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Protein

Protein phosphatase 1 regulatory subunit 16A

Gene

PPP1R16A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 16A
Alternative name(s):
Myosin phosphatase-targeting subunit 3
Gene namesi
Name:PPP1R16A
Synonyms:MYPT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000160972.9
HGNCiHGNC:14941 PPP1R16A
MIMi609172 gene
neXtProtiNX_Q96I34

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160972
PharmGKBiPA33634

Polymorphism and mutation databases

BioMutaiPPP1R16A
DMDMi22256976

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000670401 – 525Protein phosphatase 1 regulatory subunit 16AAdd BLAST525
PropeptideiPRO_0000396707526 – 528Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei433PhosphoserineCombined sources1
Lipidationi524S-palmitoyl cysteineCurated1
Modified residuei525Cysteine methyl esterBy similarity1
Lipidationi525S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ96I34
MaxQBiQ96I34
PaxDbiQ96I34
PeptideAtlasiQ96I34
PRIDEiQ96I34
ProteomicsDBi76809

PTM databases

iPTMnetiQ96I34
PhosphoSitePlusiQ96I34

Expressioni

Gene expression databases

BgeeiENSG00000160972 Expressed in 181 organ(s), highest expression level in apex of heart
CleanExiHS_PPP1R16A
ExpressionAtlasiQ96I34 baseline and differential
GenevisibleiQ96I34 HS

Organism-specific databases

HPAiHPA023755

Interactioni

Subunit structurei

Binds PP1.

Binary interactionsi

Protein-protein interaction databases

BioGridi124414, 23 interactors
ELMiQ96I34
IntActiQ96I34, 47 interactors
MINTiQ96I34
STRINGi9606.ENSP00000292539

Structurei

3D structure databases

ProteinModelPortaliQ96I34
SMRiQ96I34
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati70 – 99ANK 1Add BLAST30
Repeati103 – 132ANK 2Add BLAST30
Repeati136 – 165ANK 3Add BLAST30
Repeati231 – 260ANK 4Add BLAST30
Repeati264 – 293ANK 5Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili18 – 45Sequence analysisAdd BLAST28

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0505 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00760000119141
HOGENOMiHOG000236276
HOVERGENiHBG053644
InParanoidiQ96I34
KOiK17458
OMAiRGITQDS
OrthoDBiEOG091G06S2
PhylomeDBiQ96I34
TreeFamiTF316803

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017417 Pase-1_reg_su_16AB
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PIRSFiPIRSF038159 PP1_16AB_vert, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96I34-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEHLELLAE MPMVGRMSTQ ERLKHAQKRR AQQVKMWAQA EKEAQGKKGP
60 70 80 90 100
GERPRKEAAS QGLLKQVLFP PSVVLLEAAA RNDLEEVRQF LGSGVSPDLA
110 120 130 140 150
NEDGLTALHQ CCIDDFREMV QQLLEAGANI NACDSECWTP LHAAATCGHL
160 170 180 190 200
HLVELLIASG ANLLAVNTDG NMPYDLCDDE QTLDCLETAM ADRGITQDSI
210 220 230 240 250
EAARAVPELR MLDDIRSRLQ AGADLHAPLD HGATLLHVAA ANGFSEAAAL
260 270 280 290 300
LLEHRASLSA KDQDGWEPLH AAAYWGQVPL VELLVAHGAD LNAKSLMDET
310 320 330 340 350
PLDVCGDEEV RAKLLELKHK HDALLRAQSR QRSLLRRRTS SAGSRGKVVR
360 370 380 390 400
RVSLTQRTDL YRKQHAQEAI VWQQPPPTSP EPPEDNDDRQ TGAELRPPPP
410 420 430 440 450
EEDNPEVVRP HNGRVGGSPV RHLYSKRLDR SVSYQLSPLD STTPHTLVHD
460 470 480 490 500
KAHHTLADLK RQRAAAKLQR PPPEGPESPE TAEPGLPGDT VTPQPDCGFR
510 520
AGGDPPLLKL TAPAVEAPVE RRPCCLLM
Length:528
Mass (Da):57,811
Last modified:December 1, 2001 - v1
Checksum:iA5A2D5E1A16A438C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWZ0A0A087WWZ0_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R16A
65Annotation score:

Sequence cautioni

The sequence BAC03452 differs from that shown. Cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34 – 71Missing in BAC03452 (Ref. 1) CuratedAdd BLAST38
Sequence conflicti249A → P in BAC03452 (Ref. 1) Curated1
Sequence conflicti272A → P in BAC03452 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090471 mRNA Translation: BAC03452.1 Sequence problems.
BT006845 mRNA Translation: AAP35491.1
CH471162 Genomic DNA Translation: EAW82080.1
CH471162 Genomic DNA Translation: EAW82081.1
CH471162 Genomic DNA Translation: EAW82082.1
BC007854 mRNA Translation: AAH07854.1
BC049841 mRNA Translation: AAH49841.1
BC053506 mRNA Translation: AAH53506.1
CCDSiCCDS6429.1
RefSeqiNP_001316371.1, NM_001329442.1
NP_001316372.1, NM_001329443.1
NP_001316373.1, NM_001329444.1
NP_001316374.1, NM_001329445.1
NP_116291.1, NM_032902.6
XP_016869403.1, XM_017013914.1
UniGeneiHs.521937
Hs.734856

Genome annotation databases

EnsembliENST00000292539; ENSP00000292539; ENSG00000160972
ENST00000435887; ENSP00000391126; ENSG00000160972
GeneIDi84988
KEGGihsa:84988
UCSCiuc003zdd.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090471 mRNA Translation: BAC03452.1 Sequence problems.
BT006845 mRNA Translation: AAP35491.1
CH471162 Genomic DNA Translation: EAW82080.1
CH471162 Genomic DNA Translation: EAW82081.1
CH471162 Genomic DNA Translation: EAW82082.1
BC007854 mRNA Translation: AAH07854.1
BC049841 mRNA Translation: AAH49841.1
BC053506 mRNA Translation: AAH53506.1
CCDSiCCDS6429.1
RefSeqiNP_001316371.1, NM_001329442.1
NP_001316372.1, NM_001329443.1
NP_001316373.1, NM_001329444.1
NP_001316374.1, NM_001329445.1
NP_116291.1, NM_032902.6
XP_016869403.1, XM_017013914.1
UniGeneiHs.521937
Hs.734856

3D structure databases

ProteinModelPortaliQ96I34
SMRiQ96I34
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124414, 23 interactors
ELMiQ96I34
IntActiQ96I34, 47 interactors
MINTiQ96I34
STRINGi9606.ENSP00000292539

PTM databases

iPTMnetiQ96I34
PhosphoSitePlusiQ96I34

Polymorphism and mutation databases

BioMutaiPPP1R16A
DMDMi22256976

Proteomic databases

EPDiQ96I34
MaxQBiQ96I34
PaxDbiQ96I34
PeptideAtlasiQ96I34
PRIDEiQ96I34
ProteomicsDBi76809

Protocols and materials databases

DNASUi84988
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292539; ENSP00000292539; ENSG00000160972
ENST00000435887; ENSP00000391126; ENSG00000160972
GeneIDi84988
KEGGihsa:84988
UCSCiuc003zdd.4 human

Organism-specific databases

CTDi84988
EuPathDBiHostDB:ENSG00000160972.9
GeneCardsiPPP1R16A
HGNCiHGNC:14941 PPP1R16A
HPAiHPA023755
MIMi609172 gene
neXtProtiNX_Q96I34
OpenTargetsiENSG00000160972
PharmGKBiPA33634
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0505 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00760000119141
HOGENOMiHOG000236276
HOVERGENiHBG053644
InParanoidiQ96I34
KOiK17458
OMAiRGITQDS
OrthoDBiEOG091G06S2
PhylomeDBiQ96I34
TreeFamiTF316803

Miscellaneous databases

ChiTaRSiPPP1R16A human
GenomeRNAii84988
PROiPR:Q96I34
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160972 Expressed in 181 organ(s), highest expression level in apex of heart
CleanExiHS_PPP1R16A
ExpressionAtlasiQ96I34 baseline and differential
GenevisibleiQ96I34 HS

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017417 Pase-1_reg_su_16AB
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PIRSFiPIRSF038159 PP1_16AB_vert, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPP16A_HUMAN
AccessioniPrimary (citable) accession number: Q96I34
Secondary accession number(s): D3DWM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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