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Protein

F-box/LRR-repeat protein 20

Gene

FBXL20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 20
Alternative name(s):
F-box and leucine-rich repeat protein 20
F-box/LRR-repeat protein 2-like
Gene namesi
Name:FBXL20
Synonyms:FBL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108306.11
HGNCiHGNC:24679 FBXL20
MIMi609086 gene
neXtProtiNX_Q96IG2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000108306
PharmGKBiPA134976410

Polymorphism and mutation databases

BioMutaiFBXL20
DMDMi38503141

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198701 – 436F-box/LRR-repeat protein 20Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei417PhosphothreonineCombined sources1
Modified residuei421PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96IG2
MaxQBiQ96IG2
PaxDbiQ96IG2
PeptideAtlasiQ96IG2
PRIDEiQ96IG2
ProteomicsDBi76826
76827 [Q96IG2-2]

PTM databases

iPTMnetiQ96IG2
PhosphoSitePlusiQ96IG2
SwissPalmiQ96IG2

Expressioni

Gene expression databases

BgeeiENSG00000108306 Expressed in 207 organ(s), highest expression level in secondary oocyte
CleanExiHS_FBXL20
ExpressionAtlasiQ96IG2 baseline and differential
GenevisibleiQ96IG2 HS

Organism-specific databases

HPAiHPA044748
HPA050397

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SKP1P632083EBI-8835647,EBI-307486

Protein-protein interaction databases

BioGridi124392, 8 interactors
IntActiQ96IG2, 1 interactor
STRINGi9606.ENSP00000264658

Structurei

3D structure databases

ProteinModelPortaliQ96IG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 68F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati74 – 100LRR 1Add BLAST27
Repeati101 – 126LRR 2Add BLAST26
Repeati127 – 152LRR 3Add BLAST26
Repeati153 – 178LRR 4Add BLAST26
Repeati179 – 204LRR 5Add BLAST26
Repeati205 – 230LRR 6Add BLAST26
Repeati231 – 256LRR 7Add BLAST26
Repeati257 – 282LRR 8Add BLAST26
Repeati283 – 308LRR 9Add BLAST26
Repeati309 – 334LRR 10Add BLAST26
Repeati335 – 363LRR 11Add BLAST29
Repeati364 – 388LRR 12Add BLAST25
Repeati389 – 414LRR 13Add BLAST26

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4341 Eukaryota
ENOG410XQ54 LUCA
GeneTreeiENSGT00760000119059
HOGENOMiHOG000230659
HOVERGENiHBG051586
InParanoidiQ96IG2
KOiK10268
PhylomeDBiQ96IG2
TreeFamiTF313434

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001810 F-box_dom
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF13516 LRR_6, 4 hits
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00367 LRR_CC, 12 hits
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96IG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRDVNGVTK SRFEMFSNSD EAVINKKLPK ELLLRIFSFL DVVTLCRCAQ
60 70 80 90 100
VSRAWNVLAL DGSNWQRIDL FDFQRDIEGR VVENISKRCG GFLRKLSLRG
110 120 130 140 150
CLGVGDNALR TFAQNCRNIE VLNLNGCTKT TDATCTSLSK FCSKLRHLDL
160 170 180 190 200
ASCTSITNMS LKALSEGCPL LEQLNISWCD QVTKDGIQAL VRGCGGLKAL
210 220 230 240 250
FLKGCTQLED EALKYIGAHC PELVTLNLQT CLQITDEGLI TICRGCHKLQ
260 270 280 290 300
SLCASGCSNI TDAILNALGQ NCPRLRILEV ARCSQLTDVG FTTLARNCHE
310 320 330 340 350
LEKMDLEECV QITDSTLIQL SIHCPRLQVL SLSHCELITD DGIRHLGNGA
360 370 380 390 400
CAHDQLEVIE LDNCPLITDA SLEHLKSCHS LERIELYDCQ QITRAGIKRL
410 420 430
RTHLPNIKVH AYFAPVTPPP SVGGSRQRFC RCCIIL
Length:436
Mass (Da):48,423
Last modified:June 1, 2003 - v2
Checksum:i39CD04A505C8CE3E
GO
Isoform 2 (identifier: Q96IG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-165: Missing.

Show »
Length:404
Mass (Da):44,980
Checksum:iABE96E243C2F3A6D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KTA1J3KTA1_HUMAN
F-box and leucine-rich repeat prote...
FBXL20 hCG_1813440
438Annotation score:
J3QKL3J3QKL3_HUMAN
F-box/LRR-repeat protein 20
FBXL20
115Annotation score:
A0A2R8Y677A0A2R8Y677_HUMAN
F-box/LRR-repeat protein 20
FBXL20
20Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17S → P in BAF84533 (Ref. 1) Curated1
Sequence conflicti375L → F in BAF84533 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030769134 – 165Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ223959 mRNA Translation: ABB03906.1
AK291844 mRNA Translation: BAF84533.1
BC007557 mRNA Translation: AAH07557.2
CCDSiCCDS32640.1 [Q96IG2-1]
CCDS54116.1 [Q96IG2-2]
RefSeqiNP_001171835.1, NM_001184906.1 [Q96IG2-2]
NP_116264.2, NM_032875.2 [Q96IG2-1]
UniGeneiHs.462946

Genome annotation databases

EnsembliENST00000264658; ENSP00000264658; ENSG00000108306 [Q96IG2-1]
ENST00000394294; ENSP00000377832; ENSG00000108306 [Q96IG2-2]
ENST00000583610; ENSP00000462271; ENSG00000108306 [Q96IG2-1]
GeneIDi84961
KEGGihsa:84961
UCSCiuc002hrt.4 human [Q96IG2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ223959 mRNA Translation: ABB03906.1
AK291844 mRNA Translation: BAF84533.1
BC007557 mRNA Translation: AAH07557.2
CCDSiCCDS32640.1 [Q96IG2-1]
CCDS54116.1 [Q96IG2-2]
RefSeqiNP_001171835.1, NM_001184906.1 [Q96IG2-2]
NP_116264.2, NM_032875.2 [Q96IG2-1]
UniGeneiHs.462946

3D structure databases

ProteinModelPortaliQ96IG2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124392, 8 interactors
IntActiQ96IG2, 1 interactor
STRINGi9606.ENSP00000264658

PTM databases

iPTMnetiQ96IG2
PhosphoSitePlusiQ96IG2
SwissPalmiQ96IG2

Polymorphism and mutation databases

BioMutaiFBXL20
DMDMi38503141

Proteomic databases

EPDiQ96IG2
MaxQBiQ96IG2
PaxDbiQ96IG2
PeptideAtlasiQ96IG2
PRIDEiQ96IG2
ProteomicsDBi76826
76827 [Q96IG2-2]

Protocols and materials databases

DNASUi84961
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264658; ENSP00000264658; ENSG00000108306 [Q96IG2-1]
ENST00000394294; ENSP00000377832; ENSG00000108306 [Q96IG2-2]
ENST00000583610; ENSP00000462271; ENSG00000108306 [Q96IG2-1]
GeneIDi84961
KEGGihsa:84961
UCSCiuc002hrt.4 human [Q96IG2-1]

Organism-specific databases

CTDi84961
EuPathDBiHostDB:ENSG00000108306.11
GeneCardsiFBXL20
HGNCiHGNC:24679 FBXL20
HPAiHPA044748
HPA050397
MIMi609086 gene
neXtProtiNX_Q96IG2
OpenTargetsiENSG00000108306
PharmGKBiPA134976410
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4341 Eukaryota
ENOG410XQ54 LUCA
GeneTreeiENSGT00760000119059
HOGENOMiHOG000230659
HOVERGENiHBG051586
InParanoidiQ96IG2
KOiK10268
PhylomeDBiQ96IG2
TreeFamiTF313434

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiFBXL20 human
GenomeRNAii84961
PROiPR:Q96IG2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108306 Expressed in 207 organ(s), highest expression level in secondary oocyte
CleanExiHS_FBXL20
ExpressionAtlasiQ96IG2 baseline and differential
GenevisibleiQ96IG2 HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001810 F-box_dom
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF13516 LRR_6, 4 hits
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00367 LRR_CC, 12 hits
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFXL20_HUMAN
AccessioniPrimary (citable) accession number: Q96IG2
Secondary accession number(s): A8K729, Q38J52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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