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Protein

Membrane-spanning 4-domains subfamily A member 3

Gene

MS4A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).1 Publication

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-spanning 4-domains subfamily A member 3
Alternative name(s):
CD20 antigen-like protein
Hematopoietic-specific transmembrane protein 4
Short name:
HTm4
Gene namesi
Name:MS4A3
Synonyms:CD20L, HTM4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149516.13
HGNCiHGNC:7317 MS4A3
MIMi606498 gene
neXtProtiNX_Q96HJ5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 81ExtracellularSequence analysisAdd BLAST11
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 124CytoplasmicSequence analysisAdd BLAST22
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 175ExtracellularSequence analysisAdd BLAST30
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 214CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi932
OpenTargetsiENSG00000149516
PharmGKBiPA31112

Polymorphism and mutation databases

BioMutaiMS4A3
DMDMi29611825

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586321 – 214Membrane-spanning 4-domains subfamily A member 3Add BLAST214

Proteomic databases

EPDiQ96HJ5
PaxDbiQ96HJ5
PeptideAtlasiQ96HJ5
PRIDEiQ96HJ5
ProteomicsDBi76756
76757 [Q96HJ5-2]

PTM databases

iPTMnetiQ96HJ5
PhosphoSitePlusiQ96HJ5

Expressioni

Tissue specificityi

Expressed specifically in hematopoietic cells and tissues.

Gene expression databases

BgeeiENSG00000149516 Expressed in 77 organ(s), highest expression level in bone marrow
CleanExiHS_MS4A3
ExpressionAtlasiQ96HJ5 baseline and differential
GenevisibleiQ96HJ5 HS

Organism-specific databases

HPAiHPA019210

Interactioni

Subunit structurei

Interacts with CDKN3. Interacts with CDKN3-CDK2 complexes through its binding to CDKN3; this interaction facilitates dissociation of cyclin A from CDKN3-CDK2 complexes.2 Publications

Protein-protein interaction databases

BioGridi107370, 2 interactors
IntActiQ96HJ5, 38 interactors
STRINGi9606.ENSP00000278865

Structurei

3D structure databases

ProteinModelPortaliQ96HJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi82 – 87Poly-Phe6

Domaini

The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity.

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZNT Eukaryota
ENOG411140Q LUCA
GeneTreeiENSGT00870000136511
HOGENOMiHOG000113657
HOVERGENiHBG052512
InParanoidiQ96HJ5
KOiK22190
OMAiPIWGAVF
OrthoDBiEOG091G0IBB
PhylomeDBiQ96HJ5
TreeFamiTF335157

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030419 MS4A3
PANTHERiPTHR23320 PTHR23320, 1 hit
PTHR23320:SF74 PTHR23320:SF74, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96HJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASHEVDNAE LGSASAHGTP GSEAGPEELN TSVYQPIDGS PDYQKAKLQV
60 70 80 90 100
LGAIQILNAA MILALGVFLG SLQYPYHFQK HFFFFTFYTG YPIWGAVFFC
110 120 130 140 150
SSGTLSVVAG IKPTRTWIQN SFGMNIASAT IALVGTAFLS LNIAVNIQSL
160 170 180 190 200
RSCHSSSESP DLCNYMGSIS NGMVSLLLIL TLLELCVTIS TIAMWCNANC
210
CNSREEISSP PNSV
Length:214
Mass (Da):22,933
Last modified:December 1, 2001 - v1
Checksum:iD30C276213DB8F3D
GO
Isoform 2 (identifier: Q96HJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-98: Missing.

Show »
Length:168
Mass (Da):17,601
Checksum:iC62AC47B541A634C
GO
Isoform 3 (identifier: Q96HJ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: No experimental confirmation available.
Show »
Length:91
Mass (Da):9,625
Checksum:i4570C062BADC3B17
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PRW8E9PRW8_HUMAN
Membrane-spanning 4-domains subfami...
MS4A3
83Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24A → T in AAA62319 (PubMed:7524084).Curated1
Sequence conflicti35Q → H in AAA62319 (PubMed:7524084).Curated1
Sequence conflicti38D → N in AAA62319 (PubMed:7524084).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0457981 – 123Missing in isoform 3. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_00710953 – 98Missing in isoform 2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35848 mRNA Translation: AAA62319.1
AY095480 mRNA Translation: AAM23312.1
AY258289 Genomic DNA Translation: AAP14648.1
AP000790 Genomic DNA No translation available.
BC008487 mRNA Translation: AAH08487.1
BG494288 mRNA No translation available.
CCDSiCCDS31567.1 [Q96HJ5-1]
CCDS31568.1 [Q96HJ5-2]
CCDS41651.1 [Q96HJ5-3]
PIRiI59258
RefSeqiNP_001026836.1, NM_001031666.1 [Q96HJ5-3]
NP_001026979.1, NM_001031809.1 [Q96HJ5-2]
NP_006129.4, NM_006138.4 [Q96HJ5-1]
UniGeneiHs.99960

Genome annotation databases

EnsembliENST00000278865; ENSP00000278865; ENSG00000149516 [Q96HJ5-1]
ENST00000358152; ENSP00000350872; ENSG00000149516 [Q96HJ5-2]
ENST00000395032; ENSP00000378473; ENSG00000149516 [Q96HJ5-3]
ENST00000534744; ENSP00000434117; ENSG00000149516 [Q96HJ5-2]
GeneIDi932
KEGGihsa:932
UCSCiuc001nom.4 human [Q96HJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35848 mRNA Translation: AAA62319.1
AY095480 mRNA Translation: AAM23312.1
AY258289 Genomic DNA Translation: AAP14648.1
AP000790 Genomic DNA No translation available.
BC008487 mRNA Translation: AAH08487.1
BG494288 mRNA No translation available.
CCDSiCCDS31567.1 [Q96HJ5-1]
CCDS31568.1 [Q96HJ5-2]
CCDS41651.1 [Q96HJ5-3]
PIRiI59258
RefSeqiNP_001026836.1, NM_001031666.1 [Q96HJ5-3]
NP_001026979.1, NM_001031809.1 [Q96HJ5-2]
NP_006129.4, NM_006138.4 [Q96HJ5-1]
UniGeneiHs.99960

3D structure databases

ProteinModelPortaliQ96HJ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107370, 2 interactors
IntActiQ96HJ5, 38 interactors
STRINGi9606.ENSP00000278865

PTM databases

iPTMnetiQ96HJ5
PhosphoSitePlusiQ96HJ5

Polymorphism and mutation databases

BioMutaiMS4A3
DMDMi29611825

Proteomic databases

EPDiQ96HJ5
PaxDbiQ96HJ5
PeptideAtlasiQ96HJ5
PRIDEiQ96HJ5
ProteomicsDBi76756
76757 [Q96HJ5-2]

Protocols and materials databases

DNASUi932
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278865; ENSP00000278865; ENSG00000149516 [Q96HJ5-1]
ENST00000358152; ENSP00000350872; ENSG00000149516 [Q96HJ5-2]
ENST00000395032; ENSP00000378473; ENSG00000149516 [Q96HJ5-3]
ENST00000534744; ENSP00000434117; ENSG00000149516 [Q96HJ5-2]
GeneIDi932
KEGGihsa:932
UCSCiuc001nom.4 human [Q96HJ5-1]

Organism-specific databases

CTDi932
DisGeNETi932
EuPathDBiHostDB:ENSG00000149516.13
GeneCardsiMS4A3
HGNCiHGNC:7317 MS4A3
HPAiHPA019210
MIMi606498 gene
neXtProtiNX_Q96HJ5
OpenTargetsiENSG00000149516
PharmGKBiPA31112
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZNT Eukaryota
ENOG411140Q LUCA
GeneTreeiENSGT00870000136511
HOGENOMiHOG000113657
HOVERGENiHBG052512
InParanoidiQ96HJ5
KOiK22190
OMAiPIWGAVF
OrthoDBiEOG091G0IBB
PhylomeDBiQ96HJ5
TreeFamiTF335157

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

GeneWikiiMS4A3
GenomeRNAii932
PROiPR:Q96HJ5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149516 Expressed in 77 organ(s), highest expression level in bone marrow
CleanExiHS_MS4A3
ExpressionAtlasiQ96HJ5 baseline and differential
GenevisibleiQ96HJ5 HS

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030419 MS4A3
PANTHERiPTHR23320 PTHR23320, 1 hit
PTHR23320:SF74 PTHR23320:SF74, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMS4A3_HUMAN
AccessioniPrimary (citable) accession number: Q96HJ5
Secondary accession number(s): A8MTP8, Q8NHW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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