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Protein

Immunoglobulin superfamily member 21

Gene

IGSF21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2.By similarity

GO - Molecular functioni

  • cell adhesion molecule binding Source: GO_Central
  • protein homodimerization activity Source: GO_Central
  • signaling receptor activity Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily member 21Curated
Short name:
IgSF21Curated
Gene namesi
Name:IGSF21Combined sources
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117154.11
HGNCiHGNC:28246 IGSF21
neXtProtiNX_Q96ID5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi84966
OpenTargetsiENSG00000117154
PharmGKBiPA142671661

Polymorphism and mutation databases

BioMutaiIGSF21
DMDMi74760871

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000022333825 – 467Immunoglobulin superfamily member 21Add BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 116PROSITE-ProRule annotation
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi407N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi444N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ96ID5
MaxQBiQ96ID5
PaxDbiQ96ID5
PeptideAtlasiQ96ID5
PRIDEiQ96ID5
ProteomicsDBi76824

PTM databases

iPTMnetiQ96ID5
PhosphoSitePlusiQ96ID5

Expressioni

Gene expression databases

BgeeiENSG00000117154 Expressed in 120 organ(s), highest expression level in cerebellum
CleanExiHS_IGSF21
GenevisibleiQ96ID5 HS

Organism-specific databases

HPAiHPA044535

Interactioni

Subunit structurei

Interacts (Ig-like 1 domain) with NRXN2 (via Laminin G-like 1 domain) in a trans-interaction manner.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124396, 31 interactors
IntActiQ96ID5, 31 interactors
MINTiQ96ID5

Structurei

3D structure databases

ProteinModelPortaliQ96ID5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 132Ig-like 1Add BLAST108
Domaini344 – 429Ig-like 2Add BLAST86

Domaini

Ig-like 1 domain is indispensable for synaptogenic activity whereas Ig-like 2 domain is secondarily responsible for the activity.By similarity

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFDU Eukaryota
ENOG410XPIE LUCA
GeneTreeiENSGT00390000002421
HOGENOMiHOG000261657
HOVERGENiHBG061499
InParanoidiQ96ID5
OMAiFLTVMSP
OrthoDBiEOG091G096X
PhylomeDBiQ96ID5
TreeFamiTF331223

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96ID5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTAPSLRRC VCLLLAAILD LARGYLTVNI EPLPPVVAGD AVTLKCNFKT
60 70 80 90 100
DGRMREIVWY RVTDGGTIKQ KIFTFDAMFS TNYSHMENYR KREDLVYQST
110 120 130 140 150
VRLPEVRISD NGPYECHVGI YDRATREKVV LASGNIFLNV MAPPTSIEVV
160 170 180 190 200
AADTPAPFSR YQAQNFTLVC IVSGGKPAPM VYFKRDGEPI DAVPLSEPPA
210 220 230 240 250
ASSGPLQDSR PFRSLLHRDL DDTKMQKSLS LLDAENRGGR PYTERPSRGL
260 270 280 290 300
TPDPNILLQP TTENIPETVV SREFPRWVHS AEPTYFLRHS RTPSSDGTVE
310 320 330 340 350
VRALLTWTLN PQIDNEALFS CEVKHPALSM PMQAEVTLVA PKGPKIVMTP
360 370 380 390 400
SRARVGDTVR ILVHGFQNEV FPEPMFTWTR VGSRLLDGSA EFDGKELVLE
410 420 430 440 450
RVPAELNGSM YRCTAQNPLG STDTHTRLIV FENPNIPRGT EDSNGSIGPT
460
GARLTLVLAL TVILELT
Length:467
Mass (Da):51,835
Last modified:December 1, 2001 - v1
Checksum:iF62DD2C086A3EDAC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti369E → G in BAC11542 (PubMed:16303743).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056049245R → H. Corresponds to variant dbSNP:rs2355877Ensembl.1
Natural variantiVAR_056050379T → M. Corresponds to variant dbSNP:rs12076815Ensembl.1
Natural variantiVAR_035518467T → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs766575681Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075316 mRNA Translation: BAC11542.1
AL356101 Genomic DNA No translation available.
AL359738 Genomic DNA No translation available.
AL365209 Genomic DNA No translation available.
AL050342 Genomic DNA No translation available.
BC007618 mRNA Translation: AAH07618.1
CCDSiCCDS184.1
RefSeqiNP_116269.3, NM_032880.4
UniGeneiHs.212511

Genome annotation databases

EnsembliENST00000251296; ENSP00000251296; ENSG00000117154
GeneIDi84966
KEGGihsa:84966
UCSCiuc001bau.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075316 mRNA Translation: BAC11542.1
AL356101 Genomic DNA No translation available.
AL359738 Genomic DNA No translation available.
AL365209 Genomic DNA No translation available.
AL050342 Genomic DNA No translation available.
BC007618 mRNA Translation: AAH07618.1
CCDSiCCDS184.1
RefSeqiNP_116269.3, NM_032880.4
UniGeneiHs.212511

3D structure databases

ProteinModelPortaliQ96ID5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124396, 31 interactors
IntActiQ96ID5, 31 interactors
MINTiQ96ID5

PTM databases

iPTMnetiQ96ID5
PhosphoSitePlusiQ96ID5

Polymorphism and mutation databases

BioMutaiIGSF21
DMDMi74760871

Proteomic databases

EPDiQ96ID5
MaxQBiQ96ID5
PaxDbiQ96ID5
PeptideAtlasiQ96ID5
PRIDEiQ96ID5
ProteomicsDBi76824

Protocols and materials databases

DNASUi84966
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251296; ENSP00000251296; ENSG00000117154
GeneIDi84966
KEGGihsa:84966
UCSCiuc001bau.3 human

Organism-specific databases

CTDi84966
DisGeNETi84966
EuPathDBiHostDB:ENSG00000117154.11
GeneCardsiIGSF21
H-InvDBiHIX0019907
HGNCiHGNC:28246 IGSF21
HPAiHPA044535
neXtProtiNX_Q96ID5
OpenTargetsiENSG00000117154
PharmGKBiPA142671661
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFDU Eukaryota
ENOG410XPIE LUCA
GeneTreeiENSGT00390000002421
HOGENOMiHOG000261657
HOVERGENiHBG061499
InParanoidiQ96ID5
OMAiFLTVMSP
OrthoDBiEOG091G096X
PhylomeDBiQ96ID5
TreeFamiTF331223

Miscellaneous databases

ChiTaRSiIGSF21 human
GenomeRNAii84966
PROiPR:Q96ID5

Gene expression databases

BgeeiENSG00000117154 Expressed in 120 organ(s), highest expression level in cerebellum
CleanExiHS_IGSF21
GenevisibleiQ96ID5 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIGS21_HUMAN
AccessioniPrimary (citable) accession number: Q96ID5
Secondary accession number(s): Q8NBR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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