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UniProtKB - Q96HA1 (P121A_HUMAN)

Entry version 153 (07 Oct 2020)
Sequence version 2 (02 Sep 2008)
Previous versions | rss
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Protein

Nuclear envelope pore membrane protein POM 121

Gene

POM121

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96HA1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1169408, ISG15 antiviral mechanism
R-HSA-159227, Transport of the SLBP independent Mature mRNA
R-HSA-159230, Transport of the SLBP Dependant Mature mRNA
R-HSA-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054, Rev-mediated nuclear export of HIV RNA
R-HSA-168271, Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276, NS1 Mediated Effects on Host Pathways
R-HSA-168325, Viral Messenger RNA Synthesis
R-HSA-168333, NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822, Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746, Nuclear import of Rev protein
R-HSA-180910, Vpr-mediated nuclear import of PICs
R-HSA-191859, snRNP Assembly
R-HSA-3108214, SUMOylation of DNA damage response and repair proteins
R-HSA-3232142, SUMOylation of ubiquitinylation proteins
R-HSA-3301854, Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453, Regulation of HSF1-mediated heat shock response
R-HSA-4085377, SUMOylation of SUMOylation proteins
R-HSA-4551638, SUMOylation of chromatin organization proteins
R-HSA-4570464, SUMOylation of RNA binding proteins
R-HSA-4615885, SUMOylation of DNA replication proteins
R-HSA-5578749, Transcriptional regulation by small RNAs
R-HSA-5619107, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
R-HSA-6784531, tRNA processing in the nucleus
R-HSA-9609690, HCMV Early Events
R-HSA-9610379, HCMV Late Events
R-HSA-9615933, Postmitotic nuclear pore complex (NPC) reformation

Protein family/group databases

Transport Classification Database

More...TCDBi		1.I.1.1.3, the nuclear pore complex (npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear envelope pore membrane protein POM 121
Alternative name(s):
Nuclear envelope pore membrane protein POM 121A
Nucleoporin Nup121
Pore membrane protein of 121 kDa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POM121
Synonyms:KIAA0618, NUP121, POM121A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000196313.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:19702, POM121

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615753, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96HA1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 55HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9883

Open Targets

More...OpenTargetsi		ENSG00000196313

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134987951

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96HA1, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		POM121

Domain mapping of disease mutations (DMDM)

More...DMDMi		205829302

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003467731 – 1249Nuclear envelope pore membrane protein POM 121Add BLAST1249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei94PhosphoserineBy similarity1
Modified residuei345PhosphoserineBy similarity1
Modified residuei351PhosphoserineCombined sources1
Modified residuei371PhosphoserineCombined sources1
Modified residuei393PhosphoserineBy similarity1
Modified residuei396PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96HA1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96HA1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96HA1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96HA1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96HA1

PeptideAtlas

More...PeptideAtlasi		Q96HA1

PRoteomics IDEntifications database

More...PRIDEi		Q96HA1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		2321
76715 [Q96HA1-1]
76716 [Q96HA1-2]
76717 [Q96HA1-3]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2909, 1 O-Linked glycan (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96HA1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96HA1

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q96HA1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196313, Expressed in bone marrow and 190 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96HA1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196313, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q96HA1
With#Exp.IntAct
AGR2 [O95994]4EBI-739990,EBI-712648
CEP76 [Q8TAP6]3EBI-739990,EBI-742887
FXR2 [P51116]4EBI-739990,EBI-740459
HOMER3 [Q9NSC5]3EBI-739990,EBI-748420
PAXIP1 - isoform 3 [Q6ZW49-2]3EBI-739990,EBI-10236271
RBPMS [Q93062]4EBI-739990,EBI-740322
TEX11 [Q8IYF3]4EBI-739990,EBI-742397
Isoform 2 [Q96HA1-2]
With#Exp.IntAct
AGR2 [O95994]3EBI-11956563,EBI-712648
AP1B1 - isoform C [Q10567-3]3EBI-11956563,EBI-11978055
AP2B1 - isoform 2 [P63010-2]3EBI-11956563,EBI-11529439
BOLL - isoform 4 [Q8N9W6-4]3EBI-11956563,EBI-11983447
CCDC57 - isoform 2 [Q2TAC2-2]3EBI-11956563,EBI-10961624
CEACAM6 [P40199]3EBI-11956563,EBI-4314501
CEP76 [Q8TAP6]3EBI-11956563,EBI-742887
COG6 [Q9Y2V7]3EBI-11956563,EBI-3866319
FAM168B - isoform 2 [A1KXE4-2]3EBI-11956563,EBI-12193763
GOLGA2 [Q08379]3EBI-11956563,EBI-618309
HOMER3 [Q9NSC5]3EBI-11956563,EBI-748420
JMJD7 [P0C870]3EBI-11956563,EBI-9090173
KPNA6 [O60684]3EBI-11956563,EBI-359923
LPXN [O60711]3EBI-11956563,EBI-744222
MAGED1 [Q9Y5V3]3EBI-11956563,EBI-716006
MORN5 [Q5VZ52]3EBI-11956563,EBI-12835568
NFKBIA [P25963]3EBI-11956563,EBI-307386
OTUD6A [Q7L8S5]3EBI-11956563,EBI-11960139
SPAG5 [Q96R06]3EBI-11956563,EBI-413317
STAT3 [P40763]3EBI-11956563,EBI-518675
TFIP11 [Q9UBB9]3EBI-11956563,EBI-1105213
TRAF2 [Q12933]3EBI-11956563,EBI-355744
TRAF3 [Q13114]3EBI-11956563,EBI-357631
TRIM23 [P36406]3EBI-11956563,EBI-740098
TRIM27 [P14373]3EBI-11956563,EBI-719493
TRIM49 [P0CI25]3EBI-11956563,EBI-6427421
TRIP6 [Q15654]3EBI-11956563,EBI-742327
UBQLN2 [Q9UHD9]3EBI-11956563,EBI-947187
ZMYND12 [Q9H0C1]3EBI-11956563,EBI-12030590

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115214, 100 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-873, Nuclear pore complex

Protein interaction database and analysis system

More...IntActi		Q96HA1, 77 interactors

Molecular INTeraction database

More...MINTi		Q96HA1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000378687

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96HA1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96HA1

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 285Required for targeting to the nucleus and nuclear pore complexAdd BLAST285
Regioni1 – 34Cisternal sideSequence analysisAdd BLAST34
Regioni56 – 1249Pore sideSequence analysisAdd BLAST1194

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi144 – 214Pro-richAdd BLAST71
Compositional biasi378 – 445Ser-richAdd BLAST68
Compositional biasi751 – 947Thr-richAdd BLAST197

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains F-X-F-G repeats.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the POM121 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502R5GW, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153253

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_011366_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96HA1

KEGG Orthology (KO)

More...KOi		K14316

Identification of Orthologs from Complete Genome Data

More...OMAi		TPIHPIF

Database of Orthologous Groups

More...OrthoDBi		355024at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96HA1

TreeFam database of animal gene trees

More...TreeFami		TF323517

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026054, Nucleoporin
IPR026090, POM121

The PANTHER Classification System

More...PANTHERi		PTHR23193, PTHR23193, 2 hits
PTHR23193:SF42, PTHR23193:SF42, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96HA1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSPAAAAAGA GERRRPIASV RDGRGRGCGG PARAVLLGLS LVGLLLYLVP 
        60         70         80         90        100
AAAALAWLTV GATAAWWGLS REPRGSRPLS SFVRKARHRR PLSSFVRKAR 
       110        120        130        140        150
HRRTLFASPL AKSTANGNLL EPRTLLEGPD PAELLLMGSY LGKPGPPQPA 
       160        170        180        190        200
AAPEGQDLRD RPGRRPPARP APRSPPPRSP PPRSPPPSPP THRAHHVYPS 
       210        220        230        240        250
LPTPLLRPSR RPSPRDCGTL PNRFVITPRR RYPIHQAQYS CLGVLPTVCW 
       260        270        280        290        300
NGYHKKAVLS PRNSRMVCSP VTVRIAPPDR RFSRSAIPEQ IISSTLSSPS 
       310        320        330        340        350
SNAPDPCAKE TVLSALKEKE KKRTVEEEDQ IFLDGQENKR RRHDSSGSGH 
       360        370        380        390        400
SAFEPLVANG VPASFVPKPG SLKRGLNSQS SDDHLNKRSR SSSMSSLTGA 
       410        420        430        440        450
YASGIPSSSR NAITSSYSST RGISQLWKRN GPSSSPFSSP ASSRSQTPER 
       460        470        480        490        500
PAKKIREEEL CHHSSSSTPL AADRESQGEK AADTTPRKKQ NSNSQSTPGS 
       510        520        530        540        550
SGQRKRKVQL LPSRRGEQLT LPPPPQLGYS ITAEDLDLEK KASLQWFNQA 
       560        570        580        590        600
LEDKSDAASN SVTETPPITQ PSFTFTLPAA APASPPTSLL APSTNPLLES 
       610        620        630        640        650
LKKMQTPPSL PPCPESAGAA TTEALSPPKT PSLLPPLGLS QSGPPGLLPS 
       660        670        680        690        700
PSFDSKPPTT LLGLIPAPSM VPATDTKAPP TLQAETATKP QATSAPSPAP 
       710        720        730        740        750
KQSFLFGTQN TSPSSPAAPA ASSAPPMFKP IFTAPPKSEK EGPTPPGPSV 
       760        770        780        790        800
TATAPSSSSL PTTTSTTAPT FQPVFSSMGP PASVPLPAPF FKQTTTPATA 
       810        820        830        840        850
PTTTAPLFTG LASATSAVAP ITSASPSTDS ASKPAFGFGI NSVSSSSVST 
       860        870        880        890        900
TTSTATAASQ PFLFGAPQAS AASFTPAMGS IFQFGKPPAL PTTTTVTTFS 
       910        920        930        940        950
QSLHTAVPTA TSSSAADFSG FGSTLATSAP ATSSQPTLTF SNTSTPTFNI 
       960        970        980        990       1000
PFGSSAKSPL PSYPGANPQP AFGAAEGQPP GAAKPALAPS FGSSFTFGNS 
      1010       1020       1030       1040       1050
AAPAAAPTPA PPSMIKVVPA YVPTPIHPIF GGATHSAFGL KATASAFGAP 
      1060       1070       1080       1090       1100
ASSQPAFGGS TAVFFGAATS SGFGATTQTA SSGSSSSVFG STTPSPFTFG 
      1110       1120       1130       1140       1150
GSAAPAGSGS FGINVATPGS STTTGAFSFG AGQSGSTATS TPFAGGLGQN 
      1160       1170       1180       1190       1200
ALGTTGQSTP FAFNVSSTTE SKPVFGGTAT PTFGLNTPAP GVGTSGSSLS 
      1210       1220       1230       1240 
FGASSAPAQG FVGVAPFGSA ALSFSIGAGS KTPGARQRLQ ARRQHTRKK
Length:1,249
Mass (Da):127,720
Last modified:September 2, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEDBA86CA5D658F61
GO
Isoform 2 (identifier: Q96HA1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-265: Missing.

Show »
Length:984
Mass (Da):99,037
Checksum:i36DEDB4419EEA8E6
GO
Isoform 3 (identifier: Q96HA1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-265: Missing.
     1219-1249: SAALSFSIGAGSKTPGARQRLQARRQHTRKK → NTFAHQQEHS...QASSFPTRKE

Show »
Length:999
Mass (Da):100,864
Checksum:i73F8BEC747A1840E
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA31593 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14097 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti689K → E in BAF85237 (PubMed:14702039).Curated1
Sequence conflicti904H → P in BAB14097 (PubMed:14702039).Curated1
Sequence conflicti971A → T in BAB14097 (PubMed:14702039).Curated1
Sequence conflicti1021Y → H in BAB14097 (PubMed:14702039).Curated1
Sequence conflicti1113I → T in BAF85237 (PubMed:14702039).Curated1
Isoform 3 (identifier: Q96HA1-3)
Sequence conflicti985L → P in BAA31593 (PubMed:9734811).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0459051215A → G. Corresponds to variant dbSNP:rs3177261Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0350101 – 265Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST265
Alternative sequenceiVSP_0350111219 – 1249SAALS…HTRKK → NTFAHQQEHSPRKGPNNLSK RKLLPAVRAQGLPRRGQASS FPTRKE in isoform 3. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB014518 mRNA Translation: BAA31593.2 Different initiation.
AK022555 mRNA Translation: BAB14097.1 Different initiation.
AK292548 mRNA Translation: BAF85237.1
AC005488 Genomic DNA No translation available.
BC001518 mRNA Translation: AAH01518.2
BC008794 mRNA Translation: AAH08794.1
AB289621 mRNA Translation: BAF80887.1
AL080109 mRNA Translation: CAB45713.1
AL713666 mRNA Translation: CAD28472.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5542.1 [Q96HA1-2]
CCDS59059.1 [Q96HA1-3]

NCBI Reference Sequences

More...RefSeqi		NP_001244119.1, NM_001257190.2 [Q96HA1-3]
NP_742017.1, NM_172020.4 [Q96HA1-2]
XP_005250783.1, XM_005250726.3 [Q96HA1-1]
XP_006716259.1, XM_006716196.3 [Q96HA1-2]
XP_016868342.1, XM_017012853.1 [Q96HA1-2]
XP_016868343.1, XM_017012854.1 [Q96HA1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000358357; ENSP00000351124; ENSG00000196313 [Q96HA1-2]
ENST00000395270; ENSP00000378687; ENSG00000196313 [Q96HA1-3]
ENST00000434423; ENSP00000405562; ENSG00000196313 [Q96HA1-1]
ENST00000446813; ENSP00000393020; ENSG00000196313 [Q96HA1-3]
ENST00000627934; ENSP00000486504; ENSG00000196313 [Q96HA1-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9883

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9883

UCSC genome browser

More...UCSCi		uc003twk.3, human [Q96HA1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014518 mRNA Translation: BAA31593.2 Different initiation.
AK022555 mRNA Translation: BAB14097.1 Different initiation.
AK292548 mRNA Translation: BAF85237.1
AC005488 Genomic DNA No translation available.
BC001518 mRNA Translation: AAH01518.2
BC008794 mRNA Translation: AAH08794.1
AB289621 mRNA Translation: BAF80887.1
AL080109 mRNA Translation: CAB45713.1
AL713666 mRNA Translation: CAD28472.1
CCDSiCCDS5542.1 [Q96HA1-2]
CCDS59059.1 [Q96HA1-3]
RefSeqiNP_001244119.1, NM_001257190.2 [Q96HA1-3]
NP_742017.1, NM_172020.4 [Q96HA1-2]
XP_005250783.1, XM_005250726.3 [Q96HA1-1]
XP_006716259.1, XM_006716196.3 [Q96HA1-2]
XP_016868342.1, XM_017012853.1 [Q96HA1-2]
XP_016868343.1, XM_017012854.1 [Q96HA1-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5T6WX-ray1.90C418-427[»]
SMRiQ96HA1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115214, 100 interactors
ComplexPortaliCPX-873, Nuclear pore complex
IntActiQ96HA1, 77 interactors
MINTiQ96HA1
STRINGi9606.ENSP00000378687

Protein family/group databases

TCDBi1.I.1.1.3, the nuclear pore complex (npc) family

PTM databases

GlyConnecti2909, 1 O-Linked glycan (3 sites)
iPTMnetiQ96HA1
PhosphoSitePlusiQ96HA1
SwissPalmiQ96HA1

Polymorphism and mutation databases

BioMutaiPOM121
DMDMi205829302

Proteomic databases

EPDiQ96HA1
jPOSTiQ96HA1
MassIVEiQ96HA1
MaxQBiQ96HA1
PaxDbiQ96HA1
PeptideAtlasiQ96HA1
PRIDEiQ96HA1
ProteomicsDBi2321
76715 [Q96HA1-1]
76716 [Q96HA1-2]
76717 [Q96HA1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		53550, 68 antibodies

Genome annotation databases

EnsembliENST00000358357; ENSP00000351124; ENSG00000196313 [Q96HA1-2]
ENST00000395270; ENSP00000378687; ENSG00000196313 [Q96HA1-3]
ENST00000434423; ENSP00000405562; ENSG00000196313 [Q96HA1-1]
ENST00000446813; ENSP00000393020; ENSG00000196313 [Q96HA1-3]
ENST00000627934; ENSP00000486504; ENSG00000196313 [Q96HA1-2]
GeneIDi9883
KEGGihsa:9883
UCSCiuc003twk.3, human [Q96HA1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9883
DisGeNETi9883
EuPathDBiHostDB:ENSG00000196313.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		POM121
HGNCiHGNC:19702, POM121
HPAiENSG00000196313, Low tissue specificity
MIMi615753, gene
neXtProtiNX_Q96HA1
OpenTargetsiENSG00000196313
PharmGKBiPA134987951

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502R5GW, Eukaryota
GeneTreeiENSGT00940000153253
HOGENOMiCLU_011366_0_0_1
InParanoidiQ96HA1
KOiK14316
OMAiTPIHPIF
OrthoDBi355024at2759
PhylomeDBiQ96HA1
TreeFamiTF323517

Enzyme and pathway databases

PathwayCommonsiQ96HA1
ReactomeiR-HSA-1169408, ISG15 antiviral mechanism
R-HSA-159227, Transport of the SLBP independent Mature mRNA
R-HSA-159230, Transport of the SLBP Dependant Mature mRNA
R-HSA-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054, Rev-mediated nuclear export of HIV RNA
R-HSA-168271, Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276, NS1 Mediated Effects on Host Pathways
R-HSA-168325, Viral Messenger RNA Synthesis
R-HSA-168333, NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822, Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746, Nuclear import of Rev protein
R-HSA-180910, Vpr-mediated nuclear import of PICs
R-HSA-191859, snRNP Assembly
R-HSA-3108214, SUMOylation of DNA damage response and repair proteins
R-HSA-3232142, SUMOylation of ubiquitinylation proteins
R-HSA-3301854, Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453, Regulation of HSF1-mediated heat shock response
R-HSA-4085377, SUMOylation of SUMOylation proteins
R-HSA-4551638, SUMOylation of chromatin organization proteins
R-HSA-4570464, SUMOylation of RNA binding proteins
R-HSA-4615885, SUMOylation of DNA replication proteins
R-HSA-5578749, Transcriptional regulation by small RNAs
R-HSA-5619107, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
R-HSA-6784531, tRNA processing in the nucleus
R-HSA-9609690, HCMV Early Events
R-HSA-9610379, HCMV Late Events
R-HSA-9615933, Postmitotic nuclear pore complex (NPC) reformation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9883, 42 hits in 850 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		POM121, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		POM121

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9883
PharosiQ96HA1, Tbio

Protein Ontology

More...PROi		PR:Q96HA1
RNActiQ96HA1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196313, Expressed in bone marrow and 190 other tissues
GenevisibleiQ96HA1, HS

Family and domain databases

InterProiView protein in InterPro
IPR026054, Nucleoporin
IPR026090, POM121
PANTHERiPTHR23193, PTHR23193, 2 hits
PTHR23193:SF42, PTHR23193:SF42, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP121A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96HA1
Secondary accession number(s): A6NFS9
, A8CDT4, A8K933, A8MXF9, O75115, Q96DI0, Q9H9X1, Q9Y2N3, Q9Y4S7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: October 7, 2020
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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