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Entry version 163 (02 Dec 2020)
Sequence version 2 (14 Oct 2008)
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Protein

Zinc finger protein 419

Gene

ZNF419

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri203 – 225C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri399 – 421C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96HQ0

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 419
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF419
Synonyms:ZNF419A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000105136.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20648, ZNF419

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617410, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96HQ0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79744

Open Targets

More...
OpenTargetsi
ENSG00000105136

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134871733

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96HQ0, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF419

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572704

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475741 – 510Zinc finger protein 419Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki166Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96HQ0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96HQ0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96HQ0

PeptideAtlas

More...
PeptideAtlasi
Q96HQ0

PRoteomics IDEntifications database

More...
PRIDEi
Q96HQ0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19485
19860
19957
20201
76774 [Q96HQ0-1]
76775 [Q96HQ0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96HQ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96HQ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105136, Expressed in prostate gland and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96HQ0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96HQ0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000105136, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122856, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q96HQ0, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000388864

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96HQ0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96HQ0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 98KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri203 – 225C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri399 – 421C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164209

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_0_9_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96HQ0

Identification of Orthologs from Complete Genome Data

More...
OMAi
LTYHEEG

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96HQ0

TreeFam database of animal gene trees

More...
TreeFami
TF339848

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 11 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 11 hits
PS50157, ZINC_FINGER_C2H2_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96HQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAALRDPA QVPVAADLLT DHEEGYVTFE DVAVYFSQEE WRLLDDAQRL
60 70 80 90 100
LYRNVMLENF TLLASLGLAS SKTHEITQLE SWEEPFMPAW EVVTSAIPRG
110 120 130 140 150
CWHGAEAEEA PEQIASVGLL SSNIQQHQKQ HCGEKPLKRQ EGRVPVLRSC
160 170 180 190 200
KVHLSEKSLQ SREVGKALLI SSGVLKHQVT HTGEKSHRSS KSREAFHAGK
210 220 230 240 250
RHYKCSECGK AFGQKYLLVQ HQRLHAGKKT YECSECGKLF RDMSNLFIHQ
260 270 280 290 300
IVHTGERPYG CSNCGKSFSR NAHLIEHQRV HTGEKPFTCS ECGKAFRHNS
310 320 330 340 350
TLVQHHKIHT GVRPYECSEC GKLFSFNSSL MKHQRIHTGE RPYKCSECGK
360 370 380 390 400
FYSHKSNLIK HWRVHTGERP YKCSDCGKFF TQCSSLMQHQ KVHTGEKPFK
410 420 430 440 450
CNECGRFFRE NSTLVRHQRV HTGAKPYECR ECGKFFSQSS TLMQHRKVHI
460 470 480 490 500
GEKPFKCNEC GRLFRENSSL VKHQRVHTGA KPYECRECGK FFRHNSSLFK
510
HRRIHTGEMQ
Length:510
Mass (Da):58,564
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B4EDB2D92053826
GO
Isoform 2 (identifier: Q96HQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: E → EQ
     67-99: Missing.

Show »
Length:478
Mass (Da):54,982
Checksum:i85F42EFA54C5F720
GO
Isoform 3 (identifier: Q96HQ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-24: Missing.

Show »
Length:497
Mass (Da):57,173
Checksum:i3CA8A9B3BFD7A386
GO
Isoform 4 (identifier: Q96HQ0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-24: VPVAADLLTDHEE → Q

Show »
Length:498
Mass (Da):57,301
Checksum:i95B02897C6261409
GO
Isoform 5 (identifier: Q96HQ0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: E → EQ

Show »
Length:511
Mass (Da):58,692
Checksum:i7BC7CEE5580BC692
GO
Isoform 6 (identifier: Q96HQ0-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-24: Missing.
     67-99: Missing.

Show »
Length:464
Mass (Da):53,463
Checksum:iBF7A918F9C05A2CF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NNZ3A6NNZ3_HUMAN
Zinc finger protein 419
ZNF419
442Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHW2E5RHW2_HUMAN
Zinc finger protein 419
ZNF419
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RH62E5RH62_HUMAN
Zinc finger protein 419
ZNF419
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGL3E5RGL3_HUMAN
Zinc finger protein 419
ZNF419
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI89E5RI89_HUMAN
Zinc finger protein 419
ZNF419
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHS2E5RHS2_HUMAN
Zinc finger protein 419
ZNF419
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHZ9E5RHZ9_HUMAN
Zinc finger protein 419
ZNF419
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJT6E5RJT6_HUMAN
Zinc finger protein 419
ZNF419
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIA3E5RIA3_HUMAN
Zinc finger protein 419
ZNF419
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti194E → G in BAG65360 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046651141E → Q2 PublicationsCorresponds to variant dbSNP:rs2074076Ensembl.1
Natural variantiVAR_046652336I → V2 PublicationsCorresponds to variant dbSNP:rs2074077EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04614912 – 24Missing in isoform 3 and isoform 6. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_04710612 – 24VPVAA…TDHEE → Q in isoform 4. CuratedAdd BLAST13
Alternative sequenceiVSP_01603424E → EQ in isoform 2 and isoform 5. 1 Publication1
Alternative sequenceiVSP_01603367 – 99Missing in isoform 2 and isoform 6. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK026886 mRNA Translation: BAB15582.1
AK302135 mRNA Translation: BAG63509.1
AK304569 mRNA Translation: BAG65360.1
AK316156 mRNA Translation: BAH14527.1
AK316297 mRNA Translation: BAH14668.1
AC003005 Genomic DNA No translation available.
BC008297 mRNA Translation: AAH08297.1
BC024259 mRNA Translation: AAH24259.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42637.1 [Q96HQ0-2]
CCDS46211.1 [Q96HQ0-6]
CCDS54325.1 [Q96HQ0-5]
CCDS54326.1 [Q96HQ0-1]
CCDS54327.1 [Q96HQ0-4]
CCDS54328.1 [Q96HQ0-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001091961.1, NM_001098491.1 [Q96HQ0-5]
NP_001091962.1, NM_001098492.1 [Q96HQ0-4]
NP_001091963.1, NM_001098493.1 [Q96HQ0-3]
NP_001091964.1, NM_001098494.1 [Q96HQ0-2]
NP_001091965.1, NM_001098495.1
NP_001091966.1, NM_001098496.1 [Q96HQ0-6]
NP_001278672.1, NM_001291743.1
NP_001278673.1, NM_001291744.1
NP_001278674.1, NM_001291745.1
NP_078967.3, NM_024691.3 [Q96HQ0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000221735; ENSP00000221735; ENSG00000105136 [Q96HQ0-1]
ENST00000347466; ENSP00000299860; ENSG00000105136 [Q96HQ0-2]
ENST00000415379; ENSP00000392129; ENSG00000105136 [Q96HQ0-6]
ENST00000424930; ENSP00000388864; ENSG00000105136 [Q96HQ0-5]
ENST00000426954; ENSP00000390916; ENSG00000105136 [Q96HQ0-4]
ENST00000442920; ENSP00000414709; ENSG00000105136 [Q96HQ0-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79744

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79744

UCSC genome browser

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UCSCi
uc002qov.3, human [Q96HQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026886 mRNA Translation: BAB15582.1
AK302135 mRNA Translation: BAG63509.1
AK304569 mRNA Translation: BAG65360.1
AK316156 mRNA Translation: BAH14527.1
AK316297 mRNA Translation: BAH14668.1
AC003005 Genomic DNA No translation available.
BC008297 mRNA Translation: AAH08297.1
BC024259 mRNA Translation: AAH24259.1
CCDSiCCDS42637.1 [Q96HQ0-2]
CCDS46211.1 [Q96HQ0-6]
CCDS54325.1 [Q96HQ0-5]
CCDS54326.1 [Q96HQ0-1]
CCDS54327.1 [Q96HQ0-4]
CCDS54328.1 [Q96HQ0-3]
RefSeqiNP_001091961.1, NM_001098491.1 [Q96HQ0-5]
NP_001091962.1, NM_001098492.1 [Q96HQ0-4]
NP_001091963.1, NM_001098493.1 [Q96HQ0-3]
NP_001091964.1, NM_001098494.1 [Q96HQ0-2]
NP_001091965.1, NM_001098495.1
NP_001091966.1, NM_001098496.1 [Q96HQ0-6]
NP_001278672.1, NM_001291743.1
NP_001278673.1, NM_001291744.1
NP_001278674.1, NM_001291745.1
NP_078967.3, NM_024691.3 [Q96HQ0-1]

3D structure databases

SMRiQ96HQ0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122856, 4 interactors
IntActiQ96HQ0, 4 interactors
STRINGi9606.ENSP00000388864

PTM databases

iPTMnetiQ96HQ0
PhosphoSitePlusiQ96HQ0

Polymorphism and mutation databases

BioMutaiZNF419
DMDMi209572704

Proteomic databases

MassIVEiQ96HQ0
MaxQBiQ96HQ0
PaxDbiQ96HQ0
PeptideAtlasiQ96HQ0
PRIDEiQ96HQ0
ProteomicsDBi19485
19860
19957
20201
76774 [Q96HQ0-1]
76775 [Q96HQ0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
826, 135 antibodies

The DNASU plasmid repository

More...
DNASUi
79744

Genome annotation databases

EnsembliENST00000221735; ENSP00000221735; ENSG00000105136 [Q96HQ0-1]
ENST00000347466; ENSP00000299860; ENSG00000105136 [Q96HQ0-2]
ENST00000415379; ENSP00000392129; ENSG00000105136 [Q96HQ0-6]
ENST00000424930; ENSP00000388864; ENSG00000105136 [Q96HQ0-5]
ENST00000426954; ENSP00000390916; ENSG00000105136 [Q96HQ0-4]
ENST00000442920; ENSP00000414709; ENSG00000105136 [Q96HQ0-3]
GeneIDi79744
KEGGihsa:79744
UCSCiuc002qov.3, human [Q96HQ0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79744
DisGeNETi79744
EuPathDBiHostDB:ENSG00000105136.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF419
HGNCiHGNC:20648, ZNF419
HPAiENSG00000105136, Low tissue specificity
MIMi617410, gene
neXtProtiNX_Q96HQ0
OpenTargetsiENSG00000105136
PharmGKBiPA134871733

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000164209
HOGENOMiCLU_002678_0_9_1
InParanoidiQ96HQ0
OMAiLTYHEEG
OrthoDBi1318335at2759
PhylomeDBiQ96HQ0
TreeFamiTF339848

Enzyme and pathway databases

PathwayCommonsiQ96HQ0
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
79744, 7 hits in 869 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79744
PharosiQ96HQ0, Tdark

Protein Ontology

More...
PROi
PR:Q96HQ0
RNActiQ96HQ0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105136, Expressed in prostate gland and 235 other tissues
ExpressionAtlasiQ96HQ0, baseline and differential
GenevisibleiQ96HQ0, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 11 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 11 hits
PS50157, ZINC_FINGER_C2H2_2, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN419_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96HQ0
Secondary accession number(s): B4DXU7
, B4E348, B7ZA41, E9PCP4, E9PED0, E9PET3, E9PFX9, Q9H5P0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 14, 2008
Last modified: December 2, 2020
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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