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UniProtKB - Q96H55 (MYO19_HUMAN)

Entry version 154 (10 Feb 2021)
Sequence version 2 (20 May 2008)
Previous versions | rss
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Protein

Unconventional myosin-XIX

Gene

MYO19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed:19932026, PubMed:23568824, PubMed:25447992). Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis (PubMed:25447992). May be involved in mitochondrial transport or positioning (PubMed:23568824).By similarity1 Publication2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi132 – 139ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96H55

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Unconventional myosin-XIX1 Publication
Alternative name(s):
Myosin head domain-containing protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYO191 PublicationImported
Synonyms:MYOHD1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26234, MYO19

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617379, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96H55

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000278259.4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi135G → R: Rigor-like phenotype due to disruption of ATP-binding. Does not affect localization to mitochondrion. 1 Publication1
Mutagenesisi855R → A: Does not affect localization to mitochondrion outer membrane. 1 Publication1
Mutagenesisi882 – 883RK → AA: Abolishes localization to mitochondrion outer membrane. 1 Publication2
Mutagenesisi915R → A: Does not affect localization to mitochondrion outer membrane. 1 Publication1
Mutagenesisi923K → A: Does not affect localization to mitochondrion outer membrane. 1 Publication1
Mutagenesisi927 – 928RK → AA: Does not affect localization to mitochondrion outer membrane. 1 Publication2

Organism-specific databases

DisGeNET

More...DisGeNETi		80179

Open Targets

More...OpenTargetsi		ENSG00000278259

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162396512

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96H55, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MYO19

Domain mapping of disease mutations (DMDM)

More...DMDMi		189083208

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003329691 – 970Unconventional myosin-XIXAdd BLAST970

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei685PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96H55

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96H55

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96H55

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96H55

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96H55

PeptideAtlas

More...PeptideAtlasi		Q96H55

PRoteomics IDEntifications database

More...PRIDEi		Q96H55

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76702 [Q96H55-1]
76703 [Q96H55-2]
76704 [Q96H55-3]
76705 [Q96H55-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96H55

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96H55

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in multiple tissues and cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000278259, Expressed in skin of abdomen and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96H55, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96H55, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000278259, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains: interacts with myosin light chains MYL9 and MYL12B.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123161, 195 interactors

Protein interaction database and analysis system

More...IntActi		Q96H55, 185 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000479518

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96H55, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q96H55

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 758Myosin motorPROSITE-ProRule annotationAdd BLAST724
Domaini759 – 779IQ 1PROSITE-ProRule annotationAdd BLAST21
Domaini783 – 812IQ 2PROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni602 – 624Actin-bindingPROSITE-ProRule annotationAdd BLAST23
Regioni824 – 970MyMOMA region2 PublicationsAdd BLAST147

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The MyMOMA (MYO19-specific mitochondrial outer membrane-association) region mediates association with the mitochondrion outer membrane via electrostatic interaction.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0160, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157382

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000192_7_4_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96H55

Identification of Orthologs from Complete Genome Data

More...OMAi		CIQCCWR

Database of Orthologous Groups

More...OrthoDBi		311886at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96H55

TreeFam database of animal gene trees

More...TreeFami		TF328771

Family and domain databases

Conserved Domains Database

More...CDDi		cd14880, MYSc_Myo19, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR036035, MYSc_Myo19
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00063, Myosin_head, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00193, MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00242, MYSc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50096, IQ, 1 hit
PS51456, MYOSIN_MOTOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96H55-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLQQVNGHNP GSDGQAREYL REDLQEFLGG EVLLYKLDDL TRVNPVTLET 
        60         70         80         90        100
VLRCLQARYM ADTFYTNAGC TLVALNPFKP VPQLYSPELM REYHAAPQPQ 
       110        120        130        140        150
KLKPHVFTVG EQTYRNVKSL IEPVNQSIVV SGESGAGKTW TSRCLMKFYA 
       160        170        180        190        200
VVATSPASWE SHKIAERIEQ RILNSNPVME AFGNACTLRN NNSSRFGKFI 
       210        220        230        240        250
QLQLNRAQQM TGAAVQTYLL EKTRVACQAS SERNFHIFYQ ICKGASEDER 
       260        270        280        290        300
LQWHLPEGAA FSWLPNPERS LEEDCFEVTR EAMLHLGIDT PTQNNIFKVL 
       310        320        330        340        350
AGLLHLGNIQ FAASEDEAQP CQPMDDAKYS VRTAASLLGL PEDVLLEMVQ 
       360        370        380        390        400
IRTIRAGRQQ QVFRKPCARA ECDTRRDCLA KLIYARLFDW LVSVINSSIC 
       410        420        430        440        450
ADTDSWTTFI GLLDVYGFES FPDNSLEQLC INYANEKLQQ HFVAHYLRAQ 
       460        470        480        490        500
QEEYAVEGLE WSFINYQDNQ PCLDLIEGSP ISICSLINEE CRLNRPSSAA 
       510        520        530        540        550
QLQTRIETAL AGSPCLGHNK LSREPSFIVV HYAGPVRYHT AGLVEKNKDP 
       560        570        580        590        600
IPPELTRLLQ QSQDPLLMGL FPTNPKEKTQ EEPPGQSRAP VLTVVSKFKA 
       610        620        630        640        650
SLEQLLQVLH STTPHYIRCI KPNSQGQAQT FLQEEVLSQL EACGLVETIH 
       660        670        680        690        700
ISAAGFPIRV SHRNFVERYK LLRRLHPCTS SGPDSPYPAK GLPEWCPHSE 
       710        720        730        740        750
EATLEPLIQD ILHTLPVLTQ AAAITGDSAE AMPAPMHCGR TKVFMTDSML 
       760        770        780        790        800
ELLECGRARV LEQCARCIQG GWRRHRHREQ ERQWRAVMLI QAAIRSWLTR 
       810        820        830        840        850
KHIQRLHAAA TVIKRAWQKW RIRMACLAAK ELDGVEEKHF SQAPCSLSTS 
       860        870        880        890        900
PLQTRLLEAI IRLWPLGLVL ANTAMGVGSF QRKLVVWACL QLPRGSPSSY 
       910        920        930        940        950
TVQTAQDQAG VTSIRALPQG SIKFHCRKSP LRYADICPEP SPYSITGFNQ 
       960        970
ILLERHRLIH VTSSAFTGLG
Length:970
Mass (Da):109,135
Last modified:May 20, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3AB15AD901BE7407
GO
Isoform 2 (identifier: Q96H55-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-317: LAGLLHLGNIQFAASEDE → RRKATPLKFGRDDGQPFA
     318-970: Missing.

Show »
Length:317
Mass (Da):35,934
Checksum:iAB1DF5E7FB346C32
GO
Isoform 3 (identifier: Q96H55-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     636-636: V → A
     637-970: Missing.

Show »
Length:636
Mass (Da):71,700
Checksum:i87C9E7887746C37E
GO
Isoform 4 (identifier: Q96H55-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     439-638: Missing.

Show »
Length:770
Mass (Da):86,687
Checksum:i67F3567A38DE947A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DSL5B4DSL5_HUMAN
Unconventional myosin-XIX
MYO19
183Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WU55A0A087WU55_HUMAN
Unconventional myosin-XIX
MYO19
176Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WY49A0A087WY49_HUMAN
Unconventional myosin-XIX
MYO19
186Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZQ9A0A087WZQ9_HUMAN
Unconventional myosin-XIX
MYO19
162Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVV4A0A087WVV4_HUMAN
Unconventional myosin-XIX
MYO19
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYT7A0A087WYT7_HUMAN
Unconventional myosin-XIX
MYO19
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVH0A0A087WVH0_HUMAN
Unconventional myosin-XIX
MYO19
15Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WW10A0A087WW10_HUMAN
Unconventional myosin-XIX
MYO19
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92272 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_043018176N → S1 PublicationCorresponds to variant dbSNP:rs2306595Ensembl.1
Natural variantiVAR_043019203Q → H. Corresponds to variant dbSNP:rs9890918Ensembl.1
Natural variantiVAR_043020475L → I. Corresponds to variant dbSNP:rs7217346Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_033402300 – 317LAGLL…ASEDE → RRKATPLKFGRDDGQPFA in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_033403318 – 970Missing in isoform 2. 1 PublicationAdd BLAST653
Alternative sequenceiVSP_033404439 – 638Missing in isoform 4. 1 PublicationAdd BLAST200
Alternative sequenceiVSP_033405636V → A in isoform 3. 1 Publication1
Alternative sequenceiVSP_033406637 – 970Missing in isoform 3. 1 PublicationAdd BLAST334

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK026518 mRNA Translation: BAB15495.1
AB209035 mRNA Translation: BAD92272.1 Different initiation.
AC126327 Genomic DNA No translation available.
CH471199 Genomic DNA Translation: EAW57557.1
BC008900 mRNA Translation: AAH08900.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45654.1 [Q96H55-4]
CCDS54112.1 [Q96H55-1]
CCDS59283.1 [Q96H55-2]

NCBI Reference Sequences

More...RefSeqi		NP_001028752.1, NM_001033580.2 [Q96H55-2]
NP_001157207.1, NM_001163735.1 [Q96H55-1]
NP_079385.2, NM_025109.5 [Q96H55-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000610930; ENSP00000478437; ENSG00000278259 [Q96H55-4]
ENST00000610992; ENSP00000480125; ENSG00000278259 [Q96H55-3]
ENST00000613929; ENSP00000478355; ENSG00000278372 [Q96H55-4]
ENST00000614623; ENSP00000479518; ENSG00000278259 [Q96H55-1]
ENST00000618519; ENSP00000480242; ENSG00000278372 [Q96H55-1]
ENST00000621344; ENSP00000477559; ENSG00000278259 [Q96H55-2]
ENST00000633264; ENSP00000487617; ENSG00000278372 [Q96H55-3]
ENST00000633938; ENSP00000488204; ENSG00000278372 [Q96H55-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		80179

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:80179

UCSC genome browser

More...UCSCi		uc032fdu.2, human [Q96H55-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026518 mRNA Translation: BAB15495.1
AB209035 mRNA Translation: BAD92272.1 Different initiation.
AC126327 Genomic DNA No translation available.
CH471199 Genomic DNA Translation: EAW57557.1
BC008900 mRNA Translation: AAH08900.1
CCDSiCCDS45654.1 [Q96H55-4]
CCDS54112.1 [Q96H55-1]
CCDS59283.1 [Q96H55-2]
RefSeqiNP_001028752.1, NM_001033580.2 [Q96H55-2]
NP_001157207.1, NM_001163735.1 [Q96H55-1]
NP_079385.2, NM_025109.5 [Q96H55-4]

3D structure databases

SMRiQ96H55
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123161, 195 interactors
IntActiQ96H55, 185 interactors
STRINGi9606.ENSP00000479518

PTM databases

iPTMnetiQ96H55
PhosphoSitePlusiQ96H55

Genetic variation databases

BioMutaiMYO19
DMDMi189083208

Proteomic databases

EPDiQ96H55
jPOSTiQ96H55
MassIVEiQ96H55
MaxQBiQ96H55
PaxDbiQ96H55
PeptideAtlasiQ96H55
PRIDEiQ96H55
ProteomicsDBi76702 [Q96H55-1]
76703 [Q96H55-2]
76704 [Q96H55-3]
76705 [Q96H55-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		73086, 143 antibodies

Genome annotation databases

EnsembliENST00000610930; ENSP00000478437; ENSG00000278259 [Q96H55-4]
ENST00000610992; ENSP00000480125; ENSG00000278259 [Q96H55-3]
ENST00000613929; ENSP00000478355; ENSG00000278372 [Q96H55-4]
ENST00000614623; ENSP00000479518; ENSG00000278259 [Q96H55-1]
ENST00000618519; ENSP00000480242; ENSG00000278372 [Q96H55-1]
ENST00000621344; ENSP00000477559; ENSG00000278259 [Q96H55-2]
ENST00000633264; ENSP00000487617; ENSG00000278372 [Q96H55-3]
ENST00000633938; ENSP00000488204; ENSG00000278372 [Q96H55-2]
GeneIDi80179
KEGGihsa:80179
UCSCiuc032fdu.2, human [Q96H55-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80179
DisGeNETi80179

GeneCards: human genes, protein and diseases

More...GeneCardsi		MYO19
HGNCiHGNC:26234, MYO19
HPAiENSG00000278259, Low tissue specificity
MIMi617379, gene
neXtProtiNX_Q96H55
OpenTargetsiENSG00000278259
PharmGKBiPA162396512
VEuPathDBiHostDB:ENSG00000278259.4

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0160, Eukaryota
GeneTreeiENSGT00940000157382
HOGENOMiCLU_000192_7_4_1
InParanoidiQ96H55
OMAiCIQCCWR
OrthoDBi311886at2759
PhylomeDBiQ96H55
TreeFamiTF328771

Enzyme and pathway databases

PathwayCommonsiQ96H55

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		80179, 5 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MYO19, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		80179
PharosiQ96H55, Tbio

Protein Ontology

More...PROi		PR:Q96H55
RNActiQ96H55, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000278259, Expressed in skin of abdomen and 214 other tissues
ExpressionAtlasiQ96H55, baseline and differential
GenevisibleiQ96H55, HS

Family and domain databases

CDDicd14880, MYSc_Myo19, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR036035, MYSc_Myo19
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00063, Myosin_head, 1 hit
PRINTSiPR00193, MYOSINHEAVY
SMARTiView protein in SMART
SM00242, MYSc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096, IQ, 1 hit
PS51456, MYOSIN_MOTOR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYO19_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96H55
Secondary accession number(s): Q59GS4, Q9H5X2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: February 10, 2021
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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