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Entry version 151 (12 Aug 2020)
Sequence version 3 (18 May 2010)
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Protein

Dedicator of cytokinesis protein 6

Gene

DOCK6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q96HP0

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-983231, Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dedicator of cytokinesis protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DOCK6
Synonyms:KIAA1395
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000130158.13

Human Gene Nomenclature Database

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HGNCi
HGNC:19189, DOCK6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614194, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q96HP0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Adams-Oliver syndrome 2 (AOS2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by the congenital absence of skin (aplasia cutis congenita) in combination with transverse limb defects. Aplasia cutis congenita can be located anywhere on the body, but in the vast majority of the cases, it is present on the posterior parietal region where it is often associated with an underlying defect of the parietal bones. Limb abnormalities are typically limb truncation defects affecting the distal phalanges or entire digits (true ectrodactyly). Only rarely, metatarsals/metacarpals or more proximal limb structures are also affected. Apart from transverse limb defects, syndactyly, most commonly of second and third toes, can also be observed. The clinical features are highly variable and can also include cardiovascular malformations, brain abnormalities and vascular defects such as cutis marmorata and dilated scalp veins.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
57572

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
DOCK6

MalaCards human disease database

More...
MalaCardsi
DOCK6
MIMi614219, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000130158

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
974, Adams-Oliver syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134913824

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96HP0, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DOCK6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439370

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001899931 – 2047Dedicator of cytokinesis protein 6Add BLAST2047

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei178PhosphoserineBy similarity1
Modified residuei865Omega-N-methylarginineBy similarity1
Modified residuei872PhosphoserineCombined sources1
Modified residuei880PhosphoserineCombined sources1
Modified residuei884PhosphoserineBy similarity1
Modified residuei1308PhosphoserineCombined sources1
Modified residuei2036PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96HP0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96HP0

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96HP0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96HP0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96HP0

PeptideAtlas

More...
PeptideAtlasi
Q96HP0

PRoteomics IDEntifications database

More...
PRIDEi
Q96HP0

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
76771

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96HP0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96HP0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed at low level in spleen, cerebellum, hippocampus and in substantia nigra.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000130158, Expressed in right lung and 210 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96HP0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96HP0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000130158, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
121625, 31 interactors

Protein interaction database and analysis system

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IntActi
Q96HP0, 31 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000294618

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q96HP0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96HP0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini548 – 714C2 DOCK-typePROSITE-ProRule annotationAdd BLAST167
Domaini1587 – 2023DOCKERPROSITE-ProRule annotationAdd BLAST437

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DOCKER domain may mediate some GEF activity.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1997, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000159313

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96HP0

KEGG Orthology (KO)

More...
KOi
K21852

Identification of Orthologs from Complete Genome Data

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OMAi
ANMEGEL

Database of Orthologous Groups

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OrthoDBi
20156at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96HP0

TreeFam database of animal gene trees

More...
TreeFami
TF313629

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08696, C2_Dock-C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.740, 1 hit
1.25.40.410, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037808, C2_Dock-C
IPR035892, C2_domain_sf
IPR027007, DHR-1_domain
IPR027357, DHR-2
IPR026791, DOCK
IPR010703, DOCK_C
IPR021816, DOCK_C/D_N
IPR043161, DOCK_C_lobe_A
IPR043162, DOCK_C_lobe_C

The PANTHER Classification System

More...
PANTHERi
PTHR23317, PTHR23317, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06920, DHR-2, 1 hit
PF14429, DOCK-C2, 1 hit
PF11878, DUF3398, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51650, C2_DOCK, 1 hit
PS51651, DOCKER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q96HP0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASERRAFA HKINRTVAAE VRKQVSRERS GSPHSSRRCS SSLGVPLTEV
60 70 80 90 100
VEPLDFEDVL LSRPPDAEPG PLRDLVEFPA DDLELLLQPR ECRTTEPGIP
110 120 130 140 150
KDEKLDAQVR AAVEMYIEDW VIVHRRYQYL SAAYSPVTTD TQRERQKGLP
160 170 180 190 200
RQVFEQDASG DERSGPEDSN DSRRGSGSPE DTPRSSGASS IFDLRNLAAD
210 220 230 240 250
SLLPSLLERA APEDVDRRNE TLRRQHRPPA LLTLYPAPDE DEAVERCSRP
260 270 280 290 300
EPPREHFGQR ILVKCLSLKF EIEIEPIFGI LALYDVREKK KISENFYFDL
310 320 330 340 350
NSDSMKGLLR AHGTHPAIST LARSAIFSVT YPSPDIFLVI KLEKVLQQGD
360 370 380 390 400
ISECCEPYMV LKEVDTAKNK EKLEKLRLAA EQFCTRLGRY RMPFAWTAVH
410 420 430 440 450
LANIVSSAGQ LDRDSDSEGE RRPAWTDRRR RGPQDRASSG DDACSFSGFR
460 470 480 490 500
PATLTVTNFF KQEAERLSDE DLFKFLADMR RPSSLLRRLR PVTAQLKIDI
510 520 530 540 550
SPAPENPHFC LSPELLHIKP YPDPRGRPTK EILEFPAREV YAPHTSYRNL
560 570 580 590 600
LYVYPHSLNF SSRQGSVRNL AVRVQYMTGE DPSQALPVIF GKSSCSEFTR
610 620 630 640 650
EAFTPVVYHN KSPEFYEEFK LHLPACVTEN HHLLFTFYHV SCQPRPGTAL
660 670 680 690 700
ETPVGFTWIP LLQHGRLRTG PFCLPVSVDQ PPPSYSVLTP DVALPGMRWV
710 720 730 740 750
DGHKGVFSVE LTAVSSVHPQ DPYLDKFFTL VHVLEEGAFP FRLKDTVLSE
760 770 780 790 800
GNVEQELRAS LAALRLASPE PLVAFSHHVL DKLVRLVIRP PIISGQIVNL
810 820 830 840 850
GRGAFEAMAH VVSLVHRSLE AAQDARGHCP QLAAYVHYAF RLPGTEPSLP
860 870 880 890 900
DGAPPVTVQA ATLARGSGRP ASLYLARSKS ISSSNPDLAV APGSVDDEVS
910 920 930 940 950
RILASKLLHE ELALQWVVSS SAVREAILQH AWFFFQLMVK SMALHLLLGQ
960 970 980 990 1000
RLDTPRKLRF PGRFLDDITA LVGSVGLEVI TRVHKDVELA EHLNASLAFF
1010 1020 1030 1040 1050
LSDLLSLVDR GFVFSLVRAH YKQVATRLQS SPNPAALLTL RMEFTRILCS
1060 1070 1080 1090 1100
HEHYVTLNLP CCPLSPPASP SPSVSSTTSQ SSTFSSQAPD PKVTSMFELS
1110 1120 1130 1140 1150
GPFRQQHFLA GLLLTELALA LEPEAEGAFL LHKKAISAVH SLLCGHDTDP
1160 1170 1180 1190 1200
RYAEATVKAR VAELYLPLLS IARDTLPRLH DFAEGPGQRS RLASMLDSDT
1210 1220 1230 1240 1250
EGEGDIAGTI NPSVAMAIAG GPLAPGSRAS ISQGPPTASR AGCALSAESS
1260 1270 1280 1290 1300
RTLLACVLWV LKNTEPALLQ RWATDLTLPQ LGRLLDLLYL CLAAFEYKGK
1310 1320 1330 1340 1350
KAFERINSLT FKKSLDMKAR LEEAILGTIG ARQEMVRRSR ERSPFGNPEN
1360 1370 1380 1390 1400
VRWRKSVTHW KQTSDRVDKT KDEMEHEALV EGNLATEASL VVLDTLEIIV
1410 1420 1430 1440 1450
QTVMLSEARE SVLGAVLKVV LYSLGSAQSA LFLQHGLATQ RALVSKFPEL
1460 1470 1480 1490 1500
LFEEDTELCA DLCLRLLRHC GSRISTIRTH ASASLYLLMR QNFEIGHNFA
1510 1520 1530 1540 1550
RVKMQVTMSL SSLVGTTQNF SEEHLRRSLK TILTYAEEDM GLRDSTFAEQ
1560 1570 1580 1590 1600
VQDLMFNLHM ILTDTVKMKE HQEDPEMLID LMYRIARGYQ GSPDLRLTWL
1610 1620 1630 1640 1650
QNMAGKHAEL GNHAEAAQCM VHAAALVAEY LALLEDHRHL PVGCVSFQNI
1660 1670 1680 1690 1700
SSNVLEESAI SDDILSPDEE GFCSGKHFTE LGLVGLLEQA AGYFTMGGLY
1710 1720 1730 1740 1750
EAVNEVYKNL IPILEAHRDY KKLAAVHGKL QEAFTKIMHQ SSGWERVFGT
1760 1770 1780 1790 1800
YFRVGFYGAH FGDLDEQEFV YKEPSITKLA EISHRLEEFY TERFGDDVVE
1810 1820 1830 1840 1850
IIKDSNPVDK SKLDSQKAYI QITYVEPYFD TYELKDRVTY FDRNYGLRTF
1860 1870 1880 1890 1900
LFCTPFTPDG RAHGELPEQH KRKTLLSTDH AFPYIKTRIR VCHREETVLT
1910 1920 1930 1940 1950
PVEVAIEDMQ KKTRELAFAT EQDPPDAKML QMVLQGSVGP TVNQGPLEVA
1960 1970 1980 1990 2000
QVFLAEIPED PKLFRHHNKL RLCFKDFCKK CEDALRKNKA LIGPDQKEYH
2010 2020 2030 2040
RELERNYCRL REALQPLLTQ RLPQLMAPTP PGLRNSLNRA SFRKADL
Length:2,047
Mass (Da):229,558
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6370F02FFF80D070
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ESB7K7ESB7_HUMAN
Dedicator of cytokinesis protein 6
DOCK6
1,336Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EP20K7EP20_HUMAN
Dedicator of cytokinesis protein 6
DOCK6
464Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EP51K7EP51_HUMAN
Dedicator of cytokinesis protein 6
DOCK6
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKT0K7EKT0_HUMAN
Dedicator of cytokinesis protein 6
DOCK6
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERK2K7ERK2_HUMAN
Dedicator of cytokinesis protein 6
DOCK6
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH08335 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA92633 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_029830250P → L. Corresponds to variant dbSNP:rs12978266EnsemblClinVar.1
Natural variantiVAR_029831555P → L. Corresponds to variant dbSNP:rs12609039Ensembl.1
Natural variantiVAR_029832665G → R2 PublicationsCorresponds to variant dbSNP:rs17001264Ensembl.1
Natural variantiVAR_057522826R → C. Corresponds to variant dbSNP:rs35881692Ensembl.1
Natural variantiVAR_0298331420V → L. Corresponds to variant dbSNP:rs8108071Ensembl.1
Natural variantiVAR_0575231442A → T. Corresponds to variant dbSNP:rs34243815Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB037816 mRNA Translation: BAA92633.2 Different initiation.
AC009000 Genomic DNA No translation available.
AC011472 Genomic DNA No translation available.
BC008335 mRNA Translation: AAH08335.2 Different initiation.
BC051330 mRNA Translation: AAH51330.1
BC146786 mRNA Translation: AAI46787.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS45975.1

NCBI Reference Sequences

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RefSeqi
NP_065863.2, NM_020812.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000294618; ENSP00000294618; ENSG00000130158

Database of genes from NCBI RefSeq genomes

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GeneIDi
57572

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:57572

UCSC genome browser

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UCSCi
uc002mqs.6, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037816 mRNA Translation: BAA92633.2 Different initiation.
AC009000 Genomic DNA No translation available.
AC011472 Genomic DNA No translation available.
BC008335 mRNA Translation: AAH08335.2 Different initiation.
BC051330 mRNA Translation: AAH51330.1
BC146786 mRNA Translation: AAI46787.1
CCDSiCCDS45975.1
RefSeqiNP_065863.2, NM_020812.3

3D structure databases

SMRiQ96HP0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121625, 31 interactors
IntActiQ96HP0, 31 interactors
STRINGi9606.ENSP00000294618

PTM databases

iPTMnetiQ96HP0
PhosphoSitePlusiQ96HP0

Polymorphism and mutation databases

BioMutaiDOCK6
DMDMi296439370

Proteomic databases

EPDiQ96HP0
jPOSTiQ96HP0
MassIVEiQ96HP0
MaxQBiQ96HP0
PaxDbiQ96HP0
PeptideAtlasiQ96HP0
PRIDEiQ96HP0
ProteomicsDBi76771

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
69705, 34 antibodies

Genome annotation databases

EnsembliENST00000294618; ENSP00000294618; ENSG00000130158
GeneIDi57572
KEGGihsa:57572
UCSCiuc002mqs.6, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57572
DisGeNETi57572
EuPathDBiHostDB:ENSG00000130158.13

GeneCards: human genes, protein and diseases

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GeneCardsi
DOCK6
GeneReviewsiDOCK6
HGNCiHGNC:19189, DOCK6
HPAiENSG00000130158, Low tissue specificity
MalaCardsiDOCK6
MIMi614194, gene
614219, phenotype
neXtProtiNX_Q96HP0
OpenTargetsiENSG00000130158
Orphaneti974, Adams-Oliver syndrome
PharmGKBiPA134913824

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1997, Eukaryota
GeneTreeiENSGT00940000159313
InParanoidiQ96HP0
KOiK21852
OMAiANMEGEL
OrthoDBi20156at2759
PhylomeDBiQ96HP0
TreeFamiTF313629

Enzyme and pathway databases

PathwayCommonsiQ96HP0
ReactomeiR-HSA-983231, Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
57572, 35 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DOCK6, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Dock6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57572
PharosiQ96HP0, Tbio

Protein Ontology

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PROi
PR:Q96HP0
RNActiQ96HP0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000130158, Expressed in right lung and 210 other tissues
ExpressionAtlasiQ96HP0, baseline and differential
GenevisibleiQ96HP0, HS

Family and domain databases

CDDicd08696, C2_Dock-C, 1 hit
Gene3Di1.20.58.740, 1 hit
1.25.40.410, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR037808, C2_Dock-C
IPR035892, C2_domain_sf
IPR027007, DHR-1_domain
IPR027357, DHR-2
IPR026791, DOCK
IPR010703, DOCK_C
IPR021816, DOCK_C/D_N
IPR043161, DOCK_C_lobe_A
IPR043162, DOCK_C_lobe_C
PANTHERiPTHR23317, PTHR23317, 2 hits
PfamiView protein in Pfam
PF06920, DHR-2, 1 hit
PF14429, DOCK-C2, 1 hit
PF11878, DUF3398, 1 hit
PROSITEiView protein in PROSITE
PS51650, C2_DOCK, 1 hit
PS51651, DOCKER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDOCK6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96HP0
Secondary accession number(s): A6H8X5, Q7Z7P4, Q9P2F2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: May 18, 2010
Last modified: August 12, 2020
This is version 151 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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