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Protein

Membrane-spanning 4-domains subfamily A member 3

Gene

MS4A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Membrane-spanning 4-domains subfamily A member 3
Alternative name(s):
CD20 antigen-like protein
Hematopoietic-specific transmembrane protein 4
Short name:
HTm4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MS4A3
Synonyms:CD20L, HTM4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000149516.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7317 MS4A3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606498 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96HJ5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 81ExtracellularSequence analysisAdd BLAST11
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 124CytoplasmicSequence analysisAdd BLAST22
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 175ExtracellularSequence analysisAdd BLAST30
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 214CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
932

Open Targets

More...
OpenTargetsi
ENSG00000149516

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31112

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MS4A3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
29611825

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001586321 – 214Membrane-spanning 4-domains subfamily A member 3Add BLAST214

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96HJ5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96HJ5

PeptideAtlas

More...
PeptideAtlasi
Q96HJ5

PRoteomics IDEntifications database

More...
PRIDEi
Q96HJ5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
76756
76757 [Q96HJ5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96HJ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96HJ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed specifically in hematopoietic cells and tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000149516 Expressed in 77 organ(s), highest expression level in bone marrow

CleanEx database of gene expression profiles

More...
CleanExi
HS_MS4A3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96HJ5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96HJ5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019210

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDKN3. Interacts with CDKN3-CDK2 complexes through its binding to CDKN3; this interaction facilitates dissociation of cyclin A from CDKN3-CDK2 complexes.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107370, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q96HJ5, 38 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000278865

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96HJ5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi82 – 87Poly-Phe6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IZNT Eukaryota
ENOG411140Q LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162383

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113657

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052512

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96HJ5

KEGG Orthology (KO)

More...
KOi
K22190

Identification of Orthologs from Complete Genome Data

More...
OMAi
PIWGAVF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0IBB

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96HJ5

TreeFam database of animal gene trees

More...
TreeFami
TF335157

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030419 MS4A3

The PANTHER Classification System

More...
PANTHERi
PTHR23320 PTHR23320, 1 hit
PTHR23320:SF74 PTHR23320:SF74, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04103 CD20, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96HJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASHEVDNAE LGSASAHGTP GSEAGPEELN TSVYQPIDGS PDYQKAKLQV
60 70 80 90 100
LGAIQILNAA MILALGVFLG SLQYPYHFQK HFFFFTFYTG YPIWGAVFFC
110 120 130 140 150
SSGTLSVVAG IKPTRTWIQN SFGMNIASAT IALVGTAFLS LNIAVNIQSL
160 170 180 190 200
RSCHSSSESP DLCNYMGSIS NGMVSLLLIL TLLELCVTIS TIAMWCNANC
210
CNSREEISSP PNSV
Length:214
Mass (Da):22,933
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD30C276213DB8F3D
GO
Isoform 2 (identifier: Q96HJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-98: Missing.

Show »
Length:168
Mass (Da):17,601
Checksum:iC62AC47B541A634C
GO
Isoform 3 (identifier: Q96HJ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: No experimental confirmation available.
Show »
Length:91
Mass (Da):9,625
Checksum:i4570C062BADC3B17
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PRW8E9PRW8_HUMAN
Membrane-spanning 4-domains subfami...
MS4A3
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24A → T in AAA62319 (PubMed:7524084).Curated1
Sequence conflicti35Q → H in AAA62319 (PubMed:7524084).Curated1
Sequence conflicti38D → N in AAA62319 (PubMed:7524084).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0457981 – 123Missing in isoform 3. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_00710953 – 98Missing in isoform 2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L35848 mRNA Translation: AAA62319.1
AY095480 mRNA Translation: AAM23312.1
AY258289 Genomic DNA Translation: AAP14648.1
AP000790 Genomic DNA No translation available.
BC008487 mRNA Translation: AAH08487.1
BG494288 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31567.1 [Q96HJ5-1]
CCDS31568.1 [Q96HJ5-2]
CCDS41651.1 [Q96HJ5-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
I59258

NCBI Reference Sequences

More...
RefSeqi
NP_001026836.1, NM_001031666.1 [Q96HJ5-3]
NP_001026979.1, NM_001031809.1 [Q96HJ5-2]
NP_006129.4, NM_006138.4 [Q96HJ5-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.99960

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000278865; ENSP00000278865; ENSG00000149516 [Q96HJ5-1]
ENST00000358152; ENSP00000350872; ENSG00000149516 [Q96HJ5-2]
ENST00000395032; ENSP00000378473; ENSG00000149516 [Q96HJ5-3]
ENST00000534744; ENSP00000434117; ENSG00000149516 [Q96HJ5-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
932

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:932

UCSC genome browser

More...
UCSCi
uc001nom.4 human [Q96HJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35848 mRNA Translation: AAA62319.1
AY095480 mRNA Translation: AAM23312.1
AY258289 Genomic DNA Translation: AAP14648.1
AP000790 Genomic DNA No translation available.
BC008487 mRNA Translation: AAH08487.1
BG494288 mRNA No translation available.
CCDSiCCDS31567.1 [Q96HJ5-1]
CCDS31568.1 [Q96HJ5-2]
CCDS41651.1 [Q96HJ5-3]
PIRiI59258
RefSeqiNP_001026836.1, NM_001031666.1 [Q96HJ5-3]
NP_001026979.1, NM_001031809.1 [Q96HJ5-2]
NP_006129.4, NM_006138.4 [Q96HJ5-1]
UniGeneiHs.99960

3D structure databases

ProteinModelPortaliQ96HJ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107370, 2 interactors
IntActiQ96HJ5, 38 interactors
STRINGi9606.ENSP00000278865

PTM databases

iPTMnetiQ96HJ5
PhosphoSitePlusiQ96HJ5

Polymorphism and mutation databases

BioMutaiMS4A3
DMDMi29611825

Proteomic databases

EPDiQ96HJ5
PaxDbiQ96HJ5
PeptideAtlasiQ96HJ5
PRIDEiQ96HJ5
ProteomicsDBi76756
76757 [Q96HJ5-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
932
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278865; ENSP00000278865; ENSG00000149516 [Q96HJ5-1]
ENST00000358152; ENSP00000350872; ENSG00000149516 [Q96HJ5-2]
ENST00000395032; ENSP00000378473; ENSG00000149516 [Q96HJ5-3]
ENST00000534744; ENSP00000434117; ENSG00000149516 [Q96HJ5-2]
GeneIDi932
KEGGihsa:932
UCSCiuc001nom.4 human [Q96HJ5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
932
DisGeNETi932
EuPathDBiHostDB:ENSG00000149516.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MS4A3
HGNCiHGNC:7317 MS4A3
HPAiHPA019210
MIMi606498 gene
neXtProtiNX_Q96HJ5
OpenTargetsiENSG00000149516
PharmGKBiPA31112

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IZNT Eukaryota
ENOG411140Q LUCA
GeneTreeiENSGT00940000162383
HOGENOMiHOG000113657
HOVERGENiHBG052512
InParanoidiQ96HJ5
KOiK22190
OMAiPIWGAVF
OrthoDBiEOG091G0IBB
PhylomeDBiQ96HJ5
TreeFamiTF335157

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MS4A3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
932

Protein Ontology

More...
PROi
PR:Q96HJ5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000149516 Expressed in 77 organ(s), highest expression level in bone marrow
CleanExiHS_MS4A3
ExpressionAtlasiQ96HJ5 baseline and differential
GenevisibleiQ96HJ5 HS

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030419 MS4A3
PANTHERiPTHR23320 PTHR23320, 1 hit
PTHR23320:SF74 PTHR23320:SF74, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMS4A3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96HJ5
Secondary accession number(s): A8MTP8, Q8NHW2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: December 1, 2001
Last modified: December 5, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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