PDLIM5

Functionⁱ

May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity).By similarity

GO - Molecular functionⁱ

actin binding Source: UniProtKB
actinin binding Source: UniProtKB
cadherin binding involved in cell-cell adhesion
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
metal ion binding Source: UniProtKB-KW
protein kinase C binding Source: UniProtKB
protein N-terminus binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell growth involved in cardiac muscle cell development Source: BHF-UCL
regulation of dendritic spine morphogenesis Source: UniProtKB
regulation of synapse assembly Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6794361 Neurexins and neuroligins

Reactomeⁱ

R-HSA-6794361 Neurexins and neuroligins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: PDZ and LIM domain protein 5 Alternative name(s): Enigma homolog Enigma-like PDZ and LIM domains protein
Gene namesⁱ	Name:PDLIM5 Synonyms:ENH ORF Names:L9
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163110.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17468 PDLIM5
MIMⁱ	605904 gene
neXtProtⁱ	NX_Q96HC4

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10611
Open Targets More...OpenTargetsⁱ	ENSG00000163110
PharmGKBⁱ	PA134917248

Polymorphism and mutation databases

BioMutaⁱ	PDLIM5
DMDMⁱ	317373590

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000075877	2 – 596	PDZ and LIM domain protein 5Add BLAST		595

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources1 Publication	1
Modified residueⁱ	2	PhosphoserineBy similarity	1
Modified residueⁱ	89	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	89	N6-succinyllysine; alternateBy similarity	1
Cross-linkⁱ	89	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	111	PhosphoserineCombined sources	1
Modified residueⁱ	134	PhosphoserineCombined sources	1
Modified residueⁱ	137	PhosphoserineCombined sources	1
Modified residueⁱ	228	PhosphoserineBy similarity	1
Modified residueⁱ	260	PhosphoserineCombined sources	1
Modified residueⁱ	309	PhosphoserineCombined sources	1
Modified residueⁱ	313	PhosphoserineCombined sources	1
Modified residueⁱ	322	PhosphoserineBy similarity	1
Modified residueⁱ	350	N6-acetyllysineBy similarity	1
Modified residueⁱ	360	PhosphoserineCombined sources	1
Modified residueⁱ	362	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q96HC4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96HC4
PaxDbⁱ	Q96HC4
PeptideAtlas More...PeptideAtlasⁱ	Q96HC4
PRIDEⁱ	Q96HC4
ProteomicsDBⁱ	76730 76731 [Q96HC4-2] 76732 [Q96HC4-3] 76733 [Q96HC4-4]

PTM databases

iPTMnetⁱ	Q96HC4
PhosphoSitePlusⁱ	Q96HC4
SwissPalmⁱ	Q96HC4

Expressionⁱ

Tissue specificityⁱ

Heart and skeletal muscle specific. Expression is commonly increased in the brain of patients with bipolar disorder, schizophrenia, and major depression.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000163110 Expressed in 239 organ(s), highest expression level in biceps brachii
CleanExⁱ	HS_PDLIM5
ExpressionAtlasⁱ	Q96HC4 baseline and differential
Genevisibleⁱ	Q96HC4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB013511 HPA016740 HPA020026

HPAⁱ

CAB013511
HPA016740
HPA020026

Interactionⁱ

Subunit structureⁱ

Interacts with various PKC isoforms through the LIM domains. Interacts (via LIM domains) with SIPA1L1. Interacts (via PDZ domain) with actin and ACTN1 (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CCDC136	Q96JN2-2	3	EBI-751267,EBI-10171416
COIL	P38432	3	EBI-751267,EBI-945751
ID2	Q02363	5	EBI-751267,EBI-713450
KRT40	Q6A162	3	EBI-751267,EBI-10171697
KRTAP10-7	P60409	3	EBI-751267,EBI-10172290
ZYX	Q15942	3	EBI-751267,EBI-444225

GO - Molecular functionⁱ

actin binding Source: UniProtKB
actinin binding Source: UniProtKB
cadherin binding involved in cell-cell adhesion
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
protein kinase C binding Source: UniProtKB
protein N-terminus binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115857, 66 interactors
Database of interacting proteins More...DIPⁱ	DIP-34898N
IntActⁱ	Q96HC4, 25 interactors
Molecular INTeraction database More...MINTⁱ	Q96HC4
STRINGⁱ	9606.ENSP00000321746

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	3 – 12	Combined sources	10
Beta strandⁱ	16 – 21	Combined sources	6
Helixⁱ	22 – 24	Combined sources	3
Beta strandⁱ	26 – 33	Combined sources	8
Helixⁱ	38 – 41	Combined sources	4
Beta strandⁱ	49 – 53	Combined sources	5
Helixⁱ	63 – 71	Combined sources	9
Beta strandⁱ	75 – 82	Combined sources	8
Beta strandⁱ	409 – 411	Combined sources	3
Turnⁱ	413 – 415	Combined sources	3
Beta strandⁱ	419 – 423	Combined sources	5
Beta strandⁱ	431 – 434	Combined sources	4
Beta strandⁱ	437 – 439	Combined sources	3
Turnⁱ	441 – 443	Combined sources	3
Beta strandⁱ	447 – 449	Combined sources	3
Beta strandⁱ	454 – 456	Combined sources	3
Beta strandⁱ	458 – 463	Combined sources	6
Helixⁱ	468 – 474	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q96HC4
SMRⁱ	Q96HC4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q96HC4

EvolutionaryTraceⁱ

Q96HC4

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	2 – 85	PDZPROSITE-ProRule annotationAdd BLAST	84
Domainⁱ	418 – 477	LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	477 – 536	LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	536 – 596	LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST	61

Keywords - Domainⁱ

LIM domain, Repeat

Phylogenomic databases

eggNOGⁱ	KOG1703 Eukaryota ENOG410XRD4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118910
HOGENOMⁱ	HOG000220936
HOVERGENⁱ	HBG051478
InParanoidⁱ	Q96HC4
OMAⁱ	STNNMAY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A45
PhylomeDBⁱ	Q96HC4
TreeFamⁱ	TF106408

Family and domain databases

InterProⁱ	View protein in InterPro IPR031847 DUF4749 IPR001478 PDZ IPR036034 PDZ_sf IPR001781 Znf_LIM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15936 DUF4749, 1 hit PF00412 LIM, 3 hits PF00595 PDZ, 1 hit
SMARTⁱ	View protein in SMART SM00132 LIM, 3 hits SM00228 PDZ, 1 hit
SUPFAMⁱ	SSF50156 SSF50156, 1 hit
PROSITEⁱ	View protein in PROSITE PS00478 LIM_DOMAIN_1, 2 hits PS50023 LIM_DOMAIN_2, 3 hits PS50106 PDZ, 1 hit

Sequences (7+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 7 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96HC4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MSNYSVSLVG PAPWGFRLQG GKDFNMPLTI SSLKDGGKAA QANVRIGDVV 
        60         70         80         90        100
LSIDGINAQG MTHLEAQNKI KGCTGSLNMT LQRASAAPKP EPVPVQKGEP 
       110        120        130        140        150
KEVVKPVPIT SPAVSKVTST NNMAYNKAPR PFGSVSSPKV TSIPSPSSAF 
       160        170        180        190        200
TPAHATTSSH ASPSPVAAVT PPLFAASGLH ANANLSADQS PSALSAGKTA 
       210        220        230        240        250
VNVPRQPTVT SVCSETSQEL AEGQRRGSQG DSKQQNGPPR KHIVERYTEF 
       260        270        280        290        300
YHVPTHSDAS KKRLIEDTED WRPRTGTTQS RSFRILAQIT GTEHLKESEA 
       310        320        330        340        350
DNTKKANNSQ EPSPQLASSV ASTRSMPESL DSPTSGRPGV TSLTAAAAFK 
       360        370        380        390        400
PVGSTGVIKS PSWQRPNQGV PSTGRISNSA TYSGSVAPAN SALGQTQPSD 
       410        420        430        440        450
QDTLVQRAEH IPAGKRTPMC AHCNQVIRGP FLVALGKSWH PEEFNCAHCK 
       460        470        480        490        500
NTMAYIGFVE EKGALYCELC YEKFFAPECG RCQRKILGEV ISALKQTWHV 
       510        520        530        540        550
SCFVCVACGK PIRNNVFHLE DGEPYCETDY YALFGTICHG CEFPIEAGDM 
       560        570        580        590 
FLEALGYTWH DTCFVCSVCC ESLEGQTFFS KKDKPLCKKH AHSVNF

Length:596

Mass (Da):63,945

Last modified:January 11, 2011 - v5

Checksum:ⁱBBEAB9EDFA060736

GO

Isoform 2 (identifier: Q96HC4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-206: Missing.
     237-237: G → GKIPPKR
     307-337: NNSQEPSPQLASSVASTRSMPESLDSPTSGR → KEKIPLHVFSPKYTKLRDWHHEVSARALNVQ
     338-596: Missing.

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        10         20         30         40         50
MSNYSVSLVG PAPWGFRLQG GKDFNMPLTI SSLKDGGKAA QANVRIGDVV 
        60         70         80         90        100
LSIDGINAQG MTHLEAQNKI KGCTGSLNMT LQRASAAPKP EPVPVQKPTV 
       110        120        130        140        150
TSVCSETSQE LAEGQRRGSQ GDSKQQNGKI PPKRPPRKHI VERYTEFYHV 
       160        170        180        190        200
PTHSDASKKR LIEDTEDWRP RTGTTQSRSF RILAQITGTE HLKESEADNT 
       210        220        230 
KKAKEKIPLH VFSPKYTKLR DWHHEVSARA LNVQ

Show »

Length:234

Mass (Da):25,930

Checksum:ⁱAC29AA4B14829C09

GO

Isoform 3 (identifier: Q96HC4-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-117: GEPKEVVKPVPITSPAVSKV → KTQVTNNPGTVKIPPKRPPR
     118-240: Missing.
     307-337: NNSQEPSPQLASSVASTRSMPESLDSPTSGR → KEKIPLHVFSPKYTKLRDWHHEVSARALNVQ
     338-596: Missing.

« Hide

        10         20         30         40         50
MSNYSVSLVG PAPWGFRLQG GKDFNMPLTI SSLKDGGKAA QANVRIGDVV 
        60         70         80         90        100
LSIDGINAQG MTHLEAQNKI KGCTGSLNMT LQRASAAPKP EPVPVQKKTQ 
       110        120        130        140        150
VTNNPGTVKI PPKRPPRKHI VERYTEFYHV PTHSDASKKR LIEDTEDWRP 
       160        170        180        190        200
RTGTTQSRSF RILAQITGTE HLKESEADNT KKAKEKIPLH VFSPKYTKLR 
       210 
DWHHEVSARA LNVQ

Show »

Length:214

Mass (Da):23,823

Checksum:ⁱFB118BF53EE7CDB4

GO

Isoform 4 (identifier: Q96HC4-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
98-206: Missing.

« Hide

        10         20         30         40         50
MSNYSVSLVG PAPWGFRLQG GKDFNMPLTI SSLKDGGKAA QANVRIGDVV 
        60         70         80         90        100
LSIDGINAQG MTHLEAQNKI KGCTGSLNMT LQRASAAPKP EPVPVQKPTV 
       110        120        130        140        150
TSVCSETSQE LAEGQRRGSQ GDSKQQNGPP RKHIVERYTE FYHVPTHSDA 
       160        170        180        190        200
SKKRLIEDTE DWRPRTGTTQ SRSFRILAQI TGTEHLKESE ADNTKKANNS 
       210        220        230        240        250
QEPSPQLASS VASTRSMPES LDSPTSGRPG VTSLTAAAAF KPVGSTGVIK 
       260        270        280        290        300
SPSWQRPNQG VPSTGRISNS ATYSGSVAPA NSALGQTQPS DQDTLVQRAE 
       310        320        330        340        350
HIPAGKRTPM CAHCNQVIRG PFLVALGKSW HPEEFNCAHC KNTMAYIGFV 
       360        370        380        390        400
EEKGALYCEL CYEKFFAPEC GRCQRKILGE VISALKQTWH VSCFVCVACG 
       410        420        430        440        450
KPIRNNVFHL EDGEPYCETD YYALFGTICH GCEFPIEAGD MFLEALGYTW 
       460        470        480 
HDTCFVCSVC CESLEGQTFF SKKDKPLCKK HAHSVNF

Note: No experimental confirmation available.

Show »

Length:487

Mass (Da):53,078

Checksum:ⁱ2790407D3FF2DED5

GO

Isoform 5 (identifier: Q96HC4-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
33-136: LKDGGKAAQA...KAPRPFGSVS → AGVQWRNLGS...ATIYPEIILY
137-596: Missing.

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        10         20         30         40         50
MSNYSVSLVG PAPWGFRLQG GKDFNMPLTI SSAGVQWRNL GSPQPPSPEF 
        60         70         80         90        100
KRFSCLSLPS SWDYRHVPPR LANFVFLVET KFPYVGQAGL ELPTSGDLPT 
       110        120        130 
SASQSAKITG VSHRAWPTLF YTLLFFATIY PEIILY

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Length:136

Mass (Da):15,116

Checksum:ⁱ33801E4A7B117739

GO

Isoform 6 (identifier: Q96HC4-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-206: Missing.
     237-237: G → GKIPPKR
     307-307: N → KFDSALEDLP...TGSIHVKKTS

« Hide

        10         20         30         40         50
MSNYSVSLVG PAPWGFRLQG GKDFNMPLTI SSLKDGGKAA QANVRIGDVV 
        60         70         80         90        100
LSIDGINAQG MTHLEAQNKI KGCTGSLNMT LQRASAAPKP EPVPVQKPTV 
       110        120        130        140        150
TSVCSETSQE LAEGQRRGSQ GDSKQQNGKI PPKRPPRKHI VERYTEFYHV 
       160        170        180        190        200
PTHSDASKKR LIEDTEDWRP RTGTTQSRSF RILAQITGTE HLKESEADNT 
       210        220        230        240        250
KKAKFDSALE DLPKSGPHPP ATPQVLTIGS QVATLSKVAT TYSSLSSSTG 
       260        270        280        290        300
NVEDSFEGFR NFSTFSSPAR YSAAVLSSAA ATVSAVIATK TRLYTPERYH 
       310        320        330        340        350
SLLDALCISP VSKPLAFSYL QSSRKSTGSI HVKKTSNSQE PSPQLASSVA 
       360        370        380        390        400
STRSMPESLD SPTSGRPGVT SLTAAAAFKP VGSTGVIKSP SWQRPNQGVP 
       410        420        430        440        450
STGRISNSAT YSGSVAPANS ALGQTQPSDQ DTLVQRAEHI PAGKRTPMCA 
       460        470        480        490        500
HCNQVIRGPF LVALGKSWHP EEFNCAHCKN TMAYIGFVEE KGALYCELCY 
       510        520        530        540        550
EKFFAPECGR CQRKILGEVI SALKQTWHVS CFVCVACGKP IRNNVFHLED 
       560        570        580        590        600
GEPYCETDYY ALFGTICHGC EFPIEAGDMF LEALGYTWHD TCFVCSVCCE 
       610        620 
SLEGQTFFSK KDKPLCKKHA HSVNF

Note: No experimental confirmation available.

Show »

Length:625

Mass (Da):67,729

Checksum:ⁱFA6C01ACAE8B48B0

GO

Isoform 7 (identifier: Q96HC4-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-206: Missing.
     237-237: G → GKIPPKR
     587-596: Missing.

« Hide

        10         20         30         40         50
MSNYSVSLVG PAPWGFRLQG GKDFNMPLTI SSLKDGGKAA QANVRIGDVV 
        60         70         80         90        100
LSIDGINAQG MTHLEAQNKI KGCTGSLNMT LQRASAAPKP EPVPVQKPTV 
       110        120        130        140        150
TSVCSETSQE LAEGQRRGSQ GDSKQQNGKI PPKRPPRKHI VERYTEFYHV 
       160        170        180        190        200
PTHSDASKKR LIEDTEDWRP RTGTTQSRSF RILAQITGTE HLKESEADNT 
       210        220        230        240        250
KKANNSQEPS PQLASSVAST RSMPESLDSP TSGRPGVTSL TAAAAFKPVG 
       260        270        280        290        300
STGVIKSPSW QRPNQGVPST GRISNSATYS GSVAPANSAL GQTQPSDQDT 
       310        320        330        340        350
LVQRAEHIPA GKRTPMCAHC NQVIRGPFLV ALGKSWHPEE FNCAHCKNTM 
       360        370        380        390        400
AYIGFVEEKG ALYCELCYEK FFAPECGRCQ RKILGEVISA LKQTWHVSCF 
       410        420        430        440        450
VCVACGKPIR NNVFHLEDGE PYCETDYYAL FGTICHGCEF PIEAGDMFLE 
       460        470        480 
ALGYTWHDTC FVCSVCCESL EGQTFFSKKD KPL

Note: No experimental confirmation available.

Show »

Length:483

Mass (Da):52,645

Checksum:ⁱFE2F3A27E1EBFC11

GO

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0Y8Y3	H0Y8Y3_HUMAN	PDZ and LIM domain protein 5 PDZ and LIM domain protein 5	PDLIM5	231	Annotation score:
A0A0A0MSP3	A0A0A0MSP3_HUMAN	PDZ and LIM domain protein 5 PDZ and LIM domain protein 5	PDLIM5	271	Annotation score:
H0Y929	H0Y929_HUMAN	PDZ and LIM domain protein 5 PDZ and LIM domain protein 5	PDLIM5	85	Annotation score:
H0YBI4	H0YBI4_HUMAN	PDZ and LIM domain protein 5 PDZ and LIM domain protein 5	PDLIM5	196	Annotation score:
D6RGG6	D6RGG6_HUMAN	PDZ and LIM domain protein 5 PDZ and LIM domain protein 5	PDLIM5	47	Annotation score:
A0A0D9SFR4	A0A0D9SFR4_HUMAN	PDZ and LIM domain protein 5 PDZ and LIM domain protein 5	PDLIM5	176	Annotation score:
D6RAA1	D6RAA1_HUMAN	PDZ and LIM domain protein 5 PDZ and LIM domain protein 5	PDLIM5	38	Annotation score:
A0A0D9SFW3	A0A0D9SFW3_HUMAN	PDZ and LIM domain protein 5 PDZ and LIM domain protein 5	PDLIM5	39	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Isoform 2 (identifier: Q96HC4-2)
Sequence conflictⁱ	221	D → G in AL833438 (Ref. 6) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_023779	136	S → F1 PublicationCorresponds to variant dbSNP:rs2452600Ensembl.	1
Natural variantⁱVAR_046662	319	S → L2 PublicationsCorresponds to variant dbSNP:rs1064238Ensembl.	1
Natural variantⁱVAR_046663	345	A → T6 PublicationsCorresponds to variant dbSNP:rs966845Ensembl.	1
Natural variantⁱVAR_046664	381	T → A3 PublicationsCorresponds to variant dbSNP:rs7690296Ensembl.	1
Natural variantⁱVAR_046665	388	P → S. Corresponds to variant dbSNP:rs7690464Ensembl.	1
Natural variantⁱVAR_046666	492	S → NCombined sources6 PublicationsCorresponds to variant dbSNP:rs13107595Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_045098	33 – 136	LKDGG…FGSVS → AGVQWRNLGSPQPPSPEFKR FSCLSLPSSWDYRHVPPRLA NFVFLVETKFPYVGQAGLEL PTSGDLPTSASQSAKITGVS HRAWPTLFYTLLFFATIYPE IILY in isoform 5. 1 PublicationAdd BLAST	104
Alternative sequenceⁱVSP_039075	98 – 206	Missing in isoform 2, isoform 4, isoform 6 and isoform 7. 2 PublicationsAdd BLAST	109
Alternative sequenceⁱVSP_039206	98 – 117	GEPKE…AVSKV → KTQVTNNPGTVKIPPKRPPR in isoform 3. 2 PublicationsAdd BLAST	20
Alternative sequenceⁱVSP_039207	118 – 240	Missing in isoform 3. 2 PublicationsAdd BLAST	123
Alternative sequenceⁱVSP_045099	137 – 596	Missing in isoform 5. 1 PublicationAdd BLAST	460
Alternative sequenceⁱVSP_039076	237	G → GKIPPKR in isoform 2, isoform 6 and isoform 7. 1 Publication	1
Alternative sequenceⁱVSP_039077	307 – 337	NNSQE…PTSGR → KEKIPLHVFSPKYTKLRDWH HEVSARALNVQ in isoform 2 and isoform 3. 3 PublicationsAdd BLAST	31
Alternative sequenceⁱVSP_053796	307	N → KFDSALEDLPKSGPHPPATP QVLTIGSQVATLSKVATTYS SLSSSTGNVEDSFEGFRNFS TFSSPARYSAAVLSSAAATV SAVIATKTRLYTPERYHSLL DALCISPVSKPLAFSYLQSS RKSTGSIHVKKTS in isoform 6. Curated	1
Alternative sequenceⁱVSP_039078	338 – 596	Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST	259
Alternative sequenceⁱVSP_053797	587 – 596	Missing in isoform 7. Curated	10

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF061258 mRNA Translation: AAC15767.1 AY345240 mRNA Translation: AAR09142.1 AY598328 mRNA Translation: AAT06739.1 BT007328 mRNA Translation: AAP35992.1 AK291624 mRNA Translation: BAF84313.1 AK291898 mRNA Translation: BAF84587.1 CR610626 mRNA No translation available. AL833438 mRNA No translation available. AC093778 Genomic DNA No translation available. AC108067 Genomic DNA No translation available. AC109925 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX06054.1 BC017902 mRNA Translation: AAH17902.1 BC008741 mRNA Translation: AAH08741.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3641.1 [Q96HC4-1] CCDS47102.1 [Q96HC4-4] CCDS47103.1 [Q96HC4-2] CCDS47104.1 [Q96HC4-3] CCDS58915.1 [Q96HC4-5] CCDS58916.1 [Q96HC4-6] CCDS58917.1 [Q96HC4-7]
NCBI Reference Sequences More...RefSeqⁱ	NP_001011515.1, NM_001011515.2 [Q96HC4-2] NP_001011516.1, NM_001011516.2 [Q96HC4-3] NP_001243358.1, NM_001256429.1 [Q96HC4-5] NP_006448.4, NM_006457.4
UniGeneⁱ	Hs.480311 Hs.732677

Genome annotation databases

Ensemblⁱ	ENST00000317968; ENSP00000321746; ENSG00000163110 [Q96HC4-1] ENST00000318007; ENSP00000322021; ENSG00000163110 [Q96HC4-3] ENST00000359265; ENSP00000352210; ENSG00000163110 [Q96HC4-5] ENST00000380180; ENSP00000369527; ENSG00000163110 [Q96HC4-2] ENST00000503974; ENSP00000424297; ENSG00000163110 [Q96HC4-7] ENST00000508216; ENSP00000426804; ENSG00000163110 [Q96HC4-2] ENST00000514743; ENSP00000424360; ENSG00000163110 [Q96HC4-6] ENST00000542407; ENSP00000442187; ENSG00000163110 [Q96HC4-4] ENST00000615540; ENSP00000480359; ENSG00000163110 [Q96HC4-6]
GeneIDⁱ	10611
KEGGⁱ	hsa:10611
UCSC genome browser More...UCSCⁱ	uc003htf.5 human [Q96HC4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96HC4	Uncharacterized protein LIM (Fragment)		HUMAN		337	UniRef100_Q96HC4
Q96HC4-5	PDLIM5 isoform 5		PANTR		136	UniRef100_A0A2I3RYM4
Uncharacterized protein		PANPA		136

Protein	Similar proteins		Species	Score	Length	Source
Q96HC4	Uncharacterized protein LIM (Fragment)		HUMAN		337	UniRef90_Q96HC4
PDZ and LIM domain 5		CALJA		613
Uncharacterized protein		ICTTR		607
PDZ and LIM domain protein 5 isoform X1		Florida manatee		602
PDZ and LIM domain protein 5 isoform a		MACMU		602
+141
Q96HC4-2	PDZ and LIM domain protein 5 isoform d		CALJA		245	UniRef90_Q96HC4-2
PDZ and LIM domain protein 5-like isoform X4		BALAS		239
Uncharacterized protein		CERAT		239
Uncharacterized protein		CAVPO		239
PDZ and LIM domain protein 5		MOUSE		239
+94
Q96HC4-3	PDZ and LIM domain protein 5 isoform e		CALJA		220	UniRef90_Q96HC4-3
PDLIM5 isoform 4		PANTR		214
PDZ and LIM domain 5		GORGO		214
PDZ and LIM domain protein 5 isoform X3		LIPVE		214
PDZ and LIM domain protein 5-like isoform X6		BALAS		214
+64
Q96HC4-4	Isoform 7 of PDZ and LIM domain protein 5		HUMAN		483	UniRef90_Q96HC4-7
Uncharacterized protein		RHIRO		498
Uncharacterized protein		PAPAN		498
Uncharacterized protein		MACFA		498
Uncharacterized protein		PIG		497
+170
Q96HC4-5	PDLIM5 isoform 5		PANTR		136	UniRef90_A0A2I3RYM4
Uncharacterized protein		PANPA		136
PDZ and LIM domain 5		GORGO		136
Q96HC4-6	PDLIM5 isoform 1		PONAB		625	UniRef90_Q96HC4-6
Uncharacterized protein		RHIRO		625
PDZ and LIM domain 5		SAIBB		625
PDZ and LIM domain 5		GORGO		625
PDZ and LIM domain 5		CALJA		625
+28
Q96HC4-7	Uncharacterized protein		RHIRO		498	UniRef90_Q96HC4-7
Uncharacterized protein		PAPAN		498
Uncharacterized protein		MACFA		498
Uncharacterized protein		PIG		497
PDZ and LIM domain protein 5 isoform X5		MESAU		495
+170

Protein	Similar proteins		Species	Score	Length	Source
Q96HC4	Uncharacterized protein LIM (Fragment)		HUMAN		337	UniRef50_Q96HC4
PDZ and LIM domain 5		CALJA		613
Uncharacterized protein		ICTTR		607
PDZ and LIM domain protein 5 isoform X1		Florida manatee		602
PDZ and LIM domain 5		PANTR		602
+408
Q96HC4-2	PDZ and LIM domain protein 5 isoform d		CALJA		245	UniRef50_Q96HC4-2
Uncharacterized protein		RHIRO		239
PDZ and LIM domain protein 5		MOUSE		239
PDZ and LIM domain protein 5 isoform X10		MESAU		239
PDZ and LIM domain protein 5-like isoform X4		BALAS		239
+129
Q96HC4-3	PDZ and LIM domain protein 5 isoform e		CALJA		220	UniRef50_Q96HC4-3
PDLIM5 isoform 4		PANTR		214
PDZ and LIM domain 5		GORGO		214
PDZ and LIM domain protein 5 isoform X3		LIPVE		214
PDZ and LIM domain protein 5-like isoform X6		BALAS		214
+71
Q96HC4-4	Isoform 7 of PDZ and LIM domain protein 5		HUMAN		483	UniRef50_Q96HC4-7
Uncharacterized protein		MACFA		498
Uncharacterized protein		PAPAN		498
Uncharacterized protein		RHIRO		498
Uncharacterized protein		PIG		497
+231
Q96HC4-5	PDLIM5 isoform 5		PANTR		136	UniRef50_A0A2I3RYM4
Uncharacterized protein		PANPA		136
PDZ and LIM domain 5		GORGO		136
cDNA FLJ44704 fis, clone BRACE3016810		HUMAN		165
Uncharacterized protein		PONAB		144
+3
Q96HC4-7	Uncharacterized protein		MACFA		498	UniRef50_Q96HC4-7
Uncharacterized protein		PAPAN		498
Uncharacterized protein		RHIRO		498
Uncharacterized protein		PIG		497
PDZ and LIM domain protein 5 isoform X5		MESAU		495
+231

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF061258 mRNA Translation: AAC15767.1 AY345240 mRNA Translation: AAR09142.1 AY598328 mRNA Translation: AAT06739.1 BT007328 mRNA Translation: AAP35992.1 AK291624 mRNA Translation: BAF84313.1 AK291898 mRNA Translation: BAF84587.1 CR610626 mRNA No translation available. AL833438 mRNA No translation available. AC093778 Genomic DNA No translation available. AC108067 Genomic DNA No translation available. AC109925 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX06054.1 BC017902 mRNA Translation: AAH17902.1 BC008741 mRNA Translation: AAH08741.1
CCDSⁱ	CCDS3641.1 [Q96HC4-1] CCDS47102.1 [Q96HC4-4] CCDS47103.1 [Q96HC4-2] CCDS47104.1 [Q96HC4-3] CCDS58915.1 [Q96HC4-5] CCDS58916.1 [Q96HC4-6] CCDS58917.1 [Q96HC4-7]
RefSeqⁱ	NP_001011515.1, NM_001011515.2 [Q96HC4-2] NP_001011516.1, NM_001011516.2 [Q96HC4-3] NP_001243358.1, NM_001256429.1 [Q96HC4-5] NP_006448.4, NM_006457.4
UniGeneⁱ	Hs.480311 Hs.732677

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2DAR	NMR	-	A	400-476	[»]
	2UZC	X-ray	1.50	A/B/C/D/E	1-83	[»]
ProteinModelPortalⁱ	Q96HC4
SMRⁱ	Q96HC4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115857, 66 interactors
DIPⁱ	DIP-34898N
IntActⁱ	Q96HC4, 25 interactors
MINTⁱ	Q96HC4
STRINGⁱ	9606.ENSP00000321746

PTM databases

iPTMnetⁱ	Q96HC4
PhosphoSitePlusⁱ	Q96HC4
SwissPalmⁱ	Q96HC4

Polymorphism and mutation databases

BioMutaⁱ	PDLIM5
DMDMⁱ	317373590

Proteomic databases

EPDⁱ	Q96HC4
MaxQBⁱ	Q96HC4
PaxDbⁱ	Q96HC4
PeptideAtlasⁱ	Q96HC4
PRIDEⁱ	Q96HC4
ProteomicsDBⁱ	76730 76731 [Q96HC4-2] 76732 [Q96HC4-3] 76733 [Q96HC4-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10611
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000317968; ENSP00000321746; ENSG00000163110 [Q96HC4-1] ENST00000318007; ENSP00000322021; ENSG00000163110 [Q96HC4-3] ENST00000359265; ENSP00000352210; ENSG00000163110 [Q96HC4-5] ENST00000380180; ENSP00000369527; ENSG00000163110 [Q96HC4-2] ENST00000503974; ENSP00000424297; ENSG00000163110 [Q96HC4-7] ENST00000508216; ENSP00000426804; ENSG00000163110 [Q96HC4-2] ENST00000514743; ENSP00000424360; ENSG00000163110 [Q96HC4-6] ENST00000542407; ENSP00000442187; ENSG00000163110 [Q96HC4-4] ENST00000615540; ENSP00000480359; ENSG00000163110 [Q96HC4-6]
GeneIDⁱ	10611
KEGGⁱ	hsa:10611
UCSCⁱ	uc003htf.5 human [Q96HC4-1]

Organism-specific databases

CTDⁱ	10611
DisGeNETⁱ	10611
EuPathDBⁱ	HostDB:ENSG00000163110.14
GeneCardsⁱ	PDLIM5
H-InvDBⁱ	HIX0004384 HIX0031573
HGNCⁱ	HGNC:17468 PDLIM5
HPAⁱ	CAB013511 HPA016740 HPA020026
MIMⁱ	605904 gene
neXtProtⁱ	NX_Q96HC4
OpenTargetsⁱ	ENSG00000163110
PharmGKBⁱ	PA134917248
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1703 Eukaryota ENOG410XRD4 LUCA
GeneTreeⁱ	ENSGT00760000118910
HOGENOMⁱ	HOG000220936
HOVERGENⁱ	HBG051478
InParanoidⁱ	Q96HC4
OMAⁱ	STNNMAY
OrthoDBⁱ	EOG091G0A45
PhylomeDBⁱ	Q96HC4
TreeFamⁱ	TF106408

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6794361 Neurexins and neuroligins

Reactomeⁱ

R-HSA-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRSⁱ	PDLIM5 human
EvolutionaryTraceⁱ	Q96HC4
GeneWikiⁱ	PDLIM5
GenomeRNAiⁱ	10611
Protein Ontology More...PROⁱ	PR:Q96HC4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163110 Expressed in 239 organ(s), highest expression level in biceps brachii
CleanExⁱ	HS_PDLIM5
ExpressionAtlasⁱ	Q96HC4 baseline and differential
Genevisibleⁱ	Q96HC4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR031847 DUF4749 IPR001478 PDZ IPR036034 PDZ_sf IPR001781 Znf_LIM
Pfamⁱ	View protein in Pfam PF15936 DUF4749, 1 hit PF00412 LIM, 3 hits PF00595 PDZ, 1 hit
SMARTⁱ	View protein in SMART SM00132 LIM, 3 hits SM00228 PDZ, 1 hit
SUPFAMⁱ	SSF50156 SSF50156, 1 hit
PROSITEⁱ	View protein in PROSITE PS00478 LIM_DOMAIN_1, 2 hits PS50023 LIM_DOMAIN_2, 3 hits PS50106 PDZ, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PDLI5_HUMAN
Accessionⁱ	Q96HC4Primary (citable) accession number: Q96HC4 Secondary accession number(s): A8K6F9 Q8WVK0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
	Last sequence update:	January 11, 2011
	Last modified:	October 10, 2018
	This is version 167 of the entry and version 5 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q96HC4 (PDLI5_HUMAN)

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PDZ and LIM domain protein 5

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Cytosol

Plasma Membrane

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Keywords - Domaini

Phylogenomic databases

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Experimental Info

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Sequence databases

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Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

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PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

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Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ