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UniProtKB - Q96HN2 (SAHH3_HUMAN)

Entry version 161 (07 Apr 2021)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

Adenosylhomocysteinase 3

Gene

AHCYL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg2+-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate (PubMed:19220705).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

NAD+Note: Binds 1 NAD+ per subunit.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (AHCYL1), Adenosylhomocysteinase (AHCYL1), Adenosylhomocysteinase, Adenosylhomocysteinase (AHCY), Adenosylhomocysteinase, Adenosylhomocysteinase (AHCY), Adenosylhomocysteinase (FGFR2-AHCYL1), Adenosylhomocysteinase 3 (AHCYL2)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei236SubstrateBy similarity1
Binding sitei310SubstrateBy similarity1
Binding sitei335SubstrateBy similarity1
Binding sitei365SubstrateBy similarity1
Binding sitei369SubstrateBy similarity1
Binding sitei370NADBy similarity1
Binding sitei422NAD1 Publication1
Binding sitei457NAD1 Publication1
Binding sitei525NAD1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi336 – 338NADBy similarity3
Nucleotide bindingi401 – 406NAD1 Publication6
Nucleotide bindingi478 – 479NAD1 Publication2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96HN2

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-425381, Bicarbonate transporters

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00314;UER00076

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adenosylhomocysteinase 3 (EC:3.3.1.1)
Short name:
AdoHcyase 3
Alternative name(s):
IP(3)Rs binding protein released with IP(3) 2
Short name:
IRBIT2
Long-IRBIT1 Publication
S-adenosyl-L-homocysteine hydrolase 3
S-adenosylhomocysteine hydrolase-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AHCYL2
Synonyms:KIAA0828
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:22204, AHCYL2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616520, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96HN2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000158467.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23382

Open Targets

More...OpenTargetsi		ENSG00000158467

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162376046

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96HN2, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AHCYL2

Domain mapping of disease mutations (DMDM)

More...DMDMi		21759427

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001169092 – 611Adenosylhomocysteinase 3Add BLAST610

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei107PhosphoserineCombined sources1
Modified residuei149Phosphoserine1 Publication1
Modified residuei152Phosphoserine1 Publication1
Modified residuei155Phosphoserine1 Publication1
Modified residuei158Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated during neuronal differentiation at the LISN domain.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96HN2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96HN2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96HN2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96HN2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96HN2

PeptideAtlas

More...PeptideAtlasi		Q96HN2

PRoteomics IDEntifications database

More...PRIDEi		Q96HN2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		15179
76768 [Q96HN2-1]
76769 [Q96HN2-2]
76770 [Q96HN2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96HN2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96HN2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000158467, Expressed in rectum and 215 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96HN2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96HN2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000158467, Tissue enhanced (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer (Probable). Forms heteromultimers with AHCYL1 (via the C-terminal region) (PubMed:19220705).

Interacts with ITPR1; with lower affinity than AHCYL1 and maybe via ITPR1 (PubMed:19220705).

Interacts with SLC4A4 (By similarity).

Interacts with ZCCHC4 (PubMed:31799605).

By similarity1 Publication2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116958, 93 interactors

Protein interaction database and analysis system

More...IntActi		Q96HN2, 64 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000315931

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96HN2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1611
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96HN2

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q96HN2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 109LISN domain, inhibits interaction with ITPR11 PublicationAdd BLAST108

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1370, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182981

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_025194_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96HN2

Identification of Orthologs from Complete Genome Data

More...OMAi		QPTHLCE

Database of Orthologous Groups

More...OrthoDBi		371693at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96HN2

TreeFam database of animal gene trees

More...TreeFami		TF300415

Family and domain databases

Conserved Domains Database

More...CDDi		cd00401, SAHH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.1480, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR042172, Adenosylhomocyst_ase-like_sf
IPR000043, Adenosylhomocysteinase-like
IPR015878, Ado_hCys_hydrolase_NAD-bd
IPR036291, NAD(P)-bd_dom_sf
IPR020082, S-Ado-L-homoCys_hydrolase_CS

The PANTHER Classification System

More...PANTHERi		PTHR23420, PTHR23420, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05221, AdoHcyase, 1 hit
PF00670, AdoHcyase_NAD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00996, AdoHcyase, 1 hit
SM00997, AdoHcyase_NAD, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51735, SSF51735, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00936, ahcY, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00738, ADOHCYASE_1, 1 hit
PS00739, ADOHCYASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96HN2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVQVVSAAA AAKVPEVELK DLSPSEAESQ LGLSTAAVGA MAPPAGGGDP 
        60         70         80         90        100
EAPAPAAERP PVPGPGSGPA AALSPAAGKV PQASAMKRSD PHHQHQRHRD 
       110        120        130        140        150
GGEALVSPDG TVTEAPRTVK KQIQFADQKQ EFNKRPTKIG RRSLSRSISQ 
       160        170        180        190        200
SSTDSYSSAA SYTDSSDDET SPRDKQQKNS KGSSDFCVKN IKQAEFGRRE 
       210        220        230        240        250
IEIAEQEMPA LMALRKRAQG EKPLAGAKIV GCTHITAQTA VLMETLGALG 
       260        270        280        290        300
AQCRWAACNI YSTLNEVAAA LAESGFPVFA WKGESEDDFW WCIDRCVNVE 
       310        320        330        340        350
GWQPNMILDD GGDLTHWIYK KYPNMFKKIK GIVEESVTGV HRLYQLSKAG 
       360        370        380        390        400
KLCVPAMNVN DSVTKQKFDN LYCCRESILD GLKRTTDMMF GGKQVVVCGY 
       410        420        430        440        450
GEVGKGCCAA LKAMGSIVYV TEIDPICALQ ACMDGFRLVK LNEVIRQVDI 
       460        470        480        490        500
VITCTGNKNV VTREHLDRMK NSCIVCNMGH SNTEIDVASL RTPELTWERV 
       510        520        530        540        550
RSQVDHVIWP DGKRIVLLAE GRLLNLSCST VPTFVLSITA TTQALALIEL 
       560        570        580        590        600
YNAPEGRYKQ DVYLLPKKMD EYVASLHLPT FDAHLTELTD EQAKYLGLNK 
       610 
NGPFKPNYYR Y
Length:611
Mass (Da):66,721
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA76B1275FC0D891D
GO
Isoform 2 (identifier: Q96HN2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-122: Missing.

Show »
Length:610
Mass (Da):66,593
Checksum:iD54ED0745D3A286B
GO
Isoform 3 (identifier: Q96HN2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MSVQVVSAAAAAKVPEVE → MLGSKKKYIVNGNSGIKA
     19-121: Missing.

Show »
Length:508
Mass (Da):56,697
Checksum:i1198694128CB2301
GO
Isoform 4 (identifier: Q96HN2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MSVQVVSAAAAAKVPEVEL → MEKWDGNEGTSAFHMPEWM
     20-122: Missing.

Show »
Length:508
Mass (Da):56,944
Checksum:i197CA80AF2940465
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8B3H0Y8B3_HUMAN
Adenosylhomocysteinase 3
AHCYL2
518Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K0S0C9K0S0_HUMAN
Adenosylhomocysteinase 3
AHCYL2
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZV7C9JZV7_HUMAN
Adenosylhomocysteinase 3
AHCYL2
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA74851 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0462781 – 19MSVQV…PEVEL → MEKWDGNEGTSAFHMPEWM in isoform 4. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_0431851 – 18MSVQV…VPEVE → MLGSKKKYIVNGNSGIKA in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_04318619 – 121Missing in isoform 3. 1 PublicationAdd BLAST103
Alternative sequenceiVSP_04627920 – 122Missing in isoform 4. 1 PublicationAdd BLAST103
Alternative sequenceiVSP_040095122Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB020635 mRNA Translation: BAA74851.1 Different initiation.
AK025372 mRNA No translation available.
AK295851 mRNA Translation: BAG58657.1
AK316073 mRNA Translation: BAH14444.1
AC009244 Genomic DNA No translation available.
AC011005 Genomic DNA No translation available.
AC083866 Genomic DNA No translation available.
AC093149 Genomic DNA No translation available.
BC008349 mRNA Translation: AAH08349.1
BC024325 mRNA Translation: AAH24325.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47706.1 [Q96HN2-2]
CCDS47707.2 [Q96HN2-3]
CCDS47708.1 [Q96HN2-4]
CCDS5812.1 [Q96HN2-1]

NCBI Reference Sequences

More...RefSeqi		NP_001124192.1, NM_001130720.2 [Q96HN2-2]
NP_001124194.2, NM_001130722.2 [Q96HN2-3]
NP_001124195.1, NM_001130723.2 [Q96HN2-4]
NP_056143.1, NM_015328.3 [Q96HN2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000325006; ENSP00000315931; ENSG00000158467 [Q96HN2-1]
ENST00000446544; ENSP00000413639; ENSG00000158467 [Q96HN2-2]
ENST00000474594; ENSP00000420459; ENSG00000158467 [Q96HN2-4]
ENST00000490911; ENSP00000420801; ENSG00000158467 [Q96HN2-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23382

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23382

UCSC genome browser

More...UCSCi		uc003vot.4, human [Q96HN2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020635 mRNA Translation: BAA74851.1 Different initiation.
AK025372 mRNA No translation available.
AK295851 mRNA Translation: BAG58657.1
AK316073 mRNA Translation: BAH14444.1
AC009244 Genomic DNA No translation available.
AC011005 Genomic DNA No translation available.
AC083866 Genomic DNA No translation available.
AC093149 Genomic DNA No translation available.
BC008349 mRNA Translation: AAH08349.1
BC024325 mRNA Translation: AAH24325.1
CCDSiCCDS47706.1 [Q96HN2-2]
CCDS47707.2 [Q96HN2-3]
CCDS47708.1 [Q96HN2-4]
CCDS5812.1 [Q96HN2-1]
RefSeqiNP_001124192.1, NM_001130720.2 [Q96HN2-2]
NP_001124194.2, NM_001130722.2 [Q96HN2-3]
NP_001124195.1, NM_001130723.2 [Q96HN2-4]
NP_056143.1, NM_015328.3 [Q96HN2-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GVPX-ray2.25A/B/C/D175-607[»]
SMRiQ96HN2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116958, 93 interactors
IntActiQ96HN2, 64 interactors
STRINGi9606.ENSP00000315931

PTM databases

iPTMnetiQ96HN2
PhosphoSitePlusiQ96HN2

Genetic variation databases

BioMutaiAHCYL2
DMDMi21759427

Proteomic databases

EPDiQ96HN2
jPOSTiQ96HN2
MassIVEiQ96HN2
MaxQBiQ96HN2
PaxDbiQ96HN2
PeptideAtlasiQ96HN2
PRIDEiQ96HN2
ProteomicsDBi15179
76768 [Q96HN2-1]
76769 [Q96HN2-2]
76770 [Q96HN2-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17876, 64 antibodies

Genome annotation databases

EnsembliENST00000325006; ENSP00000315931; ENSG00000158467 [Q96HN2-1]
ENST00000446544; ENSP00000413639; ENSG00000158467 [Q96HN2-2]
ENST00000474594; ENSP00000420459; ENSG00000158467 [Q96HN2-4]
ENST00000490911; ENSP00000420801; ENSG00000158467 [Q96HN2-3]
GeneIDi23382
KEGGihsa:23382
UCSCiuc003vot.4, human [Q96HN2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23382
DisGeNETi23382

GeneCards: human genes, protein and diseases

More...GeneCardsi		AHCYL2
HGNCiHGNC:22204, AHCYL2
HPAiENSG00000158467, Tissue enhanced (intestine)
MIMi616520, gene
neXtProtiNX_Q96HN2
OpenTargetsiENSG00000158467
PharmGKBiPA162376046
VEuPathDBiHostDB:ENSG00000158467.16

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1370, Eukaryota
GeneTreeiENSGT00950000182981
HOGENOMiCLU_025194_2_1_1
InParanoidiQ96HN2
OMAiQPTHLCE
OrthoDBi371693at2759
PhylomeDBiQ96HN2
TreeFamiTF300415

Enzyme and pathway databases

UniPathwayiUPA00314;UER00076
PathwayCommonsiQ96HN2
ReactomeiR-HSA-425381, Bicarbonate transporters

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23382, 7 hits in 993 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AHCYL2, human
EvolutionaryTraceiQ96HN2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23382
PharosiQ96HN2, Tdark

Protein Ontology

More...PROi		PR:Q96HN2
RNActiQ96HN2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000158467, Expressed in rectum and 215 other tissues
ExpressionAtlasiQ96HN2, baseline and differential
GenevisibleiQ96HN2, HS

Family and domain databases

CDDicd00401, SAHH, 1 hit
Gene3Di3.40.50.1480, 2 hits
InterProiView protein in InterPro
IPR042172, Adenosylhomocyst_ase-like_sf
IPR000043, Adenosylhomocysteinase-like
IPR015878, Ado_hCys_hydrolase_NAD-bd
IPR036291, NAD(P)-bd_dom_sf
IPR020082, S-Ado-L-homoCys_hydrolase_CS
PANTHERiPTHR23420, PTHR23420, 1 hit
PfamiView protein in Pfam
PF05221, AdoHcyase, 1 hit
PF00670, AdoHcyase_NAD, 1 hit
SMARTiView protein in SMART
SM00996, AdoHcyase, 1 hit
SM00997, AdoHcyase_NAD, 1 hit
SUPFAMiSSF51735, SSF51735, 1 hit
TIGRFAMsiTIGR00936, ahcY, 1 hit
PROSITEiView protein in PROSITE
PS00738, ADOHCYASE_1, 1 hit
PS00739, ADOHCYASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAHH3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96HN2
Secondary accession number(s): B4DIZ5, D9N155, O94917
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: December 1, 2001
Last modified: April 7, 2021
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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