UniProtKB - Q96HB5 (CC120_HUMAN)
Coiled-coil domain-containing protein 120
CCDC120
Functioni
Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092).
Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092).
Recruits NIN and CEP170 to centrosomes (PubMed:28422092).
Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth.
1 PublicationGO - Biological processi
- microtubule anchoring at centrosome Source: GO_Central
- protein localization Source: GO_Central
Keywordsi
Molecular function | Developmental protein |
Enzyme and pathway databases
PathwayCommonsi | Q96HB5 |
SignaLinki | Q96HB5 |
Names & Taxonomyi
Protein namesi | Recommended name: Coiled-coil domain-containing protein 120 |
Gene namesi | Name:CCDC120 ORF Names:JM11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28910, CCDC120 |
MIMi | 300947, gene |
neXtProti | NX_Q96HB5 |
VEuPathDBi | HostDB:ENSG00000147144 |
Subcellular locationi
Endosome
- Endosome 1 Publication
Cytoskeleton
- centriole 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- neuron projection 1 Publication
- growth cone 1 Publication
Note: Localizes to the subdistal appendages of mother centrioles and proximal ends of both centrioles in interphase cells (PubMed:28422092). Recruited to subdistal appendages by ODF2 (PubMed:28422092). In differentiating neuroblastoma cells, colocalizes with CYTH2 in both neurite shaft and growth cone areas (PubMed:25326380). Partially colocalizes with endosomes along neurites in differentiating neuroblastoma cells (PubMed:25326380).2 Publications
Cytoskeleton
- centriole Source: GO_Central
Endosome
- endosome Source: UniProtKB-SubCell
Other locations
- centriolar subdistal appendage Source: GO_Central
- growth cone Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell projection, Cytoplasm, Cytoskeleton, EndosomePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000147144 |
PharmGKBi | PA145149329 |
Miscellaneous databases
Pharosi | Q96HB5, Tbio |
Genetic variation databases
BioMutai | CCDC120 |
DMDMi | 74731908 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000254141 | 1 – 630 | Coiled-coil domain-containing protein 120Add BLAST | 630 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 358 | PhosphoserineCombined sources | 1 | |
Modified residuei | 360 | PhosphoserineCombined sources | 1 | |
Modified residuei | 435 | Omega-N-methylarginineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q96HB5 |
jPOSTi | Q96HB5 |
MassIVEi | Q96HB5 |
MaxQBi | Q96HB5 |
PaxDbi | Q96HB5 |
PeptideAtlasi | Q96HB5 |
PRIDEi | Q96HB5 |
ProteomicsDBi | 25131 76728 [Q96HB5-1] 76729 [Q96HB5-2] |
PTM databases
iPTMneti | Q96HB5 |
PhosphoSitePlusi | Q96HB5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000147144, Expressed in cerebellar vermis and 118 other tissues |
ExpressionAtlasi | Q96HB5, baseline and differential |
Genevisiblei | Q96HB5, HS |
Organism-specific databases
HPAi | ENSG00000147144, Tissue enhanced (esophagus, skin) |
Interactioni
Subunit structurei
Interacts with NIN and CEP170; leading to recruit them to centrosomes (PubMed:28422092). Directly interacts with CYTH2; this interaction stabilizes CCDC120, possibly by preventing ubiquitination.
2 PublicationsBinary interactionsi
Q96HB5
Isoform 4 [Q96HB5-4]
Protein-protein interaction databases
BioGRIDi | 124658, 166 interactors |
IntActi | Q96HB5, 161 interactors |
MINTi | Q96HB5 |
STRINGi | 9606.ENSP00000474071 |
Miscellaneous databases
RNActi | Q96HB5, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 31 – 70 | Involved in CYTH2-binding1 PublicationAdd BLAST | 40 | |
Regioni | 212 – 435 | DisorderedSequence analysisAdd BLAST | 224 | |
Regioni | 457 – 534 | DisorderedSequence analysisAdd BLAST | 78 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 109 – 173 | Sequence analysisAdd BLAST | 65 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 278 – 303 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 408 – 422 | Pro residuesSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3529, Eukaryota |
GeneTreei | ENSGT00940000154102 |
HOGENOMi | CLU_029533_0_0_1 |
InParanoidi | Q96HB5 |
OMAi | AQRKQMK |
OrthoDBi | 595503at2759 |
PhylomeDBi | Q96HB5 |
TreeFami | TF328984 |
Family and domain databases
InterProi | View protein in InterPro IPR039108, CCDC120 IPR043447, CCDC120/INAVA IPR021774, DUF3338 |
PANTHERi | PTHR16093, PTHR16093, 1 hit PTHR16093:SF5, PTHR16093:SF5, 1 hit |
Pfami | View protein in Pfam PF11819, CUPID, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEVKGQLISS PTFNAPAALF GEAAPQVKSE RLRGLLDRQR TLQEALSLKL
60 70 80 90 100
QELRKVCLQE AELTGQLPPE CPLEPGERPQ LVRRRPPTAR AYPPPHPNQA
110 120 130 140 150
HHSLCPAEEL ALEALEREVS VQQQIAAAAR RLALAPDLST EQRRRRRQVQ
160 170 180 190 200
ADALRRLHEL EEQLRDVRAR LGLPVLPLPQ PLPLSTGSVI TTQGVCLGMR
210 220 230 240 250
LAQLSQEDVV LHSESSSLSE SGASHDNEEP HGCFSLAERP SPPKAWDQLR
260 270 280 290 300
AVSGGSPERR TPWKPPPSDL YGDLKSRRNS VASPTSPTRS LPRSASSFEG
310 320 330 340 350
RSVPATPVLT RGAGPQLCKP EGLHSRQWSG SQDSQMGFPR ADPASDRASL
360 370 380 390 400
FVARTRRSNS SEALLVDRAA GGGAGSPPAP LAPSASGPPV CKSSEVLYER
410 420 430 440 450
PQPTPAFSSR TAGPPDPPRA ARPSSAAPAS RGAPRLPPVC GDFLLDYSLD
460 470 480 490 500
RGLPRSGGGT GWGELPPAAE VPGPLSRRDG LLTMLPGPPP VYAADSNSPL
510 520 530 540 550
LRTKDPHTRA TRTKPCGLPP EAAEGPEVHP NPLLWMPPPT RIPSAGERSG
560 570 580 590 600
HKNLALEGLR DWYIRNSGLA AGPQRRPVLP SVGPPHPPFL HARCYEVGQA
610 620 630
LYGAPSQAPL PHSRSFTAPP VSGRYGGCFY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketS4R3T7 | S4R3T7_HUMAN | Coiled-coil domain-containing prote... | CCDC120 | 63 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054527 | 1 | M → MRREPRYQGQVGPDIHTDSE RTLSSHQPRPLDSTKM in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_042859 | 5 – 16 | Missing in isoform 2 and isoform 5. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_047104 | 626 – 630 | GGCFY → YADFLYPPELSARLSDLTLE GEQSSSSDTQTPGTLV in isoform 3, isoform 4 and isoform 5. 1 Publication | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ896186 mRNA No translation available. AK293898 mRNA Translation: BAG57285.1 AK294024 mRNA Translation: BAG57382.1 AK291370 mRNA Translation: BAF84059.1 AK300366 mRNA Translation: BAG62104.1 AK315837 mRNA Translation: BAF98728.1 AF196779 Genomic DNA No translation available. CH471224 Genomic DNA Translation: EAW50708.1 BC008769 mRNA Translation: AAH08769.1 |
CCDSi | CCDS14316.1 [Q96HB5-1] CCDS55413.1 [Q96HB5-2] CCDS55414.2 [Q96HB5-4] |
RefSeqi | NP_001156793.2, NM_001163321.2 [Q96HB5-4] NP_001156794.1, NM_001163322.2 [Q96HB5-5] NP_001156795.1, NM_001163323.2 [Q96HB5-2] NP_001258764.1, NM_001271835.1 [Q96HB5-1] NP_001258765.1, NM_001271836.1 [Q96HB5-1] NP_296375.1, NM_033626.3 [Q96HB5-1] |
Genome annotation databases
Ensembli | ENST00000496529; ENSP00000474761; ENSG00000147144 ENST00000536628; ENSP00000443351; ENSG00000147144 [Q96HB5-2] ENST00000597275; ENSP00000470294; ENSG00000147144 ENST00000603986; ENSP00000474071; ENSG00000147144 [Q96HB5-4] ENST00000606812; ENSP00000475676; ENSG00000147144 |
GeneIDi | 90060 |
KEGGi | hsa:90060 |
MANE-Selecti | ENST00000603986.6; ENSP00000474071.1; NM_001163321.4; NP_001156793.2 [Q96HB5-4] |
UCSCi | uc064zdh.1, human [Q96HB5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ896186 mRNA No translation available. AK293898 mRNA Translation: BAG57285.1 AK294024 mRNA Translation: BAG57382.1 AK291370 mRNA Translation: BAF84059.1 AK300366 mRNA Translation: BAG62104.1 AK315837 mRNA Translation: BAF98728.1 AF196779 Genomic DNA No translation available. CH471224 Genomic DNA Translation: EAW50708.1 BC008769 mRNA Translation: AAH08769.1 |
CCDSi | CCDS14316.1 [Q96HB5-1] CCDS55413.1 [Q96HB5-2] CCDS55414.2 [Q96HB5-4] |
RefSeqi | NP_001156793.2, NM_001163321.2 [Q96HB5-4] NP_001156794.1, NM_001163322.2 [Q96HB5-5] NP_001156795.1, NM_001163323.2 [Q96HB5-2] NP_001258764.1, NM_001271835.1 [Q96HB5-1] NP_001258765.1, NM_001271836.1 [Q96HB5-1] NP_296375.1, NM_033626.3 [Q96HB5-1] |
3D structure databases
SMRi | Q96HB5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124658, 166 interactors |
IntActi | Q96HB5, 161 interactors |
MINTi | Q96HB5 |
STRINGi | 9606.ENSP00000474071 |
PTM databases
iPTMneti | Q96HB5 |
PhosphoSitePlusi | Q96HB5 |
Genetic variation databases
BioMutai | CCDC120 |
DMDMi | 74731908 |
Proteomic databases
EPDi | Q96HB5 |
jPOSTi | Q96HB5 |
MassIVEi | Q96HB5 |
MaxQBi | Q96HB5 |
PaxDbi | Q96HB5 |
PeptideAtlasi | Q96HB5 |
PRIDEi | Q96HB5 |
ProteomicsDBi | 25131 76728 [Q96HB5-1] 76729 [Q96HB5-2] |
Protocols and materials databases
Antibodypediai | 347, 116 antibodies from 21 providers |
DNASUi | 90060 |
Genome annotation databases
Ensembli | ENST00000496529; ENSP00000474761; ENSG00000147144 ENST00000536628; ENSP00000443351; ENSG00000147144 [Q96HB5-2] ENST00000597275; ENSP00000470294; ENSG00000147144 ENST00000603986; ENSP00000474071; ENSG00000147144 [Q96HB5-4] ENST00000606812; ENSP00000475676; ENSG00000147144 |
GeneIDi | 90060 |
KEGGi | hsa:90060 |
MANE-Selecti | ENST00000603986.6; ENSP00000474071.1; NM_001163321.4; NP_001156793.2 [Q96HB5-4] |
UCSCi | uc064zdh.1, human [Q96HB5-1] |
Organism-specific databases
CTDi | 90060 |
GeneCardsi | CCDC120 |
HGNCi | HGNC:28910, CCDC120 |
HPAi | ENSG00000147144, Tissue enhanced (esophagus, skin) |
MIMi | 300947, gene |
neXtProti | NX_Q96HB5 |
OpenTargetsi | ENSG00000147144 |
PharmGKBi | PA145149329 |
VEuPathDBi | HostDB:ENSG00000147144 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3529, Eukaryota |
GeneTreei | ENSGT00940000154102 |
HOGENOMi | CLU_029533_0_0_1 |
InParanoidi | Q96HB5 |
OMAi | AQRKQMK |
OrthoDBi | 595503at2759 |
PhylomeDBi | Q96HB5 |
TreeFami | TF328984 |
Enzyme and pathway databases
PathwayCommonsi | Q96HB5 |
SignaLinki | Q96HB5 |
Miscellaneous databases
BioGRID-ORCSi | 90060, 1 hit in 679 CRISPR screens |
ChiTaRSi | CCDC120, human |
GenomeRNAii | 90060 |
Pharosi | Q96HB5, Tbio |
PROi | PR:Q96HB5 |
RNActi | Q96HB5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000147144, Expressed in cerebellar vermis and 118 other tissues |
ExpressionAtlasi | Q96HB5, baseline and differential |
Genevisiblei | Q96HB5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039108, CCDC120 IPR043447, CCDC120/INAVA IPR021774, DUF3338 |
PANTHERi | PTHR16093, PTHR16093, 1 hit PTHR16093:SF5, PTHR16093:SF5, 1 hit |
Pfami | View protein in Pfam PF11819, CUPID, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CC120_HUMAN | |
Accessioni | Q96HB5Primary (citable) accession number: Q96HB5 Secondary accession number(s): A8K5Q5 F5GZU4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot