UniProtKB - Q96HJ5 (MS4A3_HUMAN)
Membrane-spanning 4-domains subfamily A member 3
MS4A3
Functioni
Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).
1 PublicationGO - Biological processi
- cell surface receptor signaling pathway Source: GO_Central
- regulation of cell cycle Source: InterPro
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | Q96HJ5 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
SignaLinki | Q96HJ5 |
Names & Taxonomyi
Protein namesi | Recommended name: Membrane-spanning 4-domains subfamily A member 3Alternative name(s): CD20 antigen-like protein Hematopoietic-specific transmembrane protein 4 Short name: HTm4 |
Gene namesi | Name:MS4A3 Synonyms:CD20L, HTM4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7317, MS4A3 |
MIMi | 606498, gene |
neXtProti | NX_Q96HJ5 |
VEuPathDBi | HostDB:ENSG00000149516 |
Subcellular locationi
Other locations
- Endomembrane system By similarity; Multi-pass membrane protein By similarity
- perinuclear region By similarity
Note: Located in the perinuclear area.
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
- specific granule membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 49 | CytoplasmicSequence analysisAdd BLAST | 49 | |
Transmembranei | 50 – 70 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 71 – 81 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 82 – 102 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 103 – 124 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 125 – 145 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 146 – 175 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 176 – 196 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 197 – 214 | CytoplasmicSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 932 |
OpenTargetsi | ENSG00000149516 |
PharmGKBi | PA31112 |
Miscellaneous databases
Pharosi | Q96HJ5, Tbio |
Genetic variation databases
BioMutai | MS4A3 |
DMDMi | 29611825 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000158632 | 1 – 214 | Membrane-spanning 4-domains subfamily A member 3Add BLAST | 214 |
Proteomic databases
EPDi | Q96HJ5 |
MassIVEi | Q96HJ5 |
PaxDbi | Q96HJ5 |
PeptideAtlasi | Q96HJ5 |
PRIDEi | Q96HJ5 |
PTM databases
iPTMneti | Q96HJ5 |
PhosphoSitePlusi | Q96HJ5 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000149516, Expressed in bone marrow and 104 other tissues |
ExpressionAtlasi | Q96HJ5, baseline and differential |
Genevisiblei | Q96HJ5, HS |
Organism-specific databases
HPAi | ENSG00000149516, Tissue enriched (bone) |
Interactioni
Subunit structurei
Interacts with CDKN3.
Interacts with CDKN3-CDK2 complexes through its binding to CDKN3; this interaction facilitates dissociation of cyclin A from CDKN3-CDK2 complexes.
2 PublicationsBinary interactionsi
Q96HJ5
Protein-protein interaction databases
BioGRIDi | 107370, 39 interactors |
IntActi | Q96HJ5, 37 interactors |
STRINGi | 9606.ENSP00000278865 |
Miscellaneous databases
RNActi | Q96HJ5, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 31 | DisorderedSequence analysisAdd BLAST | 31 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502T41X, Eukaryota |
GeneTreei | ENSGT00940000162383 |
HOGENOMi | CLU_091032_6_2_1 |
InParanoidi | Q96HJ5 |
OMAi | QRHFFFF |
OrthoDBi | 1239340at2759 |
PhylomeDBi | Q96HJ5 |
TreeFami | TF335157 |
Family and domain databases
InterProi | View protein in InterPro IPR007237, CD20-like IPR030417, MS4A IPR030419, MS4A3 |
PANTHERi | PTHR23320, PTHR23320, 1 hit PTHR23320:SF74, PTHR23320:SF74, 1 hit |
Pfami | View protein in Pfam PF04103, CD20, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASHEVDNAE LGSASAHGTP GSEAGPEELN TSVYQPIDGS PDYQKAKLQV
60 70 80 90 100
LGAIQILNAA MILALGVFLG SLQYPYHFQK HFFFFTFYTG YPIWGAVFFC
110 120 130 140 150
SSGTLSVVAG IKPTRTWIQN SFGMNIASAT IALVGTAFLS LNIAVNIQSL
160 170 180 190 200
RSCHSSSESP DLCNYMGSIS NGMVSLLLIL TLLELCVTIS TIAMWCNANC
210
CNSREEISSP PNSV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PRW8 | E9PRW8_HUMAN | Membrane-spanning 4-domains subfami... | MS4A3 | 83 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 24 | A → T in AAA62319 (PubMed:7524084).Curated | 1 | |
Sequence conflicti | 35 | Q → H in AAA62319 (PubMed:7524084).Curated | 1 | |
Sequence conflicti | 38 | D → N in AAA62319 (PubMed:7524084).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045798 | 1 – 123 | Missing in isoform 3. 1 PublicationAdd BLAST | 123 | |
Alternative sequenceiVSP_007109 | 53 – 98 | Missing in isoform 2. 1 PublicationAdd BLAST | 46 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L35848 mRNA Translation: AAA62319.1 AY095480 mRNA Translation: AAM23312.1 AY258289 Genomic DNA Translation: AAP14648.1 AP000790 Genomic DNA No translation available. BC008487 mRNA Translation: AAH08487.1 BG494288 mRNA No translation available. |
CCDSi | CCDS31567.1 [Q96HJ5-1] CCDS31568.1 [Q96HJ5-2] CCDS41651.1 [Q96HJ5-3] |
PIRi | I59258 |
RefSeqi | NP_001026836.1, NM_001031666.1 [Q96HJ5-3] NP_001026979.1, NM_001031809.1 [Q96HJ5-2] NP_006129.4, NM_006138.4 [Q96HJ5-1] |
Genome annotation databases
Ensembli | ENST00000278865.8; ENSP00000278865.3; ENSG00000149516.14 ENST00000358152.6; ENSP00000350872.2; ENSG00000149516.14 [Q96HJ5-2] ENST00000395032.6; ENSP00000378473.2; ENSG00000149516.14 [Q96HJ5-3] ENST00000534744.1; ENSP00000434117.1; ENSG00000149516.14 [Q96HJ5-2] |
GeneIDi | 932 |
KEGGi | hsa:932 |
MANE-Selecti | ENST00000278865.8; ENSP00000278865.3; NM_006138.5; NP_006129.4 |
UCSCi | uc001nom.4, human [Q96HJ5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L35848 mRNA Translation: AAA62319.1 AY095480 mRNA Translation: AAM23312.1 AY258289 Genomic DNA Translation: AAP14648.1 AP000790 Genomic DNA No translation available. BC008487 mRNA Translation: AAH08487.1 BG494288 mRNA No translation available. |
CCDSi | CCDS31567.1 [Q96HJ5-1] CCDS31568.1 [Q96HJ5-2] CCDS41651.1 [Q96HJ5-3] |
PIRi | I59258 |
RefSeqi | NP_001026836.1, NM_001031666.1 [Q96HJ5-3] NP_001026979.1, NM_001031809.1 [Q96HJ5-2] NP_006129.4, NM_006138.4 [Q96HJ5-1] |
3D structure databases
AlphaFoldDBi | Q96HJ5 |
SMRi | Q96HJ5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107370, 39 interactors |
IntActi | Q96HJ5, 37 interactors |
STRINGi | 9606.ENSP00000278865 |
PTM databases
iPTMneti | Q96HJ5 |
PhosphoSitePlusi | Q96HJ5 |
Genetic variation databases
BioMutai | MS4A3 |
DMDMi | 29611825 |
Proteomic databases
EPDi | Q96HJ5 |
MassIVEi | Q96HJ5 |
PaxDbi | Q96HJ5 |
PeptideAtlasi | Q96HJ5 |
PRIDEi | Q96HJ5 |
Protocols and materials databases
Antibodypediai | 14413, 168 antibodies from 22 providers |
DNASUi | 932 |
Genome annotation databases
Ensembli | ENST00000278865.8; ENSP00000278865.3; ENSG00000149516.14 ENST00000358152.6; ENSP00000350872.2; ENSG00000149516.14 [Q96HJ5-2] ENST00000395032.6; ENSP00000378473.2; ENSG00000149516.14 [Q96HJ5-3] ENST00000534744.1; ENSP00000434117.1; ENSG00000149516.14 [Q96HJ5-2] |
GeneIDi | 932 |
KEGGi | hsa:932 |
MANE-Selecti | ENST00000278865.8; ENSP00000278865.3; NM_006138.5; NP_006129.4 |
UCSCi | uc001nom.4, human [Q96HJ5-1] |
Organism-specific databases
CTDi | 932 |
DisGeNETi | 932 |
GeneCardsi | MS4A3 |
HGNCi | HGNC:7317, MS4A3 |
HPAi | ENSG00000149516, Tissue enriched (bone) |
MIMi | 606498, gene |
neXtProti | NX_Q96HJ5 |
OpenTargetsi | ENSG00000149516 |
PharmGKBi | PA31112 |
VEuPathDBi | HostDB:ENSG00000149516 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502T41X, Eukaryota |
GeneTreei | ENSGT00940000162383 |
HOGENOMi | CLU_091032_6_2_1 |
InParanoidi | Q96HJ5 |
OMAi | QRHFFFF |
OrthoDBi | 1239340at2759 |
PhylomeDBi | Q96HJ5 |
TreeFami | TF335157 |
Enzyme and pathway databases
PathwayCommonsi | Q96HJ5 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
SignaLinki | Q96HJ5 |
Miscellaneous databases
BioGRID-ORCSi | 932, 9 hits in 1075 CRISPR screens |
GeneWikii | MS4A3 |
GenomeRNAii | 932 |
Pharosi | Q96HJ5, Tbio |
PROi | PR:Q96HJ5 |
RNActi | Q96HJ5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000149516, Expressed in bone marrow and 104 other tissues |
ExpressionAtlasi | Q96HJ5, baseline and differential |
Genevisiblei | Q96HJ5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007237, CD20-like IPR030417, MS4A IPR030419, MS4A3 |
PANTHERi | PTHR23320, PTHR23320, 1 hit PTHR23320:SF74, PTHR23320:SF74, 1 hit |
Pfami | View protein in Pfam PF04103, CD20, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MS4A3_HUMAN | |
Accessioni | Q96HJ5Primary (citable) accession number: Q96HJ5 Secondary accession number(s): A8MTP8, Q8NHW2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families