UniProtKB - Q96I59 (SYNM_HUMAN)

BLAST

>sp|Q96I59|SYNM_HUMAN Probable asparagine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=NARS2 PE=1 SV=3
MLGVRCLLRSVRFCSSAPFPKHKPSAKLSVRDALGAQNASGERIKIQGWIRSVRSQKEVL
FLHVNDGSSLESLQVVADSGLDSRELNFGSSVEVQGQLIKSPSKRQNVELKAEKIKVIGN
CDAKDFPIKYKERHPLEYLRQYPHFRCRTNVLGSILRIRSEATAAIHSFFKDSGFVHIHT
PIITSNDSEGAGELFQLEPSGKLKVPEENFFNVPAFLTVSGQLHLEVMSGAFTQVFTFGP
TFRAENSQSRRHLAEFYMIEAEISFVDSLQDLMQVIEELFKATTMMVLSKCPEDVELCHK
FIAPGQKDRLEHMLKNNFLIISYTEAVEILKQASQNFTFTPEWGADLRTEHEKYLVKHCG
NIPVFVINYPLTLKPFYMRDNEDGPQHTVAAVDLLVPGVGELFGGGLREERYHFLEERLA
RSGLTEVYQWYLDLRRFGSVPHGGFGMGFERYLQCILGVDNIKDVIPFPRFPHSCLL

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History
Entry version 148 (07 Nov 2018)
Sequence version 3 (18 May 2010)
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Protein

Probable asparagine--tRNA ligase, mitochondrial

Gene

NARS2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Catalytic activityⁱ

ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).

GO - Molecular functionⁱ

asparagine-tRNA ligase activity Source: UniProtKB
ATP binding Source: UniProtKB-KW
nucleic acid binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

asparaginyl-tRNA aminoacylation Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Aminoacyl-tRNA synthetase, Ligase
Biological process	Protein biosynthesis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-379726 Mitochondrial tRNA aminoacylation

Reactomeⁱ

R-HSA-379726 Mitochondrial tRNA aminoacylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable asparagine--tRNA ligase, mitochondrial (EC:6.1.1.22) Alternative name(s): Asparaginyl-tRNA synthetase Short name: AsnRS
Gene namesⁱ	Name:NARS2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000137513.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26274 NARS2
MIMⁱ	612803 gene
neXtProtⁱ	NX_Q96I59

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Combined oxidative phosphorylation deficiency 24 (COXPD24)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive mitochondrial disorder with wide phenotypic variability. Some patients have a milder form affecting only skeletal muscle, whereas others may have a more severe disorder, reminiscent of Alpers syndrome. Alpers syndrome is a progressive neurodegenerative disorder that presents in infancy or early childhood and is characterized by diffuse degeneration of cerebral gray matter.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_073250	214	P → L in COXPD24. 1 PublicationCorresponds to variant dbSNP:rs730882155EnsemblClinVar.		1

Leigh syndrome (LS)1 Publication

The disease may be caused by mutations affecting the gene represented in this entry.

Disease descriptionAn early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_073724	381	N → S in LS; does not form homodimers; does not affect localization to mitochondrion. 1 Publication		1

Keywords - Diseaseⁱ

Deafness, Disease mutation, Leigh syndrome, Non-syndromic deafness, Primary mitochondrial disease

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79731
MalaCards human disease database More...MalaCardsⁱ	NARS2
MIMⁱ	256000 phenotype 616239 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000137513
Orphanetⁱ	444458 Combined oxidative phosphorylation defect type 24
PharmGKBⁱ	PA143485554

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00174 L-Asparagine

DrugBankⁱ

DB00174 L-Asparagine

Polymorphism and mutation databases

BioMutaⁱ	NARS2
DMDMⁱ	296452944

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 14	MitochondrionSequence analysisAdd BLAST		14
ChainⁱPRO_0000250722	15 – 477	Probable asparagine--tRNA ligase, mitochondrialAdd BLAST		463

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	353	N6-acetyllysineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q96I59
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96I59
PaxDbⁱ	Q96I59
PeptideAtlas More...PeptideAtlasⁱ	Q96I59
PRIDEⁱ	Q96I59
ProteomicsDBⁱ	76813

PTM databases

iPTMnetⁱ	Q96I59
PhosphoSitePlusⁱ	Q96I59

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000137513 Expressed in 213 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_NARS2
ExpressionAtlasⁱ	Q96I59 baseline and differential
Genevisibleⁱ	Q96I59 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA026793

HPAⁱ

HPA026793

Interactionⁱ

Subunit structureⁱ

Homodimer.1 Publication

Protein-protein interaction databases

BioGridⁱ	122846, 27 interactors
IntActⁱ	Q96I59, 13 interactors
STRINGⁱ	9606.ENSP00000281038

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96I59
SMRⁱ	Q96I59
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the class-II aminoacyl-tRNA synthetase family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG0554 Eukaryota COG0017 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074970
HOGENOMⁱ	HOG000226033
HOVERGENⁱ	HBG067799
InParanoidⁱ	Q96I59
KEGG Orthology (KO) More...KOⁱ	K01893
OMAⁱ	VAWICGL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07DH
PhylomeDBⁱ	Q96I59
TreeFamⁱ	TF315088

Family and domain databases

HAMAPⁱ	MF_00534 Asn_tRNA_synth, 1 hit
InterProⁱ	View protein in InterPro IPR004364 aa-tRNA-synt_II IPR006195 aa-tRNA-synth_II IPR004522 Asn-tRNA-ligase IPR002312 Asp/Asn-tRNA-synth_IIb IPR012340 NA-bd_OB-fold IPR004365 NA-bd_OB_tRNA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00152 tRNA-synt_2, 1 hit PF01336 tRNA_anti-codon, 1 hit
PRINTSⁱ	PR01042 TRNASYNTHASP
SUPFAMⁱ	SSF50249 SSF50249, 1 hit
TIGRFAMsⁱ	TIGR00457 asnS, 1 hit
PROSITEⁱ	View protein in PROSITE PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96I59-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGVRCLLRS VRFCSSAPFP KHKPSAKLSV RDALGAQNAS GERIKIQGWI 
        60         70         80         90        100
RSVRSQKEVL FLHVNDGSSL ESLQVVADSG LDSRELNFGS SVEVQGQLIK 
       110        120        130        140        150
SPSKRQNVEL KAEKIKVIGN CDAKDFPIKY KERHPLEYLR QYPHFRCRTN 
       160        170        180        190        200
VLGSILRIRS EATAAIHSFF KDSGFVHIHT PIITSNDSEG AGELFQLEPS 
       210        220        230        240        250
GKLKVPEENF FNVPAFLTVS GQLHLEVMSG AFTQVFTFGP TFRAENSQSR 
       260        270        280        290        300
RHLAEFYMIE AEISFVDSLQ DLMQVIEELF KATTMMVLSK CPEDVELCHK 
       310        320        330        340        350
FIAPGQKDRL EHMLKNNFLI ISYTEAVEIL KQASQNFTFT PEWGADLRTE 
       360        370        380        390        400
HEKYLVKHCG NIPVFVINYP LTLKPFYMRD NEDGPQHTVA AVDLLVPGVG 
       410        420        430        440        450
ELFGGGLREE RYHFLEERLA RSGLTEVYQW YLDLRRFGSV PHGGFGMGFE 
       460        470 
RYLQCILGVD NIKDVIPFPR FPHSCLL

Length:477

Mass (Da):54,090

Last modified:May 18, 2010 - v3

Checksum:ⁱ1F4C78E0B6F5500C

Isoform 2 (identifier: Q96I59-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-227: Missing.

« Hide

        10         20         30         40         50
MSGAFTQVFT FGPTFRAENS QSRRHLAEFY MIEAEISFVD SLQDLMQVIE 
        60         70         80         90        100
ELFKATTMMV LSKCPEDVEL CHKFIAPGQK DRLEHMLKNN FLIISYTEAV 
       110        120        130        140        150
EILKQASQNF TFTPEWGADL RTEHEKYLVK HCGNIPVFVI NYPLTLKPFY 
       160        170        180        190        200
MRDNEDGPQH TVAAVDLLVP GVGELFGGGL REERYHFLEE RLARSGLTEV 
       210        220        230        240        250
YQWYLDLRRF GSVPHGGFGM GFERYLQCIL GVDNIKDVIP FPRFPHSCLL

Note: No experimental confirmation available.

Show »

Length:250

Mass (Da):28,783

Checksum:ⁱDF015513014C4FA9

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PRK2	E9PRK2_HUMAN	Probable asparagine--tRNA ligase, m... Probable asparagine--tRNA ligase, mitochondrial	NARS2	241	Annotation score:
H0YEL9	H0YEL9_HUMAN	Probable asparagine--tRNA ligase, m... Probable asparagine--tRNA ligase, mitochondrial	NARS2	106	Annotation score:
H0YE96	H0YE96_HUMAN	Probable asparagine--tRNA ligase, m... Probable asparagine--tRNA ligase, mitochondrial	NARS2	81	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_052636	87	N → T1 PublicationCorresponds to variant dbSNP:rs10501429EnsemblClinVar.	1
Natural variantⁱVAR_073723	213	V → F Found in non-syndromic deafness patients; unknown pathological significance; does not affect homodimerization; does not affect localization to mitochondrion. 1 Publication	1
Natural variantⁱVAR_073250	214	P → L in COXPD24. 1 PublicationCorresponds to variant dbSNP:rs730882155EnsemblClinVar.	1
Natural variantⁱVAR_073724	381	N → S in LS; does not form homodimers; does not affect localization to mitochondrion. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054120	1 – 227	Missing in isoform 2. CuratedAdd BLAST		227

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP003086 Genomic DNA No translation available. AP003110 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW75061.1 BC007800 mRNA Translation: AAH07800.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS58164.1 [Q96I59-2] CCDS8261.1 [Q96I59-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001230180.1, NM_001243251.1 [Q96I59-2] NP_078954.4, NM_024678.5 [Q96I59-1] XP_016873792.1, XM_017018303.1 [Q96I59-2]
UniGeneⁱ	Hs.503389

Genome annotation databases

Ensemblⁱ	ENST00000281038; ENSP00000281038; ENSG00000137513 [Q96I59-1] ENST00000528850; ENSP00000432635; ENSG00000137513 [Q96I59-2]
GeneIDⁱ	79731
KEGGⁱ	hsa:79731
UCSC genome browser More...UCSCⁱ	uc001ozi.3 human [Q96I59-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96I59	Isoform 2 of Probable asparagine--tRNA ligase, mitochondrial		HUMAN		250	UniRef90_Q96I59
Uncharacterized protein		MACNE		530
Putative asparaginyl-tRNA synthetase, mitochondrial isoform 1		MACMU		477
Uncharacterized protein		NOMLE		477
Uncharacterized protein		MACFA		477
+52

Protein	Similar proteins		Species	Score	Length	Source
Q96I59	Probable asparagine--tRNA ligase, mitochondrial		MOUSE		477	UniRef50_Q96I59
Isoform 2 of Probable asparagine--tRNA ligase, mitochondrial		HUMAN		250
Uncharacterized protein		MACNE		530
Uncharacterized protein		PAPAN		477
Uncharacterized protein		AOTNA		477
+110

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AP003086 Genomic DNA No translation available. AP003110 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW75061.1 BC007800 mRNA Translation: AAH07800.2
CCDSⁱ	CCDS58164.1 [Q96I59-2] CCDS8261.1 [Q96I59-1]
RefSeqⁱ	NP_001230180.1, NM_001243251.1 [Q96I59-2] NP_078954.4, NM_024678.5 [Q96I59-1] XP_016873792.1, XM_017018303.1 [Q96I59-2]
UniGeneⁱ	Hs.503389

3D structure databases

ProteinModelPortalⁱ	Q96I59
SMRⁱ	Q96I59
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122846, 27 interactors
IntActⁱ	Q96I59, 13 interactors
STRINGⁱ	9606.ENSP00000281038

Chemistry databases

DrugBankⁱ	DB00174 L-Asparagine

DrugBankⁱ

DB00174 L-Asparagine

PTM databases

iPTMnetⁱ	Q96I59
PhosphoSitePlusⁱ	Q96I59

Polymorphism and mutation databases

BioMutaⁱ	NARS2
DMDMⁱ	296452944

Proteomic databases

EPDⁱ	Q96I59
MaxQBⁱ	Q96I59
PaxDbⁱ	Q96I59
PeptideAtlasⁱ	Q96I59
PRIDEⁱ	Q96I59
ProteomicsDBⁱ	76813

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000281038; ENSP00000281038; ENSG00000137513 [Q96I59-1] ENST00000528850; ENSP00000432635; ENSG00000137513 [Q96I59-2]
GeneIDⁱ	79731
KEGGⁱ	hsa:79731
UCSCⁱ	uc001ozi.3 human [Q96I59-1]

Organism-specific databases

CTDⁱ	79731
DisGeNETⁱ	79731
EuPathDBⁱ	HostDB:ENSG00000137513.9
GeneCardsⁱ	NARS2
HGNCⁱ	HGNC:26274 NARS2
HPAⁱ	HPA026793
MalaCardsⁱ	NARS2
MIMⁱ	256000 phenotype 612803 gene 616239 phenotype
neXtProtⁱ	NX_Q96I59
OpenTargetsⁱ	ENSG00000137513
Orphanetⁱ	444458 Combined oxidative phosphorylation defect type 24
PharmGKBⁱ	PA143485554
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0554 Eukaryota COG0017 LUCA
GeneTreeⁱ	ENSGT00550000074970
HOGENOMⁱ	HOG000226033
HOVERGENⁱ	HBG067799
InParanoidⁱ	Q96I59
KOⁱ	K01893
OMAⁱ	VAWICGL
OrthoDBⁱ	EOG091G07DH
PhylomeDBⁱ	Q96I59
TreeFamⁱ	TF315088

Enzyme and pathway databases

Reactomeⁱ	R-HSA-379726 Mitochondrial tRNA aminoacylation

Reactomeⁱ

R-HSA-379726 Mitochondrial tRNA aminoacylation

Miscellaneous databases

ChiTaRSⁱ	NARS2 human
GenomeRNAiⁱ	79731
Protein Ontology More...PROⁱ	PR:Q96I59
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000137513 Expressed in 213 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_NARS2
ExpressionAtlasⁱ	Q96I59 baseline and differential
Genevisibleⁱ	Q96I59 HS

Family and domain databases

HAMAPⁱ	MF_00534 Asn_tRNA_synth, 1 hit
InterProⁱ	View protein in InterPro IPR004364 aa-tRNA-synt_II IPR006195 aa-tRNA-synth_II IPR004522 Asn-tRNA-ligase IPR002312 Asp/Asn-tRNA-synth_IIb IPR012340 NA-bd_OB-fold IPR004365 NA-bd_OB_tRNA
Pfamⁱ	View protein in Pfam PF00152 tRNA-synt_2, 1 hit PF01336 tRNA_anti-codon, 1 hit
PRINTSⁱ	PR01042 TRNASYNTHASP
SUPFAMⁱ	SSF50249 SSF50249, 1 hit
TIGRFAMsⁱ	TIGR00457 asnS, 1 hit
PROSITEⁱ	View protein in PROSITE PS50862 AA_TRNA_LIGASE_II, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SYNM_HUMAN
Accessionⁱ	Q96I59Primary (citable) accession number: Q96I59 Secondary accession number(s): G3V178
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Aminoacyl-tRNA synthetases
List of aminoacyl-tRNA synthetase entries

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UniProtKB - Q96I59 (SYNM_HUMAN)

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Probable asparagine--tRNA ligase, mitochondrial

NARS2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Cytosol

Mitochondrion

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ