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Protein

Sentrin-specific protease 5

Gene

SENP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei646By similarity1
Active sitei663By similarity1
Active sitei713Curated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processCell cycle, Cell division, Ubl conjugation pathway

Enzyme and pathway databases

BRENDAi3.4.22.B73 2681
ReactomeiR-HSA-3065679 SUMO is proteolytically processed

Protein family/group databases

MEROPSiC48.008

Names & Taxonomyi

Protein namesi
Recommended name:
Sentrin-specific protease 5 (EC:3.4.22.-)
Alternative name(s):
Sentrin/SUMO-specific protease SENP5
Gene namesi
Name:SENP5
ORF Names:FKSG45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000119231.10
HGNCiHGNC:28407 SENP5
MIMi612845 gene
neXtProtiNX_Q96HI0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi713C → A: Abolishes enzymatic activity. 2 Publications1

Organism-specific databases

DisGeNETi205564
OpenTargetsiENSG00000119231
PharmGKBiPA134917083

Polymorphism and mutation databases

BioMutaiSENP5
DMDMi296452962

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017231 – 755Sentrin-specific protease 5Add BLAST755

Proteomic databases

EPDiQ96HI0
MaxQBiQ96HI0
PaxDbiQ96HI0
PeptideAtlasiQ96HI0
PRIDEiQ96HI0
ProteomicsDBi76753

PTM databases

iPTMnetiQ96HI0
PhosphoSitePlusiQ96HI0

Expressioni

Gene expression databases

BgeeiENSG00000119231
CleanExiHS_SENP5
ExpressionAtlasiQ96HI0 baseline and differential
GenevisibleiQ96HI0 HS

Interactioni

Subunit structurei

Interacts with CCAR2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ESR1P033722EBI-3895753,EBI-78473

Protein-protein interaction databases

BioGridi128497, 23 interactors
DIPiDIP-62043N
IntActiQ96HI0, 2 interactors
STRINGi9606.ENSP00000327197

Structurei

3D structure databases

ProteinModelPortaliQ96HI0
SMRiQ96HI0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni567 – 724ProteaseAdd BLAST158

Sequence similaritiesi

Belongs to the peptidase C48 family.Curated

Phylogenomic databases

eggNOGiKOG0778 Eukaryota
COG5160 LUCA
GeneTreeiENSGT00530000062941
HOGENOMiHOG000070166
HOVERGENiHBG062231
InParanoidiQ96HI0
KOiK08594
OMAiWRKGIHL
OrthoDBiEOG091G092N
PhylomeDBiQ96HI0
TreeFamiTF316289

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR003653 Peptidase_C48_C
IPR033465 SENP5
PANTHERiPTHR12606:SF10 PTHR12606:SF10, 1 hit
PfamiView protein in Pfam
PF02902 Peptidase_C48, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50600 ULP_PROTEASE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96HI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKQRKILWR KGIHLAFSEK WNTGFGGFKK FYFHQHLCIL KAKLGRPVTW
60 70 80 90 100
NRQLRHFQGR KKALQIQKTW IKDEPLCAKT KFNVATQNVS TLSSKVKRKD
110 120 130 140 150
AKHFISSSKT LLRLQAEKLL SSAKNSDHEY CREKNLLKAV TDFPSNSALG
160 170 180 190 200
QANGHRPRTD PQPSDFPMKF NGESQSPGES GTIVVTLNNH KRKGFCYGCC
210 220 230 240 250
QGPEHHRNGG PLIPKKFQLN QHRRIKLSPL MMYEKLSMIR FRYRILRSQH
260 270 280 290 300
FRTKSKVCKL RKAQRSWVQK VTGDHQETRR ENGEGGSCSP FPSPEPKDPS
310 320 330 340 350
CRHQPYFPDM DSSAVVKGTN SHVPDCHTKG SSFLGKELSL DEAFPDQQNG
360 370 380 390 400
SATNAWDQSS CSSPKWECTE LIHDIPLPEH RSNTMFISET EREIMTLGQE
410 420 430 440 450
NQTSSVSDDR VKLSVSGADT SVSSVDGPVS QKAVQNENSY QMEEDGSLKQ
460 470 480 490 500
SILSSELLDH PYCKSPLEAP LVCSGLKLEN QVGGGKNSQK ASPVDDEQLS
510 520 530 540 550
VCLSGFLDEV MKKYGSLVPL SEKEVLGRLK DVFNEDFSNR KPFINREITN
560 570 580 590 600
YRARHQKCNF RIFYNKHMLD MDDLATLDGQ NWLNDQVINM YGELIMDAVP
610 620 630 640 650
DKVHFFNSFF HRQLVTKGYN GVKRWTKKVD LFKKSLLLIP IHLEVHWSLI
660 670 680 690 700
TVTLSNRIIS FYDSQGIHFK FCVENIRKYL LTEAREKNRP EFLQGWQTAV
710 720 730 740 750
TKCIPQQKND SDCGVFVLQY CKCLALEQPF QFSQEDMPRV RKRIYKELCE

CRLMD
Length:755
Mass (Da):86,693
Last modified:May 18, 2010 - v3
Checksum:i90D7B34B2853CEE4
GO
Isoform 2 (identifier: Q96HI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     629-674: Missing.

Note: No experimental confirmation available.
Show »
Length:709
Mass (Da):81,310
Checksum:iBA608D50017296EC
GO

Sequence cautioni

The sequence AAK69630 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75P → H in AAH30705 (PubMed:15489334).Curated1
Sequence conflicti538S → C in AAK69630 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05704583N → S. Corresponds to variant dbSNP:rs35434690Ensembl.1
Natural variantiVAR_061732340L → F. Corresponds to variant dbSNP:rs34251880Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056415629 – 674Missing in isoform 2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302305 mRNA Translation: BAG63644.1
AC011322 Genomic DNA No translation available.
AC016949 Genomic DNA No translation available.
AC127904 Genomic DNA No translation available.
BC008589 mRNA Translation: AAH08589.1
BC030705 mRNA Translation: AAH30705.1
AF335474 mRNA Translation: AAK69630.1 Different initiation.
CCDSiCCDS3322.1 [Q96HI0-1]
CCDS77876.1 [Q96HI0-2]
RefSeqiNP_001294974.1, NM_001308045.1 [Q96HI0-2]
NP_689912.2, NM_152699.4 [Q96HI0-1]
XP_011510846.1, XM_011512544.2 [Q96HI0-1]
XP_016861359.1, XM_017005870.1 [Q96HI0-2]
UniGeneiHs.240770

Genome annotation databases

EnsembliENST00000323460; ENSP00000327197; ENSG00000119231 [Q96HI0-1]
ENST00000445299; ENSP00000390231; ENSG00000119231 [Q96HI0-2]
GeneIDi205564
KEGGihsa:205564
UCSCiuc003fwz.5 human [Q96HI0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSENP5_HUMAN
AccessioniPrimary (citable) accession number: Q96HI0
Secondary accession number(s): B4DY82, Q96SA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

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