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Protein

Transmembrane protein 80

Gene

TMEM80

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 80
Gene namesi
Name:TMEM80
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000177042.14
HGNCiHGNC:27453 TMEM80
neXtProtiNX_Q96HE8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177042
PharmGKBiPA142670734

Polymorphism and mutation databases

DMDMi209572717

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002878731 – 216Transmembrane protein 80Add BLAST216

Proteomic databases

PaxDbiQ96HE8
PRIDEiQ96HE8
ProteomicsDBi76738
76739 [Q96HE8-2]

PTM databases

iPTMnetiQ96HE8
PhosphoSitePlusiQ96HE8

Expressioni

Gene expression databases

BgeeiENSG00000177042
CleanExiHS_TMEM80
ExpressionAtlasiQ96HE8 baseline and differential
GenevisibleiQ96HE8 HS

Organism-specific databases

HPAiHPA059592
HPA067046

Interactioni

Protein-protein interaction databases

IntActiQ96HE8, 56 interactors
STRINGi9606.ENSP00000380646

Structurei

3D structure databases

ProteinModelPortaliQ96HE8
SMRiQ96HE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0JJ Eukaryota
ENOG4112C55 LUCA
GeneTreeiENSGT00390000002170
HOGENOMiHOG000008106
HOVERGENiHBG059533
InParanoidiQ96HE8
PhylomeDBiQ96HE8
TreeFamiTF323824

Family and domain databases

InterProiView protein in InterPro
IPR019184 Uncharacterised_TM-17
PANTHERiPTHR13531 PTHR13531, 1 hit
PfamiView protein in Pfam
PF09799 Transmemb_17, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

Isoform 1 (identifier: Q96HE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPNVGSPPL PFRKCPSGAG RTNRASAVAR TSAPETRRGR APSSGDAKMA
60 70 80 90 100
EGARARGPRG CRDRDGPAGG AGKMAAPRRG RGSSTVLSSV PLQMLFYLSG
110 120 130 140 150
TYYALYFLAT LLMITYKSQV FSYPHRYLVL DLALLFLMGI LEAVRLYLGT
160 170 180 190 200
RGNLTEAERP LAASLALTAG TALLSAHFLL WQALVLWADW ALSATLLALH
210
GLEAVLQVVA IAAFTR
Length:216
Mass (Da):23,077
Last modified:April 25, 2018 - v4
Checksum:i6F6A7055D9F33772
GO
Isoform 2 (identifier: Q96HE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     73-80: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:160
Mass (Da):17,292
Checksum:iAAE06786801A0C5D
GO

Sequence cautioni

The sequence CB962031 differs from that shown. Sequence of unknown origin at the N-terminal part.Curated
The sequence EAX02373 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0595311 – 48Missing in isoform 2. CuratedAdd BLAST48
Alternative sequenceiVSP_05953273 – 80Missing in isoform 2. Curated8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131934 Genomic DNA No translation available.
BC008671 mRNA Translation: AAH08671.2
CB962031 mRNA No translation available.
CH471158 Genomic DNA Translation: EAX02373.1 Sequence problems.
CCDSiCCDS41587.2 [Q96HE8-1]
RefSeqiNP_001035928.2, NM_001042463.2 [Q96HE8-1]
NP_001263182.1, NM_001276253.1
NP_001263203.1, NM_001276274.1
NP_777600.3, NM_174940.3
UniGeneiHs.448664

Genome annotation databases

EnsembliENST00000397510; ENSP00000380646; ENSG00000177042 [Q96HE8-1]
ENST00000397512; ENSP00000380648; ENSG00000177042 [Q96HE8-2]
GeneIDi283232
KEGGihsa:283232
UCSCiuc057xju.1 human [Q96HE8-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTMM80_HUMAN
AccessioniPrimary (citable) accession number: Q96HE8
Secondary accession number(s): A0A0A0MS80
, A8MQ01, A8MXY8, B7WNU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: April 25, 2018
Last modified: July 18, 2018
This is version 108 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM

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