UniProtKB - Q96HQ2 (C2AIL_HUMAN)
Protein
CDKN2AIP N-terminal-like protein
Gene
CDKN2AIPNL
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: CDKN2AIP N-terminal-like proteinAlternative name(s): CDKN2A-interacting protein N-terminal-like protein |
Gene namesi | Name:CDKN2AIPNL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000237190.3 |
HGNCi | HGNC:30545, CDKN2AIPNL |
neXtProti | NX_Q96HQ2 |
Subcellular locationi
Nucleus
- nucleolus Source: GO_Central
- nucleoplasm Source: GO_Central
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 81 | Y → A: Abolishes binding to XRN2. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 91368 |
OpenTargetsi | ENSG00000237190 |
PharmGKBi | PA162382150 |
Miscellaneous databases
Pharosi | Q96HQ2, Tdark |
Polymorphism and mutation databases
BioMutai | CDKN2AIPNL |
DMDMi | 74731962 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000325926 | 1 – 116 | CDKN2AIP N-terminal-like proteinAdd BLAST | 116 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources1 Publication | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q96HQ2 |
jPOSTi | Q96HQ2 |
MassIVEi | Q96HQ2 |
MaxQBi | Q96HQ2 |
PaxDbi | Q96HQ2 |
PeptideAtlasi | Q96HQ2 |
PRIDEi | Q96HQ2 |
ProteomicsDBi | 76776 [Q96HQ2-1] 76777 [Q96HQ2-2] |
TopDownProteomicsi | Q96HQ2-1 [Q96HQ2-1] |
PTM databases
iPTMneti | Q96HQ2 |
MetOSitei | Q96HQ2 |
PhosphoSitePlusi | Q96HQ2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000237190, Expressed in quadriceps femoris and 196 other tissues |
Genevisiblei | Q96HQ2, HS |
Organism-specific databases
HPAi | ENSG00000237190, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with XRN2; the interaction is direct.
1 PublicationBinary interactionsi
Hide detailsQ96HQ2
With | #Exp. | IntAct |
---|---|---|
AGR2 [O95994] | 3 | EBI-10038935,EBI-712648 |
CTAG1B [P78358] | 3 | EBI-10038935,EBI-1188472 |
NTAQ1 [Q96HA8] | 3 | EBI-10038935,EBI-741158 |
XRN2 [Q9H0D6] | 2 | EBI-10038935,EBI-372110 |
Protein-protein interaction databases
BioGRIDi | 124820, 16 interactors |
DIPi | DIP-61982N |
IntActi | Q96HQ2, 15 interactors |
STRINGi | 9606.ENSP00000394183 |
Miscellaneous databases
RNActi | Q96HQ2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 116 | XRN2-binding (XTBD)PROSITE-ProRule annotationAdd BLAST | 93 |
Sequence similaritiesi
Belongs to the CARF family.Curated
Phylogenomic databases
eggNOGi | ENOG502S4FT, Eukaryota |
GeneTreei | ENSGT00940000157177 |
HOGENOMi | CLU_148771_0_0_1 |
InParanoidi | Q96HQ2 |
OMAi | WESDKHW |
OrthoDBi | 1524198at2759 |
PhylomeDBi | Q96HQ2 |
TreeFami | TF333807 |
Family and domain databases
InterProi | View protein in InterPro IPR021859, XTBD |
Pfami | View protein in Pfam PF11952, XTBD, 1 hit |
PROSITEi | View protein in PROSITE PS51827, XTBD, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q96HQ2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVGGEAAAAV EELVSGVRQA ADFAEQFRSY SESEKQWKAR MEFILRHLPD
60 70 80 90 100
YRDPPDGSGR LDQLLSLSMV WANHLFLGCS YNKDLLDKVM EMADGIEVED
110
LPQFTTRSEL MKKHQS
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_032486 | 81 – 116 | YNKDL…KKHQS → PRGPK in isoform 2. 1 PublicationAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471062 Genomic DNA Translation: EAW62260.1 CH471062 Genomic DNA Translation: EAW62261.1 BC008293 mRNA Translation: AAH08293.1 BC018086 mRNA Translation: AAH18086.1 |
CCDSi | CCDS4175.1 [Q96HQ2-1] |
RefSeqi | NP_542387.1, NM_080656.2 [Q96HQ2-1] |
Genome annotation databases
Ensembli | ENST00000395009; ENSP00000378456; ENSG00000237190 [Q96HQ2-2] ENST00000458198; ENSP00000394183; ENSG00000237190 [Q96HQ2-1] |
GeneIDi | 91368 |
KEGGi | hsa:91368 |
UCSCi | uc011cxs.3, human [Q96HQ2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471062 Genomic DNA Translation: EAW62260.1 CH471062 Genomic DNA Translation: EAW62261.1 BC008293 mRNA Translation: AAH08293.1 BC018086 mRNA Translation: AAH18086.1 |
CCDSi | CCDS4175.1 [Q96HQ2-1] |
RefSeqi | NP_542387.1, NM_080656.2 [Q96HQ2-1] |
3D structure databases
SMRi | Q96HQ2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124820, 16 interactors |
DIPi | DIP-61982N |
IntActi | Q96HQ2, 15 interactors |
STRINGi | 9606.ENSP00000394183 |
PTM databases
iPTMneti | Q96HQ2 |
MetOSitei | Q96HQ2 |
PhosphoSitePlusi | Q96HQ2 |
Polymorphism and mutation databases
BioMutai | CDKN2AIPNL |
DMDMi | 74731962 |
Proteomic databases
EPDi | Q96HQ2 |
jPOSTi | Q96HQ2 |
MassIVEi | Q96HQ2 |
MaxQBi | Q96HQ2 |
PaxDbi | Q96HQ2 |
PeptideAtlasi | Q96HQ2 |
PRIDEi | Q96HQ2 |
ProteomicsDBi | 76776 [Q96HQ2-1] 76777 [Q96HQ2-2] |
TopDownProteomicsi | Q96HQ2-1 [Q96HQ2-1] |
Protocols and materials databases
Antibodypediai | 64397, 35 antibodies |
DNASUi | 91368 |
Genome annotation databases
Ensembli | ENST00000395009; ENSP00000378456; ENSG00000237190 [Q96HQ2-2] ENST00000458198; ENSP00000394183; ENSG00000237190 [Q96HQ2-1] |
GeneIDi | 91368 |
KEGGi | hsa:91368 |
UCSCi | uc011cxs.3, human [Q96HQ2-1] |
Organism-specific databases
CTDi | 91368 |
DisGeNETi | 91368 |
EuPathDBi | HostDB:ENSG00000237190.3 |
GeneCardsi | CDKN2AIPNL |
HGNCi | HGNC:30545, CDKN2AIPNL |
HPAi | ENSG00000237190, Low tissue specificity |
neXtProti | NX_Q96HQ2 |
OpenTargetsi | ENSG00000237190 |
PharmGKBi | PA162382150 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S4FT, Eukaryota |
GeneTreei | ENSGT00940000157177 |
HOGENOMi | CLU_148771_0_0_1 |
InParanoidi | Q96HQ2 |
OMAi | WESDKHW |
OrthoDBi | 1524198at2759 |
PhylomeDBi | Q96HQ2 |
TreeFami | TF333807 |
Enzyme and pathway databases
PathwayCommonsi | Q96HQ2 |
Miscellaneous databases
BioGRID-ORCSi | 91368, 20 hits in 840 CRISPR screens |
ChiTaRSi | CDKN2AIPNL, human |
GenomeRNAii | 91368 |
Pharosi | Q96HQ2, Tdark |
PROi | PR:Q96HQ2 |
RNActi | Q96HQ2, protein |
Gene expression databases
Bgeei | ENSG00000237190, Expressed in quadriceps femoris and 196 other tissues |
Genevisiblei | Q96HQ2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR021859, XTBD |
Pfami | View protein in Pfam PF11952, XTBD, 1 hit |
PROSITEi | View protein in PROSITE PS51827, XTBD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C2AIL_HUMAN | |
Accessioni | Q96HQ2Primary (citable) accession number: Q96HQ2 Secondary accession number(s): Q8WVE3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families