UniProtKB - Q96H55 (MYO19_HUMAN)
Protein
Unconventional myosin-XIX
Gene
MYO19
Organism
Homo sapiens (Human)
Status
Functioni
Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed:19932026, PubMed:23568824, PubMed:25447992). Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis (PubMed:25447992). May be involved in mitochondrial transport or positioning (PubMed:23568824).By similarity1 Publication2 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 132 – 139 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- actin binding Source: UniProtKB
- actin-dependent ATPase activity Source: GO_Central
- actin filament binding Source: GO_Central
- ATPase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- microfilament motor activity Source: GO_Central
- myosin light chain binding Source: Ensembl
- plus-end directed microfilament motor activity Source: Ensembl
GO - Biological processi
- actin filament organization Source: GO_Central
- mitochondrion migration along actin filament Source: MGI
- regulation of cytokinesis Source: UniProtKB
- regulation of mitochondrial fission Source: UniProtKB
- vesicle transport along actin filament Source: GO_Central
Keywordsi
Molecular function | Actin-binding, Motor protein, Myosin |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q96H55 |
Names & Taxonomyi
Protein namesi | Recommended name: Unconventional myosin-XIX1 PublicationAlternative name(s): Myosin head domain-containing protein 1Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26234, MYO19 |
MIMi | 617379, gene |
neXtProti | NX_Q96H55 |
VEuPathDBi | HostDB:ENSG00000278259.4 |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane 5 Publications; Peripheral membrane protein 1 Publication
Cytoskeleton
- cytoskeleton 1 Publication
Cytoskeleton
- actin cytoskeleton Source: GO_Central
- myosin complex Source: UniProtKB-KW
Cytosol
- cytosol Source: HPA
Mitochondrion
- mitochondrial outer membrane Source: UniProtKB
- mitochondrion Source: UniProtKB
Other locations
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Membrane, Mitochondrion, Mitochondrion outer membranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 135 | G → R: Rigor-like phenotype due to disruption of ATP-binding. Does not affect localization to mitochondrion. 1 Publication | 1 | |
Mutagenesisi | 855 | R → A: Does not affect localization to mitochondrion outer membrane. 1 Publication | 1 | |
Mutagenesisi | 882 – 883 | RK → AA: Abolishes localization to mitochondrion outer membrane. 1 Publication | 2 | |
Mutagenesisi | 915 | R → A: Does not affect localization to mitochondrion outer membrane. 1 Publication | 1 | |
Mutagenesisi | 923 | K → A: Does not affect localization to mitochondrion outer membrane. 1 Publication | 1 | |
Mutagenesisi | 927 – 928 | RK → AA: Does not affect localization to mitochondrion outer membrane. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 80179 |
OpenTargetsi | ENSG00000278259 |
PharmGKBi | PA162396512 |
Miscellaneous databases
Pharosi | Q96H55, Tbio |
Genetic variation databases
BioMutai | MYO19 |
DMDMi | 189083208 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000332969 | 1 – 970 | Unconventional myosin-XIXAdd BLAST | 970 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 685 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q96H55 |
jPOSTi | Q96H55 |
MassIVEi | Q96H55 |
MaxQBi | Q96H55 |
PaxDbi | Q96H55 |
PeptideAtlasi | Q96H55 |
PRIDEi | Q96H55 |
ProteomicsDBi | 76702 [Q96H55-1] 76703 [Q96H55-2] 76704 [Q96H55-3] 76705 [Q96H55-4] |
PTM databases
iPTMneti | Q96H55 |
PhosphoSitePlusi | Q96H55 |
Expressioni
Tissue specificityi
Widely expressed in multiple tissues and cell lines.1 Publication
Gene expression databases
Bgeei | ENSG00000278259, Expressed in skin of abdomen and 214 other tissues |
ExpressionAtlasi | Q96H55, baseline and differential |
Genevisiblei | Q96H55, HS |
Organism-specific databases
HPAi | ENSG00000278259, Low tissue specificity |
Interactioni
Subunit structurei
Myosin is a hexamer of 2 heavy chains and 4 light chains: interacts with myosin light chains MYL9 and MYL12B.
By similarityGO - Molecular functioni
- actin binding Source: UniProtKB
- actin filament binding Source: GO_Central
- myosin light chain binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 123161, 195 interactors |
IntActi | Q96H55, 185 interactors |
STRINGi | 9606.ENSP00000479518 |
Miscellaneous databases
RNActi | Q96H55, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 758 | Myosin motorPROSITE-ProRule annotationAdd BLAST | 724 | |
Domaini | 759 – 779 | IQ 1PROSITE-ProRule annotationAdd BLAST | 21 | |
Domaini | 783 – 812 | IQ 2PROSITE-ProRule annotationAdd BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 602 – 624 | Actin-bindingPROSITE-ProRule annotationAdd BLAST | 23 | |
Regioni | 824 – 970 | MyMOMA region2 PublicationsAdd BLAST | 147 |
Domaini
The MyMOMA (MYO19-specific mitochondrial outer membrane-association) region mediates association with the mitochondrion outer membrane via electrostatic interaction.2 Publications
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0160, Eukaryota |
GeneTreei | ENSGT00940000157382 |
HOGENOMi | CLU_000192_7_4_1 |
InParanoidi | Q96H55 |
OMAi | CIQCCWR |
OrthoDBi | 311886at2759 |
PhylomeDBi | Q96H55 |
TreeFami | TF328771 |
Family and domain databases
CDDi | cd14880, MYSc_Myo19, 1 hit |
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR036035, MYSc_Myo19 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00063, Myosin_head, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96H55-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLQQVNGHNP GSDGQAREYL REDLQEFLGG EVLLYKLDDL TRVNPVTLET
60 70 80 90 100
VLRCLQARYM ADTFYTNAGC TLVALNPFKP VPQLYSPELM REYHAAPQPQ
110 120 130 140 150
KLKPHVFTVG EQTYRNVKSL IEPVNQSIVV SGESGAGKTW TSRCLMKFYA
160 170 180 190 200
VVATSPASWE SHKIAERIEQ RILNSNPVME AFGNACTLRN NNSSRFGKFI
210 220 230 240 250
QLQLNRAQQM TGAAVQTYLL EKTRVACQAS SERNFHIFYQ ICKGASEDER
260 270 280 290 300
LQWHLPEGAA FSWLPNPERS LEEDCFEVTR EAMLHLGIDT PTQNNIFKVL
310 320 330 340 350
AGLLHLGNIQ FAASEDEAQP CQPMDDAKYS VRTAASLLGL PEDVLLEMVQ
360 370 380 390 400
IRTIRAGRQQ QVFRKPCARA ECDTRRDCLA KLIYARLFDW LVSVINSSIC
410 420 430 440 450
ADTDSWTTFI GLLDVYGFES FPDNSLEQLC INYANEKLQQ HFVAHYLRAQ
460 470 480 490 500
QEEYAVEGLE WSFINYQDNQ PCLDLIEGSP ISICSLINEE CRLNRPSSAA
510 520 530 540 550
QLQTRIETAL AGSPCLGHNK LSREPSFIVV HYAGPVRYHT AGLVEKNKDP
560 570 580 590 600
IPPELTRLLQ QSQDPLLMGL FPTNPKEKTQ EEPPGQSRAP VLTVVSKFKA
610 620 630 640 650
SLEQLLQVLH STTPHYIRCI KPNSQGQAQT FLQEEVLSQL EACGLVETIH
660 670 680 690 700
ISAAGFPIRV SHRNFVERYK LLRRLHPCTS SGPDSPYPAK GLPEWCPHSE
710 720 730 740 750
EATLEPLIQD ILHTLPVLTQ AAAITGDSAE AMPAPMHCGR TKVFMTDSML
760 770 780 790 800
ELLECGRARV LEQCARCIQG GWRRHRHREQ ERQWRAVMLI QAAIRSWLTR
810 820 830 840 850
KHIQRLHAAA TVIKRAWQKW RIRMACLAAK ELDGVEEKHF SQAPCSLSTS
860 870 880 890 900
PLQTRLLEAI IRLWPLGLVL ANTAMGVGSF QRKLVVWACL QLPRGSPSSY
910 920 930 940 950
TVQTAQDQAG VTSIRALPQG SIKFHCRKSP LRYADICPEP SPYSITGFNQ
960 970
ILLERHRLIH VTSSAFTGLG
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4DSL5 | B4DSL5_HUMAN | Unconventional myosin-XIX | MYO19 | 183 | Annotation score: | ||
A0A087WU55 | A0A087WU55_HUMAN | Unconventional myosin-XIX | MYO19 | 176 | Annotation score: | ||
A0A087WY49 | A0A087WY49_HUMAN | Unconventional myosin-XIX | MYO19 | 186 | Annotation score: | ||
A0A087WZQ9 | A0A087WZQ9_HUMAN | Unconventional myosin-XIX | MYO19 | 162 | Annotation score: | ||
A0A087WVV4 | A0A087WVV4_HUMAN | Unconventional myosin-XIX | MYO19 | 109 | Annotation score: | ||
A0A087WYT7 | A0A087WYT7_HUMAN | Unconventional myosin-XIX | MYO19 | 65 | Annotation score: | ||
A0A087WVH0 | A0A087WVH0_HUMAN | Unconventional myosin-XIX | MYO19 | 15 | Annotation score: | ||
A0A087WW10 | A0A087WW10_HUMAN | Unconventional myosin-XIX | MYO19 | 44 | Annotation score: |
Sequence cautioni
The sequence BAD92272 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043018 | 176 | N → S1 PublicationCorresponds to variant dbSNP:rs2306595Ensembl. | 1 | |
Natural variantiVAR_043019 | 203 | Q → H. Corresponds to variant dbSNP:rs9890918Ensembl. | 1 | |
Natural variantiVAR_043020 | 475 | L → I. Corresponds to variant dbSNP:rs7217346Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_033402 | 300 – 317 | LAGLL…ASEDE → RRKATPLKFGRDDGQPFA in isoform 2. 1 PublicationAdd BLAST | 18 | |
Alternative sequenceiVSP_033403 | 318 – 970 | Missing in isoform 2. 1 PublicationAdd BLAST | 653 | |
Alternative sequenceiVSP_033404 | 439 – 638 | Missing in isoform 4. 1 PublicationAdd BLAST | 200 | |
Alternative sequenceiVSP_033405 | 636 | V → A in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_033406 | 637 – 970 | Missing in isoform 3. 1 PublicationAdd BLAST | 334 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK026518 mRNA Translation: BAB15495.1 AB209035 mRNA Translation: BAD92272.1 Different initiation. AC126327 Genomic DNA No translation available. CH471199 Genomic DNA Translation: EAW57557.1 BC008900 mRNA Translation: AAH08900.1 |
CCDSi | CCDS45654.1 [Q96H55-4] CCDS54112.1 [Q96H55-1] CCDS59283.1 [Q96H55-2] |
RefSeqi | NP_001028752.1, NM_001033580.2 [Q96H55-2] NP_001157207.1, NM_001163735.1 [Q96H55-1] NP_079385.2, NM_025109.5 [Q96H55-4] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK026518 mRNA Translation: BAB15495.1 AB209035 mRNA Translation: BAD92272.1 Different initiation. AC126327 Genomic DNA No translation available. CH471199 Genomic DNA Translation: EAW57557.1 BC008900 mRNA Translation: AAH08900.1 |
CCDSi | CCDS45654.1 [Q96H55-4] CCDS54112.1 [Q96H55-1] CCDS59283.1 [Q96H55-2] |
RefSeqi | NP_001028752.1, NM_001033580.2 [Q96H55-2] NP_001157207.1, NM_001163735.1 [Q96H55-1] NP_079385.2, NM_025109.5 [Q96H55-4] |
3D structure databases
SMRi | Q96H55 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123161, 195 interactors |
IntActi | Q96H55, 185 interactors |
STRINGi | 9606.ENSP00000479518 |
PTM databases
iPTMneti | Q96H55 |
PhosphoSitePlusi | Q96H55 |
Genetic variation databases
BioMutai | MYO19 |
DMDMi | 189083208 |
Proteomic databases
EPDi | Q96H55 |
jPOSTi | Q96H55 |
MassIVEi | Q96H55 |
MaxQBi | Q96H55 |
PaxDbi | Q96H55 |
PeptideAtlasi | Q96H55 |
PRIDEi | Q96H55 |
ProteomicsDBi | 76702 [Q96H55-1] 76703 [Q96H55-2] 76704 [Q96H55-3] 76705 [Q96H55-4] |
Protocols and materials databases
Antibodypediai | 73086, 143 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 80179 |
DisGeNETi | 80179 |
GeneCardsi | MYO19 |
HGNCi | HGNC:26234, MYO19 |
HPAi | ENSG00000278259, Low tissue specificity |
MIMi | 617379, gene |
neXtProti | NX_Q96H55 |
OpenTargetsi | ENSG00000278259 |
PharmGKBi | PA162396512 |
VEuPathDBi | HostDB:ENSG00000278259.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0160, Eukaryota |
GeneTreei | ENSGT00940000157382 |
HOGENOMi | CLU_000192_7_4_1 |
InParanoidi | Q96H55 |
OMAi | CIQCCWR |
OrthoDBi | 311886at2759 |
PhylomeDBi | Q96H55 |
TreeFami | TF328771 |
Enzyme and pathway databases
PathwayCommonsi | Q96H55 |
Miscellaneous databases
BioGRID-ORCSi | 80179, 5 hits in 873 CRISPR screens |
ChiTaRSi | MYO19, human |
GenomeRNAii | 80179 |
Pharosi | Q96H55, Tbio |
PROi | PR:Q96H55 |
RNActi | Q96H55, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000278259, Expressed in skin of abdomen and 214 other tissues |
ExpressionAtlasi | Q96H55, baseline and differential |
Genevisiblei | Q96H55, HS |
Family and domain databases
CDDi | cd14880, MYSc_Myo19, 1 hit |
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR036035, MYSc_Myo19 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00063, Myosin_head, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYO19_HUMAN | |
Accessioni | Q96H55Primary (citable) accession number: Q96H55 Secondary accession number(s): Q59GS4, Q9H5X2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | May 20, 2008 | |
Last modified: | February 10, 2021 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families