UniProtKB - Q96I24 (FUBP3_HUMAN)
Protein
Far upstream element-binding protein 3
Gene
FUBP3
Organism
Homo sapiens (Human)
Status
Functioni
May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression.
GO - Molecular functioni
- mRNA binding Source: GO_Central
- RNA binding Source: UniProtKB
- single-stranded DNA binding Source: MGI
GO - Biological processi
- positive regulation of gene expression Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of gene expression Source: GO_Central
- transcription, DNA-templated Source: UniProtKB
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q96I24 |
Names & Taxonomyi
Protein namesi | Recommended name: Far upstream element-binding protein 3Short name: FUSE-binding protein 3 |
Gene namesi | Name:FUBP3 Synonyms:FBP3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4005, FUBP3 |
MIMi | 603536, gene |
neXtProti | NX_Q96I24 |
VEuPathDBi | HostDB:ENSG00000107164.15 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 8939 |
OpenTargetsi | ENSG00000107164 |
PharmGKBi | PA28421 |
Miscellaneous databases
Pharosi | Q96I24, Tbio |
Genetic variation databases
BioMutai | FUBP3 |
DMDMi | 37078499 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000050140 | 2 – 572 | Far upstream element-binding protein 3Add BLAST | 571 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Cross-linki | 15 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 57 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 76 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 296 | PhosphoserineCombined sources | 1 | |
Modified residuei | 539 | PhosphoserineCombined sources | 1 | |
Modified residuei | 569 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q96I24 |
jPOSTi | Q96I24 |
MassIVEi | Q96I24 |
MaxQBi | Q96I24 |
PaxDbi | Q96I24 |
PeptideAtlasi | Q96I24 |
PRIDEi | Q96I24 |
ProteomicsDBi | 76805 [Q96I24-1] 76806 [Q96I24-2] |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00377261 |
PTM databases
iPTMneti | Q96I24 |
MetOSitei | Q96I24 |
PhosphoSitePlusi | Q96I24 |
SwissPalmi | Q96I24 |
Expressioni
Tissue specificityi
Detected in a number of cell lines.
Gene expression databases
Bgeei | ENSG00000107164, Expressed in brain and 239 other tissues |
ExpressionAtlasi | Q96I24, baseline and differential |
Genevisiblei | Q96I24, HS |
Organism-specific databases
HPAi | ENSG00000107164, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ96I24
With | #Exp. | IntAct |
---|---|---|
QKI [Q96PU8] | 4 | EBI-954200,EBI-945792 |
Isoform 2 [Q96I24-2]
With | #Exp. | IntAct |
---|---|---|
RBPMS2 [Q6ZRY4] | 3 | EBI-12267436,EBI-11987469 |
Protein-protein interaction databases
BioGRIDi | 114451, 99 interactors |
DIPi | DIP-50124N |
IntActi | Q96I24, 51 interactors |
MINTi | Q96I24 |
STRINGi | 9606.ENSP00000318177 |
Miscellaneous databases
RNActi | Q96I24, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 77 – 141 | KH 1PROSITE-ProRule annotationAdd BLAST | 65 | |
Domaini | 162 – 228 | KH 2PROSITE-ProRule annotationAdd BLAST | 67 | |
Domaini | 253 – 317 | KH 3PROSITE-ProRule annotationAdd BLAST | 65 | |
Domaini | 354 – 421 | KH 4PROSITE-ProRule annotationAdd BLAST | 68 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG1676, Eukaryota |
GeneTreei | ENSGT00940000156744 |
HOGENOMi | CLU_014285_1_1_1 |
InParanoidi | Q96I24 |
OMAi | GDWSMGT |
PhylomeDBi | Q96I24 |
TreeFami | TF313654 |
Family and domain databases
Gene3Di | 3.30.1370.10, 4 hits |
InterProi | View protein in InterPro IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf |
Pfami | View protein in Pfam PF00013, KH_1, 4 hits |
SMARTi | View protein in SMART SM00322, KH, 4 hits |
SUPFAMi | SSF54791, SSF54791, 4 hits |
PROSITEi | View protein in PROSITE PS50084, KH_TYPE_1, 4 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96I24-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAELVQGQSA PVGMKAEGFV DALHRVRQIA AKIDSIPHLN NSTPLVDPSV
60 70 80 90 100
YGYGVQKRPL DDGVGNQLGA LVHQRTVITE EFKVPDKMVG FIIGRGGEQI
110 120 130 140 150
SRIQAESGCK IQIASESSGI PERPCVLTGT PESIEQAKRL LGQIVDRCRN
160 170 180 190 200
GPGFHNDIDS NSTIQEILIP ASKVGLVIGR GGETIKQLQE RTGVKMVMIQ
210 220 230 240 250
DGPLPTGADK PLRITGDAFK VQQAREMVLE IIREKDQADF RGVRGDFNSR
260 270 280 290 300
MGGGSIEVSV PRFAVGIVIG RNGEMIKKIQ NDAGVRIQFK PDDGISPERA
310 320 330 340 350
AQVMGPPDRC QHAAHIISEL ILTAQERDGF GGLAAARGRG RGRGDWSVGA
360 370 380 390 400
PGGVQEITYT VPADKCGLVI GKGGENIKSI NQQSGAHVEL QRNPPPNSDP
410 420 430 440 450
NLRRFTIRGV PQQIEVARQL IDEKVGGTNL GAPGAFGQSP FSQPPAPPHQ
460 470 480 490 500
NTFPPRSSGC FPNMAAKVNG NPHSTPVSGP PAFLTQGWGS TYQAWQQPTQ
510 520 530 540 550
QVPSQQSQPQ SSQPNYSKAW EDYYKKQSHA ASAAPQASSP PDYTMAWAEY
560 570
YRQQVAFYGQ TLGQAQAHSQ EQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A494C1K6 | A0A494C1K6_HUMAN | Far upstream element-binding protei... | FUBP3 | 44 | Annotation score: |
Sequence cautioni
The sequence AAC50893 differs from that shown. Reason: Frameshift.Curated
The sequence AAH01325 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 72 | V → D in AAC50893 (PubMed:8940189).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008323 | 1 – 64 | MAELV…LDDGV → MPPI in isoform 2. 1 PublicationAdd BLAST | 64 | |
Alternative sequenceiVSP_008324 | 298 – 548 | Missing in isoform 2. 1 PublicationAdd BLAST | 251 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U69127 mRNA Translation: AAC50893.1 Frameshift. AK295155 mRNA Translation: BAG58170.1 AL353695 Genomic DNA No translation available. AL359092 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87937.1 BC001325 mRNA Translation: AAH01325.1 Frameshift. BC007874 mRNA Translation: AAH07874.1 BC137338 mRNA Translation: AAI37339.1 BC137340 mRNA Translation: AAI37341.1 |
CCDSi | CCDS43893.1 [Q96I24-1] |
RefSeqi | NP_003925.1, NM_003934.1 [Q96I24-1] |
Genome annotation databases
Ensembli | ENST00000319725; ENSP00000318177; ENSG00000107164 [Q96I24-1] |
GeneIDi | 8939 |
KEGGi | hsa:8939 |
UCSCi | uc004bzr.2, human [Q96I24-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U69127 mRNA Translation: AAC50893.1 Frameshift. AK295155 mRNA Translation: BAG58170.1 AL353695 Genomic DNA No translation available. AL359092 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87937.1 BC001325 mRNA Translation: AAH01325.1 Frameshift. BC007874 mRNA Translation: AAH07874.1 BC137338 mRNA Translation: AAI37339.1 BC137340 mRNA Translation: AAI37341.1 |
CCDSi | CCDS43893.1 [Q96I24-1] |
RefSeqi | NP_003925.1, NM_003934.1 [Q96I24-1] |
3D structure databases
SMRi | Q96I24 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114451, 99 interactors |
DIPi | DIP-50124N |
IntActi | Q96I24, 51 interactors |
MINTi | Q96I24 |
STRINGi | 9606.ENSP00000318177 |
PTM databases
iPTMneti | Q96I24 |
MetOSitei | Q96I24 |
PhosphoSitePlusi | Q96I24 |
SwissPalmi | Q96I24 |
Genetic variation databases
BioMutai | FUBP3 |
DMDMi | 37078499 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00377261 |
Proteomic databases
EPDi | Q96I24 |
jPOSTi | Q96I24 |
MassIVEi | Q96I24 |
MaxQBi | Q96I24 |
PaxDbi | Q96I24 |
PeptideAtlasi | Q96I24 |
PRIDEi | Q96I24 |
ProteomicsDBi | 76805 [Q96I24-1] 76806 [Q96I24-2] |
Protocols and materials databases
Antibodypediai | 31511, 284 antibodies |
DNASUi | 8939 |
Genome annotation databases
Ensembli | ENST00000319725; ENSP00000318177; ENSG00000107164 [Q96I24-1] |
GeneIDi | 8939 |
KEGGi | hsa:8939 |
UCSCi | uc004bzr.2, human [Q96I24-1] |
Organism-specific databases
CTDi | 8939 |
DisGeNETi | 8939 |
GeneCardsi | FUBP3 |
HGNCi | HGNC:4005, FUBP3 |
HPAi | ENSG00000107164, Low tissue specificity |
MIMi | 603536, gene |
neXtProti | NX_Q96I24 |
OpenTargetsi | ENSG00000107164 |
PharmGKBi | PA28421 |
VEuPathDBi | HostDB:ENSG00000107164.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1676, Eukaryota |
GeneTreei | ENSGT00940000156744 |
HOGENOMi | CLU_014285_1_1_1 |
InParanoidi | Q96I24 |
OMAi | GDWSMGT |
PhylomeDBi | Q96I24 |
TreeFami | TF313654 |
Enzyme and pathway databases
PathwayCommonsi | Q96I24 |
Miscellaneous databases
BioGRID-ORCSi | 8939, 5 hits in 877 CRISPR screens |
ChiTaRSi | FUBP3, human |
GenomeRNAii | 8939 |
Pharosi | Q96I24, Tbio |
PROi | PR:Q96I24 |
RNActi | Q96I24, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000107164, Expressed in brain and 239 other tissues |
ExpressionAtlasi | Q96I24, baseline and differential |
Genevisiblei | Q96I24, HS |
Family and domain databases
Gene3Di | 3.30.1370.10, 4 hits |
InterProi | View protein in InterPro IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf |
Pfami | View protein in Pfam PF00013, KH_1, 4 hits |
SMARTi | View protein in SMART SM00322, KH, 4 hits |
SUPFAMi | SSF54791, SSF54791, 4 hits |
PROSITEi | View protein in PROSITE PS50084, KH_TYPE_1, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FUBP3_HUMAN | |
Accessioni | Q96I24Primary (citable) accession number: Q96I24 Secondary accession number(s): A3KFK8 Q9BVB6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2003 |
Last sequence update: | September 26, 2003 | |
Last modified: | February 10, 2021 | |
This is version 181 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM