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Entry version 136 (11 Dec 2019)
Sequence version 3 (18 May 2010)
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Protein

Zinc transporter ZIP13

Gene

SLC39A13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a zinc-influx transporter.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.5.4.12 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc transporter ZIP13
Alternative name(s):
LIV-1 subfamily of ZIP zinc transporter 9
Short name:
LZT-Hs9
Solute carrier family 39 member 13
Zrt- and Irt-like protein 13
Short name:
ZIP-13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC39A13
Synonyms:ZIP13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000165915.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20859 SLC39A13

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608735 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96H72

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 7LumenalSequence analysis7
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 68CytoplasmicSequence analysisAdd BLAST40
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 108LumenalSequence analysisAdd BLAST19
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 149CytoplasmicSequence analysisAdd BLAST20
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 235LumenalSequence analysisAdd BLAST65
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 278CytoplasmicSequence analysisAdd BLAST22
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 316LumenalSequence analysisAdd BLAST17
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Topological domaini338 – 349CytoplasmicSequence analysisAdd BLAST12
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Topological domaini371LumenalSequence analysis1

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ehlers-Danlos syndrome, spondylodysplastic type, 3 (EDSSPD3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Ehlers-Danlos syndrome, a group of connective tissue disorders characterized by skin hyperextensibility, articular hypermobility, and tissue fragility. EDSSPD3 is an autosomal recessive form characterized by a generalized skeletal dysplasia involving mainly the spine and striking clinical abnormalities of the hands, in addition to classic features of Ehlers-Danlos syndrome. Clinical features include postnatal growth retardation, moderate short stature, protuberant eyes with bluish sclerae, hands with finely wrinkled palms, atrophy of the thenar muscles, and tapering fingers. Radiologic features include mild to moderate platyspondyly, mild to moderate osteopenia of the spine, small ileum, flat proximal femoral epiphyses, short, wide femoral necks, and broad metaphyses (elbows, knees, wrists, and interphalangeal joints).
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054127162 – 164Missing in EDSSPD3. 1 Publication3

Keywords - Diseasei

Ehlers-Danlos syndrome

Organism-specific databases

DisGeNET

More...
DisGeNETi
91252

MalaCards human disease database

More...
MalaCardsi
SLC39A13
MIMi612350 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000165915

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
157965 SLC39A13-related spondylodysplastic Ehlers-Danlos syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134948414

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96H72 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC39A13

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452971

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003123091 – 371Zinc transporter ZIP13Add BLAST371

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96H72

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96H72

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96H72

PeptideAtlas

More...
PeptideAtlasi
Q96H72

PRoteomics IDEntifications database

More...
PRIDEi
Q96H72

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76707 [Q96H72-1]
76708 [Q96H72-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96H72

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96H72

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000165915 Expressed in 198 organ(s), highest expression level in cortex of kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96H72 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96H72 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043971

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124808, 4 interactors

Protein interaction database and analysis system

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IntActi
Q96H72, 7 interactors

Molecular INTeraction database

More...
MINTi
Q96H72

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354689

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96H72 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi257 – 262XEXPHE-motif6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi146 – 150Poly-Gln5
Compositional biasi187 – 191Poly-Ala5
Compositional biasi353 – 356Poly-Leu4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2694 Eukaryota
COG0428 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157349

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000185308

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96H72

KEGG Orthology (KO)

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KOi
K14719

Identification of Orthologs from Complete Genome Data

More...
OMAi
TGDSVHC

Database of Orthologous Groups

More...
OrthoDBi
657777at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96H72

TreeFam database of animal gene trees

More...
TreeFami
TF318470

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003689 ZIP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02535 Zip, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96H72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGCPCPGCG MAGPRLLFLT ALALELLERA GGSQPALRSR GTATACRLDN
60 70 80 90 100
KESESWGALL SGERLDTWIC SLLGSLMVGL SGVFPLLVIP LEMGTMLRSE
110 120 130 140 150
AGAWRLKQLL SFALGGLLGN VFLHLLPEAW AYTCSASPGG EGQSLQQQQQ
160 170 180 190 200
LGLWVIAGIL TFLALEKMFL DSKEEGTSQA PNKDPTAAAA ALNGGHCLAQ
210 220 230 240 250
PAAEPGLGAV VRSIKVSGYL NLLANTIDNF THGLAVAASF LVSKKIGLLT
260 270 280 290 300
TMAILLHEIP HEVGDFAILL RAGFDRWSAA KLQLSTALGG LLGAGFAICT
310 320 330 340 350
QSPKGVVGCS PAAEETAAWV LPFTSGGFLY IALVNVLPDL LEEEDPWRSL
360 370
QQLLLLCAGI VVMVLFSLFV D
Length:371
Mass (Da):39,011
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE3E9AF33A2EB4E42
GO
Isoform 2 (identifier: Q96H72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     307-313: Missing.

Show »
Length:364
Mass (Da):38,425
Checksum:i7534E39568C15C7B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1B2G3V1B2_HUMAN
Solute carrier family 39 (Zinc tran...
SLC39A13 hCG_1730570
325Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNE7E9PNE7_HUMAN
Zinc transporter ZIP13
SLC39A13
321Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNN7E9PNN7_HUMAN
Zinc transporter ZIP13
SLC39A13
258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRH4E9PRH4_HUMAN
Zinc transporter ZIP13
SLC39A13
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K4DIA9K4DIA9_HUMAN
Zinc transporter ZIP13
SLC39A13
248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PSA8E9PSA8_HUMAN
Zinc transporter ZIP13
SLC39A13
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K4DIB5K4DIB5_HUMAN
Zinc transporter ZIP13
SLC39A13
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC05365 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03748428E → G3 PublicationsCorresponds to variant dbSNP:rs2010519EnsemblClinVar.1
Natural variantiVAR_054127162 – 164Missing in EDSSPD3. 1 Publication3
Natural variantiVAR_037485346P → L. Corresponds to variant dbSNP:rs35978122EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029819307 – 313Missing in isoform 2. 3 Publications7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK098651 mRNA Translation: BAC05365.1 Frameshift.
AC090559 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW67918.1
CH471064 Genomic DNA Translation: EAW67919.1
CH471064 Genomic DNA Translation: EAW67920.1
CH471064 Genomic DNA Translation: EAW67921.1
CH471064 Genomic DNA Translation: EAW67922.1
CH471064 Genomic DNA Translation: EAW67923.1
BC008853 mRNA Translation: AAH08853.2
BC019016 mRNA Translation: AAH19016.1
AL133581 mRNA Translation: CAH56389.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS44592.1 [Q96H72-1]
CCDS7934.1 [Q96H72-2]

NCBI Reference Sequences

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RefSeqi
NP_001121697.1, NM_001128225.2 [Q96H72-1]
NP_001317174.1, NM_001330245.1
NP_689477.2, NM_152264.4
XP_011518769.1, XM_011520467.1 [Q96H72-1]
XP_011518770.1, XM_011520468.2 [Q96H72-1]
XP_016874029.1, XM_017018540.1 [Q96H72-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000354884; ENSP00000346956; ENSG00000165915 [Q96H72-2]
ENST00000362021; ENSP00000354689; ENSG00000165915 [Q96H72-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
91252

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:91252

UCSC genome browser

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UCSCi
uc001nff.5 human [Q96H72-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098651 mRNA Translation: BAC05365.1 Frameshift.
AC090559 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW67918.1
CH471064 Genomic DNA Translation: EAW67919.1
CH471064 Genomic DNA Translation: EAW67920.1
CH471064 Genomic DNA Translation: EAW67921.1
CH471064 Genomic DNA Translation: EAW67922.1
CH471064 Genomic DNA Translation: EAW67923.1
BC008853 mRNA Translation: AAH08853.2
BC019016 mRNA Translation: AAH19016.1
AL133581 mRNA Translation: CAH56389.1
CCDSiCCDS44592.1 [Q96H72-1]
CCDS7934.1 [Q96H72-2]
RefSeqiNP_001121697.1, NM_001128225.2 [Q96H72-1]
NP_001317174.1, NM_001330245.1
NP_689477.2, NM_152264.4
XP_011518769.1, XM_011520467.1 [Q96H72-1]
XP_011518770.1, XM_011520468.2 [Q96H72-1]
XP_016874029.1, XM_017018540.1 [Q96H72-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi124808, 4 interactors
IntActiQ96H72, 7 interactors
MINTiQ96H72
STRINGi9606.ENSP00000354689

Protein family/group databases

TCDBi2.A.5.4.12 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

PTM databases

iPTMnetiQ96H72
PhosphoSitePlusiQ96H72

Polymorphism and mutation databases

BioMutaiSLC39A13
DMDMi296452971

Proteomic databases

MassIVEiQ96H72
MaxQBiQ96H72
PaxDbiQ96H72
PeptideAtlasiQ96H72
PRIDEiQ96H72
ProteomicsDBi76707 [Q96H72-1]
76708 [Q96H72-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
91252

Genome annotation databases

EnsembliENST00000354884; ENSP00000346956; ENSG00000165915 [Q96H72-2]
ENST00000362021; ENSP00000354689; ENSG00000165915 [Q96H72-1]
GeneIDi91252
KEGGihsa:91252
UCSCiuc001nff.5 human [Q96H72-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
91252
DisGeNETi91252
EuPathDBiHostDB:ENSG00000165915.13

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC39A13
HGNCiHGNC:20859 SLC39A13
HPAiHPA043971
MalaCardsiSLC39A13
MIMi608735 gene
612350 phenotype
neXtProtiNX_Q96H72
OpenTargetsiENSG00000165915
Orphaneti157965 SLC39A13-related spondylodysplastic Ehlers-Danlos syndrome
PharmGKBiPA134948414

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2694 Eukaryota
COG0428 LUCA
GeneTreeiENSGT00940000157349
HOGENOMiHOG000185308
InParanoidiQ96H72
KOiK14719
OMAiTGDSVHC
OrthoDBi657777at2759
PhylomeDBiQ96H72
TreeFamiTF318470

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC39A13 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
91252
PharosiQ96H72 Tbio

Protein Ontology

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PROi
PR:Q96H72
RNActiQ96H72 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000165915 Expressed in 198 organ(s), highest expression level in cortex of kidney
ExpressionAtlasiQ96H72 baseline and differential
GenevisibleiQ96H72 HS

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
PfamiView protein in Pfam
PF02535 Zip, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS39AD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96H72
Secondary accession number(s): D3DQR6
, D3DQR7, E9PLY1, E9PQV3, Q659D9, Q8N7C9, Q8WV10
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 18, 2010
Last modified: December 11, 2019
This is version 136 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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