Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 141

Gene

TMEM141

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 141
Gene namesi
Name:TMEM141
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000244187.7
HGNCiHGNC:28211 TMEM141
neXtProtiNX_Q96I45

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000244187
PharmGKBiPA144596262

Polymorphism and mutation databases

BioMutaiTMEM141

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002795071 – 108Transmembrane protein 141Add BLAST108

Proteomic databases

EPDiQ96I45
MaxQBiQ96I45
PaxDbiQ96I45
PeptideAtlasiQ96I45
PRIDEiQ96I45
ProteomicsDBi76811

Expressioni

Gene expression databases

BgeeiENSG00000244187
CleanExiHS_TMEM141
GenevisibleiQ96I45 HS

Organism-specific databases

HPAiHPA014615
HPA050244

Interactioni

Protein-protein interaction databases

BioGridi124429, 4 interactors
IntActiQ96I45, 2 interactors

Structurei

Secondary structure

1108
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Helixi6 – 16Combined sources11
Helixi20 – 39Combined sources20
Helixi40 – 43Combined sources4
Helixi44 – 53Combined sources10
Beta strandi56 – 60Combined sources5
Helixi62 – 95Combined sources34

3D structure databases

ProteinModelPortaliQ96I45
SMRiQ96I45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM141 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0CX Eukaryota
ENOG4111TIE LUCA
GeneTreeiENSGT00390000001064
HOGENOMiHOG000154608
HOVERGENiHBG067289
InParanoidiQ96I45
OMAiCQSHAFM
OrthoDBiEOG091G0X78
PhylomeDBiQ96I45
TreeFamiTF330755

Family and domain databases

Gene3Di1.10.3350.20, 1 hit
InterProiView protein in InterPro
IPR026788 Tmem141
IPR038259 Tmem141_sf
PfamiView protein in Pfam
PF15110 TMEM141, 1 hit

Sequencei

Sequence statusi: Complete.

Q96I45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNLGLSRVD DAVAAKHPGL GEYAACQSHA FMKGVFTFVT GTGMAFGLQM
60 70 80 90 100
FIQRKFPYPL QWSLLVAVVA GSVVSYGVTR VESEKCNNLW LFLETGQLPK

DRSTDQRS
Length:108
Mass (Da):11,875
Last modified:December 1, 2001 - v1
Checksum:i948494B8AC757657
GO

Sequence cautioni

The sequence CAI12680 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355987 Genomic DNA Translation: CAI12679.1
AL355987 Genomic DNA Translation: CAI12680.1 Sequence problems.
CH471090 Genomic DNA Translation: EAW88277.1
BC007834 mRNA Translation: AAH07834.1
CCDSiCCDS7007.1
RefSeqiNP_116317.1, NM_032928.3
UniGeneiHs.356744

Genome annotation databases

EnsembliENST00000290079; ENSP00000290079; ENSG00000244187
GeneIDi85014
KEGGihsa:85014
UCSCiuc004cje.5 human

Similar proteinsi

Entry informationi

Entry nameiTM141_HUMAN
AccessioniPrimary (citable) accession number: Q96I45
Secondary accession number(s): A6NIZ7, Q5T5R5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 1, 2001
Last modified: July 18, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health