLGS VLLTRCPFWG CFSQLMLYAE RAEARRKPDI
60 70 80 90 100
PVPYLYFDMG AAVLCASFMS FGVKRRWFAL GAALQLAIST YAAYIGGYVH
110 120 130 140 150
YGDWLKVRMY SRTVAIIGGF LVLASGAGEL YRRKPRSRSL QSTGQVFLGI
160 170 180 190 200
YLICVAYSLQ HSKEDRLAYL NHLPGGELMI QLFFVLYGIL ALAFLSGYYV
210 220 230 240 250
TLAAQILAVL LPPVMLLIDG NVAYWHNTRR VEFWNQMKLL GESVGIFGTA

VILATDG
Length:257
Mass (Da):28,795
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2939392B69AFB2D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EM07K7EM07_HUMAN
Transmembrane protein 101
TMEM101
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EM72K7EM72_HUMAN
Transmembrane protein 101
TMEM101
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERS4K7ERS4_HUMAN
Transmembrane protein 101
TMEM101
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPU9K7EPU9_HUMAN
Transmembrane protein 101
TMEM101
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB097008 mRNA Translation: BAC77361.1
AK313855 mRNA Translation: BAG36583.1
CH471178 Genomic DNA Translation: EAW51642.1
BC007438 mRNA Translation: AAH07438.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11474.1

NCBI Reference Sequences

More...
RefSeqi
NP_001291742.1, NM_001304813.1
NP_001291743.1, NM_001304814.1
NP_115752.1, NM_032376.3
XP_005257794.1, XM_005257737.2
XP_011523648.1, XM_011525346.1
XP_011523649.1, XM_011525347.1
XP_011523651.1, XM_011525349.1
XP_011523653.1, XM_011525351.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000206380; ENSP00000206380; ENSG00000091947
ENST00000589334; ENSP00000468025; ENSG00000091947

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84336

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84336

UCSC genome browser

More...
UCSCi
uc002ieu.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097008 mRNA Translation: BAC77361.1
AK313855 mRNA Translation: BAG36583.1
CH471178 Genomic DNA Translation: EAW51642.1
BC007438 mRNA Translation: AAH07438.1
CCDSiCCDS11474.1
RefSeqiNP_001291742.1, NM_001304813.1
NP_001291743.1, NM_001304814.1
NP_115752.1, NM_032376.3
XP_005257794.1, XM_005257737.2
XP_011523648.1, XM_011525346.1
XP_011523649.1, XM_011525347.1
XP_011523651.1, XM_011525349.1
XP_011523653.1, XM_011525351.1

3D structure databases

SMRiQ96IK0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124060, 3 interactors
IntActiQ96IK0, 11 interactors
MINTiQ96IK0
STRINGi9606.ENSP00000468025

Polymorphism and mutation databases

BioMutaiTMEM101
DMDMi74732068

Proteomic databases

EPDiQ96IK0
jPOSTiQ96IK0
MassIVEiQ96IK0
MaxQBiQ96IK0
PaxDbiQ96IK0
PeptideAtlasiQ96IK0
PRIDEiQ96IK0
ProteomicsDBi76835

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
84336

Genome annotation databases

EnsembliENST00000206380; ENSP00000206380; ENSG00000091947
ENST00000589334; ENSP00000468025; ENSG00000091947
GeneIDi84336
KEGGihsa:84336
UCSCiuc002ieu.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84336
EuPathDBiHostDB:ENSG00000091947.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM101
HGNCiHGNC:28653 TMEM101
HPAiHPA039739
neXtProtiNX_Q96IK0
OpenTargetsiENSG00000091947
PharmGKBiPA142670750

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IG43 Eukaryota
ENOG410XR0V LUCA
GeneTreeiENSGT00390000011938
HOGENOMiHOG000232137
InParanoidiQ96IK0
OMAiCMVYSLQ
OrthoDBi1351524at2759
PhylomeDBiQ96IK0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TMEM101 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84336
PharosiQ96IK0 Tdark

Protein Ontology

More...
PROi
PR:Q96IK0
RNActiQ96IK0 protein

Gene expression databases

BgeeiENSG00000091947 Expressed in 185 organ(s), highest expression level in vagina
ExpressionAtlasiQ96IK0 baseline and differential
GenevisibleiQ96IK0 HS

Family and domain databases

InterProiView protein in InterPro
IPR029371 TMEM101
PANTHERiPTHR31034 PTHR31034, 1 hit
PfamiView protein in Pfam
PF15111 TMEM101, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM101_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96IK0
Secondary accession number(s): B2R9N6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 1, 2001
Last modified: December 11, 2019
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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