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Protein
Submitted name:

Homeobox-containing protein PKNOX1

Gene

PKNOX1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi259 – 321HomeoboxPROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotationImported

Names & Taxonomyi

Protein namesi
Submitted name:
Homeobox-containing protein PKNOX1Imported
Submitted name:
PBX/knotted 1 homeobox 1Imported
Submitted name:
PBX/knotted 1 homeobox 1, isoform CRA_bImported
Gene namesi
Name:PKNOX1Imported
ORF Names:hCG_2043122Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000160199.14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33354

Expressioni

Gene expression databases

BgeeiENSG00000160199 Expressed in 210 organ(s), highest expression level in left lobe of thyroid gland

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ96I87, 2 interactors
Q96I87, 2 interactors

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini257 – 320HomeoboxInterPro annotationAdd BLAST64

Keywords - Domaini

HomeoboxPROSITE-ProRule annotationSAAS annotationImported

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
HOVERGENiHBG055193
OMAiITAPVNM
OrthoDBiEOG091G09WJ

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR032453 PKNOX/Meis_N
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
PF16493 Meis_PKNOX_N, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q96I87-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMATQTLSID SYQDGQQMQV VTELKTEQDP NCSEPDAEGV SPPPVESQTP
60 70 80 90 100
MDVDKQAIYR HPLFPLLALL FEKCEQSTQG SEGTTSASFD VDIENFVRKQ
110 120 130 140 150
EKEGKPFFCE DPETDNLMVK AIQVLRIHLL ELEKVNELCK DFCSRYIACL
160 170 180 190 200
KTKMNSETLL SGEPGSPYSP VQSQQIQSAI TGTISPQGIV VPASALQQGN
210 220 230 240 250
VAMATVAGGT VYQPVTVVTP QGQVVTQTLS PGTIRIQNSQ LQLQLNQDLS
260 270 280 290 300
ILHQDDGSSK NKRGVLPKHA TNVMRSWLFQ HIGHPYPTED EKKQIAAQTN
310 320 330 340 350
LTLLQVNNWF INARRRILQP MLDSSCSETP KTKKKTAQNR PVQRFWPDSI
360 370 380 390 400
ASGVAQPPPS ELTMSEGAVV TITTPVNMNV DSLQSLSSDG ATLAVQQVMM
410 420 430
AGQSEDESVD STEEDAGALA PAHISGLVLE NSDSLQ
Length:436
Mass (Da):47,607
Last modified:December 1, 2001 - v1
Checksum:i381E901F435AC5F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007746 mRNA Translation: AAH07746.1
AY196965 mRNA Translation: AAO45825.1
CH471079 Genomic DNA Translation: EAX09518.1
RefSeqiNP_001273187.1, NM_001286258.1
NP_001307623.1, NM_001320694.1
NP_004562.2, NM_004571.4
UniGeneiHs.431043

Genome annotation databases

GeneIDi5316
KEGGihsa:5316
UCSCiuc002zcq.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007746 mRNA Translation: AAH07746.1
AY196965 mRNA Translation: AAO45825.1
CH471079 Genomic DNA Translation: EAX09518.1
RefSeqiNP_001273187.1, NM_001286258.1
NP_001307623.1, NM_001320694.1
NP_004562.2, NM_004571.4
UniGeneiHs.431043

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96I87, 2 interactors
Q96I87, 2 interactors

Protocols and materials databases

DNASUi5316
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5316
KEGGihsa:5316
UCSCiuc002zcq.3 human

Organism-specific databases

CTDi5316
EuPathDBiHostDB:ENSG00000160199.14
PharmGKBiPA33354

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
HOVERGENiHBG055193
OMAiITAPVNM
OrthoDBiEOG091G09WJ

Miscellaneous databases

ChiTaRSiPKNOX1 human
GenomeRNAii5316

Gene expression databases

BgeeiENSG00000160199 Expressed in 210 organ(s), highest expression level in left lobe of thyroid gland

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR032453 PKNOX/Meis_N
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
PF16493 Meis_PKNOX_N, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ96I87_HUMAN
AccessioniPrimary (citable) accession number: Q96I87
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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