UniProtKB - Q96HC4 (PDLI5_HUMAN)
PDZ and LIM domain protein 5
PDLIM5
Functioni
GO - Molecular functioni
- actin binding Source: UniProtKB
- actinin binding Source: UniProtKB
- cadherin binding involved in cell-cell adhesion Source: BHF-UCL
- metal ion binding Source: UniProtKB-KW
- muscle alpha-actinin binding Source: GO_Central
- protein kinase C binding Source: UniProtKB
- protein N-terminus binding Source: Ensembl
GO - Biological processi
- actin cytoskeleton organization Source: GO_Central
- cell growth involved in cardiac muscle cell development Source: BHF-UCL
- heart development Source: GO_Central
- muscle structure development Source: GO_Central
- regulation of dendritic spine morphogenesis Source: UniProtKB
- regulation of synapse assembly Source: UniProtKB
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96HC4 |
Reactomei | R-HSA-6794361, Neurexins and neuroligins |
Names & Taxonomyi
Protein namesi | Recommended name: PDZ and LIM domain protein 5Alternative name(s): Enigma homolog Enigma-like PDZ and LIM domains protein |
Gene namesi | Name:PDLIM5 Synonyms:ENH ORF Names:L9 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000163110.14 |
HGNCi | HGNC:17468, PDLIM5 |
MIMi | 605904, gene |
neXtProti | NX_Q96HC4 |
Subcellular locationi
Cytosol
- cytosol By similarity
Other locations
- postsynaptic density By similarity
- presynapse By similarity
- postsynapse By similarity
Note: Detected both at presynaptic and postsynaptic sites, exclusively at excitatory synapses, but not inhibitory synapses, in hippocampal neurons.By similarity
Cytoskeleton
- actin cytoskeleton Source: LIFEdb
- filamentous actin Source: GO_Central
- stress fiber Source: GO_Central
Cytosol
- cytosol Source: UniProtKB
Other locations
- adherens junction Source: BHF-UCL
- cell projection Source: UniProtKB-KW
- membrane Source: UniProtKB
- postsynaptic density Source: UniProtKB
- presynapse Source: UniProtKB-SubCell
- Z disc Source: GO_Central
Keywords - Cellular componenti
Cell junction, Cell projection, Cytoplasm, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 10611 |
OpenTargetsi | ENSG00000163110 |
PharmGKBi | PA134917248 |
Miscellaneous databases
Pharosi | Q96HC4, Tbio |
Polymorphism and mutation databases
BioMutai | PDLIM5 |
DMDMi | 317373590 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000075877 | 2 – 596 | PDZ and LIM domain protein 5Add BLAST | 595 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources1 Publication | 1 | |
Modified residuei | 2 | PhosphoserineBy similarity | 1 | |
Modified residuei | 89 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 89 | N6-succinyllysine; alternateBy similarity | 1 | |
Cross-linki | 89 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 111 | PhosphoserineCombined sources | 1 | |
Modified residuei | 134 | PhosphoserineCombined sources | 1 | |
Modified residuei | 137 | PhosphoserineCombined sources | 1 | |
Modified residuei | 228 | PhosphoserineBy similarity | 1 | |
Modified residuei | 260 | PhosphoserineCombined sources | 1 | |
Modified residuei | 309 | PhosphoserineCombined sources | 1 | |
Modified residuei | 313 | PhosphoserineCombined sources | 1 | |
Modified residuei | 322 | PhosphoserineBy similarity | 1 | |
Modified residuei | 350 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 360 | PhosphoserineCombined sources | 1 | |
Modified residuei | 362 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q96HC4 |
jPOSTi | Q96HC4 |
MassIVEi | Q96HC4 |
MaxQBi | Q96HC4 |
PaxDbi | Q96HC4 |
PeptideAtlasi | Q96HC4 |
PRIDEi | Q96HC4 |
ProteomicsDBi | 13553 19211 62593 76730 [Q96HC4-1] 76731 [Q96HC4-2] 76732 [Q96HC4-3] 76733 [Q96HC4-4] |
PTM databases
GlyGeni | Q96HC4, 6 sites, 1 O-linked glycan (6 sites) |
iPTMneti | Q96HC4 |
MetOSitei | Q96HC4 |
PhosphoSitePlusi | Q96HC4 |
SwissPalmi | Q96HC4 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000163110, Expressed in biceps brachii and 249 other tissues |
ExpressionAtlasi | Q96HC4, baseline and differential |
Genevisiblei | Q96HC4, HS |
Organism-specific databases
HPAi | ENSG00000163110, Tissue enhanced (heart muscle, skeletal muscle) |
Interactioni
Subunit structurei
Interacts with various PKC isoforms through the LIM domains.
Interacts (via LIM domains) with SIPA1L1.
Interacts (via PDZ domain) with actin and ACTN1 (By similarity).
By similarityBinary interactionsi
Hide detailsQ96HC4
GO - Molecular functioni
- actin binding Source: UniProtKB
- actinin binding Source: UniProtKB
- cadherin binding involved in cell-cell adhesion Source: BHF-UCL
- muscle alpha-actinin binding Source: GO_Central
- protein kinase C binding Source: UniProtKB
- protein N-terminus binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 115857, 87 interactors |
DIPi | DIP-34898N |
IntActi | Q96HC4, 41 interactors |
MINTi | Q96HC4 |
STRINGi | 9606.ENSP00000480359 |
Miscellaneous databases
RNActi | Q96HC4, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q96HC4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q96HC4 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 85 | PDZPROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 418 – 477 | LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 477 – 536 | LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 536 – 596 | LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST | 61 |
Keywords - Domaini
LIM domain, RepeatPhylogenomic databases
eggNOGi | KOG1703, Eukaryota |
GeneTreei | ENSGT00940000155292 |
HOGENOMi | CLU_038114_3_0_1 |
InParanoidi | Q96HC4 |
OMAi | STNNMAY |
OrthoDBi | 1013114at2759 |
PhylomeDBi | Q96HC4 |
TreeFami | TF106408 |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR031847, DUF4749 IPR001478, PDZ IPR036034, PDZ_sf IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF15936, DUF4749, 1 hit PF00412, LIM, 3 hits PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00132, LIM, 3 hits SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 3 hits PS50106, PDZ, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSNYSVSLVG PAPWGFRLQG GKDFNMPLTI SSLKDGGKAA QANVRIGDVV
60 70 80 90 100
LSIDGINAQG MTHLEAQNKI KGCTGSLNMT LQRASAAPKP EPVPVQKGEP
110 120 130 140 150
KEVVKPVPIT SPAVSKVTST NNMAYNKAPR PFGSVSSPKV TSIPSPSSAF
160 170 180 190 200
TPAHATTSSH ASPSPVAAVT PPLFAASGLH ANANLSADQS PSALSAGKTA
210 220 230 240 250
VNVPRQPTVT SVCSETSQEL AEGQRRGSQG DSKQQNGPPR KHIVERYTEF
260 270 280 290 300
YHVPTHSDAS KKRLIEDTED WRPRTGTTQS RSFRILAQIT GTEHLKESEA
310 320 330 340 350
DNTKKANNSQ EPSPQLASSV ASTRSMPESL DSPTSGRPGV TSLTAAAAFK
360 370 380 390 400
PVGSTGVIKS PSWQRPNQGV PSTGRISNSA TYSGSVAPAN SALGQTQPSD
410 420 430 440 450
QDTLVQRAEH IPAGKRTPMC AHCNQVIRGP FLVALGKSWH PEEFNCAHCK
460 470 480 490 500
NTMAYIGFVE EKGALYCELC YEKFFAPECG RCQRKILGEV ISALKQTWHV
510 520 530 540 550
SCFVCVACGK PIRNNVFHLE DGEPYCETDY YALFGTICHG CEFPIEAGDM
560 570 580 590
FLEALGYTWH DTCFVCSVCC ESLEGQTFFS KKDKPLCKKH AHSVNF
The sequence of this isoform differs from the canonical sequence as follows:
98-117: GEPKEVVKPVPITSPAVSKV → KTQVTNNPGTVKIPPKRPPR
118-240: Missing.
307-337: NNSQEPSPQLASSVASTRSMPESLDSPTSGR → KEKIPLHVFSPKYTKLRDWHHEVSARALNVQ
338-596: Missing.
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y8Y3 | H0Y8Y3_HUMAN | PDZ and LIM domain protein 5 | PDLIM5 | 231 | Annotation score: | ||
A0A0A0MSP3 | A0A0A0MSP3_HUMAN | PDZ and LIM domain protein 5 | PDLIM5 | 271 | Annotation score: | ||
H0YBI4 | H0YBI4_HUMAN | PDZ and LIM domain protein 5 | PDLIM5 | 196 | Annotation score: | ||
A0A0D9SFR4 | A0A0D9SFR4_HUMAN | PDZ and LIM domain protein 5 | PDLIM5 | 176 | Annotation score: | ||
H0Y929 | H0Y929_HUMAN | PDZ and LIM domain protein 5 | PDLIM5 | 85 | Annotation score: | ||
D6RAA1 | D6RAA1_HUMAN | PDZ and LIM domain protein 5 | PDLIM5 | 38 | Annotation score: | ||
D6RGG6 | D6RGG6_HUMAN | PDZ and LIM domain protein 5 | PDLIM5 | 47 | Annotation score: | ||
A0A0D9SFW3 | A0A0D9SFW3_HUMAN | PDZ and LIM domain protein 5 | PDLIM5 | 39 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 2 (identifier: Q96HC4-2) | |||||
Sequence conflicti | 221 | D → G in AL833438 (Ref. 6) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023779 | 136 | S → F1 PublicationCorresponds to variant dbSNP:rs2452600Ensembl. | 1 | |
Natural variantiVAR_046662 | 319 | S → L2 PublicationsCorresponds to variant dbSNP:rs1064238Ensembl. | 1 | |
Natural variantiVAR_046663 | 345 | A → T6 PublicationsCorresponds to variant dbSNP:rs966845Ensembl. | 1 | |
Natural variantiVAR_046664 | 381 | T → A3 PublicationsCorresponds to variant dbSNP:rs7690296Ensembl. | 1 | |
Natural variantiVAR_046665 | 388 | P → S. Corresponds to variant dbSNP:rs7690464Ensembl. | 1 | |
Natural variantiVAR_046666 | 492 | S → NCombined sources6 PublicationsCorresponds to variant dbSNP:rs13107595Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045098 | 33 – 136 | LKDGG…FGSVS → AGVQWRNLGSPQPPSPEFKR FSCLSLPSSWDYRHVPPRLA NFVFLVETKFPYVGQAGLEL PTSGDLPTSASQSAKITGVS HRAWPTLFYTLLFFATIYPE IILY in isoform 5. 1 PublicationAdd BLAST | 104 | |
Alternative sequenceiVSP_039075 | 98 – 206 | Missing in isoform 2, isoform 4, isoform 6 and isoform 7. 2 PublicationsAdd BLAST | 109 | |
Alternative sequenceiVSP_039206 | 98 – 117 | GEPKE…AVSKV → KTQVTNNPGTVKIPPKRPPR in isoform 3. 2 PublicationsAdd BLAST | 20 | |
Alternative sequenceiVSP_039207 | 118 – 240 | Missing in isoform 3. 2 PublicationsAdd BLAST | 123 | |
Alternative sequenceiVSP_045099 | 137 – 596 | Missing in isoform 5. 1 PublicationAdd BLAST | 460 | |
Alternative sequenceiVSP_039076 | 237 | G → GKIPPKR in isoform 2, isoform 6 and isoform 7. 1 Publication | 1 | |
Alternative sequenceiVSP_039077 | 307 – 337 | NNSQE…PTSGR → KEKIPLHVFSPKYTKLRDWH HEVSARALNVQ in isoform 2 and isoform 3. 3 PublicationsAdd BLAST | 31 | |
Alternative sequenceiVSP_053796 | 307 | N → KFDSALEDLPKSGPHPPATP QVLTIGSQVATLSKVATTYS SLSSSTGNVEDSFEGFRNFS TFSSPARYSAAVLSSAAATV SAVIATKTRLYTPERYHSLL DALCISPVSKPLAFSYLQSS RKSTGSIHVKKTS in isoform 6. Curated | 1 | |
Alternative sequenceiVSP_039078 | 338 – 596 | Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST | 259 | |
Alternative sequenceiVSP_053797 | 587 – 596 | Missing in isoform 7. Curated | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF061258 mRNA Translation: AAC15767.1 AY345240 mRNA Translation: AAR09142.1 AY598328 mRNA Translation: AAT06739.1 BT007328 mRNA Translation: AAP35992.1 AK291624 mRNA Translation: BAF84313.1 AK291898 mRNA Translation: BAF84587.1 CR610626 mRNA No translation available. AL833438 mRNA No translation available. AC093778 Genomic DNA No translation available. AC108067 Genomic DNA No translation available. AC109925 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX06054.1 BC017902 mRNA Translation: AAH17902.1 BC008741 mRNA Translation: AAH08741.1 |
CCDSi | CCDS3641.1 [Q96HC4-1] CCDS47102.1 [Q96HC4-4] CCDS47103.1 [Q96HC4-2] CCDS47104.1 [Q96HC4-3] CCDS58915.1 [Q96HC4-5] CCDS58917.1 [Q96HC4-7] |
RefSeqi | NP_001011515.1, NM_001011515.2 [Q96HC4-2] NP_001011516.1, NM_001011516.2 [Q96HC4-3] NP_001243358.1, NM_001256429.1 [Q96HC4-5] NP_006448.4, NM_006457.4 [Q96HC4-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF061258 mRNA Translation: AAC15767.1 AY345240 mRNA Translation: AAR09142.1 AY598328 mRNA Translation: AAT06739.1 BT007328 mRNA Translation: AAP35992.1 AK291624 mRNA Translation: BAF84313.1 AK291898 mRNA Translation: BAF84587.1 CR610626 mRNA No translation available. AL833438 mRNA No translation available. AC093778 Genomic DNA No translation available. AC108067 Genomic DNA No translation available. AC109925 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX06054.1 BC017902 mRNA Translation: AAH17902.1 BC008741 mRNA Translation: AAH08741.1 |
CCDSi | CCDS3641.1 [Q96HC4-1] CCDS47102.1 [Q96HC4-4] CCDS47103.1 [Q96HC4-2] CCDS47104.1 [Q96HC4-3] CCDS58915.1 [Q96HC4-5] CCDS58917.1 [Q96HC4-7] |
RefSeqi | NP_001011515.1, NM_001011515.2 [Q96HC4-2] NP_001011516.1, NM_001011516.2 [Q96HC4-3] NP_001243358.1, NM_001256429.1 [Q96HC4-5] NP_006448.4, NM_006457.4 [Q96HC4-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DAR | NMR | - | A | 400-476 | [»] | |
2UZC | X-ray | 1.50 | A/B/C/D/E | 1-83 | [»] | |
SMRi | Q96HC4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115857, 87 interactors |
DIPi | DIP-34898N |
IntActi | Q96HC4, 41 interactors |
MINTi | Q96HC4 |
STRINGi | 9606.ENSP00000480359 |
PTM databases
GlyGeni | Q96HC4, 6 sites, 1 O-linked glycan (6 sites) |
iPTMneti | Q96HC4 |
MetOSitei | Q96HC4 |
PhosphoSitePlusi | Q96HC4 |
SwissPalmi | Q96HC4 |
Polymorphism and mutation databases
BioMutai | PDLIM5 |
DMDMi | 317373590 |
Proteomic databases
EPDi | Q96HC4 |
jPOSTi | Q96HC4 |
MassIVEi | Q96HC4 |
MaxQBi | Q96HC4 |
PaxDbi | Q96HC4 |
PeptideAtlasi | Q96HC4 |
PRIDEi | Q96HC4 |
ProteomicsDBi | 13553 19211 62593 76730 [Q96HC4-1] 76731 [Q96HC4-2] 76732 [Q96HC4-3] 76733 [Q96HC4-4] |
Protocols and materials databases
Antibodypediai | 4614, 383 antibodies |
DNASUi | 10611 |
Genome annotation databases
Organism-specific databases
CTDi | 10611 |
DisGeNETi | 10611 |
EuPathDBi | HostDB:ENSG00000163110.14 |
GeneCardsi | PDLIM5 |
HGNCi | HGNC:17468, PDLIM5 |
HPAi | ENSG00000163110, Tissue enhanced (heart muscle, skeletal muscle) |
MIMi | 605904, gene |
neXtProti | NX_Q96HC4 |
OpenTargetsi | ENSG00000163110 |
PharmGKBi | PA134917248 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1703, Eukaryota |
GeneTreei | ENSGT00940000155292 |
HOGENOMi | CLU_038114_3_0_1 |
InParanoidi | Q96HC4 |
OMAi | STNNMAY |
OrthoDBi | 1013114at2759 |
PhylomeDBi | Q96HC4 |
TreeFami | TF106408 |
Enzyme and pathway databases
PathwayCommonsi | Q96HC4 |
Reactomei | R-HSA-6794361, Neurexins and neuroligins |
Miscellaneous databases
BioGRID-ORCSi | 10611, 7 hits in 850 CRISPR screens |
ChiTaRSi | PDLIM5, human |
EvolutionaryTracei | Q96HC4 |
GeneWikii | PDLIM5 |
GenomeRNAii | 10611 |
Pharosi | Q96HC4, Tbio |
PROi | PR:Q96HC4 |
RNActi | Q96HC4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163110, Expressed in biceps brachii and 249 other tissues |
ExpressionAtlasi | Q96HC4, baseline and differential |
Genevisiblei | Q96HC4, HS |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR031847, DUF4749 IPR001478, PDZ IPR036034, PDZ_sf IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF15936, DUF4749, 1 hit PF00412, LIM, 3 hits PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00132, LIM, 3 hits SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 3 hits PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PDLI5_HUMAN | |
Accessioni | Q96HC4Primary (citable) accession number: Q96HC4 Secondary accession number(s): A8K6F9 Q8WVK0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | January 11, 2011 | |
Last modified: | December 2, 2020 | |
This is version 184 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations