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Protein

Integrator complex subunit 4

Gene

INTS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).1 Publication1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • snRNA processing Source: HGNC
  • snRNA transcription by RNA polymerase II Source: Reactome

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6807505 RNA polymerase II transcribes snRNA genes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrator complex subunit 4
Short name:
Int4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INTS4
ORF Names:MSTP093
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000149262.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25048 INTS4

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611348 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96HW7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
92105

Open Targets

More...
OpenTargetsi
ENSG00000149262

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA144596421

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
INTS4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
118572560

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002595381 – 963Integrator complex subunit 4Add BLAST963

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei26N6-acetyllysineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki791Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki791Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96HW7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96HW7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96HW7

PeptideAtlas

More...
PeptideAtlasi
Q96HW7

PRoteomics IDEntifications database

More...
PRIDEi
Q96HW7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
76789
76790 [Q96HW7-2]
76791 [Q96HW7-3]
76792 [Q96HW7-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96HW7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96HW7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q96HW7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000149262 Expressed in 199 organ(s), highest expression level in buccal mucosa cell

CleanEx database of gene expression profiles

More...
CleanExi
HS_INTS4

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96HW7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96HW7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042378

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124909, 53 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q96HW7

Protein interaction database and analysis system

More...
IntActi
Q96HW7, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000434466

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96HW7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati66 – 105HEAT 1Add BLAST40
Repeati145 – 183HEAT 2Add BLAST39
Repeati190 – 228HEAT 3Add BLAST39
Repeati229 – 263HEAT 4Add BLAST35
Repeati277 – 313HEAT 5Add BLAST37
Repeati369 – 405HEAT 6Add BLAST37
Repeati406 – 444HEAT 7Add BLAST39
Repeati446 – 484HEAT 8Add BLAST39

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Integrator subunit 4 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2259 Eukaryota
ENOG410XPX8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010128

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG081801

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96HW7

KEGG Orthology (KO)

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KOi
K13141

Identification of Orthologs from Complete Genome Data

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OMAi
EDPSHQF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01FC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96HW7

TreeFam database of animal gene trees

More...
TreeFami
TF315047

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR026003 Cohesin_HEAT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12765 Cohesin_HEAT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96HW7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAHLKKRVY EEFTKVVQPQ EEIATKKLRL TKPSKSAALH IDLCKATSPA
60 70 80 90 100
DALQYLLQFA RKPVEAESVE GVVRILLEHY YKENDPSVRL KIASLLGLLS
110 120 130 140 150
KTAGFSPDCI MDDAINILQN EKSHQVLAQL LDTLLAIGTK LPENQAIQMR
160 170 180 190 200
LVDVACKHLT DTSHGVRNKC LQLLGNLGSL EKSVTKDAEG LAARDVQKII
210 220 230 240 250
GDYFSDQDPR VRTAAIKAML QLHERGLKLH QTIYNQACKL LSDDYEQVRS
260 270 280 290 300
AAVQLIWVVS QLYPESIVPI PSSNEEIRLV DDAFGKICHM VSDGSWVVRV
310 320 330 340 350
QAAKLLGSME QVSSHFLEQT LDKKLMSDLR RKRTAHERAK ELYSSGEFSS
360 370 380 390 400
GRKWGDDAPK EEVDTGAVNL IESGACGAFV HGLEDEMYEV RIAAVEALCM
410 420 430 440 450
LAQSSPSFAE KCLDFLVDMF NDEIEEVRLQ SIHTMRKISN NITLREDQLD
460 470 480 490 500
TVLAVLEDSS RDIREALHEL LCCTNVSTKE GIHLALVELL KNLTKYPTDR
510 520 530 540 550
DSIWKCLKFL GSRHPTLVLP LVPELLSTHP FFDTAEPDMD DPAYIAVLVL
560 570 580 590 600
IFNAAKTCPT MPALFSDHTF RHYAYLRDSL SHLVPALRLP GRKLVSSAVS
610 620 630 640 650
PSIIPQEDPS QQFLQQSLER VYSLQHLDPQ GAQELLEFTI RDLQRLGELQ
660 670 680 690 700
SELAGVADFS ATYLRCQLLL IKALQEKLWN VAAPLYLKQS DLASAAAKQI
710 720 730 740 750
MEETYKMEFM YSGVENKQVV IIHHMRLQAK ALQLIVTART TRGLDPLFGM
760 770 780 790 800
CEKFLQEVDF FQRYFIADLP HLQDSFVDKL LDLMPRLMTS KPAEVVKILQ
810 820 830 840 850
TMLRQSAFLH LPLPEQIHKA SATIIEPAGE SDNPLRFTSG LVVALDVDAT
860 870 880 890 900
LEHVQDPQNT VKVQVLYPDG QAQMIHPKPA DFRNPGPGRH RLITQVYLSH
910 920 930 940 950
TAWTEACQVE VRLLLAYNSS ARIPKCPWME GGEMSPQVET SIEGTIPFSK
960
PVKVYIMPKP ARR
Length:963
Mass (Da):108,171
Last modified:October 31, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD56D6480EFC962D7
GO
Isoform 2 (identifier: Q96HW7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     506-963: Missing.

Show »
Length:505
Mass (Da):56,550
Checksum:iADA236E485D9C524
GO
Isoform 3 (identifier: Q96HW7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-148: Missing.
     149-156: MRLVDVAC → MPSTSCRM
     642-659: DLQRLGELQSELAGVADF → VEVSPWWPGWSQTPELK
     660-963: Missing.

Note: No experimental confirmation available.
Show »
Length:510
Mass (Da):57,382
Checksum:i20099F1864BA11D5
GO
Isoform 4 (identifier: Q96HW7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-626: Missing.
     627-640: LDPQGAQELLEFTI → MPALKQTASQVTQTL

Note: No experimental confirmation available.
Show »
Length:338
Mass (Da):38,117
Checksum:i22006C401EB45360
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PIM3E9PIM3_HUMAN
Integrator complex subunit 4
INTS4
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAA7F8WAA7_HUMAN
Integrator complex subunit 4
INTS4
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti584V → M in AAQ13616 (Ref. 1) Curated1
Sequence conflicti900 – 901HT → PP in AAQ13616 (Ref. 1) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0214471 – 626Missing in isoform 4. 1 PublicationAdd BLAST626
Alternative sequenceiVSP_0214481 – 148Missing in isoform 3. 1 PublicationAdd BLAST148
Alternative sequenceiVSP_021449149 – 156MRLVDVAC → MPSTSCRM in isoform 3. 1 Publication8
Alternative sequenceiVSP_021450506 – 963Missing in isoform 2. 1 PublicationAdd BLAST458
Alternative sequenceiVSP_021451627 – 640LDPQG…LEFTI → MPALKQTASQVTQTL in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_021452642 – 659DLQRL…GVADF → VEVSPWWPGWSQTPELK in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_021453660 – 963Missing in isoform 3. 1 PublicationAdd BLAST304

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF172822 mRNA Translation: AAQ13616.1
BC006369 mRNA Translation: AAH06369.1
BC008013 mRNA Translation: AAH08013.1
BC009859 mRNA Translation: AAH09859.2
BC009995 mRNA Translation: AAH09995.1
BC015664 mRNA Translation: AAH15664.1
BK005723 mRNA Translation: DAA05723.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31644.1 [Q96HW7-1]

NCBI Reference Sequences

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RefSeqi
NP_291025.3, NM_033547.3 [Q96HW7-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.533723

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000529807; ENSP00000433644; ENSG00000149262 [Q96HW7-2]
ENST00000534064; ENSP00000434466; ENSG00000149262 [Q96HW7-1]
ENST00000535943; ENSP00000441084; ENSG00000149262 [Q96HW7-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
92105

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:92105

UCSC genome browser

More...
UCSCi
uc001oys.4 human [Q96HW7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172822 mRNA Translation: AAQ13616.1
BC006369 mRNA Translation: AAH06369.1
BC008013 mRNA Translation: AAH08013.1
BC009859 mRNA Translation: AAH09859.2
BC009995 mRNA Translation: AAH09995.1
BC015664 mRNA Translation: AAH15664.1
BK005723 mRNA Translation: DAA05723.1
CCDSiCCDS31644.1 [Q96HW7-1]
RefSeqiNP_291025.3, NM_033547.3 [Q96HW7-1]
UniGeneiHs.533723

3D structure databases

ProteinModelPortaliQ96HW7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124909, 53 interactors
CORUMiQ96HW7
IntActiQ96HW7, 14 interactors
STRINGi9606.ENSP00000434466

PTM databases

iPTMnetiQ96HW7
PhosphoSitePlusiQ96HW7
SwissPalmiQ96HW7

Polymorphism and mutation databases

BioMutaiINTS4
DMDMi118572560

Proteomic databases

EPDiQ96HW7
MaxQBiQ96HW7
PaxDbiQ96HW7
PeptideAtlasiQ96HW7
PRIDEiQ96HW7
ProteomicsDBi76789
76790 [Q96HW7-2]
76791 [Q96HW7-3]
76792 [Q96HW7-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
92105
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000529807; ENSP00000433644; ENSG00000149262 [Q96HW7-2]
ENST00000534064; ENSP00000434466; ENSG00000149262 [Q96HW7-1]
ENST00000535943; ENSP00000441084; ENSG00000149262 [Q96HW7-4]
GeneIDi92105
KEGGihsa:92105
UCSCiuc001oys.4 human [Q96HW7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
92105
DisGeNETi92105
EuPathDBiHostDB:ENSG00000149262.16

GeneCards: human genes, protein and diseases

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GeneCardsi
INTS4

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0022772
HIX0023207
HIX0058362
HGNCiHGNC:25048 INTS4
HPAiHPA042378
MIMi611348 gene
neXtProtiNX_Q96HW7
OpenTargetsiENSG00000149262
PharmGKBiPA144596421

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2259 Eukaryota
ENOG410XPX8 LUCA
GeneTreeiENSGT00390000010128
HOVERGENiHBG081801
InParanoidiQ96HW7
KOiK13141
OMAiEDPSHQF
OrthoDBiEOG091G01FC
PhylomeDBiQ96HW7
TreeFamiTF315047

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
INTS4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
92105

Protein Ontology

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PROi
PR:Q96HW7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000149262 Expressed in 199 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_INTS4
ExpressionAtlasiQ96HW7 baseline and differential
GenevisibleiQ96HW7 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR026003 Cohesin_HEAT
PfamiView protein in Pfam
PF12765 Cohesin_HEAT, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINT4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96HW7
Secondary accession number(s): Q2YD62
, Q6PJG4, Q7Z4E7, Q96G32, Q96GA1, Q9BRC0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 7, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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