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Entry version 138 (07 Oct 2020)
Sequence version 1 (01 Dec 2001)
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Protein

SH3 domain-containing YSC84-like protein 1

Gene

SH3YL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96HL8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH3 domain-containing YSC84-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SH3YL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000035115.21

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29546, SH3YL1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96HL8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26751

Open Targets

More...
OpenTargetsi
ENSG00000035115

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394643

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96HL8, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SH3YL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751912

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003415601 – 342SH3 domain-containing YSC84-like protein 1Add BLAST342

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96HL8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96HL8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96HL8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96HL8

PeptideAtlas

More...
PeptideAtlasi
Q96HL8

PRoteomics IDEntifications database

More...
PRIDEi
Q96HL8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76760 [Q96HL8-1]
76761 [Q96HL8-2]
76762 [Q96HL8-3]
76763 [Q96HL8-4]
76764 [Q96HL8-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96HL8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96HL8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000035115, Expressed in nephron tubule and 242 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96HL8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96HL8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000035115, Tissue enhanced (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SH3D19.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
117811, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q96HL8, 7 interactors

Molecular INTeraction database

More...
MINTi
Q96HL8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000348471

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96HL8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1342
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q96HL8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96HL8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q96HL8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini283 – 342SH3PROSITE-ProRule annotationAdd BLAST60

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SH3YL1 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1843, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000048137

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015320_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96HL8

KEGG Orthology (KO)

More...
KOi
K20523

Identification of Orthologs from Complete Genome Data

More...
OMAi
DSDNDWW

Database of Orthologous Groups

More...
OrthoDBi
1090526at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96HL8

TreeFam database of animal gene trees

More...
TreeFami
TF331022

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11841, SH3_SH3YL1_like, 1 hit
cd11525, SYLF_SH3YL1_like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR035511, SH3YL1_SH3
IPR033643, SYLF_SH3YL1-like
IPR007461, Ysc84_actin-binding

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00018, SH3_1, 1 hit
PF04366, Ysc84, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96HL8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNNPIPSNLK SEAKKAAKIL REFTEITSRN GPDKIIPAHV IAKAKGLAIL
60 70 80 90 100
SVIKAGFLVT ARGGSGIVVA RLPDGKWSAP SAIGIAGLGG GFEIGIEVSD
110 120 130 140 150
LVIILNYDRA VEAFAKGGNL TLGGNLTVAV GPLGRNLEGN VALRSSAAVF
160 170 180 190 200
TYCKSRGLFA GVSLEGSCLI ERKETNRKFY CQDIRAYDIL FGDTPRPAQA
210 220 230 240 250
EDLYEILDSF TEKYENEGQR INARKAAREQ RKSSAKELPP KPLSRPQQSS
260 270 280 290 300
APVQLNSGSQ SNRNEYKLYP GLSSYHERVG NLNQPIEVTA LYSFEGQQPG
310 320 330 340
DLNFQAGDRI TVISKTDSHF DWWEGKLRGQ TGIFPANYVT MN
Length:342
Mass (Da):37,148
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA12F0276A870B863
GO
Isoform 2 (identifier: Q96HL8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     262-280: Missing.

Show »
Length:323
Mass (Da):34,884
Checksum:i0978372B41715F8F
GO
Isoform 3 (identifier: Q96HL8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.
     97-97: E → M

Show »
Length:246
Mass (Da):27,353
Checksum:iCCB998B271C72E7E
GO
Isoform 4 (identifier: Q96HL8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.
     97-97: E → M
     262-280: Missing.

Show »
Length:227
Mass (Da):25,088
Checksum:i42B6CACE64E66697
GO
Isoform 5 (identifier: Q96HL8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-342: VSDLVIILNY...IFPANYVTMN → THLQLHIPSEHCPGCLP

Show »
Length:114
Mass (Da):11,809
Checksum:i28BF2A1DA409BE24
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C499H7C499_HUMAN
SH3 domain-containing YSC84-like pr...
SH3YL1
255Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1B8H7C1B8_HUMAN
SH3 domain-containing YSC84-like pr...
SH3YL1
230Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JJI3C9JJI3_HUMAN
SH3 domain-containing YSC84-like pr...
SH3YL1
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GYQ6F5GYQ6_HUMAN
SH3 domain-containing YSC84-like pr...
SH3YL1
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J4Z8C9J4Z8_HUMAN
SH3 domain-containing YSC84-like pr...
SH3YL1
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3I7S4R3I7_HUMAN
SH3 domain-containing YSC84-like pr...
SH3YL1
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4P → H in AAH34974 (PubMed:15489334).Curated1
Sequence conflicti4P → H in AAH30778 (PubMed:15489334).Curated1
Sequence conflicti104I → V in BAF85001 (PubMed:14702039).Curated1
Sequence conflicti141V → M in BAF85001 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0343321 – 96Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST96
Alternative sequenceiVSP_03433397E → M in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_03433498 – 342VSDLV…YVTMN → THLQLHIPSEHCPGCLP in isoform 5. 1 PublicationAdd BLAST245
Alternative sequenceiVSP_034335262 – 280Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK026507 mRNA Translation: BAB15493.1
AK292312 mRNA Translation: BAF85001.1
CR457361 mRNA Translation: CAG33642.1
AL050373 mRNA Translation: CAB43679.2
AC079779 Genomic DNA Translation: AAY14957.1
BC008374 mRNA Translation: AAH08374.1
BC008375 mRNA Translation: AAH08375.1
BC030778 mRNA Translation: AAH30778.1
BC034974 mRNA Translation: AAH34974.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42646.2 [Q96HL8-1]
CCDS54332.1 [Q96HL8-2]
CCDS62841.1 [Q96HL8-4]
CCDS62842.1 [Q96HL8-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001153069.1, NM_001159597.2 [Q96HL8-2]
NP_001269611.1, NM_001282682.1 [Q96HL8-4]
NP_001269616.1, NM_001282687.1 [Q96HL8-3]
NP_056492.2, NM_015677.3 [Q96HL8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356150; ENSP00000348471; ENSG00000035115 [Q96HL8-1]
ENST00000402632; ENSP00000384910; ENSG00000035115 [Q96HL8-5]
ENST00000403657; ENSP00000385668; ENSG00000035115 [Q96HL8-4]
ENST00000403658; ENSP00000383928; ENSG00000035115 [Q96HL8-4]
ENST00000403712; ENSP00000384276; ENSG00000035115 [Q96HL8-2]
ENST00000405430; ENSP00000384269; ENSG00000035115 [Q96HL8-1]
ENST00000626873; ENSP00000485824; ENSG00000035115 [Q96HL8-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26751

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26751

UCSC genome browser

More...
UCSCi
uc002qvx.5, human [Q96HL8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026507 mRNA Translation: BAB15493.1
AK292312 mRNA Translation: BAF85001.1
CR457361 mRNA Translation: CAG33642.1
AL050373 mRNA Translation: CAB43679.2
AC079779 Genomic DNA Translation: AAY14957.1
BC008374 mRNA Translation: AAH08374.1
BC008375 mRNA Translation: AAH08375.1
BC030778 mRNA Translation: AAH30778.1
BC034974 mRNA Translation: AAH34974.1
CCDSiCCDS42646.2 [Q96HL8-1]
CCDS54332.1 [Q96HL8-2]
CCDS62841.1 [Q96HL8-4]
CCDS62842.1 [Q96HL8-3]
RefSeqiNP_001153069.1, NM_001159597.2 [Q96HL8-2]
NP_001269611.1, NM_001282682.1 [Q96HL8-4]
NP_001269616.1, NM_001282687.1 [Q96HL8-3]
NP_056492.2, NM_015677.3 [Q96HL8-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D8HNMR-A276-342[»]
BMRBiQ96HL8
SMRiQ96HL8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi117811, 12 interactors
IntActiQ96HL8, 7 interactors
MINTiQ96HL8
STRINGi9606.ENSP00000348471

PTM databases

iPTMnetiQ96HL8
PhosphoSitePlusiQ96HL8

Polymorphism and mutation databases

BioMutaiSH3YL1
DMDMi74751912

Proteomic databases

EPDiQ96HL8
jPOSTiQ96HL8
MassIVEiQ96HL8
PaxDbiQ96HL8
PeptideAtlasiQ96HL8
PRIDEiQ96HL8
ProteomicsDBi76760 [Q96HL8-1]
76761 [Q96HL8-2]
76762 [Q96HL8-3]
76763 [Q96HL8-4]
76764 [Q96HL8-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
49866, 37 antibodies

The DNASU plasmid repository

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DNASUi
26751

Genome annotation databases

EnsembliENST00000356150; ENSP00000348471; ENSG00000035115 [Q96HL8-1]
ENST00000402632; ENSP00000384910; ENSG00000035115 [Q96HL8-5]
ENST00000403657; ENSP00000385668; ENSG00000035115 [Q96HL8-4]
ENST00000403658; ENSP00000383928; ENSG00000035115 [Q96HL8-4]
ENST00000403712; ENSP00000384276; ENSG00000035115 [Q96HL8-2]
ENST00000405430; ENSP00000384269; ENSG00000035115 [Q96HL8-1]
ENST00000626873; ENSP00000485824; ENSG00000035115 [Q96HL8-3]
GeneIDi26751
KEGGihsa:26751
UCSCiuc002qvx.5, human [Q96HL8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26751
DisGeNETi26751
EuPathDBiHostDB:ENSG00000035115.21

GeneCards: human genes, protein and diseases

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GeneCardsi
SH3YL1
HGNCiHGNC:29546, SH3YL1
HPAiENSG00000035115, Tissue enhanced (pancreas)
neXtProtiNX_Q96HL8
OpenTargetsiENSG00000035115
PharmGKBiPA128394643

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1843, Eukaryota
GeneTreeiENSGT00510000048137
HOGENOMiCLU_015320_2_1_1
InParanoidiQ96HL8
KOiK20523
OMAiDSDNDWW
OrthoDBi1090526at2759
PhylomeDBiQ96HL8
TreeFamiTF331022

Enzyme and pathway databases

PathwayCommonsiQ96HL8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
26751, 5 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SH3YL1, human
EvolutionaryTraceiQ96HL8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26751
PharosiQ96HL8, Tdark

Protein Ontology

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PROi
PR:Q96HL8
RNActiQ96HL8, protein

Gene expression databases

BgeeiENSG00000035115, Expressed in nephron tubule and 242 other tissues
ExpressionAtlasiQ96HL8, baseline and differential
GenevisibleiQ96HL8, HS

Family and domain databases

CDDicd11841, SH3_SH3YL1_like, 1 hit
cd11525, SYLF_SH3YL1_like, 1 hit
InterProiView protein in InterPro
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR035511, SH3YL1_SH3
IPR033643, SYLF_SH3YL1-like
IPR007461, Ysc84_actin-binding
PfamiView protein in Pfam
PF00018, SH3_1, 1 hit
PF04366, Ysc84, 1 hit
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00326, SH3, 1 hit
SUPFAMiSSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSH3Y1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96HL8
Secondary accession number(s): A8K8E7
, B7WNJ4, B7WPL6, Q8NEL2, Q9H5X4, Q9Y3V5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 1, 2001
Last modified: October 7, 2020
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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