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Protein

Protein N-terminal glutamine amidohydrolase

Gene

WDYHV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei28By similarity1
Active sitei81By similarity1
Active sitei97By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:ENSG00000156795-MONOMER

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
Q96HA8 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein N-terminal glutamine amidohydrolase (EC:3.5.1.122By similarity)
Alternative name(s):
Protein NH2-terminal glutamine deamidase
Short name:
N-terminal Gln amidase
Short name:
Nt(Q)-amidase
WDYHV motif-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDYHV1
Synonyms:C8orf32, NTAQ1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000156795.6

Human Gene Nomenclature Database

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HGNCi
HGNC:25490 WDYHV1

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q96HA8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000156795

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA164727566

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
WDYHV1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
152112225

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002794091 – 205Protein N-terminal glutamine amidohydrolaseAdd BLAST205

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96HA8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96HA8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96HA8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96HA8

PeptideAtlas

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PeptideAtlasi
Q96HA8

PRoteomics IDEntifications database

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PRIDEi
Q96HA8

ProteomicsDB human proteome resource

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ProteomicsDBi
76725

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q96HA8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96HA8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000156795 Expressed in 214 organ(s), highest expression level in heart

CleanEx database of gene expression profiles

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CleanExi
HS_WDYHV1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96HA8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96HA8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024823
HPA053680

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ACTBP607093EBI-741158,EBI-353944
ACTG1P632615EBI-741158,EBI-351292
AESQ08117-24EBI-741158,EBI-11741437
AMOTQ4VCS5-23EBI-741158,EBI-3891843
AMOTL2Q9Y2J4-43EBI-741158,EBI-10187270
APIPQ96GX93EBI-741158,EBI-359248
ASLP044245EBI-741158,EBI-750131
BIRC2Q134903EBI-741158,EBI-514538
BLMHQ138673EBI-741158,EBI-718504
C1orf50Q9BV195EBI-741158,EBI-2874661
CAPN3P208073EBI-741158,EBI-5655000
CCDC102BQ68D863EBI-741158,EBI-10171570
CCDC184Q52MB23EBI-741158,EBI-10179526
CDAP323205EBI-741158,EBI-9250559
CDR2Q018503EBI-741158,EBI-1181367
CEP55Q53EZ44EBI-741158,EBI-747776
COG6Q9Y2V74EBI-741158,EBI-3866319
COILP384323EBI-741158,EBI-945751
CRYAAP024895EBI-741158,EBI-6875961
CTHP329293EBI-741158,EBI-749763
DAB1O755533EBI-741158,EBI-7875264
DCTPP1Q9H7733EBI-741158,EBI-723569
DHPSP493663EBI-741158,EBI-741925
EDARADDQ8WWZ33EBI-741158,EBI-2949647
EIF2B1Q142325EBI-741158,EBI-491065
ETV6P412123EBI-741158,EBI-1372759
FTH1Q6NZ443EBI-741158,EBI-10180219
GAS7O608613EBI-741158,EBI-2683717
GAS7O60861-14EBI-741158,EBI-11745923
GMDSO605475EBI-741158,EBI-746373
GOLGA2Q083797EBI-741158,EBI-618309
HEL-S-182mPV9HW603EBI-741158,EBI-10180762
HEL-S-70V9HW803EBI-741158,EBI-10175326
HPRT1P004928EBI-741158,EBI-748210
HSD17B14Q9BPX110EBI-741158,EBI-742664
JUPP149233EBI-741158,EBI-702484
KCNH1O952593EBI-741158,EBI-2909270
KCTD1Q719H93EBI-741158,EBI-9027502
KLHL12Q53G597EBI-741158,EBI-740929
KRT31Q153233EBI-741158,EBI-948001
KRTAP10-5P603703EBI-741158,EBI-10172150
KRTAP10-7P604093EBI-741158,EBI-10172290
KRTAP4-2Q9BYR53EBI-741158,EBI-10172511
KRTAP5-9P263715EBI-741158,EBI-3958099
KRTAP9-2Q9BYQ45EBI-741158,EBI-1044640
KRTAP9-4Q9BYQ23EBI-741158,EBI-10185730
LONRF1Q17RB83EBI-741158,EBI-2341787
LZTFL1Q9NQ483EBI-741158,EBI-2824799
LZTS2Q9BRK43EBI-741158,EBI-741037
MAGEA11P43364-23EBI-741158,EBI-10178634
MARCH10Q8NA823EBI-741158,EBI-2341554
MIFI4AY873EBI-741158,EBI-10287234
MTUS2Q5JR593EBI-741158,EBI-742948
MTUS2Q5JR59-34EBI-741158,EBI-11522433
NAGKQ9UJ70-24EBI-741158,EBI-11526455
NECAB2Q7Z6G3-27EBI-741158,EBI-10172876
NME1P155315EBI-741158,EBI-741141
NPLQ9BXD53EBI-741158,EBI-10287915
NT5C1AQ9BXI34EBI-741158,EBI-10441581
NUDT14O958483EBI-741158,EBI-536866
PCBD1P614573EBI-741158,EBI-740475
PNMA1Q8ND905EBI-741158,EBI-302345
PNMA5Q96PV45EBI-741158,EBI-10171633
PPCDCQ96CD25EBI-741158,EBI-724333
PRMT1Q998733EBI-741158,EBI-78738
PRPS2P119083EBI-741158,EBI-4290895
PS1TP5BP1Q1KLZ03EBI-741158,EBI-9978131
PSME3P612894EBI-741158,EBI-355546
PYGMP112173EBI-741158,EBI-357469
RABAC1Q9UI148EBI-741158,EBI-712367
RAD54LQ926983EBI-741158,EBI-5333483
RBPMSQ930623EBI-741158,EBI-740322
ROPN1Q9HAT04EBI-741158,EBI-1378139
RPIAP492476EBI-741158,EBI-744831
SEPT3Q9UH033EBI-741158,EBI-727037
SFNP319473EBI-741158,EBI-476295
SIAH1Q8IUQ43EBI-741158,EBI-747107
SPERTQ8NA61-24EBI-741158,EBI-11524851
STX11O755583EBI-741158,EBI-714135
TCL1AP562794EBI-741158,EBI-749995
THAP1Q9NVV96EBI-741158,EBI-741515
TMEM239Q8WW343EBI-741158,EBI-9675724
TNRA1L3063EBI-741158,EBI-10182881
TOLLIPQ9H0E23EBI-741158,EBI-74615
TRIM27P143735EBI-741158,EBI-719493
TRIM54Q9BYV25EBI-741158,EBI-2130429
TRIP13Q156453EBI-741158,EBI-358993
TSC22D1Q157143EBI-741158,EBI-712609
VAC14Q08AM63EBI-741158,EBI-2107455
VPS37CA5D8V64EBI-741158,EBI-2559305
XIAPP981703EBI-741158,EBI-517127
ZBTB8AQ96BR93EBI-741158,EBI-742740
ZNF341Q9BYN73EBI-741158,EBI-9089622

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120405, 135 interactors

Protein interaction database and analysis system

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IntActi
Q96HA8, 374 interactors

Molecular INTeraction database

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MINTi
Q96HA8

STRING: functional protein association networks

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STRINGi
9606.ENSP00000287387

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1205
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3C9QX-ray1.50A2-205[»]
4W79X-ray1.50A2-202[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q96HA8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96HA8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q96HA8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NTAQ1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3261 Eukaryota
ENOG4111G3S LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000014398

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000007890

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG102197

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96HA8

KEGG Orthology (KO)

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KOi
K21286

Identification of Orthologs from Complete Genome Data

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OMAi
VHRFGSQ

Database of Orthologous Groups

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OrthoDBi
1337506at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96HA8

TreeFam database of animal gene trees

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TreeFami
TF105807

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.10.620.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037132 N_Gln_amidohydro_ab_roll_sf
IPR039733 NTAQ1
IPR023128 Prot_N_Gln_amidohydro_ab_roll

The PANTHER Classification System

More...
PANTHERi
PTHR13035 PTHR13035, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09764 Nt_Gln_amidase, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96HA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGNGPAAVH YQPASPPRDA CVYSSCYCEE NIWKLCEYIK NHDQYPLEEC
60 70 80 90 100
YAVFISNERK MIPIWKQQAR PGDGPVIWDY HVVLLHVSSG GQNFIYDLDT
110 120 130 140 150
VLPFPCLFDT YVEDAFKSDD DIHPQFRRKF RVIRADSYLK NFASDRSHMK
160 170 180 190 200
DSSGNWREPP PPYPCIETGD SKMNLNDFIS MDPKVGWGAV YTLSEFTHRF

GSKNC
Length:205
Mass (Da):23,680
Last modified:March 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF858AB0C73928CA9
GO
Isoform 2 (identifier: Q96HA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Note: No experimental confirmation available.
Show »
Length:145
Mass (Da):16,736
Checksum:iAC61BBE11D3642F1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RHC2E5RHC2_HUMAN
Protein N-terminal glutamine amidoh...
WDYHV1
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIY9E5RIY9_HUMAN
Protein N-terminal glutamine amidoh...
WDYHV1
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITD7A0A3B3ITD7_HUMAN
Protein N-terminal glutamine amidoh...
WDYHV1
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITI2A0A3B3ITI2_HUMAN
Protein N-terminal glutamine amidoh...
WDYHV1
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBV4H0YBV4_HUMAN
Protein N-terminal glutamine amidoh...
WDYHV1
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS49A0A3B3IS49_HUMAN
Protein N-terminal glutamine amidoh...
WDYHV1
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03088232I → V1 PublicationCorresponds to variant dbSNP:rs6999234Ensembl.1
Natural variantiVAR_03088393N → S1 PublicationCorresponds to variant dbSNP:rs7014678Ensembl.1
Natural variantiVAR_030884116F → I1 PublicationCorresponds to variant dbSNP:rs6470147Ensembl.1
Natural variantiVAR_030885134R → C1 PublicationCorresponds to variant dbSNP:rs3824250Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0552681 – 60Missing in isoform 2. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK001066 mRNA Translation: BAA91488.1
AK293492 mRNA Translation: BAG56979.1
AC021305 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW92038.1
BC008781 mRNA Translation: AAH08781.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS6344.1 [Q96HA8-1]
CCDS64965.1 [Q96HA8-2]

NCBI Reference Sequences

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RefSeqi
NP_001269953.1, NM_001283024.1 [Q96HA8-2]
NP_060494.1, NM_018024.2 [Q96HA8-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.18029

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000287387; ENSP00000287387; ENSG00000156795 [Q96HA8-1]
ENST00000523984; ENSP00000430427; ENSG00000156795 [Q96HA8-2]
ENST00000524254; ENSP00000497832; ENSG00000156795 [Q96HA8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55093

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55093

UCSC genome browser

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UCSCi
uc003yqn.3 human [Q96HA8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001066 mRNA Translation: BAA91488.1
AK293492 mRNA Translation: BAG56979.1
AC021305 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW92038.1
BC008781 mRNA Translation: AAH08781.1
CCDSiCCDS6344.1 [Q96HA8-1]
CCDS64965.1 [Q96HA8-2]
RefSeqiNP_001269953.1, NM_001283024.1 [Q96HA8-2]
NP_060494.1, NM_018024.2 [Q96HA8-1]
UniGeneiHs.18029

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3C9QX-ray1.50A2-205[»]
4W79X-ray1.50A2-202[»]
ProteinModelPortaliQ96HA8
SMRiQ96HA8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120405, 135 interactors
IntActiQ96HA8, 374 interactors
MINTiQ96HA8
STRINGi9606.ENSP00000287387

Protein family/group databases

MoonDBiQ96HA8 Predicted

PTM databases

iPTMnetiQ96HA8
PhosphoSitePlusiQ96HA8

Polymorphism and mutation databases

BioMutaiWDYHV1
DMDMi152112225

Proteomic databases

EPDiQ96HA8
jPOSTiQ96HA8
MaxQBiQ96HA8
PaxDbiQ96HA8
PeptideAtlasiQ96HA8
PRIDEiQ96HA8
ProteomicsDBi76725

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55093
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287387; ENSP00000287387; ENSG00000156795 [Q96HA8-1]
ENST00000523984; ENSP00000430427; ENSG00000156795 [Q96HA8-2]
ENST00000524254; ENSP00000497832; ENSG00000156795 [Q96HA8-2]
GeneIDi55093
KEGGihsa:55093
UCSCiuc003yqn.3 human [Q96HA8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55093
EuPathDBiHostDB:ENSG00000156795.6

GeneCards: human genes, protein and diseases

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GeneCardsi
WDYHV1
HGNCiHGNC:25490 WDYHV1
HPAiHPA024823
HPA053680
neXtProtiNX_Q96HA8
OpenTargetsiENSG00000156795
PharmGKBiPA164727566

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3261 Eukaryota
ENOG4111G3S LUCA
GeneTreeiENSGT00390000014398
HOGENOMiHOG000007890
HOVERGENiHBG102197
InParanoidiQ96HA8
KOiK21286
OMAiVHRFGSQ
OrthoDBi1337506at2759
PhylomeDBiQ96HA8
TreeFamiTF105807

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000156795-MONOMER

Miscellaneous databases

EvolutionaryTraceiQ96HA8

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
C8orf32

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55093

Protein Ontology

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PROi
PR:Q96HA8

Gene expression databases

BgeeiENSG00000156795 Expressed in 214 organ(s), highest expression level in heart
CleanExiHS_WDYHV1
ExpressionAtlasiQ96HA8 baseline and differential
GenevisibleiQ96HA8 HS

Family and domain databases

Gene3Di3.10.620.10, 1 hit
InterProiView protein in InterPro
IPR037132 N_Gln_amidohydro_ab_roll_sf
IPR039733 NTAQ1
IPR023128 Prot_N_Gln_amidohydro_ab_roll
PANTHERiPTHR13035 PTHR13035, 1 hit
PfamiView protein in Pfam
PF09764 Nt_Gln_amidase, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNTAQ1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96HA8
Secondary accession number(s): B4DE68, Q9NW95
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: January 16, 2019
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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