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Protein

RNA exonuclease 5

Gene

REXO5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA exonuclease 5Imported (EC:3.1.-.-)
Alternative name(s):
Exonuclease NEF-sp
Gene namesi
Name:REXO5Imported
ORF Names:44M2.3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000005189.19
HGNCiHGNC:24661 REXO5
neXtProtiNX_Q96IC2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000005189

Polymorphism and mutation databases

BioMutaiNA
DMDMi74760869

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002873451 – 774RNA exonuclease 5Add BLAST774

Proteomic databases

EPDiQ96IC2
MaxQBiQ96IC2
PaxDbiQ96IC2
PeptideAtlasiQ96IC2
PRIDEiQ96IC2
ProteomicsDBi76822
76823 [Q96IC2-2]

PTM databases

iPTMnetiQ96IC2
PhosphoSitePlusiQ96IC2

Expressioni

Gene expression databases

BgeeiENSG00000005189
ExpressionAtlasiQ96IC2 baseline and differential
GenevisibleiQ96IC2 HS

Organism-specific databases

HPAiHPA040755
HPA040868

Interactioni

Protein-protein interaction databases

BioGridi123570, 12 interactors
IntActiQ96IC2, 2 interactors
STRINGi9606.ENSP00000261377

Structurei

3D structure databases

ProteinModelPortaliQ96IC2
SMRiQ96IC2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini228 – 376ExonucleaseAdd BLAST149
Domaini505 – 579RRM 1PROSITE-ProRule annotationAdd BLAST75
Domaini600 – 679RRM 2PROSITE-ProRule annotationAdd BLAST80

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2248 Eukaryota
COG0847 LUCA
GeneTreeiENSGT00920000149175
HOVERGENiHBG101031
InParanoidiQ96IC2
KOiK14570
OMAiKPSWCQL
OrthoDBiEOG091G0I6S
PhylomeDBiQ96IC2

Family and domain databases

CDDicd06145 REX1_like, 1 hit
Gene3Di3.30.420.10, 1 hit
3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034922 REX1-like_exo
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00929 RNase_T, 1 hit
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00479 EXOIII, 1 hit
SM00360 RRM, 2 hits
SUPFAMiSSF53098 SSF53098, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96IC2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPEREGTER HPRKVRESRQ APNKLVGAAE AMKAGWDLEE SQPEAKKARL
60 70 80 90 100
STILFTDNCE VTHDQLCELL KYAVLGKSNV PKPSWCQLFH QNHLNNVVVF
110 120 130 140 150
VLQGMSQLHF YRFYLEFGCL RKAFRHKFRL PPPSSDFLAD VVGLQTEQRA
160 170 180 190 200
GDLPKTMEGP LPSNAKAAIN LQDDPIIQKY GSKKVGLTRC LLTKEEMRTF
210 220 230 240 250
HFPLQGFPDC ENFLLTKCNG SIADNSPLFG LDCEMCLTSK GRELTRISLV
260 270 280 290 300
AEGGCCVMDE LVKPENKILD YLTSFSGITK KILNPVTTKL KDVQRQLKAL
310 320 330 340 350
LPPDAVLVGH SLDLDLRALK MIHPYVIDTS LLYVREQGRR FKLKFLAKVI
360 370 380 390 400
LGKDIQCPDR LGHDATEDAR TILELARYFL KHGPKKIAEL NLEALANHQE
410 420 430 440 450
IQAAGQEPKN TAEVLQHPNT SVLECLDSVG QKLLFLTRET DAGELPSSRN
460 470 480 490 500
CQTIKCLSNK EVLEQARVEI PLFPFSIVQF SFKAFSPVLT EEMNKRMRIK
510 520 530 540 550
WTEISTVYAG PFSKNCNLRA LKRLFKSFGP VQSMTFVLET RQPHLCIQYE
560 570 580 590 600
VLEAAQLAIE SLDGILVDGI CIKVQRPVTE LTLDCDTLVN ELEGDSENQG
610 620 630 640 650
SIYLSGVSET FKEQLLQEPR LFLGLEAVIL PKDLKSGKQK KYCFLKFKSF
660 670 680 690 700
GSAQQALNIL TGKDWKLKGR HALTPRHLHA WLRGLPPEST RLPGLRVVPP
710 720 730 740 750
PFEQEALQTL KLDHPKIAAW RWSRKIGKLY NSLCPGTLCL ILLPGTKSTH
760 770
GSLSGLGLMG IKEEEESAGP GLCS
Length:774
Mass (Da):86,886
Last modified:December 1, 2001 - v1
Checksum:i3860D67555EDF91F
GO
Isoform 2 (identifier: Q96IC2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     543-573: Missing.

Show »
Length:743
Mass (Da):83,536
Checksum:iB8DB32F3E54A1E3B
GO

Sequence cautioni

The sequence AAC31668 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18S → G in AAK17192 (Ref. 1) Curated1
Sequence conflicti213F → S in AK057254 (PubMed:14702039).Curated1
Sequence conflicti748S → R in AAC31668 (PubMed:10493829).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025443543 – 573Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332193 mRNA Translation: AAK17192.1
AL136763 mRNA Translation: CAB66697.1
AK057254 mRNA No translation available.
AK314458 mRNA Translation: BAG37066.1
AC004381 Genomic DNA Translation: AAC31668.1 Sequence problems.
CH471228 Genomic DNA Translation: EAW66838.1
BC007646 mRNA Translation: AAH07646.1
BC068503 mRNA Translation: AAH68503.1
AL162035 mRNA Translation: CAB82386.1
CCDSiCCDS10591.1 [Q96IC2-1]
CCDS45437.1 [Q96IC2-2]
PIRiT47187
RefSeqiNP_001138396.1, NM_001144924.1 [Q96IC2-2]
NP_001185982.1, NM_001199053.1 [Q96IC2-1]
NP_112203.2, NM_030941.2 [Q96IC2-1]
XP_005255661.1, XM_005255604.1 [Q96IC2-1]
XP_011544265.1, XM_011545963.1 [Q96IC2-1]
XP_016879228.1, XM_017023739.1 [Q96IC2-2]
UniGeneiHs.177926

Genome annotation databases

EnsembliENST00000261377; ENSP00000261377; ENSG00000005189 [Q96IC2-1]
ENST00000348433; ENSP00000261378; ENSG00000005189 [Q96IC2-2]
ENST00000564274; ENSP00000457616; ENSG00000005189 [Q96IC2-1]
GeneIDi81691
KEGGihsa:81691
UCSCiuc002dhv.4 human [Q96IC2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiREXO5_HUMAN
AccessioniPrimary (citable) accession number: Q96IC2
Secondary accession number(s): B2RB19
, O60364, Q96MB1, Q9BXH9, Q9H0K2, Q9NSM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 1, 2001
Last modified: July 18, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM

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