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Entry version 123 (16 Oct 2019)
Sequence version 2 (18 May 2010)
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Protein

Zinc finger CCCH-type antiviral protein 1-like

Gene

ZC3HAV1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Despite its name, it does not contain a canonical C3H1-type zinc-finger.Curated

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger CCCH-type antiviral protein 1-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZC3HAV1L
Synonyms:C7orf39
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22423 ZC3HAV1L

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96H79

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000146858

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145147600

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96H79

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZC3HAV1L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296453031

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003314592 – 300Zinc finger CCCH-type antiviral protein 1-likeAdd BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96H79

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96H79

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96H79

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96H79

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96H79

PeptideAtlas

More...
PeptideAtlasi
Q96H79

PRoteomics IDEntifications database

More...
PRIDEi
Q96H79

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76710 [Q96H79-1]
76711 [Q96H79-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96H79

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96H79

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000146858 Expressed in 93 organ(s), highest expression level in kidney

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96H79 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020386
HPA050741

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124907, 22 interactors

Protein interaction database and analysis system

More...
IntActi
Q96H79, 7 interactors

Molecular INTeraction database

More...
MINTi
Q96H79

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000275766

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96H79

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKYR Eukaryota
ENOG4111C4T LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00710000106871

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000090210

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96H79

Identification of Orthologs from Complete Genome Data

More...
OMAi
HLCRRHM

Database of Orthologous Groups

More...
OrthoDBi
782733at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96H79

TreeFam database of animal gene trees

More...
TreeFami
TF338389

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036388 WH-like_DNA-bd_sf
IPR041360 ZAP_HTH
IPR026693 Zc3hav1-like

The PANTHER Classification System

More...
PANTHERi
PTHR47621 PTHR47621, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18606 HTH_53, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96H79-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEPTVCSFL TKVLCAHGGR MFLKDLRGHV ELSEARLRDV LQRAGPERFL
60 70 80 90 100
LQEVETQEGL GDAEAEAAAG AVGGGGTSAW RVVAVSSVRL CARYQRGECQ
110 120 130 140 150
ACDQLHFCRR HMLGKCPNRD CWSTCTLSHD IHTPVNMQVL KSHGLFGLNE
160 170 180 190 200
NQLRILLLQN DPCLLPEVCL LYNKGEALYG YCNLKDKCNK FHVCKSFVKG
210 220 230 240 250
ECKLQTCKRS HQLIHAASLK LLQDQGLNIP SVVNFQIIST YKHMKLHKML
260 270 280 290 300
ENTDNSSPST EHSQGLEKQG VHAAGAAEAG PLASVPAQSA KKPCPVSCEK
Length:300
Mass (Da):32,962
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F3B6BABA5CA0E3B
GO
Isoform 2 (identifier: Q96H79-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-102: SVRLCARYQRGECQAC → GTIGACHHTQLIFLGF
     103-300: Missing.

Note: No experimental confirmation available.
Show »
Length:102
Mass (Da):10,778
Checksum:i18C9E173F4FB939D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti244M → I in AAH08842 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03321087 – 102SVRLC…ECQAC → GTIGACHHTQLIFLGF in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_033211103 – 300Missing in isoform 2. 1 PublicationAdd BLAST198

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC083868 Genomic DNA No translation available.
BC008842 mRNA Translation: AAH08842.1
BC020784 mRNA Translation: AAH20784.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5850.1 [Q96H79-1]

NCBI Reference Sequences

More...
RefSeqi
NP_542391.2, NM_080660.3 [Q96H79-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000275766; ENSP00000275766; ENSG00000146858 [Q96H79-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
92092

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:92092

UCSC genome browser

More...
UCSCi
uc003vum.1 human [Q96H79-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083868 Genomic DNA No translation available.
BC008842 mRNA Translation: AAH08842.1
BC020784 mRNA Translation: AAH20784.1
CCDSiCCDS5850.1 [Q96H79-1]
RefSeqiNP_542391.2, NM_080660.3 [Q96H79-1]

3D structure databases

SMRiQ96H79
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124907, 22 interactors
IntActiQ96H79, 7 interactors
MINTiQ96H79
STRINGi9606.ENSP00000275766

PTM databases

iPTMnetiQ96H79
PhosphoSitePlusiQ96H79

Polymorphism and mutation databases

BioMutaiZC3HAV1L
DMDMi296453031

Proteomic databases

EPDiQ96H79
jPOSTiQ96H79
MassIVEiQ96H79
MaxQBiQ96H79
PaxDbiQ96H79
PeptideAtlasiQ96H79
PRIDEiQ96H79
ProteomicsDBi76710 [Q96H79-1]
76711 [Q96H79-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
92092

Genome annotation databases

EnsembliENST00000275766; ENSP00000275766; ENSG00000146858 [Q96H79-1]
GeneIDi92092
KEGGihsa:92092
UCSCiuc003vum.1 human [Q96H79-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
92092

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZC3HAV1L
HGNCiHGNC:22423 ZC3HAV1L
HPAiHPA020386
HPA050741
neXtProtiNX_Q96H79
OpenTargetsiENSG00000146858
PharmGKBiPA145147600

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKYR Eukaryota
ENOG4111C4T LUCA
GeneTreeiENSGT00710000106871
HOGENOMiHOG000090210
InParanoidiQ96H79
OMAiHLCRRHM
OrthoDBi782733at2759
PhylomeDBiQ96H79
TreeFamiTF338389

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZC3HAV1L human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
92092
PharosiQ96H79

Protein Ontology

More...
PROi
PR:Q96H79

Gene expression databases

BgeeiENSG00000146858 Expressed in 93 organ(s), highest expression level in kidney
GenevisibleiQ96H79 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR036388 WH-like_DNA-bd_sf
IPR041360 ZAP_HTH
IPR026693 Zc3hav1-like
PANTHERiPTHR47621 PTHR47621, 1 hit
PfamiView protein in Pfam
PF18606 HTH_53, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZCCHL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96H79
Secondary accession number(s): Q8WUD9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 18, 2010
Last modified: October 16, 2019
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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