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Entry version 111 (07 Oct 2020)
Sequence version 2 (01 Mar 2004)
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Protein
Submitted name:

PFKM protein

Gene

PFKM

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+ARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.ARBA annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Hexokinase (HK3), Hexokinase, Hexokinase-3 (HK3), Hexokinase, Hexokinase-4 (GCK), Hexokinase, Phosphotransferase (GCK), Phosphotransferase (GCK), Phosphotransferase (HK2), Hexokinase (HK2), Phosphotransferase (GCK), Hexokinase, Phosphotransferase (GCK), Phosphotransferase, Hexokinase, Phosphotransferase, Hexokinase HKDC1 (HKDC1), Hexokinase-1 (HK1), Hexokinase-2 (HK2), Hexokinase, Phosphotransferase (HK2), Hexokinase, Hexokinase (HK1), Hexokinase, Phosphotransferase (GCK), Hexokinase, Hexokinase (DKFZp686M1669), Phosphotransferase (HK3)
  2. Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI)
  3. ATP-dependent 6-phosphofructokinase, muscle type (PFKM), Liver phosphofructokinase isoform a variant, ATP-dependent 6-phosphofructokinase, muscle type (PFKM), PFKL protein (PFKL), cDNA FLJ30173 fis, clone BRACE2000969, highly similar to 6-phosphofructokinase, liver type, ATP-dependent 6-phosphofructokinase, muscle type (PFKM), Phosphofructokinase muscle isoform 4 (PFKM), ATP-dependent 6-phosphofructokinase, muscle type (PFKM), PFKL protein (PFKL), ATP-dependent 6-phosphofructokinase (PFKM), ATP-dependent 6-phosphofructokinase, muscle type (PFKM), Phosphofructokinase muscle isoform 3 (PFKM), cDNA FLJ61026, highly similar to Homo sapiens phosphofructokinase, liver (PFKL), transcript variant 1, mRNA, ATP-dependent 6-phosphofructokinase, muscle type (PFKM), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), ATP-dependent 6-phosphofructokinase (PFKM), Phosphofructokinase-P (PFK-P), PFKM protein (PFKM), ATP-dependent 6-phosphofructokinase, muscle type (PFKM), Phosphofructokinase muscle isoform 2 (PFKM), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), cDNA FLJ56281, highly similar to 6-phosphofructokinase, muscle type, ATP-dependent 6-phosphofructokinase, muscle type (PFKM), Uncharacterized protein DKFZp686L2097 (DKFZp686L2097), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), Uncharacterized protein DKFZp686G1648 (DKFZp686G1648), ATP-dependent 6-phosphofructokinase, muscle type (PFKM), ATP-dependent 6-phosphofructokinase, muscle type (PFKM), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), ATP-dependent 6-phosphofructokinase, liver type (PFKL), Similar to phosphofructokinase, platelet, ATP-dependent 6-phosphofructokinase, platelet type (PFKP), PFKM protein (PFKM), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), cDNA FLJ40373 fis, clone TESTI2035003, highly similar to 6-phosphofructokinase type C, ATP-dependent 6-phosphofructokinase, muscle type (PFKM), ATP-dependent 6-phosphofructokinase, platelet type (PFKP), PFKP protein (PFKP)
  4. Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase C (ALDOC), Fructose-bisphosphate aldolase (HEL-S-87p), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase (ALDOA), Fructose-bisphosphate aldolase B (ALDOB), Fructose-bisphosphate aldolase A (ALDOA), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (ALDOC)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseARBA annotation, Transferase
Biological processGlycolysisARBA annotation
LigandMagnesiumARBA annotation, Metal-bindingARBA annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00109;UER00182

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
PFKM proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PFKMImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

AcetylationARBA annotation, PhosphoproteinARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q96I60

PRoteomics IDEntifications database

More...
PRIDEi
Q96I60

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 280PFKInterPro annotationAdd BLAST265
Domaini370 – 653PFKInterPro annotationAdd BLAST284

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili569 – 589Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00764, Eukaryotic_PFK, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_03184, Phosphofructokinase_I_E, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009161, 6-Pfructokinase_euk
IPR022953, ATP_PFK
IPR041914, PFK_vert-type
IPR015912, Phosphofructokinase_CS
IPR000023, Phosphofructokinase_dom
IPR035966, PKF_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00365, PFK, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000533, ATP_PFK_euk, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00476, PHFRCTKINASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53784, SSF53784, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00433, PHOSPHOFRUCTOKINASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q96I60-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
HEEHHAAKTL GIGKAIAVLT SGGDAQGMNA AVRAVVRVGI FTGARVFFVH
60 70 80 90 100
EGYQGLVDGG DHIKEATWES VSMMLQLGGT VIGSARCKDF REREGRLRAA
110 120 130 140 150
YNLVKRGITN LCVIGGDGSL TGADTFRSEW SDLLSDLQKA GKITDEEATK
160 170 180 190 200
SSYLNIVGLV GSIDNDFCGT DMTIGTDSAL HRIMEIVDAI TTTAQSHQRT
210 220 230 240 250
FVLEVMGRHC GYLALVTSLS CGADWVFIPE CPPDDDWEEH LCRRLSETRT
260 270 280 290 300
RGSRLNIIIV AEGAIDKNGK PITSEDIKNG SRMGVEAVMA LLEGTPDTPA
310 320 330 340 350
CVVSLSGNQA VRLPLMECVQ VTKDVTKAMD EKKFDEALKL RGRSFMNNWE
360 370 380 390 400
VYKLLAHVRP PVSKSGSHTV AVMNVGAPAA GMNAAVRSTV RIGLIQGNRV
410 420 430 440 450
LVVHDGFEGL AKGQIEEAGW SYVGGWTGQG GSKLGTKRTL PKKSFEQISA
460 470 480 490 500
NITKFNIQGL VIIGGFEAYT GGLELMEGRK QFDELCIPFV VIPATVSNNV
510 520 530 540 550
PGSDFSVGAD TALNTICTTC DRIKQSAAGT KRRVFIIETM GGYCGYLATM
560 570 580 590 600
AGLAAGADAA YIFEEPFTIR DLQANVEHLV QKMKTTVKRG LVLRNEKCNE
610 620 630 640 650
NYTTDFIFNL YSEEGKGIFD SRKNVLGHMQ QGGSPTPFDR NFATKMGAKA
660 670 680 690 700
MNWMSGKIKE SYRNGRIFAN TPDSGCVLGM RKRALVFQPV AELKDQTDFE
710 720 730 740
HRIPKEQWWL KLRPILKILA KYEIDLDTSD HAHLEHITRK RSGEAAV
Length:747
Mass (Da):81,543
Last modified:March 1, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6F41B011E72C9CD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC007798 mRNA Translation: AAH07798.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007798 mRNA Translation: AAH07798.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ96I60
PRIDEiQ96I60

Enzyme and pathway databases

UniPathwayiUPA00109;UER00182

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PFKM, human

Family and domain databases

CDDicd00764, Eukaryotic_PFK, 1 hit
HAMAPiMF_03184, Phosphofructokinase_I_E, 1 hit
InterProiView protein in InterPro
IPR009161, 6-Pfructokinase_euk
IPR022953, ATP_PFK
IPR041914, PFK_vert-type
IPR015912, Phosphofructokinase_CS
IPR000023, Phosphofructokinase_dom
IPR035966, PKF_sf
PfamiView protein in Pfam
PF00365, PFK, 2 hits
PIRSFiPIRSF000533, ATP_PFK_euk, 2 hits
PRINTSiPR00476, PHFRCTKINASE
SUPFAMiSSF53784, SSF53784, 2 hits
PROSITEiView protein in PROSITE
PS00433, PHOSPHOFRUCTOKINASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ96I60_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96I60
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: March 1, 2004
Last modified: October 7, 2020
This is version 111 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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