MS4A3

Functionⁱ

Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).1 Publication

GO - Biological processⁱ

neutrophil degranulation Source: Reactome
regulation of cell cycle Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor

Molecular function

Receptor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation

Reactomeⁱ

R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Membrane-spanning 4-domains subfamily A member 3 Alternative name(s): CD20 antigen-like protein Hematopoietic-specific transmembrane protein 4 Short name: HTm4
Gene namesⁱ	Name:MS4A3 Synonyms:CD20L, HTM4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000149516.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7317 MS4A3
MIMⁱ	606498 gene
neXtProtⁱ	NX_Q96HJ5

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 49	CytoplasmicSequence analysisAdd BLAST	49
Transmembraneⁱ	50 – 70	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	71 – 81	ExtracellularSequence analysisAdd BLAST	11
Transmembraneⁱ	82 – 102	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	103 – 124	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	125 – 145	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	146 – 175	ExtracellularSequence analysisAdd BLAST	30
Transmembraneⁱ	176 – 196	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	197 – 214	CytoplasmicSequence analysisAdd BLAST	18

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	932
Open Targets More...OpenTargetsⁱ	ENSG00000149516
PharmGKBⁱ	PA31112

Polymorphism and mutation databases

BioMutaⁱ	MS4A3
DMDMⁱ	29611825

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000158632	1 – 214	Membrane-spanning 4-domains subfamily A member 3Add BLAST		214

Proteomic databases

EPDⁱ	Q96HJ5
PaxDbⁱ	Q96HJ5
PeptideAtlas More...PeptideAtlasⁱ	Q96HJ5
PRIDEⁱ	Q96HJ5
ProteomicsDBⁱ	76756 76757 [Q96HJ5-2]

PTM databases

iPTMnetⁱ	Q96HJ5
PhosphoSitePlusⁱ	Q96HJ5

Expressionⁱ

Tissue specificityⁱ

Expressed specifically in hematopoietic cells and tissues.

Gene expression databases

Bgeeⁱ	ENSG00000149516 Expressed in 77 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_MS4A3
ExpressionAtlasⁱ	Q96HJ5 baseline and differential
Genevisibleⁱ	Q96HJ5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019210

HPAⁱ

HPA019210

Interactionⁱ

Subunit structureⁱ

Interacts with CDKN3. Interacts with CDKN3-CDK2 complexes through its binding to CDKN3; this interaction facilitates dissociation of cyclin A from CDKN3-CDK2 complexes.2 Publications

Protein-protein interaction databases

BioGridⁱ	107370, 2 interactors
IntActⁱ	Q96HJ5, 38 interactors
STRINGⁱ	9606.ENSP00000278865

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96HJ5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	82 – 87	Poly-Phe		6

Domainⁱ

The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity.

Sequence similaritiesⁱ

Belongs to the MS4A family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IZNT Eukaryota ENOG411140Q LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136511
HOGENOMⁱ	HOG000113657
HOVERGENⁱ	HBG052512
InParanoidⁱ	Q96HJ5
KEGG Orthology (KO) More...KOⁱ	K22190
OMAⁱ	PIWGAVF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IBB
PhylomeDBⁱ	Q96HJ5
TreeFamⁱ	TF335157

Family and domain databases

InterProⁱ	View protein in InterPro IPR007237 CD20-like IPR030417 MS4A IPR030419 MS4A3
PANTHERⁱ	PTHR23320 PTHR23320, 1 hit PTHR23320:SF74 PTHR23320:SF74, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04103 CD20, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q96HJ5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASHEVDNAE LGSASAHGTP GSEAGPEELN TSVYQPIDGS PDYQKAKLQV 
        60         70         80         90        100
LGAIQILNAA MILALGVFLG SLQYPYHFQK HFFFFTFYTG YPIWGAVFFC 
       110        120        130        140        150
SSGTLSVVAG IKPTRTWIQN SFGMNIASAT IALVGTAFLS LNIAVNIQSL 
       160        170        180        190        200
RSCHSSSESP DLCNYMGSIS NGMVSLLLIL TLLELCVTIS TIAMWCNANC 
       210 
CNSREEISSP PNSV

Length:214

Mass (Da):22,933

Last modified:December 1, 2001 - v1

Checksum:ⁱD30C276213DB8F3D

GO

Isoform 2 (identifier: Q96HJ5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
53-98: Missing.

« Hide

        10         20         30         40         50
MASHEVDNAE LGSASAHGTP GSEAGPEELN TSVYQPIDGS PDYQKAKLQV 
        60         70         80         90        100
LGFCSSGTLS VVAGIKPTRT WIQNSFGMNI ASATIALVGT AFLSLNIAVN 
       110        120        130        140        150
IQSLRSCHSS SESPDLCNYM GSISNGMVSL LLILTLLELC VTISTIAMWC 
       160 
NANCCNSREE ISSPPNSV

Show »

Length:168

Mass (Da):17,601

Checksum:ⁱC62AC47B541A634C

GO

Isoform 3 (identifier: Q96HJ5-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-123: Missing.

« Hide

        10         20         30         40         50
MNIASATIAL VGTAFLSLNI AVNIQSLRSC HSSSESPDLC NYMGSISNGM 
        60         70         80         90 
VSLLLILTLL ELCVTISTIA MWCNANCCNS REEISSPPNS V

Note: No experimental confirmation available.

Show »

Length:91

Mass (Da):9,625

Checksum:ⁱ4570C062BADC3B17

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E9PRW8	E9PRW8_HUMAN		Membrane-spanning 4-domains subfami... Membrane-spanning 4-domains subfamily A member 3	MS4A3	83	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	24	A → T in AAA62319 (PubMed:7524084).Curated	1
Sequence conflictⁱ	35	Q → H in AAA62319 (PubMed:7524084).Curated	1
Sequence conflictⁱ	38	D → N in AAA62319 (PubMed:7524084).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045798	1 – 123	Missing in isoform 3. 1 PublicationAdd BLAST		123
Alternative sequenceⁱVSP_007109	53 – 98	Missing in isoform 2. 1 PublicationAdd BLAST		46

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L35848 mRNA Translation: AAA62319.1 AY095480 mRNA Translation: AAM23312.1 AY258289 Genomic DNA Translation: AAP14648.1 AP000790 Genomic DNA No translation available. BC008487 mRNA Translation: AAH08487.1 BG494288 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31567.1 [Q96HJ5-1] CCDS31568.1 [Q96HJ5-2] CCDS41651.1 [Q96HJ5-3]
PIRⁱ	I59258
NCBI Reference Sequences More...RefSeqⁱ	NP_001026836.1, NM_001031666.1 [Q96HJ5-3] NP_001026979.1, NM_001031809.1 [Q96HJ5-2] NP_006129.4, NM_006138.4 [Q96HJ5-1]
UniGeneⁱ	Hs.99960

Genome annotation databases

Ensemblⁱ	ENST00000278865; ENSP00000278865; ENSG00000149516 [Q96HJ5-1] ENST00000358152; ENSP00000350872; ENSG00000149516 [Q96HJ5-2] ENST00000395032; ENSP00000378473; ENSG00000149516 [Q96HJ5-3] ENST00000534744; ENSP00000434117; ENSG00000149516 [Q96HJ5-2]
GeneIDⁱ	932
KEGGⁱ	hsa:932
UCSC genome browser More...UCSCⁱ	uc001nom.4 human [Q96HJ5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96HJ5	Isoform 3 of Membrane-spanning 4-domains subfamily A member 3		HUMAN		91	UniRef100_Q96HJ5
UPI0005D03D3A		HUMAN		154

Protein	Similar proteins		Species	Score	Length	Source
Q96HJ5	Isoform 3 of Membrane-spanning 4-domains subfamily A member 3		HUMAN		91	UniRef90_Q96HJ5
Membrane spanning 4-domains A3		GORGO		213
MS4A3 isoform 4		PANTR		212
Uncharacterized protein		PANPA		212
MS4A3 isoform 1		PANTR		90
+4
Q96HJ5-2	MS4A3 isoform 3		PANTR		167	UniRef90_Q96HJ5-2
Uncharacterized protein		PANPA		167
Membrane spanning 4-domains A3		GORGO		167

Protein	Similar proteins		Species	Score	Length	Source
Q96HJ5	Membrane-spanning 4-domains subfamily A member 3		MOUSE		213	UniRef50_Q96HJ5
Isoform 3 of Membrane-spanning 4-domains subfamily A member 3		HUMAN		91
Membrane spanning 4-domains A3		GORGO		213
MS4A3 isoform 4		PANTR		212
Uncharacterized protein		PANPA		212
+64
Q96HJ5-2	Uncharacterized protein		PANPA		167	UniRef50_Q96HJ5-2
Membrane spanning 4-domains A3		GORGO		167
MS4A3 isoform 3		PANTR		167
Uncharacterized protein		AOTNA		168
Uncharacterized protein		COLAP		183
+17

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L35848 mRNA Translation: AAA62319.1 AY095480 mRNA Translation: AAM23312.1 AY258289 Genomic DNA Translation: AAP14648.1 AP000790 Genomic DNA No translation available. BC008487 mRNA Translation: AAH08487.1 BG494288 mRNA No translation available.
CCDSⁱ	CCDS31567.1 [Q96HJ5-1] CCDS31568.1 [Q96HJ5-2] CCDS41651.1 [Q96HJ5-3]
PIRⁱ	I59258
RefSeqⁱ	NP_001026836.1, NM_001031666.1 [Q96HJ5-3] NP_001026979.1, NM_001031809.1 [Q96HJ5-2] NP_006129.4, NM_006138.4 [Q96HJ5-1]
UniGeneⁱ	Hs.99960

3D structure databases

ProteinModelPortalⁱ	Q96HJ5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107370, 2 interactors
IntActⁱ	Q96HJ5, 38 interactors
STRINGⁱ	9606.ENSP00000278865

PTM databases

iPTMnetⁱ	Q96HJ5
PhosphoSitePlusⁱ	Q96HJ5

Polymorphism and mutation databases

BioMutaⁱ	MS4A3
DMDMⁱ	29611825

Proteomic databases

EPDⁱ	Q96HJ5
PaxDbⁱ	Q96HJ5
PeptideAtlasⁱ	Q96HJ5
PRIDEⁱ	Q96HJ5
ProteomicsDBⁱ	76756 76757 [Q96HJ5-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	932
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000278865; ENSP00000278865; ENSG00000149516 [Q96HJ5-1] ENST00000358152; ENSP00000350872; ENSG00000149516 [Q96HJ5-2] ENST00000395032; ENSP00000378473; ENSG00000149516 [Q96HJ5-3] ENST00000534744; ENSP00000434117; ENSG00000149516 [Q96HJ5-2]
GeneIDⁱ	932
KEGGⁱ	hsa:932
UCSCⁱ	uc001nom.4 human [Q96HJ5-1]

Organism-specific databases

CTDⁱ	932
DisGeNETⁱ	932
EuPathDBⁱ	HostDB:ENSG00000149516.13
GeneCardsⁱ	MS4A3
HGNCⁱ	HGNC:7317 MS4A3
HPAⁱ	HPA019210
MIMⁱ	606498 gene
neXtProtⁱ	NX_Q96HJ5
OpenTargetsⁱ	ENSG00000149516
PharmGKBⁱ	PA31112
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IZNT Eukaryota ENOG411140Q LUCA
GeneTreeⁱ	ENSGT00870000136511
HOGENOMⁱ	HOG000113657
HOVERGENⁱ	HBG052512
InParanoidⁱ	Q96HJ5
KOⁱ	K22190
OMAⁱ	PIWGAVF
OrthoDBⁱ	EOG091G0IBB
PhylomeDBⁱ	Q96HJ5
TreeFamⁱ	TF335157

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation

Reactomeⁱ

R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

GeneWikiⁱ	MS4A3
GenomeRNAiⁱ	932
Protein Ontology More...PROⁱ	PR:Q96HJ5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000149516 Expressed in 77 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_MS4A3
ExpressionAtlasⁱ	Q96HJ5 baseline and differential
Genevisibleⁱ	Q96HJ5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007237 CD20-like IPR030417 MS4A IPR030419 MS4A3
PANTHERⁱ	PTHR23320 PTHR23320, 1 hit PTHR23320:SF74 PTHR23320:SF74, 1 hit
Pfamⁱ	View protein in Pfam PF04103 CD20, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MS4A3_HUMAN
Accessionⁱ	Q96HJ5Primary (citable) accession number: Q96HJ5 Secondary accession number(s): A8MTP8, Q8NHW2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 4, 2003
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniProtKB - Q96HJ5 (MS4A3_HUMAN)

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Membrane-spanning 4-domains subfamily A member 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ