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UniProtKB - Q96HJ5 (MS4A3_HUMAN)

Entry version 158 (25 May 2022)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
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Protein

Membrane-spanning 4-domains subfamily A member 3

Gene

MS4A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96HJ5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6798695, Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96HJ5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Membrane-spanning 4-domains subfamily A member 3
Alternative name(s):
CD20 antigen-like protein
Hematopoietic-specific transmembrane protein 4
Short name:
HTm4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MS4A3
Synonyms:CD20L, HTM4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7317, MS4A3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606498, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96HJ5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000149516

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 81ExtracellularSequence analysisAdd BLAST11
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 124CytoplasmicSequence analysisAdd BLAST22
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Topological domaini146 – 175ExtracellularSequence analysisAdd BLAST30
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 214CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		932

Open Targets

More...OpenTargetsi		ENSG00000149516

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31112

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96HJ5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MS4A3

Domain mapping of disease mutations (DMDM)

More...DMDMi		29611825

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001586321 – 214Membrane-spanning 4-domains subfamily A member 3Add BLAST214

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96HJ5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96HJ5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96HJ5

PeptideAtlas

More...PeptideAtlasi		Q96HJ5

PRoteomics IDEntifications database

More...PRIDEi		Q96HJ5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96HJ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96HJ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed specifically in hematopoietic cells and tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000149516, Expressed in bone marrow and 104 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96HJ5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96HJ5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000149516, Tissue enriched (bone)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDKN3.

Interacts with CDKN3-CDK2 complexes through its binding to CDKN3; this interaction facilitates dissociation of cyclin A from CDKN3-CDK2 complexes.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q96HJ5
With#Exp.IntAct
ADIPOQ [Q15848]3EBI-12806656,EBI-10827839
ATP6V0B [Q99437]5EBI-12806656,EBI-3904417
BMP10 [O95393]3EBI-12806656,EBI-3922513
BNIP3 [Q12983]3EBI-12806656,EBI-749464
C4orf3 - isoform 2 [Q8WVX3-2]3EBI-12806656,EBI-12003442
CCDC167 [Q9P0B6]3EBI-12806656,EBI-9083477
CD53 [P19397]3EBI-12806656,EBI-6657396
CD72 [P21854]3EBI-12806656,EBI-307924
CLDN1 [O95832]3EBI-12806656,EBI-723889
CLDN6 [P56747]5EBI-12806656,EBI-12955011
EFNA5 [P52803]3EBI-12806656,EBI-1753674
EMP3 [P54852]3EBI-12806656,EBI-3907816
ERG28 [Q9UKR5]3EBI-12806656,EBI-711490
IFITM3 [Q01628]3EBI-12806656,EBI-7932862
IGFBP5 [P24593]3EBI-12806656,EBI-720480
MS4A13 [Q5J8X5]3EBI-12806656,EBI-12070086
NKG7 [Q16617]3EBI-12806656,EBI-3919611
PLP1 - isoform DM-20 [P60201-2]3EBI-12806656,EBI-12188331
PLPP6 [Q8IY26]3EBI-12806656,EBI-11721828
SEC22A [Q96IW7]3EBI-12806656,EBI-8652744
SGTA [O43765]3EBI-12806656,EBI-347996
SLC22A14 [Q9Y267]4EBI-12806656,EBI-12824155
SLC5A4 [Q9NY91]3EBI-12806656,EBI-12409133
SMCO4 [Q9NRQ5]3EBI-12806656,EBI-8640191
SMIM3 [Q9BZL3]3EBI-12806656,EBI-741850
STX8 [Q9UNK0]3EBI-12806656,EBI-727240
TEX264 [Q9Y6I9]4EBI-12806656,EBI-10329860
TM4SF18 [Q96CE8]3EBI-12806656,EBI-13351685
TMBIM6 [P55061]3EBI-12806656,EBI-1045825
TMEM107 [Q6UX40]3EBI-12806656,EBI-12845616
TMEM140 [Q9NV12]3EBI-12806656,EBI-2844246
TMEM182 [Q6ZP80]5EBI-12806656,EBI-10255122
TMEM218 [A2RU14]5EBI-12806656,EBI-10173151
TMEM239 - isoform 2 [Q8WW34-2]3EBI-12806656,EBI-11528917
VKORC1L1 [Q8N0U8]3EBI-12806656,EBI-11337915
YIPF6 [Q96EC8]3EBI-12806656,EBI-751210
ZFPL1 [O95159]3EBI-12806656,EBI-718439

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107370, 39 interactors

Protein interaction database and analysis system

More...IntActi		Q96HJ5, 37 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000278865

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96HJ5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q96HJ5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96HJ5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 31DisorderedSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502T41X, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162383

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_091032_6_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96HJ5

Identification of Orthologs from Complete Genome Data

More...OMAi		QRHFFFF

Database of Orthologous Groups

More...OrthoDBi		1239340at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96HJ5

TreeFam database of animal gene trees

More...TreeFami		TF335157

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007237, CD20-like
IPR030417, MS4A
IPR030419, MS4A3

The PANTHER Classification System

More...PANTHERi		PTHR23320, PTHR23320, 1 hit
PTHR23320:SF74, PTHR23320:SF74, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04103, CD20, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96HJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASHEVDNAE LGSASAHGTP GSEAGPEELN TSVYQPIDGS PDYQKAKLQV 
        60         70         80         90        100
LGAIQILNAA MILALGVFLG SLQYPYHFQK HFFFFTFYTG YPIWGAVFFC 
       110        120        130        140        150
SSGTLSVVAG IKPTRTWIQN SFGMNIASAT IALVGTAFLS LNIAVNIQSL 
       160        170        180        190        200
RSCHSSSESP DLCNYMGSIS NGMVSLLLIL TLLELCVTIS TIAMWCNANC 
       210 
CNSREEISSP PNSV
Length:214
Mass (Da):22,933
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD30C276213DB8F3D
GO
Isoform 2 (identifier: Q96HJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-98: Missing.

Show »
Length:168
Mass (Da):17,601
Checksum:iC62AC47B541A634C
GO
Isoform 3 (identifier: Q96HJ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Show »
Length:91
Mass (Da):9,625
Checksum:i4570C062BADC3B17
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PRW8E9PRW8_HUMAN
Membrane-spanning 4-domains subfami...
MS4A3
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24A → T in AAA62319 (PubMed:7524084).Curated1
Sequence conflicti35Q → H in AAA62319 (PubMed:7524084).Curated1
Sequence conflicti38D → N in AAA62319 (PubMed:7524084).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0457981 – 123Missing in isoform 3. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_00710953 – 98Missing in isoform 2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L35848 mRNA Translation: AAA62319.1
AY095480 mRNA Translation: AAM23312.1
AY258289 Genomic DNA Translation: AAP14648.1
AP000790 Genomic DNA No translation available.
BC008487 mRNA Translation: AAH08487.1
BG494288 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31567.1 [Q96HJ5-1]
CCDS31568.1 [Q96HJ5-2]
CCDS41651.1 [Q96HJ5-3]

Protein sequence database of the Protein Information Resource

More...PIRi		I59258

NCBI Reference Sequences

More...RefSeqi		NP_001026836.1, NM_001031666.1 [Q96HJ5-3]
NP_001026979.1, NM_001031809.1 [Q96HJ5-2]
NP_006129.4, NM_006138.4 [Q96HJ5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000278865.8; ENSP00000278865.3; ENSG00000149516.14
ENST00000358152.6; ENSP00000350872.2; ENSG00000149516.14 [Q96HJ5-2]
ENST00000395032.6; ENSP00000378473.2; ENSG00000149516.14 [Q96HJ5-3]
ENST00000534744.1; ENSP00000434117.1; ENSG00000149516.14 [Q96HJ5-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		932

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:932

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000278865.8; ENSP00000278865.3; NM_006138.5; NP_006129.4

UCSC genome browser

More...UCSCi		uc001nom.4, human [Q96HJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35848 mRNA Translation: AAA62319.1
AY095480 mRNA Translation: AAM23312.1
AY258289 Genomic DNA Translation: AAP14648.1
AP000790 Genomic DNA No translation available.
BC008487 mRNA Translation: AAH08487.1
BG494288 mRNA No translation available.
CCDSiCCDS31567.1 [Q96HJ5-1]
CCDS31568.1 [Q96HJ5-2]
CCDS41651.1 [Q96HJ5-3]
PIRiI59258
RefSeqiNP_001026836.1, NM_001031666.1 [Q96HJ5-3]
NP_001026979.1, NM_001031809.1 [Q96HJ5-2]
NP_006129.4, NM_006138.4 [Q96HJ5-1]

3D structure databases

AlphaFoldDBiQ96HJ5
SMRiQ96HJ5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi107370, 39 interactors
IntActiQ96HJ5, 37 interactors
STRINGi9606.ENSP00000278865

PTM databases

iPTMnetiQ96HJ5
PhosphoSitePlusiQ96HJ5

Genetic variation databases

BioMutaiMS4A3
DMDMi29611825

Proteomic databases

EPDiQ96HJ5
MassIVEiQ96HJ5
PaxDbiQ96HJ5
PeptideAtlasiQ96HJ5
PRIDEiQ96HJ5

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		14413, 168 antibodies from 22 providers

The DNASU plasmid repository

More...DNASUi		932

Genome annotation databases

EnsembliENST00000278865.8; ENSP00000278865.3; ENSG00000149516.14
ENST00000358152.6; ENSP00000350872.2; ENSG00000149516.14 [Q96HJ5-2]
ENST00000395032.6; ENSP00000378473.2; ENSG00000149516.14 [Q96HJ5-3]
ENST00000534744.1; ENSP00000434117.1; ENSG00000149516.14 [Q96HJ5-2]
GeneIDi932
KEGGihsa:932
MANE-SelectiENST00000278865.8; ENSP00000278865.3; NM_006138.5; NP_006129.4
UCSCiuc001nom.4, human [Q96HJ5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		932
DisGeNETi932

GeneCards: human genes, protein and diseases

More...GeneCardsi		MS4A3
HGNCiHGNC:7317, MS4A3
HPAiENSG00000149516, Tissue enriched (bone)
MIMi606498, gene
neXtProtiNX_Q96HJ5
OpenTargetsiENSG00000149516
PharmGKBiPA31112
VEuPathDBiHostDB:ENSG00000149516

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502T41X, Eukaryota
GeneTreeiENSGT00940000162383
HOGENOMiCLU_091032_6_2_1
InParanoidiQ96HJ5
OMAiQRHFFFF
OrthoDBi1239340at2759
PhylomeDBiQ96HJ5
TreeFamiTF335157

Enzyme and pathway databases

PathwayCommonsiQ96HJ5
ReactomeiR-HSA-6798695, Neutrophil degranulation
SignaLinkiQ96HJ5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		932, 9 hits in 1075 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MS4A3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		932
PharosiQ96HJ5, Tbio

Protein Ontology

More...PROi		PR:Q96HJ5
RNActiQ96HJ5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000149516, Expressed in bone marrow and 104 other tissues
ExpressionAtlasiQ96HJ5, baseline and differential
GenevisibleiQ96HJ5, HS

Family and domain databases

InterProiView protein in InterPro
IPR007237, CD20-like
IPR030417, MS4A
IPR030419, MS4A3
PANTHERiPTHR23320, PTHR23320, 1 hit
PTHR23320:SF74, PTHR23320:SF74, 1 hit
PfamiView protein in Pfam
PF04103, CD20, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMS4A3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96HJ5
Secondary accession number(s): A8MTP8, Q8NHW2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: December 1, 2001
Last modified: May 25, 2022
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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