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Protein

Solute carrier family 25 member 44

Gene

SLC25A44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.29.14.7 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 44
Gene namesi
Name:SLC25A44
Synonyms:KIAA0446
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000160785.13
HGNCiHGNC:29036 SLC25A44
MIMi610824 gene
neXtProtiNX_Q96H78

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 42Helical; Name=1Sequence analysisAdd BLAST23
Transmembranei71 – 90Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei113 – 133Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei185 – 201Helical; Name=4Sequence analysisAdd BLAST17
Transmembranei222 – 239Helical; Name=5Sequence analysisAdd BLAST18
Transmembranei278 – 296Helical; Name=6Sequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160785
PharmGKBiPA162403705

Polymorphism and mutation databases

DMDMi74751902

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002530641 – 314Solute carrier family 25 member 44Add BLAST314

Proteomic databases

EPDiQ96H78
MaxQBiQ96H78
PaxDbiQ96H78
PeptideAtlasiQ96H78
PRIDEiQ96H78
ProteomicsDBi76709

PTM databases

iPTMnetiQ96H78
PhosphoSitePlusiQ96H78

Expressioni

Gene expression databases

BgeeiENSG00000160785 Expressed in 228 organ(s), highest expression level in amniotic fluid
CleanExiHS_SLC25A44
ExpressionAtlasiQ96H78 baseline and differential
GenevisibleiQ96H78 HS

Organism-specific databases

HPAiHPA065411

Interactioni

Protein-protein interaction databases

BioGridi115028, 6 interactors
STRINGi9606.ENSP00000352497

Structurei

3D structure databases

ProteinModelPortaliQ96H78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 100Solcar 1Add BLAST83
Repeati107 – 210Solcar 2Add BLAST104
Repeati220 – 302Solcar 3Add BLAST83

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0765 Eukaryota
ENOG410XTGQ LUCA
GeneTreeiENSGT00530000062944
HOGENOMiHOG000234169
HOVERGENiHBG054957
InParanoidiQ96H78
KOiK15121
PhylomeDBiQ96H78
TreeFamiTF354268

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR040062 Mitochondrial_carrier_protein
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PANTHERiPTHR24089 PTHR24089, 1 hit
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q96H78-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDKRNIQII EWEHLDKKKF YVFGVAMTMM IRVSVYPFTL IRTRLQVQKG
60 70 80 90 100
KSLYHGTFDA FIKILRADGI TGLYRGFLVN TFTLISGQCY VTTYELTRKF
110 120 130 140 150
VADYSQSNTV KSLVAGGSAS LVAQSITVPI DVVSQHLMMQ RKGEKMGRFQ
160 170 180 190 200
VRGNPEGQGV VAFGQTKDII RQILQADGLR GFYRGYVASL LTYIPNSAVW
210 220 230 240 250
WPFYHFYAEQ LSYLCPKECP HIVFQAVSGP LAAATASILT NPMDVIRTRV
260 270 280 290 300
QVEGKNSIIL TFRQLMAEEG PWGLMKGLSA RIISATPSTI VIVVGYESLK
310
KLSLRPELVD SRHW
Length:314
Mass (Da):35,392
Last modified:December 1, 2001 - v1
Checksum:i978AE43CBDF0FBDF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PGQ0E9PGQ0_HUMAN
Solute carrier family 25 member 44
SLC25A44
322Annotation score:

Sequence cautioni

The sequence BAA32291 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti208A → AAIVFPWIP in BAA32291 (PubMed:9455484).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05013452S → I. Corresponds to variant dbSNP:rs11576750Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007915 mRNA Translation: BAA32291.3 Different initiation.
AK074912 mRNA Translation: BAC11287.1
AK075002 mRNA Translation: BAC11347.1
AL135927 Genomic DNA No translation available.
BC008843 mRNA Translation: AAH08843.1
BC039854 mRNA Translation: AAH39854.1
CCDSiCCDS1133.1
RefSeqiNP_001273113.1, NM_001286184.1
NP_055470.1, NM_014655.3
XP_006711720.1, XM_006711657.3
XP_011508482.1, XM_011510180.1
XP_011508483.1, XM_011510181.1
XP_016858393.1, XM_017002904.1
XP_016858394.1, XM_017002905.1
XP_016858395.1, XM_017002906.1
UniGeneiHs.532375
Hs.626091

Genome annotation databases

EnsembliENST00000359511; ENSP00000352497; ENSG00000160785
GeneIDi9673
KEGGihsa:9673
UCSCiuc001fnp.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007915 mRNA Translation: BAA32291.3 Different initiation.
AK074912 mRNA Translation: BAC11287.1
AK075002 mRNA Translation: BAC11347.1
AL135927 Genomic DNA No translation available.
BC008843 mRNA Translation: AAH08843.1
BC039854 mRNA Translation: AAH39854.1
CCDSiCCDS1133.1
RefSeqiNP_001273113.1, NM_001286184.1
NP_055470.1, NM_014655.3
XP_006711720.1, XM_006711657.3
XP_011508482.1, XM_011510180.1
XP_011508483.1, XM_011510181.1
XP_016858393.1, XM_017002904.1
XP_016858394.1, XM_017002905.1
XP_016858395.1, XM_017002906.1
UniGeneiHs.532375
Hs.626091

3D structure databases

ProteinModelPortaliQ96H78
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115028, 6 interactors
STRINGi9606.ENSP00000352497

Protein family/group databases

TCDBi2.A.29.14.7 the mitochondrial carrier (mc) family

PTM databases

iPTMnetiQ96H78
PhosphoSitePlusiQ96H78

Polymorphism and mutation databases

DMDMi74751902

Proteomic databases

EPDiQ96H78
MaxQBiQ96H78
PaxDbiQ96H78
PeptideAtlasiQ96H78
PRIDEiQ96H78
ProteomicsDBi76709

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359511; ENSP00000352497; ENSG00000160785
GeneIDi9673
KEGGihsa:9673
UCSCiuc001fnp.5 human

Organism-specific databases

CTDi9673
EuPathDBiHostDB:ENSG00000160785.13
GeneCardsiSLC25A44
HGNCiHGNC:29036 SLC25A44
HPAiHPA065411
MIMi610824 gene
neXtProtiNX_Q96H78
OpenTargetsiENSG00000160785
PharmGKBiPA162403705
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0765 Eukaryota
ENOG410XTGQ LUCA
GeneTreeiENSGT00530000062944
HOGENOMiHOG000234169
HOVERGENiHBG054957
InParanoidiQ96H78
KOiK15121
PhylomeDBiQ96H78
TreeFamiTF354268

Miscellaneous databases

ChiTaRSiSLC25A44 human
GenomeRNAii9673
PROiPR:Q96H78
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160785 Expressed in 228 organ(s), highest expression level in amniotic fluid
CleanExiHS_SLC25A44
ExpressionAtlasiQ96H78 baseline and differential
GenevisibleiQ96H78 HS

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR040062 Mitochondrial_carrier_protein
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PANTHERiPTHR24089 PTHR24089, 1 hit
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiS2544_HUMAN
AccessioniPrimary (citable) accession number: Q96H78
Secondary accession number(s): O75034
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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