SLC25A44

Functionⁱ

GO - Molecular functionⁱ

transmembrane transporter activity Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Protein family/group databases

TCDBⁱ	2.A.29.14.7 the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.14.7 the mitochondrial carrier (mc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Solute carrier family 25 member 44
Gene namesⁱ	Name:SLC25A44 Synonyms:KIAA0446
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000160785.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29036 SLC25A44
MIMⁱ	610824 gene
neXtProtⁱ	NX_Q96H78

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	20 – 42	Helical; Name=1Sequence analysisAdd BLAST	23
Transmembraneⁱ	71 – 90	Helical; Name=2Sequence analysisAdd BLAST	20
Transmembraneⁱ	113 – 133	Helical; Name=3Sequence analysisAdd BLAST	21
Transmembraneⁱ	185 – 201	Helical; Name=4Sequence analysisAdd BLAST	17
Transmembraneⁱ	222 – 239	Helical; Name=5Sequence analysisAdd BLAST	18
Transmembraneⁱ	278 – 296	Helical; Name=6Sequence analysisAdd BLAST	19

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000160785
PharmGKBⁱ	PA162403705

Polymorphism and mutation databases

DMDMⁱ	74751902

DMDMⁱ

74751902

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000253064	1 – 314	Solute carrier family 25 member 44Add BLAST		314

Proteomic databases

EPDⁱ	Q96H78
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96H78
PaxDbⁱ	Q96H78
PeptideAtlas More...PeptideAtlasⁱ	Q96H78
PRIDEⁱ	Q96H78
ProteomicsDBⁱ	76709

PTM databases

iPTMnetⁱ	Q96H78
PhosphoSitePlusⁱ	Q96H78

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000160785 Expressed in 228 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_SLC25A44
ExpressionAtlasⁱ	Q96H78 baseline and differential
Genevisibleⁱ	Q96H78 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA065411

HPAⁱ

HPA065411

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	115028, 6 interactors
STRINGⁱ	9606.ENSP00000352497

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96H78
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	18 – 100	Solcar 1Add BLAST	83
Repeatⁱ	107 – 210	Solcar 2Add BLAST	104
Repeatⁱ	220 – 302	Solcar 3Add BLAST	83

Sequence similaritiesⁱ

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0765 Eukaryota ENOG410XTGQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062944
HOGENOMⁱ	HOG000234169
HOVERGENⁱ	HBG054957
InParanoidⁱ	Q96H78
KEGG Orthology (KO) More...KOⁱ	K15121
PhylomeDBⁱ	Q96H78
TreeFamⁱ	TF354268

Family and domain databases

Gene3Dⁱ	1.50.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR002067 Mit_carrier IPR040062 Mitochondrial_carrier_protein IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
PANTHERⁱ	PTHR24089 PTHR24089, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
PRINTSⁱ	PR00926 MITOCARRIER
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q96H78-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEDKRNIQII EWEHLDKKKF YVFGVAMTMM IRVSVYPFTL IRTRLQVQKG 
        60         70         80         90        100
KSLYHGTFDA FIKILRADGI TGLYRGFLVN TFTLISGQCY VTTYELTRKF 
       110        120        130        140        150
VADYSQSNTV KSLVAGGSAS LVAQSITVPI DVVSQHLMMQ RKGEKMGRFQ 
       160        170        180        190        200
VRGNPEGQGV VAFGQTKDII RQILQADGLR GFYRGYVASL LTYIPNSAVW 
       210        220        230        240        250
WPFYHFYAEQ LSYLCPKECP HIVFQAVSGP LAAATASILT NPMDVIRTRV 
       260        270        280        290        300
QVEGKNSIIL TFRQLMAEEG PWGLMKGLSA RIISATPSTI VIVVGYESLK 
       310 
KLSLRPELVD SRHW

Length:314

Mass (Da):35,392

Last modified:December 1, 2001 - v1

Checksum:ⁱ978AE43CBDF0FBDF

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E9PGQ0	E9PGQ0_HUMAN		Solute carrier family 25 member 44 Solute carrier family 25 member 44	SLC25A44	322	Annotation score:

Sequence cautionⁱ

The sequence BAA32291 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	208	A → AAIVFPWIP in BAA32291 (PubMed:9455484).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050134	52	S → I. Corresponds to variant dbSNP:rs11576750Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB007915 mRNA Translation: BAA32291.3 Different initiation. AK074912 mRNA Translation: BAC11287.1 AK075002 mRNA Translation: BAC11347.1 AL135927 Genomic DNA No translation available. BC008843 mRNA Translation: AAH08843.1 BC039854 mRNA Translation: AAH39854.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1133.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001273113.1, NM_001286184.1 NP_055470.1, NM_014655.3 XP_006711720.1, XM_006711657.3 XP_011508482.1, XM_011510180.1 XP_011508483.1, XM_011510181.1 XP_016858393.1, XM_017002904.1 XP_016858394.1, XM_017002905.1 XP_016858395.1, XM_017002906.1
UniGeneⁱ	Hs.532375 Hs.626091

Genome annotation databases

Ensemblⁱ	ENST00000359511; ENSP00000352497; ENSG00000160785
GeneIDⁱ	9673
KEGGⁱ	hsa:9673
UCSC genome browser More...UCSCⁱ	uc001fnp.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96H78	Solute carrier family 25 member 44		MACMU		314	UniRef100_Q96H78
SLC25A44 isoform 2		PANTR		314
Solute carrier family 25 member 44		MACFA		314
Uncharacterized protein		CERAT		314
Uncharacterized protein		PANPA		314
+2

Protein	Similar proteins		Species	Score	Length	Source
Q96H78	Solute carrier family 25 member 44		MACMU		314	UniRef90_Q96H78
SLC25A44 isoform 2		PANTR		314
Solute carrier family 25 member 44		MACFA		314
Uncharacterized protein		CERAT		314
Uncharacterized protein		PANPA		314
+41

Protein	Similar proteins		Species	Score	Length	Source
Q96H78	Solute carrier family 25 member 44		PONAB		314	UniRef50_Q96H78
Solute carrier family 25 member 44		MOUSE		314
Solute carrier family 25 member 44		MACMU		314
SLC25A44 isoform 2		PANTR		314
Solute carrier family 25 member 44		MACFA		314
+208

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB007915 mRNA Translation: BAA32291.3 Different initiation. AK074912 mRNA Translation: BAC11287.1 AK075002 mRNA Translation: BAC11347.1 AL135927 Genomic DNA No translation available. BC008843 mRNA Translation: AAH08843.1 BC039854 mRNA Translation: AAH39854.1
CCDSⁱ	CCDS1133.1
RefSeqⁱ	NP_001273113.1, NM_001286184.1 NP_055470.1, NM_014655.3 XP_006711720.1, XM_006711657.3 XP_011508482.1, XM_011510180.1 XP_011508483.1, XM_011510181.1 XP_016858393.1, XM_017002904.1 XP_016858394.1, XM_017002905.1 XP_016858395.1, XM_017002906.1
UniGeneⁱ	Hs.532375 Hs.626091

3D structure databases

ProteinModelPortalⁱ	Q96H78
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115028, 6 interactors
STRINGⁱ	9606.ENSP00000352497

Protein family/group databases

TCDBⁱ	2.A.29.14.7 the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.14.7 the mitochondrial carrier (mc) family

PTM databases

iPTMnetⁱ	Q96H78
PhosphoSitePlusⁱ	Q96H78

Polymorphism and mutation databases

DMDMⁱ	74751902

DMDMⁱ

74751902

Proteomic databases

EPDⁱ	Q96H78
MaxQBⁱ	Q96H78
PaxDbⁱ	Q96H78
PeptideAtlasⁱ	Q96H78
PRIDEⁱ	Q96H78
ProteomicsDBⁱ	76709

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000359511; ENSP00000352497; ENSG00000160785
GeneIDⁱ	9673
KEGGⁱ	hsa:9673
UCSCⁱ	uc001fnp.5 human

Organism-specific databases

CTDⁱ	9673
EuPathDBⁱ	HostDB:ENSG00000160785.13
GeneCardsⁱ	SLC25A44
HGNCⁱ	HGNC:29036 SLC25A44
HPAⁱ	HPA065411
MIMⁱ	610824 gene
neXtProtⁱ	NX_Q96H78
OpenTargetsⁱ	ENSG00000160785
PharmGKBⁱ	PA162403705
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0765 Eukaryota ENOG410XTGQ LUCA
GeneTreeⁱ	ENSGT00530000062944
HOGENOMⁱ	HOG000234169
HOVERGENⁱ	HBG054957
InParanoidⁱ	Q96H78
KOⁱ	K15121
PhylomeDBⁱ	Q96H78
TreeFamⁱ	TF354268

Miscellaneous databases

ChiTaRSⁱ	SLC25A44 human
GenomeRNAiⁱ	9673
Protein Ontology More...PROⁱ	PR:Q96H78
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000160785 Expressed in 228 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_SLC25A44
ExpressionAtlasⁱ	Q96H78 baseline and differential
Genevisibleⁱ	Q96H78 HS

Family and domain databases

Gene3Dⁱ	1.50.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR002067 Mit_carrier IPR040062 Mitochondrial_carrier_protein IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
PANTHERⁱ	PTHR24089 PTHR24089, 1 hit
Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
PRINTSⁱ	PR00926 MITOCARRIER
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S2544_HUMAN
Accessionⁱ	Q96H78Primary (citable) accession number: Q96H78 Secondary accession number(s): O75034
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96H78 (S2544_HUMAN)

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Solute carrier family 25 member 44

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ