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UniProtKB - Q96II5 (Q96II5_HUMAN)
Protein
Non-specific serine/threonine protein kinase
Gene
ARAF
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 339 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- protein serine/threonine kinase activity Source: UniProtKB-KW
GO - Biological processi
- intracellular signal transduction Source: InterPro
- negative regulation of apoptotic process Source: UniProt
- positive regulation of protein phosphorylation Source: UniProt
- regulation of intracellular signal transduction Source: UniProt
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseARBA annotation, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding, ZincARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Gene namesi | Name:ARAFImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000078061 |
Expressioni
Gene expression databases
Bgeei | ENSG00000078061, Expressed in muscle of leg and 229 other tissues |
ExpressionAtlasi | Q96II5, baseline and differential |
Interactioni
Binary interactionsi
Q96II5
With | #Exp. | IntAct |
---|---|---|
AGTRAP [Q6RW13] | 3 | EBI-9383168,EBI-741181 |
KRAS [P01116] | 3 | EBI-9383168,EBI-367415 |
MAP2K2 [P36507] | 4 | EBI-9383168,EBI-1056930 |
NRAS [P01111] | 3 | EBI-9383168,EBI-721993 |
Protein-protein interaction databases
IntActi | Q96II5, 11 interactors |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 91 | RBDInterPro annotationAdd BLAST | 73 | |
Domaini | 98 – 144 | Phorbol-ester/DAG-typeInterPro annotationAdd BLAST | 47 | |
Domaini | 313 – 573 | Protein kinaseInterPro annotationAdd BLAST | 261 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 162 – 210 | DisorderedSequence analysisAdd BLAST | 49 | |
Regioni | 243 – 293 | DisorderedSequence analysisAdd BLAST | 51 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 162 – 191 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 243 – 274 | Polar residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 275 – 293 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.ARBA annotation
Phylogenomic databases
OMAi | LMQLTAQ |
OrthoDBi | 243095at2759 |
Family and domain databases
CDDi | cd00029, C1, 1 hit |
InterProi | View protein in InterPro IPR020454, DAG/PE-bd IPR011009, Kinase-like_dom_sf IPR002219, PE/DAG-bd IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR003116, RBD_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF02196, RBD, 1 hit |
PRINTSi | PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00455, RBD, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50898, RBD, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96II5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPPRGPPAN GAEPSRAVGT VKVYLPNKQR TVVTVRDGMS VYDSLDKALK
60 70 80 90 100
VRGLNQDCCV VYRLIKGRKT VTAWDTAIAP LDGEELIVEV LEDVPLTMHN
110 120 130 140 150
FVRKTFFSLA FCDFCLKFLF HGFRCQTCGY KFHQHCSSKV PTVCVDMSTN
160 170 180 190 200
RQQPSRFYHS VQDLSGGSRQ HEAPSNRPLN ELLTPQGPSP RTQHCDPEHF
210 220 230 240 250
PFPAPANAPL QRIRSTSTPN VHMVSTTAPM DSNLIQLTGQ SFSTDAAGSR
260 270 280 290 300
GGSDGTPRGS PSPASVSSGR KSPHSKSPAE QRERKSLADD KKKVKNLGYR
310 320 330 340 350
DSGYYWEVPP SEVQLLKRIG TGSFGTVFRG RWHGDVAVKV LKVSQPTAEQ
360 370 380 390 400
AQAFKNEMQV LRKTRHVNIL LFMGFMTRPG FAIITQWCEG SSLYHHLHVA
410 420 430 440 450
DTRFDMVQLI DVARQTAQGM DYLHAKNIIH RDLKSNNIFL HEGLTVKIGD
460 470 480 490 500
FGLATVKTRW SGAQPLEQPS GSVLWMAAEV IRMQDPNPYS FQSDVYAYGV
510 520 530 540 550
VLYELMTGSL PYSHIGCRDQ IIFMVGRGYL SPDLSKISSN CPKAMRRLLS
560 570 580 590 600
DCLKFQREER PLFPQILATI ELLQRSLPKI ERSASEPSLH RTQADELPAC
LLSAARLVP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC007514 mRNA Translation: AAH07514.1 |
RefSeqi | NP_001243125.1, NM_001256196.1 |
Genome annotation databases
GeneIDi | 369 |
UCSCi | uc033ecb.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC007514 mRNA Translation: AAH07514.1 |
RefSeqi | NP_001243125.1, NM_001256196.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q96II5, 11 interactors |
Proteomic databases
MaxQBi | Q96II5 |
PeptideAtlasi | Q96II5 |
PRIDEi | Q96II5 |
Protocols and materials databases
Antibodypediai | 11388, 698 antibodies from 39 providers |
DNASUi | 369 |
Genome annotation databases
GeneIDi | 369 |
UCSCi | uc033ecb.2, human |
Organism-specific databases
CTDi | 369 |
VEuPathDBi | HostDB:ENSG00000078061 |
Phylogenomic databases
OMAi | LMQLTAQ |
OrthoDBi | 243095at2759 |
Miscellaneous databases
BioGRID-ORCSi | 369, 11 hits in 710 CRISPR screens |
ChiTaRSi | ARAF, human |
GenomeRNAii | 369 |
Gene expression databases
Bgeei | ENSG00000078061, Expressed in muscle of leg and 229 other tissues |
ExpressionAtlasi | Q96II5, baseline and differential |
Family and domain databases
CDDi | cd00029, C1, 1 hit |
InterProi | View protein in InterPro IPR020454, DAG/PE-bd IPR011009, Kinase-like_dom_sf IPR002219, PE/DAG-bd IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR003116, RBD_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF02196, RBD, 1 hit |
PRINTSi | PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00455, RBD, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50898, RBD, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q96II5_HUMAN | |
Accessioni | Q96II5Primary (citable) accession number: Q96II5 Secondary accession number(s): A6NIT1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 1, 2001 |
Last sequence update: | December 1, 2001 | |
Last modified: | January 19, 2022 | |
This is version 178 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |