UniProtKB - Q96H40 (ZN486_HUMAN)
Protein
Zinc finger protein 486
Gene
ZNF486
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 154 – 176 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 210 – 232 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 238 – 260 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 266 – 288 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 294 – 316 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 322 – 344 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 350 – 372 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 378 – 400 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 406 – 428 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 434 – 456 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q96H40 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 486Alternative name(s): KRAB domain only protein 2 |
Gene namesi | Name:ZNF486 Synonyms:KRBO2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000256229.7 |
HGNCi | HGNC:20807, ZNF486 |
neXtProti | NX_Q96H40 |
Subcellular locationi
Nucleus
- Nucleus Curated
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000256229 |
PharmGKBi | PA134919932 |
Miscellaneous databases
Pharosi | Q96H40, Tdark |
Polymorphism and mutation databases
BioMutai | ZNF486 |
DMDMi | 325511409 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047611 | 1 – 463 | Zinc finger protein 486Add BLAST | 463 |
Proteomic databases
EPDi | Q96H40 |
jPOSTi | Q96H40 |
MassIVEi | Q96H40 |
PaxDbi | Q96H40 |
PeptideAtlasi | Q96H40 |
PRIDEi | Q96H40 |
ProteomicsDBi | 76700 |
PTM databases
iPTMneti | Q96H40 |
PhosphoSitePlusi | Q96H40 |
Expressioni
Gene expression databases
Bgeei | ENSG00000256229, Expressed in buccal mucosa cell and 207 other tissues |
ExpressionAtlasi | Q96H40, baseline and differential |
Genevisiblei | Q96H40, HS |
Organism-specific databases
HPAi | ENSG00000256229, Tissue enhanced (thyroid) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124749, 1 interactor |
STRINGi | 9606.ENSP00000335042 |
Miscellaneous databases
RNActi | Q96H40, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 84 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 154 – 176 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 210 – 232 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 238 – 260 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 266 – 288 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 294 – 316 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 322 – 344 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 350 – 372 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 378 – 400 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 406 – 428 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 434 – 456 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000153236 |
HOGENOMi | CLU_002678_44_0_1 |
InParanoidi | Q96H40 |
OMAi | FSTFTTH |
OrthoDBi | 1318335at2759 |
TreeFami | TF342117 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q96H40-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGPLRSLEM ESLQFRDVAV EFSLEEWHCL DTAQQNLYRD VMLENYRHLV
60 70 80 90 100
FLGIIVSKPD LITCLEQGIK PLTMKRHEMI AKPPVVCSHF AQDLWPEQSI
110 120 130 140 150
KDSYQKVILR KFEKCGHGNL HFKKGCESVD ECKLHKRGYN GLNQCLTTTQ
160 170 180 190 200
SKIFQCGKYV KVFHQFSNSK RHKRRHTEKK PLKYIEGDKA FNQSSTHTTH
210 220 230 240 250
KKIDTGEKPY KCEECGKAFN RSSHLTTHKI THTREKPYKC EECGKVFKYF
260 270 280 290 300
SSFTTHKKIH SGEKPYICEE CGKAFMYPYT LTTHKIIHTG EQPYKCKECD
310 320 330 340 350
KAFNHPATLS SHKKIHTGEK PYTCDKCGKA FISSSILSKH EKIHTGEKPY
360 370 380 390 400
KCEECGKAFT RSSHLTMHKI IHTGEKPYKC EECGKAFTWS AGLHKHRRTH
410 420 430 440 450
TGEKPYKCEE CGKAYTTSSN LTEHKTTHTG EKPYKCKECG KAFNWSSDLN
460
KHKRIHIGQK PRT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0QXQ0 | M0QXQ0_HUMAN | Zinc finger protein 486 | ZNF486 | 128 | Annotation score: |
Sequence cautioni
The sequence AAH08936 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011447 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84874.1 BC008936 mRNA Translation: AAH08936.2 Sequence problems. BC117268 mRNA Translation: AAI17269.1 |
CCDSi | CCDS46029.1 |
RefSeqi | NP_443084.2, NM_052852.3 |
Genome annotation databases
Ensembli | ENST00000335117; ENSP00000335042; ENSG00000256229 |
GeneIDi | 90649 |
KEGGi | hsa:90649 |
UCSCi | uc002nou.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011447 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84874.1 BC008936 mRNA Translation: AAH08936.2 Sequence problems. BC117268 mRNA Translation: AAI17269.1 |
CCDSi | CCDS46029.1 |
RefSeqi | NP_443084.2, NM_052852.3 |
3D structure databases
SMRi | Q96H40 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124749, 1 interactor |
STRINGi | 9606.ENSP00000335042 |
PTM databases
iPTMneti | Q96H40 |
PhosphoSitePlusi | Q96H40 |
Polymorphism and mutation databases
BioMutai | ZNF486 |
DMDMi | 325511409 |
Proteomic databases
EPDi | Q96H40 |
jPOSTi | Q96H40 |
MassIVEi | Q96H40 |
PaxDbi | Q96H40 |
PeptideAtlasi | Q96H40 |
PRIDEi | Q96H40 |
ProteomicsDBi | 76700 |
Protocols and materials databases
Antibodypediai | 56810, 83 antibodies |
DNASUi | 90649 |
Genome annotation databases
Ensembli | ENST00000335117; ENSP00000335042; ENSG00000256229 |
GeneIDi | 90649 |
KEGGi | hsa:90649 |
UCSCi | uc002nou.4, human |
Organism-specific databases
CTDi | 90649 |
EuPathDBi | HostDB:ENSG00000256229.7 |
GeneCardsi | ZNF486 |
HGNCi | HGNC:20807, ZNF486 |
HPAi | ENSG00000256229, Tissue enhanced (thyroid) |
neXtProti | NX_Q96H40 |
OpenTargetsi | ENSG00000256229 |
PharmGKBi | PA134919932 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000153236 |
HOGENOMi | CLU_002678_44_0_1 |
InParanoidi | Q96H40 |
OMAi | FSTFTTH |
OrthoDBi | 1318335at2759 |
TreeFami | TF342117 |
Enzyme and pathway databases
PathwayCommonsi | Q96H40 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 90649, 117 hits in 845 CRISPR screens |
GenomeRNAii | 90649 |
Pharosi | Q96H40, Tdark |
PROi | PR:Q96H40 |
RNActi | Q96H40, protein |
Gene expression databases
Bgeei | ENSG00000256229, Expressed in buccal mucosa cell and 207 other tissues |
ExpressionAtlasi | Q96H40, baseline and differential |
Genevisiblei | Q96H40, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN486_HUMAN | |
Accessioni | Q96H40Primary (citable) accession number: Q96H40 Secondary accession number(s): Q0VG00 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | March 8, 2011 | |
Last modified: | December 2, 2020 | |
This is version 142 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM