HES6

Functionⁱ

Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity).By similarity

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 10851137
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
protein dimerization activity Source: InterPro
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific double-stranded DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription coregulator activity
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 10851137
transcription corepressor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
Notch signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of neurogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of transcription, DNA-templated
Source: ProtInc
Traceable author statementⁱ
- 10851137
somitogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Repressor
Biological process	Differentiation, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	Q96HZ4

SIGNORⁱ

Q96HZ4

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription cofactor HES-6 Alternative name(s): C-HAIRY1 Class B basic helix-loop-helix protein 41 Short name: bHLHb41 Hairy and enhancer of split 6
Gene namesⁱ	Name:HES6Imported Synonyms:BHLHB41
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000144485.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18254 HES6
MIMⁱ	610331 gene
neXtProtⁱ	NX_Q96HZ4

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55502
Open Targets More...OpenTargetsⁱ	ENSG00000144485
PharmGKBⁱ	PA29253

Polymorphism and mutation databases

DMDMⁱ	50400609

DMDMⁱ

50400609

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127214	1 – 224	Transcription cofactor HES-6Add BLAST		224

Proteomic databases

PaxDbⁱ	Q96HZ4
PeptideAtlas More...PeptideAtlasⁱ	Q96HZ4
PRIDEⁱ	Q96HZ4
ProteomicsDBⁱ	76797 76798 [Q96HZ4-2] 76799 [Q96HZ4-3]

PTM databases

iPTMnetⁱ	Q96HZ4
PhosphoSitePlusⁱ	Q96HZ4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000144485 Expressed in 135 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_HES6
ExpressionAtlasⁱ	Q96HZ4 baseline and differential
Genevisibleⁱ	Q96HZ4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA061763

HPAⁱ

HPA061763

Interactionⁱ

Subunit structureⁱ

Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Interacts with HES1 (By similarity).By similarity

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	120682, 9 interactors
ELMⁱ	Q96HZ4
IntActⁱ	Q96HZ4, 5 interactors
Molecular INTeraction database More...MINTⁱ	Q96HZ4
STRINGⁱ	9606.ENSP00000272937

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96HZ4
SMRⁱ	Q96HZ4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	25 – 77	bHLHPROSITE-ProRule annotationAdd BLAST		53
Domainⁱ	96 – 129	OrangePROSITE-ProRule annotationAdd BLAST		34

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	221 – 224	WRPW motif		4

Domainⁱ

The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).

Phylogenomic databases

eggNOGⁱ	KOG4304 Eukaryota ENOG4111F0X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00700000104168
HOGENOMⁱ	HOG000236346
HOVERGENⁱ	HBG107098
InParanoidⁱ	Q96HZ4
KEGG Orthology (KO) More...KOⁱ	K09087
OMAⁱ	QSVWRPW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OZ5
PhylomeDBⁱ	Q96HZ4
TreeFamⁱ	TF351373

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR003650 Orange_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07527 Hairy_orange, 1 hit PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS51054 ORANGE, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96HZ4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPPAAPGRD RVGREDEDGW ETRGDRKARK PLVEKKRRAR INESLQELRL 
        60         70         80         90        100
LLAGAEVQAK LENAEVLELT VRRVQGVLRG RAREREQLQA EASERFAAGY 
       110        120        130        140        150
IQCMHEVHTF VSTCQAIDAT VAAELLNHLL ESMPLREGSS FQDLLGDALA 
       160        170        180        190        200
GPPRAPGRSG WPAGGAPGSP IPSPPGPGDD LCSDLEEAPE AELSQAPAEG 
       210        220 
PDLVPAALGS LTTAQIARSV WRPW

Length:224

Mass (Da):24,129

Last modified:December 1, 2001 - v1

Checksum:ⁱE361BDDDCACBAD6F

GO

Isoform 2 (identifier: Q96HZ4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
84-224: EREQLQAEAS...QIARSVWRPW → GEWRRGGRGR...EPSARVHAAA

« Hide

        10         20         30         40         50
MAPPAAPGRD RVGREDEDGW ETRGDRKARK PLVEKKRRAR INESLQELRL 
        60         70         80         90        100
LLAGAEVQAK LENAEVLELT VRRVQGVLRG RARGEWRRGG RGRRPRAPVT 
       110        120        130        140        150
PARRRTSLPA PLSCRRRGLP PEQGAPPRLL GEPRPRGPGG LGHAVAAHRA 
       160        170        180        190        200
GRGSLPPTLG PRARAAAGGS ERALRCRLHP VHARGAHVRV HVPGHRRYRR 
       210 
CRAPEPSARV HAAA

Note: No experimental confirmation available.

Show »

Length:214

Mass (Da):23,483

Checksum:ⁱ0E0CA15863669591

GO

Isoform 3 (identifier: Q96HZ4-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
57-58: Missing.

« Hide

        10         20         30         40         50
MAPPAAPGRD RVGREDEDGW ETRGDRKARK PLVEKKRRAR INESLQELRL 
        60         70         80         90        100
LLAGAEAKLE NAEVLELTVR RVQGVLRGRA REREQLQAEA SERFAAGYIQ 
       110        120        130        140        150
CMHEVHTFVS TCQAIDATVA AELLNHLLES MPLREGSSFQ DLLGDALAGP 
       160        170        180        190        200
PRAPGRSGWP AGGAPGSPIP SPPGPGDDLC SDLEEAPEAE LSQAPAEGPD 
       210        220 
LVPAALGSLT TAQIARSVWR PW

Show »

Length:222

Mass (Da):23,902

Checksum:ⁱ4DA65A241AAFC073

GO

Isoform 4 (identifier: Q96HZ4-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
71-112: VRRVQGVLRG...CMHEVHTFVS → SASSCRRKRA...PSTLPSLPSS
113-224: Missing.

« Hide

        10         20         30         40         50
MAPPAAPGRD RVGREDEDGW ETRGDRKARK PLVEKKRRAR INESLQELRL 
        60         70         80         90        100
LLAGAEVQAK LENAEVLELT SASSCRRKRA SASLPATSSA CTRCTRSCPR 
       110 
ARPSTLPSLP SS

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »

Length:112

Mass (Da):12,240

Checksum:ⁱ32921239A0C1F118

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B9A070	B9A070_HUMAN	Transcription cofactor HES-6 Transcription cofactor HES-6	HES6	195	Annotation score:
B8ZZP9	B8ZZP9_HUMAN	Transcription cofactor HES-6 Transcription cofactor HES-6	HES6	94	Annotation score:
C9JF41	C9JF41_HUMAN	Transcription cofactor HES-6 Transcription cofactor HES-6	HES6	144	Annotation score:
H7C020	H7C020_HUMAN	Transcription cofactor HES-6 Transcription cofactor HES-6	HES6	85	Annotation score:
H7C1R4	H7C1R4_HUMAN	Transcription cofactor HES-6 Transcription cofactor HES-6	HES6	16	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	205	P → R in BAA96082 (PubMed:10851137).Curated		1
Sequence conflictⁱ	210 – 211	SL → AV in BAA96082 (PubMed:10851137).Curated		2

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_019540	218	R → Q. Corresponds to variant dbSNP:rs3739061Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_040128	57 – 58	Missing in isoform 3. 1 Publication	2
Alternative sequenceⁱVSP_055615	71 – 112	VRRVQ…HTFVS → SASSCRRKRASASLPATSSA CTRCTRSCPRARPSTLPSLP SS in isoform 4. CuratedAdd BLAST	42
Alternative sequenceⁱVSP_011152	84 – 224	EREQL…VWRPW → GEWRRGGRGRRPRAPVTPAR RRTSLPAPLSCRRRGLPPEQ GAPPRLLGEPRPRGPGGLGH AVAAHRAGRGSLPPTLGPRA RAAAGGSERALRCRLHPVHA RGAHVRVHVPGHRRYRRCRA PEPSARVHAAA in isoform 2. 1 PublicationAdd BLAST	141
Alternative sequenceⁱVSP_055616	113 – 224	Missing in isoform 4. CuratedAdd BLAST	112

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB035179 mRNA Translation: BAA96082.1 AF260237 mRNA Translation: AAK51634.1 AK075040 mRNA Translation: BAC11368.1 AK293111 mRNA Translation: BAF85800.1 AC016757 Genomic DNA Translation: AAY24337.1 CH471063 Genomic DNA Translation: EAW71151.1 BC007939 mRNA Translation: AAH07939.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2527.1 [Q96HZ4-1] CCDS46556.1 [Q96HZ4-3] CCDS63180.1 [Q96HZ4-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001136325.1, NM_001142853.2 [Q96HZ4-3] NP_001269363.1, NM_001282434.1 [Q96HZ4-4] NP_061115.2, NM_018645.5 [Q96HZ4-1]
UniGeneⁱ	Hs.42949

Genome annotation databases

Ensemblⁱ	ENST00000272937; ENSP00000272937; ENSG00000144485 [Q96HZ4-1] ENST00000409002; ENSP00000387155; ENSG00000144485 [Q96HZ4-3] ENST00000409160; ENSP00000387215; ENSG00000144485 [Q96HZ4-2] ENST00000409574; ENSP00000387008; ENSG00000144485 [Q96HZ4-4]
GeneIDⁱ	55502
KEGGⁱ	hsa:55502
UCSC genome browser More...UCSCⁱ	uc002vxz.4 human [Q96HZ4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96HZ4	Hes family bHLH transcription factor 6		CALJA		224	UniRef90_Q96HZ4
HES6 isoform 2		PANTR		224
Transcription cofactor HES-6 isoform a		MACMU		224
Uncharacterized protein		Cebus capucinus imitator		224
Uncharacterized protein		CHLSB		224
+1
Q96HZ4-2	HES6 isoform 4		PONAB		214	UniRef90_Q96HZ4-2
HES6 isoform 4		PANTR		214
Q96HZ4-3	Hes family bHLH transcription factor 6		OTOGA		226	UniRef90_Q96HZ4-3
Uncharacterized protein		PROCO		224
HES6 isoform 2		PONAB		224
Uncharacterized protein		FELCA		224
Uncharacterized protein		AOTNA		224
+11

Protein	Similar proteins		Species	Score	Length	Source
Q96HZ4	Transcription cofactor HES-6		MOUSE		224	UniRef50_Q9JHE6
Hairy and enhancer of split 6 (Drosophila), isoform CRA_a		RAT		224
Uncharacterized protein		NEOLE		224
transcription cofactor HES-6		DIPOR		225
Uncharacterized protein		PIG		224
+136
Q96HZ4-2	HES6 isoform 4		PANTR		214	UniRef50_Q96HZ4-2
HES6 isoform 4		PONAB		214
UPI000B4FE42F		AOTNA		267
Q96HZ4-4	transcription cofactor HES-6 isoform X3		Enhydra lutris kenyoni		112	UniRef50_Q96HZ4-4
transcription cofactor HES-6 isoform X3		NEOSC		112
transcription cofactor HES-6 isoform X3		PHYCD		112
transcription cofactor HES-6 isoform X3		LIPVE		112
UPI000DC19607		THEGE		112
+29

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB035179 mRNA Translation: BAA96082.1 AF260237 mRNA Translation: AAK51634.1 AK075040 mRNA Translation: BAC11368.1 AK293111 mRNA Translation: BAF85800.1 AC016757 Genomic DNA Translation: AAY24337.1 CH471063 Genomic DNA Translation: EAW71151.1 BC007939 mRNA Translation: AAH07939.1
CCDSⁱ	CCDS2527.1 [Q96HZ4-1] CCDS46556.1 [Q96HZ4-3] CCDS63180.1 [Q96HZ4-4]
RefSeqⁱ	NP_001136325.1, NM_001142853.2 [Q96HZ4-3] NP_001269363.1, NM_001282434.1 [Q96HZ4-4] NP_061115.2, NM_018645.5 [Q96HZ4-1]
UniGeneⁱ	Hs.42949

3D structure databases

ProteinModelPortalⁱ	Q96HZ4
SMRⁱ	Q96HZ4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120682, 9 interactors
ELMⁱ	Q96HZ4
IntActⁱ	Q96HZ4, 5 interactors
MINTⁱ	Q96HZ4
STRINGⁱ	9606.ENSP00000272937

PTM databases

iPTMnetⁱ	Q96HZ4
PhosphoSitePlusⁱ	Q96HZ4

Polymorphism and mutation databases

DMDMⁱ	50400609

DMDMⁱ

50400609

Proteomic databases

PaxDbⁱ	Q96HZ4
PeptideAtlasⁱ	Q96HZ4
PRIDEⁱ	Q96HZ4
ProteomicsDBⁱ	76797 76798 [Q96HZ4-2] 76799 [Q96HZ4-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000272937; ENSP00000272937; ENSG00000144485 [Q96HZ4-1] ENST00000409002; ENSP00000387155; ENSG00000144485 [Q96HZ4-3] ENST00000409160; ENSP00000387215; ENSG00000144485 [Q96HZ4-2] ENST00000409574; ENSP00000387008; ENSG00000144485 [Q96HZ4-4]
GeneIDⁱ	55502
KEGGⁱ	hsa:55502
UCSCⁱ	uc002vxz.4 human [Q96HZ4-1]

Organism-specific databases

CTDⁱ	55502
DisGeNETⁱ	55502
EuPathDBⁱ	HostDB:ENSG00000144485.10
GeneCardsⁱ	HES6
HGNCⁱ	HGNC:18254 HES6
HPAⁱ	HPA061763
MIMⁱ	610331 gene
neXtProtⁱ	NX_Q96HZ4
OpenTargetsⁱ	ENSG00000144485
PharmGKBⁱ	PA29253
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4304 Eukaryota ENOG4111F0X LUCA
GeneTreeⁱ	ENSGT00700000104168
HOGENOMⁱ	HOG000236346
HOVERGENⁱ	HBG107098
InParanoidⁱ	Q96HZ4
KOⁱ	K09087
OMAⁱ	QSVWRPW
OrthoDBⁱ	EOG091G0OZ5
PhylomeDBⁱ	Q96HZ4
TreeFamⁱ	TF351373

Enzyme and pathway databases

SIGNORⁱ	Q96HZ4

SIGNORⁱ

Q96HZ4

Miscellaneous databases

ChiTaRSⁱ	HES6 human
GeneWikiⁱ	HES6
GenomeRNAiⁱ	55502
Protein Ontology More...PROⁱ	PR:Q96HZ4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000144485 Expressed in 135 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_HES6
ExpressionAtlasⁱ	Q96HZ4 baseline and differential
Genevisibleⁱ	Q96HZ4 HS

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR003650 Orange_dom
Pfamⁱ	View protein in Pfam PF07527 Hairy_orange, 1 hit PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS51054 ORANGE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HES6_HUMAN
Accessionⁱ	Q96HZ4Primary (citable) accession number: Q96HZ4 Secondary accession number(s): A8KAP6 , B8ZZA9, Q53SN9, Q8N2J2, Q96T93, Q9P2S3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96HZ4 (HES6_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Transcription cofactor HES-6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ