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Protein

Coiled-coil domain-containing protein 34

Gene

CCDC34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Antigen recognized by autologous antibody in patients with renal-cell carcinoma.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 34
Alternative name(s):
Renal carcinoma antigen NY-REN-41
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC34
Synonyms:RAMA3
ORF Names:L15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000109881.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25079 CCDC34

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612324 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96HJ3

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving CCDC34 is found in a patient with hamartoma of the retinal pigment epithelium and retina. Translocation t(11;18) (p13;p11.2).1 Publication

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000109881

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672189

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC34

Domain mapping of disease mutations (DMDM)

More...
DMDMi
190358750

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003391111 – 373Coiled-coil domain-containing protein 34Add BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei52PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96HJ3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96HJ3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96HJ3

PeptideAtlas

More...
PeptideAtlasi
Q96HJ3

PRoteomics IDEntifications database

More...
PRIDEi
Q96HJ3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
76754
76755 [Q96HJ3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96HJ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96HJ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000109881 Expressed in 183 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_CCDC34

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96HJ3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037574

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124792, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q96HJ3, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000330240

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96HJ3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96HJ3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili152 – 286Sequence analysisAdd BLAST135

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi78 – 102Asp-richAdd BLAST25

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IX0G Eukaryota
ENOG4111SGQ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111271

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111409

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG067911

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96HJ3

KEGG Orthology (KO)

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KOi
K16753

Identification of Orthologs from Complete Genome Data

More...
OMAi
KEKYEEW

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0N1R

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96HJ3

TreeFam database of animal gene trees

More...
TreeFami
TF333383

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025259 CCDC34

The PANTHER Classification System

More...
PANTHERi
PTHR23247 PTHR23247, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96HJ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWAAGRWGPT FPSSYAGFSA DCRPRSRPSS DSCSVPMTGA RGQGLEVVRS
60 70 80 90 100
PSPPLPLSCS NSTRSLLSPL GHQSFQFDED DGDGEDEEDV DDEEDVDEDA
110 120 130 140 150
HDSEAKVASL RGMELQGCAS TQVESENNQE EQKQVRLPES RLTPWEVWFI
160 170 180 190 200
GKEKEERDRL QLKALEELNQ QLEKRKEMEE REKRKIIAEE KHKEWVQKKN
210 220 230 240 250
EQKRKEREQK INKEMEEKAA KELEKEYLQE KAKEKYQEWL KKKNAEECER
260 270 280 290 300
KKKEKEKEKQ QQAEIQEKKE IAEKKFQEWL ENAKHKPRPA AKSYGYANGK
310 320 330 340 350
LTGFYSGNSY PEPAFYNPIP WKPIHMPPPK EAKDLSGRKS KRPVISQPHK
360 370
SSSLVIHKAR SNLCLGTLCR IQR
Length:373
Mass (Da):43,225
Last modified:June 10, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i050F7D3647C94167
GO
Isoform 2 (identifier: Q96HJ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-229: KRKEREQKINKEMEEKAAKELEKEYLQ → VRRGKWIHTLTSLLQNISSYYTSLPRF
     230-373: Missing.

Show »
Length:229
Mass (Da):26,256
Checksum:i4B8DB30BB6C66F6C
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD42874 differs from that shown. Reason: Frameshift at positions 9 and 21.Curated
The sequence AAO13807 differs from that shown. Reason: Frameshift at positions 142 and 243.Curated
The sequence AAO13807 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3A → P in AAD42874 (PubMed:10508479).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04386653P → S. Corresponds to variant dbSNP:rs11549824Ensembl.1
Natural variantiVAR_050750192H → N. Corresponds to variant dbSNP:rs12364852Ensembl.1
Natural variantiVAR_043867264E → A1 PublicationCorresponds to variant dbSNP:rs17244028Ensembl.1
Natural variantiVAR_043868319I → V. Corresponds to variant dbSNP:rs16925453Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034096203 – 229KRKER…KEYLQ → VRRGKWIHTLTSLLQNISSY YTSLPRF in isoform 2. 3 PublicationsAdd BLAST27
Alternative sequenceiVSP_034097230 – 373Missing in isoform 2. 3 PublicationsAdd BLAST144

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY598334 mRNA Translation: AAT06745.1
AK313358 mRNA Translation: BAG36159.1
AC090597 Genomic DNA No translation available.
BC008496 mRNA Translation: AAH08496.1
AF155108 mRNA Translation: AAD42874.1 Frameshift.
AF382034 mRNA Translation: AAO13807.1 Sequence problems.
AF301222 mRNA Translation: AAG39935.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31448.1 [Q96HJ3-1]
CCDS7863.1 [Q96HJ3-2]

NCBI Reference Sequences

More...
RefSeqi
NP_110398.1, NM_030771.1 [Q96HJ3-1]
NP_542385.1, NM_080654.2 [Q96HJ3-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.143733

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000317945; ENSP00000321563; ENSG00000109881 [Q96HJ3-2]
ENST00000328697; ENSP00000330240; ENSG00000109881 [Q96HJ3-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
91057

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:91057

UCSC genome browser

More...
UCSCi
uc001mrh.2 human [Q96HJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598334 mRNA Translation: AAT06745.1
AK313358 mRNA Translation: BAG36159.1
AC090597 Genomic DNA No translation available.
BC008496 mRNA Translation: AAH08496.1
AF155108 mRNA Translation: AAD42874.1 Frameshift.
AF382034 mRNA Translation: AAO13807.1 Sequence problems.
AF301222 mRNA Translation: AAG39935.1
CCDSiCCDS31448.1 [Q96HJ3-1]
CCDS7863.1 [Q96HJ3-2]
RefSeqiNP_110398.1, NM_030771.1 [Q96HJ3-1]
NP_542385.1, NM_080654.2 [Q96HJ3-2]
UniGeneiHs.143733

3D structure databases

ProteinModelPortaliQ96HJ3
SMRiQ96HJ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124792, 2 interactors
IntActiQ96HJ3, 2 interactors
STRINGi9606.ENSP00000330240

PTM databases

iPTMnetiQ96HJ3
PhosphoSitePlusiQ96HJ3

Polymorphism and mutation databases

BioMutaiCCDC34
DMDMi190358750

Proteomic databases

EPDiQ96HJ3
MaxQBiQ96HJ3
PaxDbiQ96HJ3
PeptideAtlasiQ96HJ3
PRIDEiQ96HJ3
ProteomicsDBi76754
76755 [Q96HJ3-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
91057
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317945; ENSP00000321563; ENSG00000109881 [Q96HJ3-2]
ENST00000328697; ENSP00000330240; ENSG00000109881 [Q96HJ3-1]
GeneIDi91057
KEGGihsa:91057
UCSCiuc001mrh.2 human [Q96HJ3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
91057
EuPathDBiHostDB:ENSG00000109881.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC34
HGNCiHGNC:25079 CCDC34
HPAiHPA037574
MIMi612324 gene
neXtProtiNX_Q96HJ3
OpenTargetsiENSG00000109881
PharmGKBiPA142672189

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IX0G Eukaryota
ENOG4111SGQ LUCA
GeneTreeiENSGT00730000111271
HOGENOMiHOG000111409
HOVERGENiHBG067911
InParanoidiQ96HJ3
KOiK16753
OMAiKEKYEEW
OrthoDBiEOG091G0N1R
PhylomeDBiQ96HJ3
TreeFamiTF333383

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCDC34 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
91057

Protein Ontology

More...
PROi
PR:Q96HJ3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000109881 Expressed in 183 organ(s), highest expression level in testis
CleanExiHS_CCDC34
GenevisibleiQ96HJ3 HS

Family and domain databases

InterProiView protein in InterPro
IPR025259 CCDC34
PANTHERiPTHR23247 PTHR23247, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCD34_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96HJ3
Secondary accession number(s): B2R8G2
, Q8IX69, Q9H2A6, Q9Y599
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 7, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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