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UniProtKB - Q96H55 (MYO19_HUMAN)

Protein

Unconventional myosin-XIX

Gene

MYO19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed:19932026, PubMed:23568824, PubMed:25447992). Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis (PubMed:25447992). May be involved in mitochondrial transport or positioning (PubMed:23568824).By similarity1 Publication2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi132 – 139ATPPROSITE-ProRule annotation8

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • mitochondrion migration along actin filament Source: MGI
  • regulation of cytokinesis Source: UniProtKB
  • regulation of mitochondrial fission Source: UniProtKB
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-XIX1 Publication
Alternative name(s):
Myosin head domain-containing protein 1Imported
Gene namesi
Name:MYO191 PublicationImported
Synonyms:MYOHD1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000278259.4
HGNCiHGNC:26234 MYO19
MIMi617379 gene
neXtProtiNX_Q96H55

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi135G → R: Rigor-like phenotype due to disruption of ATP-binding. Does not affect localization to mitochondrion. 1 Publication1
Mutagenesisi855R → A: Does not affect localization to mitochondrion outer membrane. 1 Publication1
Mutagenesisi882 – 883RK → AA: Abolishes localization to mitochondrion outer membrane. 1 Publication2
Mutagenesisi915R → A: Does not affect localization to mitochondrion outer membrane. 1 Publication1
Mutagenesisi923K → A: Does not affect localization to mitochondrion outer membrane. 1 Publication1
Mutagenesisi927 – 928RK → AA: Does not affect localization to mitochondrion outer membrane. 1 Publication2

Organism-specific databases

OpenTargetsiENSG00000278259
PharmGKBiPA162396512

Polymorphism and mutation databases

BioMutaiMYO19
DMDMi189083208

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003329691 – 970Unconventional myosin-XIXAdd BLAST970

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei685PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96H55
MaxQBiQ96H55
PaxDbiQ96H55
PeptideAtlasiQ96H55
PRIDEiQ96H55
ProteomicsDBi76702
76703 [Q96H55-2]
76704 [Q96H55-3]
76705 [Q96H55-4]

PTM databases

iPTMnetiQ96H55
PhosphoSitePlusiQ96H55

Expressioni

Tissue specificityi

Widely expressed in multiple tissues and cell lines.1 Publication

Gene expression databases

BgeeiENSG00000278259 Expressed in 200 organ(s), highest expression level in skin of abdomen
CleanExiHS_MYO19
ExpressionAtlasiQ96H55 baseline and differential
GenevisibleiQ96H55 HS

Organism-specific databases

HPAiHPA021415
HPA059715

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains: interacts with myosin light chains MYL9 and MYL12B.By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi123161, 186 interactors
IntActiQ96H55, 177 interactors
STRINGi9606.ENSP00000409936

Structurei

3D structure databases

ProteinModelPortaliQ96H55
SMRiQ96H55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 758Myosin motorPROSITE-ProRule annotationAdd BLAST724
Domaini759 – 779IQ 1PROSITE-ProRule annotationAdd BLAST21
Domaini783 – 812IQ 2PROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni602 – 624Actin-bindingPROSITE-ProRule annotationAdd BLAST23
Regioni824 – 970MyMOMA region2 PublicationsAdd BLAST147

Domaini

The MyMOMA (MYO19-specific mitochondrial outer membrane-association) region mediates association with the mitochondrion outer membrane via electrostatic interaction.2 Publications

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0160 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00930000150810
HOGENOMiHOG000008082
HOVERGENiHBG108164
InParanoidiQ96H55
OMAiVHCGKTK
OrthoDBiEOG091G01I9
PhylomeDBiQ96H55
TreeFamiTF328771

Family and domain databases

CDDicd14880 MYSc_Myo19, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR036035 MYSc_Myo19
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96H55-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLQQVNGHNP GSDGQAREYL REDLQEFLGG EVLLYKLDDL TRVNPVTLET 
        60         70         80         90        100
VLRCLQARYM ADTFYTNAGC TLVALNPFKP VPQLYSPELM REYHAAPQPQ 
       110        120        130        140        150
KLKPHVFTVG EQTYRNVKSL IEPVNQSIVV SGESGAGKTW TSRCLMKFYA 
       160        170        180        190        200
VVATSPASWE SHKIAERIEQ RILNSNPVME AFGNACTLRN NNSSRFGKFI 
       210        220        230        240        250
QLQLNRAQQM TGAAVQTYLL EKTRVACQAS SERNFHIFYQ ICKGASEDER 
       260        270        280        290        300
LQWHLPEGAA FSWLPNPERS LEEDCFEVTR EAMLHLGIDT PTQNNIFKVL 
       310        320        330        340        350
AGLLHLGNIQ FAASEDEAQP CQPMDDAKYS VRTAASLLGL PEDVLLEMVQ 
       360        370        380        390        400
IRTIRAGRQQ QVFRKPCARA ECDTRRDCLA KLIYARLFDW LVSVINSSIC 
       410        420        430        440        450
ADTDSWTTFI GLLDVYGFES FPDNSLEQLC INYANEKLQQ HFVAHYLRAQ 
       460        470        480        490        500
QEEYAVEGLE WSFINYQDNQ PCLDLIEGSP ISICSLINEE CRLNRPSSAA 
       510        520        530        540        550
QLQTRIETAL AGSPCLGHNK LSREPSFIVV HYAGPVRYHT AGLVEKNKDP 
       560        570        580        590        600
IPPELTRLLQ QSQDPLLMGL FPTNPKEKTQ EEPPGQSRAP VLTVVSKFKA 
       610        620        630        640        650
SLEQLLQVLH STTPHYIRCI KPNSQGQAQT FLQEEVLSQL EACGLVETIH 
       660        670        680        690        700
ISAAGFPIRV SHRNFVERYK LLRRLHPCTS SGPDSPYPAK GLPEWCPHSE 
       710        720        730        740        750
EATLEPLIQD ILHTLPVLTQ AAAITGDSAE AMPAPMHCGR TKVFMTDSML 
       760        770        780        790        800
ELLECGRARV LEQCARCIQG GWRRHRHREQ ERQWRAVMLI QAAIRSWLTR 
       810        820        830        840        850
KHIQRLHAAA TVIKRAWQKW RIRMACLAAK ELDGVEEKHF SQAPCSLSTS 
       860        870        880        890        900
PLQTRLLEAI IRLWPLGLVL ANTAMGVGSF QRKLVVWACL QLPRGSPSSY 
       910        920        930        940        950
TVQTAQDQAG VTSIRALPQG SIKFHCRKSP LRYADICPEP SPYSITGFNQ 
       960        970
ILLERHRLIH VTSSAFTGLG
Length:970
Mass (Da):109,135
Last modified:May 20, 2008 - v2
Checksum:i3AB15AD901BE7407
GO
Isoform 2 (identifier: Q96H55-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-317: LAGLLHLGNIQFAASEDE → RRKATPLKFGRDDGQPFA
     318-970: Missing.

Show »
Length:317
Mass (Da):35,934
Checksum:iAB1DF5E7FB346C32
GO
Isoform 3 (identifier: Q96H55-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     636-636: V → A
     637-970: Missing.

Show »
Length:636
Mass (Da):71,700
Checksum:i87C9E7887746C37E
GO
Isoform 4 (identifier: Q96H55-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     439-638: Missing.

Show »
Length:770
Mass (Da):86,687
Checksum:i67F3567A38DE947A
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WU55A0A087WU55_HUMAN
Unconventional myosin-XIX
MYO19
176Annotation score:
A0A087WZQ9A0A087WZQ9_HUMAN
Unconventional myosin-XIX
MYO19
162Annotation score:
B4DSL5B4DSL5_HUMAN
Unconventional myosin-XIX
MYO19
183Annotation score:
A0A087WY49A0A087WY49_HUMAN
Unconventional myosin-XIX
MYO19
186Annotation score:
A0A087WVV4A0A087WVV4_HUMAN
Unconventional myosin-XIX
MYO19
109Annotation score:
A0A087WYT7A0A087WYT7_HUMAN
Unconventional myosin-XIX
MYO19
65Annotation score:
A0A087WW10A0A087WW10_HUMAN
Unconventional myosin-XIX
MYO19
44Annotation score:
A0A087WVH0A0A087WVH0_HUMAN
Unconventional myosin-XIX
MYO19
15Annotation score:

Sequence cautioni

The sequence BAD92272 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043018176N → S1 PublicationCorresponds to variant dbSNP:rs2306595Ensembl.1
Natural variantiVAR_043019203Q → H. Corresponds to variant dbSNP:rs9890918Ensembl.1
Natural variantiVAR_043020475L → I. Corresponds to variant dbSNP:rs7217346Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033402300 – 317LAGLL…ASEDE → RRKATPLKFGRDDGQPFA in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_033403318 – 970Missing in isoform 2. 1 PublicationAdd BLAST653
Alternative sequenceiVSP_033404439 – 638Missing in isoform 4. 1 PublicationAdd BLAST200
Alternative sequenceiVSP_033405636V → A in isoform 3. 1 Publication1
Alternative sequenceiVSP_033406637 – 970Missing in isoform 3. 1 PublicationAdd BLAST334

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026518 mRNA Translation: BAB15495.1
AB209035 mRNA Translation: BAD92272.1 Different initiation.
AC126327 Genomic DNA No translation available.
CH471199 Genomic DNA Translation: EAW57557.1
BC008900 mRNA Translation: AAH08900.1
CCDSiCCDS45654.1 [Q96H55-4]
CCDS54112.1 [Q96H55-1]
CCDS59283.1 [Q96H55-2]
RefSeqiNP_001028752.1, NM_001033580.2 [Q96H55-2]
NP_001157207.1, NM_001163735.1 [Q96H55-1]
NP_079385.2, NM_025109.5 [Q96H55-4]
UniGeneiHs.302051

Genome annotation databases

EnsembliENST00000610930; ENSP00000478437; ENSG00000278259 [Q96H55-4]
ENST00000610992; ENSP00000480125; ENSG00000278259 [Q96H55-3]
ENST00000613929; ENSP00000478355; ENSG00000278372 [Q96H55-4]
ENST00000614623; ENSP00000479518; ENSG00000278259 [Q96H55-1]
ENST00000618519; ENSP00000480242; ENSG00000278372 [Q96H55-1]
ENST00000621344; ENSP00000477559; ENSG00000278259 [Q96H55-2]
ENST00000633264; ENSP00000487617; ENSG00000278372 [Q96H55-3]
ENST00000633938; ENSP00000488204; ENSG00000278372 [Q96H55-2]
GeneIDi80179
KEGGihsa:80179
UCSCiuc032fdu.2 human [Q96H55-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026518 mRNA Translation: BAB15495.1
AB209035 mRNA Translation: BAD92272.1 Different initiation.
AC126327 Genomic DNA No translation available.
CH471199 Genomic DNA Translation: EAW57557.1
BC008900 mRNA Translation: AAH08900.1
CCDSiCCDS45654.1 [Q96H55-4]
CCDS54112.1 [Q96H55-1]
CCDS59283.1 [Q96H55-2]
RefSeqiNP_001028752.1, NM_001033580.2 [Q96H55-2]
NP_001157207.1, NM_001163735.1 [Q96H55-1]
NP_079385.2, NM_025109.5 [Q96H55-4]
UniGeneiHs.302051

3D structure databases

ProteinModelPortaliQ96H55
SMRiQ96H55
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123161, 186 interactors
IntActiQ96H55, 177 interactors
STRINGi9606.ENSP00000409936

PTM databases

iPTMnetiQ96H55
PhosphoSitePlusiQ96H55

Polymorphism and mutation databases

BioMutaiMYO19
DMDMi189083208

Proteomic databases

EPDiQ96H55
MaxQBiQ96H55
PaxDbiQ96H55
PeptideAtlasiQ96H55
PRIDEiQ96H55
ProteomicsDBi76702
76703 [Q96H55-2]
76704 [Q96H55-3]
76705 [Q96H55-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000610930; ENSP00000478437; ENSG00000278259 [Q96H55-4]
ENST00000610992; ENSP00000480125; ENSG00000278259 [Q96H55-3]
ENST00000613929; ENSP00000478355; ENSG00000278372 [Q96H55-4]
ENST00000614623; ENSP00000479518; ENSG00000278259 [Q96H55-1]
ENST00000618519; ENSP00000480242; ENSG00000278372 [Q96H55-1]
ENST00000621344; ENSP00000477559; ENSG00000278259 [Q96H55-2]
ENST00000633264; ENSP00000487617; ENSG00000278372 [Q96H55-3]
ENST00000633938; ENSP00000488204; ENSG00000278372 [Q96H55-2]
GeneIDi80179
KEGGihsa:80179
UCSCiuc032fdu.2 human [Q96H55-1]

Organism-specific databases

CTDi80179
EuPathDBiHostDB:ENSG00000278259.4
GeneCardsiMYO19
H-InvDBiHIX0014287
HGNCiHGNC:26234 MYO19
HPAiHPA021415
HPA059715
MIMi617379 gene
neXtProtiNX_Q96H55
OpenTargetsiENSG00000278259
PharmGKBiPA162396512
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0160 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00930000150810
HOGENOMiHOG000008082
HOVERGENiHBG108164
InParanoidiQ96H55
OMAiVHCGKTK
OrthoDBiEOG091G01I9
PhylomeDBiQ96H55
TreeFamiTF328771

Miscellaneous databases

ChiTaRSiMYO19 human
GenomeRNAii80179
PROiPR:Q96H55
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000278259 Expressed in 200 organ(s), highest expression level in skin of abdomen
CleanExiHS_MYO19
ExpressionAtlasiQ96H55 baseline and differential
GenevisibleiQ96H55 HS

Family and domain databases

CDDicd14880 MYSc_Myo19, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR036035 MYSc_Myo19
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYO19_HUMAN
AccessioniPrimary (citable) accession number: Q96H55
Secondary accession number(s): Q59GS4, Q9H5X2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 7, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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