UniProtKB - Q96HR8 (NAF1_HUMAN)

BLAST

>sp|Q96HR8|NAF1_HUMAN H/ACA ribonucleoprotein complex non-core subunit NAF1 OS=Homo sapiens OX=9606 GN=NAF1 PE=1 SV=2
MEVVEAAAAQLETLKFNGTDFGVGEGPAAPSPGSAPVPGTQPPLQSFEGSPDAGQTVEVK
PAGEQPLQPVLNAVAAGTPAPQPQPPAESPACGDCVTSPGAAEPARAPDSLETSDSDSDS
DSETDSDSSSSSSSSSSSSSSSSSSCISLPPVLSDGDDDLQIEKENKNFPLKTKDELLLN
ELPSVEELTIILPEDIELKPLGMVSSIIEQLVIIESMTNLPPVNEETVIFKSDRQAAGKI
FEIFGPVAHPFYVLRFNSSDHIESKGIKIKETMYFAPSMKDFTQYIFTEKLKQDKGSDAS
WKNDQEPPPEALDFSDDEKEKEAKQRKKSQIQGRKKLKSEFNEPGEDFTEVHQNWNAHSS
ASEHAKGYRNREFTRGFSRARYPRSCHGRPPPQHFYNSEHMVSQETSGFPSQRQNNPIMP
QYPFPLPVFDMHNFPLRPPPPPPPPPVNMGWATPNMAAHPLLNLPYSLPPPPPPPPLPPP
PSSGDSNSHFGPYY

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History
Entry version 126 (12 Sep 2018)
Sequence version 2 (18 May 2010)
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Protein

H/ACA ribonucleoprotein complex non-core subunit NAF1

Gene

NAF1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4.1 Publication

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16618814
telomerase RNA binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 18082603
- 22527283

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

box H/ACA snoRNP assembly Source: BHF-UCL
positive regulation of telomerase activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 27510903
positive regulation of telomerase RNA localization to Cajal body
Source: BHF-UCL
Inferred from high throughput mutant phenotypeⁱ
- 25467444
positive regulation of telomere maintenance via telomerase
Source: BHF-UCL
Traceable author statementⁱ
- 22527283
positive regulation of telomere maintenance via telomere lengthening
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 27510903
ribosome biogenesis
Source: UniProtKB
Inferred from direct assayⁱ
- 16618814
RNA stabilization Source: BHF-UCL
snoRNA guided rRNA pseudouridine synthesis Source: BHF-UCL
telomerase holoenzyme complex assembly
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 27510903
telomerase RNA stabilization
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 27510903

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, RNA-binding
Biological process	Ribosome biogenesis, rRNA processing

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: H/ACA ribonucleoprotein complex non-core subunit NAF1 Short name: hNAF1
Gene namesⁱ	Name:NAF1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000145414.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25126 NAF1
MIMⁱ	617868 gene
neXtProtⁱ	NX_Q96HR8

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	92345
Open Targets More...OpenTargetsⁱ	ENSG00000145414
PharmGKBⁱ	PA162396775

Polymorphism and mutation databases

BioMutaⁱ	NAF1
DMDMⁱ	296439238

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000315637	1 – 494	H/ACA ribonucleoprotein complex non-core subunit NAF1Add BLAST		494

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	315	PhosphoserineCombined sources	1
Cross-linkⁱ	338	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q96HR8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96HR8
PaxDbⁱ	Q96HR8
PeptideAtlas More...PeptideAtlasⁱ	Q96HR8
PRIDEⁱ	Q96HR8
ProteomicsDBⁱ	76779

PTM databases

iPTMnetⁱ	Q96HR8
PhosphoSitePlusⁱ	Q96HR8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000145414 Expressed in 193 organ(s), highest expression level in skeletal muscle tissue
CleanExⁱ	HS_NAF1
ExpressionAtlasⁱ	Q96HR8 baseline and differential
Genevisibleⁱ	Q96HR8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA036241 HPA036242 HPA066090

HPAⁱ

HPA036241
HPA036242
HPA066090

Interactionⁱ

Subunit structureⁱ

During assembly of the complex, component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs) which contains NOLA2/NHP2, NOLA3/NOP10, NAF1 and DKC1/NOLA4. Interacts directly with DKC1/NOLA4.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
BCL2	P10415	2	EBI-2515597,EBI-77694
DAB1	O75553	3	EBI-2515597,EBI-7875264
DKC1	O60832	7	EBI-2515597,EBI-713091
Dkc1	P40615	3	EBI-2515597,EBI-5746997	From Rattus norvegicus.
FAM168A	Q92567	3	EBI-2515597,EBI-7957930
RBFOX2	O43251	3	EBI-2515597,EBI-746056
SNX33	Q8WV41	3	EBI-2515597,EBI-2481535

Protein-protein interaction databases

BioGridⁱ	124938, 78 interactors
IntActⁱ	Q96HR8, 69 interactors
Molecular INTeraction database More...MINTⁱ	Q96HR8
STRINGⁱ	9606.ENSP00000274054

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	199 – 207	Combined sources	9
Beta strandⁱ	209 – 216	Combined sources	8
Beta strandⁱ	228 – 230	Combined sources	3
Beta strandⁱ	234 – 245	Combined sources	12
Beta strandⁱ	247 – 249	Combined sources	3
Beta strandⁱ	251 – 254	Combined sources	4
Helixⁱ	259 – 265	Combined sources	7
Beta strandⁱ	272 – 275	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q96HR8
SMRⁱ	Q96HR8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q96HR8

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	110 – 148	Ser-richAdd BLAST		39
Compositional biasⁱ	417 – 481	Pro-richAdd BLAST		65

Sequence similaritiesⁱ

Belongs to the NAF1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2236 Eukaryota ENOG4111RRE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004697
HOGENOMⁱ	HOG000168512
HOVERGENⁱ	HBG108169
InParanoidⁱ	Q96HR8
KEGG Orthology (KO) More...KOⁱ	K14763
OMAⁱ	YHPSYNP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GBB
PhylomeDBⁱ	Q96HR8
TreeFamⁱ	TF313273

Family and domain databases

Gene3Dⁱ	2.40.10.230, 1 hit
InterProⁱ	View protein in InterPro IPR038664 Gar1/Naf1_Cbf5-bd_sf IPR007504 H/ACA_rnp_Gar1/Naf1 IPR009000 Transl_B-barrel_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04410 Gar1, 1 hit
SUPFAMⁱ	SSF50447 SSF50447, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q96HR8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVVEAAAAQ LETLKFNGTD FGVGEGPAAP SPGSAPVPGT QPPLQSFEGS 
        60         70         80         90        100
PDAGQTVEVK PAGEQPLQPV LNAVAAGTPA PQPQPPAESP ACGDCVTSPG 
       110        120        130        140        150
AAEPARAPDS LETSDSDSDS DSETDSDSSS SSSSSSSSSS SSSSSCISLP 
       160        170        180        190        200
PVLSDGDDDL QIEKENKNFP LKTKDELLLN ELPSVEELTI ILPEDIELKP 
       210        220        230        240        250
LGMVSSIIEQ LVIIESMTNL PPVNEETVIF KSDRQAAGKI FEIFGPVAHP 
       260        270        280        290        300
FYVLRFNSSD HIESKGIKIK ETMYFAPSMK DFTQYIFTEK LKQDKGSDAS 
       310        320        330        340        350
WKNDQEPPPE ALDFSDDEKE KEAKQRKKSQ IQGRKKLKSE FNEPGEDFTE 
       360        370        380        390        400
VHQNWNAHSS ASEHAKGYRN REFTRGFSRA RYPRSCHGRP PPQHFYNSEH 
       410        420        430        440        450
MVSQETSGFP SQRQNNPIMP QYPFPLPVFD MHNFPLRPPP PPPPPPVNMG 
       460        470        480        490 
WATPNMAAHP LLNLPYSLPP PPPPPPLPPP PSSGDSNSHF GPYY

Length:494

Mass (Da):53,717

Last modified:May 18, 2010 - v2

Checksum:ⁱ5A0C9B635A982A62

Isoform 2 (identifier: Q96HR8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
346-389: EDFTEVHQNW...ARYPRSCHGR → TGISHRYCGL...TCYFSLLSMQ
390-494: Missing.

« Hide

        10         20         30         40         50
MEVVEAAAAQ LETLKFNGTD FGVGEGPAAP SPGSAPVPGT QPPLQSFEGS 
        60         70         80         90        100
PDAGQTVEVK PAGEQPLQPV LNAVAAGTPA PQPQPPAESP ACGDCVTSPG 
       110        120        130        140        150
AAEPARAPDS LETSDSDSDS DSETDSDSSS SSSSSSSSSS SSSSSCISLP 
       160        170        180        190        200
PVLSDGDDDL QIEKENKNFP LKTKDELLLN ELPSVEELTI ILPEDIELKP 
       210        220        230        240        250
LGMVSSIIEQ LVIIESMTNL PPVNEETVIF KSDRQAAGKI FEIFGPVAHP 
       260        270        280        290        300
FYVLRFNSSD HIESKGIKIK ETMYFAPSMK DFTQYIFTEK LKQDKGSDAS 
       310        320        330        340        350
WKNDQEPPPE ALDFSDDEKE KEAKQRKKSQ IQGRKKLKSE FNEPGTGISH 
       360        370        380 
RYCGLGSRPL QSSESHKLFG FQMHIKVTFT CYFSLLSMQ

Note: No experimental confirmation available.

Show »

Length:389

Mass (Da):41,895

Checksum:ⁱA05B634D1CA4001D

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D6RIB3	D6RIB3_HUMAN		H/ACA ribonucleoprotein complex non... H/ACA ribonucleoprotein complex non-core subunit NAF1	NAF1	42	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_057795	43	P → S. Corresponds to variant dbSNP:rs12331663Ensembl.		1
Natural variantⁱVAR_063101	162	I → V1 PublicationCorresponds to variant dbSNP:rs4691896Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_046217	346 – 389	EDFTE…SCHGR → TGISHRYCGLGSRPLQSSES HKLFGFQMHIKVTFTCYFSL LSMQ in isoform 2. 1 PublicationAdd BLAST		44
Alternative sequenceⁱVSP_046218	390 – 494	Missing in isoform 2. 1 PublicationAdd BLAST		105

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK308601 mRNA No translation available. AC022272 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX04843.1 CH471056 Genomic DNA Translation: EAX04844.1 BC008207 mRNA Translation: AAH08207.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3803.1 [Q96HR8-1] CCDS47159.1 [Q96HR8-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001122403.1, NM_001128931.1 [Q96HR8-2] NP_612395.2, NM_138386.2 [Q96HR8-1] XP_011530712.1, XM_011532410.2 [Q96HR8-1]
UniGeneⁱ	Hs.129095 Hs.733548

Genome annotation databases

Ensemblⁱ	ENST00000274054; ENSP00000274054; ENSG00000145414 [Q96HR8-1] ENST00000422287; ENSP00000408963; ENSG00000145414 [Q96HR8-2]
GeneIDⁱ	92345
KEGGⁱ	hsa:92345
UCSC genome browser More...UCSCⁱ	uc003iqj.4 human [Q96HR8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96HR8	Uncharacterized protein		COLAP		498	UniRef90_Q96HR8
Uncharacterized protein		AOTNA		498
Uncharacterized protein		MACMU		497
Uncharacterized protein		CERAT		497
Uncharacterized protein		PAPAN		497
+27
Q96HR8-2	Uncharacterized protein		PAPAN		393	UniRef90_Q96HR8-2
Uncharacterized protein		COLAP		392
Uncharacterized protein		MANLE		391
Uncharacterized protein		RHIRO		390
NAF1 isoform 2		PANTR		389
+12

Protein	Similar proteins		Species	Score	Length	Source
Q96HR8	Uncharacterized protein		AOTNA		498	UniRef50_Q96HR8
Uncharacterized protein		COLAP		498
Uncharacterized protein		MACMU		497
Uncharacterized protein		CHLSB		497
Uncharacterized protein		PAPAN		497
+85
Q96HR8-2	H/ACA ribonucleoprotein complex non-core subunit NAF1		RAT		457	UniRef50_Q96HR8-2
Uncharacterized protein		PAPAN		393
Uncharacterized protein		COLAP		392
Uncharacterized protein		MANLE		391
Uncharacterized protein		RHIRO		390
+58

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK308601 mRNA No translation available. AC022272 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX04843.1 CH471056 Genomic DNA Translation: EAX04844.1 BC008207 mRNA Translation: AAH08207.1
CCDSⁱ	CCDS3803.1 [Q96HR8-1] CCDS47159.1 [Q96HR8-2]
RefSeqⁱ	NP_001122403.1, NM_001128931.1 [Q96HR8-2] NP_612395.2, NM_138386.2 [Q96HR8-1] XP_011530712.1, XM_011532410.2 [Q96HR8-1]
UniGeneⁱ	Hs.129095 Hs.733548

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2EQN	NMR	-	A	181-276	[»]
ProteinModelPortalⁱ	Q96HR8
SMRⁱ	Q96HR8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124938, 78 interactors
IntActⁱ	Q96HR8, 69 interactors
MINTⁱ	Q96HR8
STRINGⁱ	9606.ENSP00000274054

PTM databases

iPTMnetⁱ	Q96HR8
PhosphoSitePlusⁱ	Q96HR8

Polymorphism and mutation databases

BioMutaⁱ	NAF1
DMDMⁱ	296439238

Proteomic databases

EPDⁱ	Q96HR8
MaxQBⁱ	Q96HR8
PaxDbⁱ	Q96HR8
PeptideAtlasⁱ	Q96HR8
PRIDEⁱ	Q96HR8
ProteomicsDBⁱ	76779

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000274054; ENSP00000274054; ENSG00000145414 [Q96HR8-1] ENST00000422287; ENSP00000408963; ENSG00000145414 [Q96HR8-2]
GeneIDⁱ	92345
KEGGⁱ	hsa:92345
UCSCⁱ	uc003iqj.4 human [Q96HR8-1]

Organism-specific databases

CTDⁱ	92345
DisGeNETⁱ	92345
EuPathDBⁱ	HostDB:ENSG00000145414.8
GeneCardsⁱ	NAF1
H-InvDBⁱ	HIX0004605
HGNCⁱ	HGNC:25126 NAF1
HPAⁱ	HPA036241 HPA036242 HPA066090
MIMⁱ	617868 gene
neXtProtⁱ	NX_Q96HR8
OpenTargetsⁱ	ENSG00000145414
PharmGKBⁱ	PA162396775
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2236 Eukaryota ENOG4111RRE LUCA
GeneTreeⁱ	ENSGT00390000004697
HOGENOMⁱ	HOG000168512
HOVERGENⁱ	HBG108169
InParanoidⁱ	Q96HR8
KOⁱ	K14763
OMAⁱ	YHPSYNP
OrthoDBⁱ	EOG091G0GBB
PhylomeDBⁱ	Q96HR8
TreeFamⁱ	TF313273

Miscellaneous databases

EvolutionaryTraceⁱ	Q96HR8
GenomeRNAiⁱ	92345
Protein Ontology More...PROⁱ	PR:Q96HR8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000145414 Expressed in 193 organ(s), highest expression level in skeletal muscle tissue
CleanExⁱ	HS_NAF1
ExpressionAtlasⁱ	Q96HR8 baseline and differential
Genevisibleⁱ	Q96HR8 HS

Family and domain databases

Gene3Dⁱ	2.40.10.230, 1 hit
InterProⁱ	View protein in InterPro IPR038664 Gar1/Naf1_Cbf5-bd_sf IPR007504 H/ACA_rnp_Gar1/Naf1 IPR009000 Transl_B-barrel_sf
Pfamⁱ	View protein in Pfam PF04410 Gar1, 1 hit
SUPFAMⁱ	SSF50447 SSF50447, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NAF1_HUMAN
Accessionⁱ	Q96HR8Primary (citable) accession number: Q96HR8 Secondary accession number(s): D3DP28, E9PAZ2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	May 18, 2010
	Last modified:	September 12, 2018
	This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q96HR8 (NAF1_HUMAN)

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H/ACA ribonucleoprotein complex non-core subunit NAF1

NAF1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ