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Protein

Protein ABHD8

Gene

ABHD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei252Charge relay systemBy similarity1
Active sitei370Charge relay systemBy similarity1
Active sitei398Charge relay systemBy similarity1

GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Protein family/group databases

ESTHERihuman-ABHD8 Epoxide_hydrolase
MEROPSiS33.011

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ABHD8Curated (EC:3.-.-.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 8Curated
Short name:
Abhydrolase domain-containing protein 8Imported
Gene namesi
Name:ABHD8Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000127220.5
HGNCiHGNC:23759 ABHD8
neXtProtiNX_Q96I13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127220
PharmGKBiPA134994313

Polymorphism and mutation databases

BioMutaiABHD8
DMDMi74732007

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002813821 – 439Protein ABHD8Add BLAST439

Proteomic databases

PaxDbiQ96I13
PeptideAtlasiQ96I13
PRIDEiQ96I13
ProteomicsDBi76801

PTM databases

iPTMnetiQ96I13
PhosphoSitePlusiQ96I13

Expressioni

Gene expression databases

BgeeiENSG00000127220 Expressed in 115 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_ABHD8
ExpressionAtlasiQ96I13 baseline and differential
GenevisibleiQ96I13 HS

Organism-specific databases

HPAiHPA037658
HPA058209

Interactioni

Protein-protein interaction databases

BioGridi122722, 4 interactors
IntActiQ96I13, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ96I13
SMRiQ96I13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini177 – 279AB hydrolase-1Sequence analysisAdd BLAST103

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiENOG410IR1S Eukaryota
ENOG41120U2 LUCA
GeneTreeiENSGT00390000007336
HOGENOMiHOG000261674
HOVERGENiHBG080814
InParanoidiQ96I13
KOiK13701
OMAiCCLLGAP
OrthoDBiEOG091G09BH
PhylomeDBiQ96I13
TreeFamiTF331708

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR000639 Epox_hydrolase-like
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PRINTSiPR00111 ABHYDROLASE
PR00412 EPOXHYDRLASE
SUPFAMiSSF53474 SSF53474, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q96I13-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTGVTDGIF CCLLGTPPNA VGPLESVESS DGYTFVEVKP GRVLRVKHAG
60 70 80 90 100
PAPAAAPPPP SSASSDAAQG DLSGLVRCQR RITVYRNGRL LVENLGRAPR
110 120 130 140 150
ADLLHGQNGS GEPPAALEVE LADPAGSDGR LAPGSAGSGS GSGSGGRRRR
160 170 180 190 200
ARRPKRTIHI DCEKRITSCK GAQADVVLFF IHGVGGSLAI WKEQLDFFVR
210 220 230 240 250
LGYEVVAPDL AGHGASSAPQ VAAAYTFYAL AEDMRAIFKR YAKKRNVLIG
260 270 280 290 300
HSYGVSFCTF LAHEYPDLVH KVIMINGGGP TALEPSFCSI FNMPTCVLHC
310 320 330 340 350
LSPCLAWSFL KAGFARQGAK EKQLLKEGNA FNVSSFVLRA MMSGQYWPEG
360 370 380 390 400
DEVYHAELTV PVLLVHGMHD KFVPVEEDQR MAEILLLAFL KLIDEGSHMV
410 420 430
MLECPETVNT LLHEFLLWEP EPSPKALPEP LPAPPEDKK
Length:439
Mass (Da):47,331
Last modified:December 1, 2001 - v1
Checksum:i5D6DBB7BDD4A87C3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZA8M0QZA8_HUMAN
Protein ABHD8
ABHD8
130Annotation score:
M0QX40M0QX40_HUMAN
Protein ABHD8
ABHD8
175Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103L → P in BAB13900 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021805 mRNA Translation: BAB13900.1
BC007895 mRNA Translation: AAH07895.1
BC020173 mRNA Translation: AAH20173.1
BC039087 mRNA Translation: AAH39087.1
CCDSiCCDS12355.1
RefSeqiNP_078803.4, NM_024527.4
UniGeneiHs.515664

Genome annotation databases

EnsembliENST00000247706; ENSP00000247706; ENSG00000127220
GeneIDi79575
KEGGihsa:79575
UCSCiuc002ngb.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021805 mRNA Translation: BAB13900.1
BC007895 mRNA Translation: AAH07895.1
BC020173 mRNA Translation: AAH20173.1
BC039087 mRNA Translation: AAH39087.1
CCDSiCCDS12355.1
RefSeqiNP_078803.4, NM_024527.4
UniGeneiHs.515664

3D structure databases

ProteinModelPortaliQ96I13
SMRiQ96I13
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122722, 4 interactors
IntActiQ96I13, 2 interactors

Protein family/group databases

ESTHERihuman-ABHD8 Epoxide_hydrolase
MEROPSiS33.011

PTM databases

iPTMnetiQ96I13
PhosphoSitePlusiQ96I13

Polymorphism and mutation databases

BioMutaiABHD8
DMDMi74732007

Proteomic databases

PaxDbiQ96I13
PeptideAtlasiQ96I13
PRIDEiQ96I13
ProteomicsDBi76801

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247706; ENSP00000247706; ENSG00000127220
GeneIDi79575
KEGGihsa:79575
UCSCiuc002ngb.4 human

Organism-specific databases

CTDi79575
EuPathDBiHostDB:ENSG00000127220.5
GeneCardsiABHD8
HGNCiHGNC:23759 ABHD8
HPAiHPA037658
HPA058209
neXtProtiNX_Q96I13
OpenTargetsiENSG00000127220
PharmGKBiPA134994313
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR1S Eukaryota
ENOG41120U2 LUCA
GeneTreeiENSGT00390000007336
HOGENOMiHOG000261674
HOVERGENiHBG080814
InParanoidiQ96I13
KOiK13701
OMAiCCLLGAP
OrthoDBiEOG091G09BH
PhylomeDBiQ96I13
TreeFamiTF331708

Miscellaneous databases

GenomeRNAii79575
PROiPR:Q96I13

Gene expression databases

BgeeiENSG00000127220 Expressed in 115 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_ABHD8
ExpressionAtlasiQ96I13 baseline and differential
GenevisibleiQ96I13 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR000639 Epox_hydrolase-like
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PRINTSiPR00111 ABHYDROLASE
PR00412 EPOXHYDRLASE
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiABHD8_HUMAN
AccessioniPrimary (citable) accession number: Q96I13
Secondary accession number(s): Q9HAE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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