UniProtKB - Q96H15 (TIMD4_HUMAN)
Protein
T-cell immunoglobulin and mucin domain-containing protein 4
Gene
TIMD4
Organism
Homo sapiens (Human)
Status
Functioni
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity).By similarity
Enzyme and pathway databases
PathwayCommonsi | Q96H15 |
Names & Taxonomyi
Protein namesi | Recommended name: T-cell immunoglobulin and mucin domain-containing protein 4Short name: TIMD-4 Alternative name(s): T-cell immunoglobulin mucin receptor 4 Short name: TIM-4 T-cell membrane protein 4 |
Gene namesi | Name:TIMD4 Synonyms:TIM4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25132, TIMD4 |
MIMi | 610096, gene |
neXtProti | NX_Q96H15 |
VEuPathDBi | HostDB:ENSG00000145850.8 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 314 | ExtracellularSequence analysisAdd BLAST | 290 | |
Transmembranei | 315 – 335 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 336 – 378 | CytoplasmicSequence analysisAdd BLAST | 43 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 91937 |
OpenTargetsi | ENSG00000145850 |
PharmGKBi | PA134989118 |
Miscellaneous databases
Pharosi | Q96H15, Tbio |
Genetic variation databases
BioMutai | TIMD4 |
DMDMi | 296452930 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000042103 | 25 – 378 | T-cell immunoglobulin and mucin domain-containing protein 4Add BLAST | 354 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 40 ↔ 112 | PROSITE-ProRule annotation | ||
Disulfide bondi | 53 ↔ 64 | PROSITE-ProRule annotation | ||
Disulfide bondi | 59 ↔ 111 | PROSITE-ProRule annotation | ||
Glycosylationi | 291 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 358 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q96H15 |
PeptideAtlasi | Q96H15 |
PRIDEi | Q96H15 |
ProteomicsDBi | 6068 76694 [Q96H15-1] |
PTM databases
GlyGeni | Q96H15, 1 site |
iPTMneti | Q96H15 |
PhosphoSitePlusi | Q96H15 |
Expressioni
Gene expression databases
Bgeei | ENSG00000145850, Expressed in right testis and 116 other tissues |
ExpressionAtlasi | Q96H15, baseline and differential |
Genevisiblei | Q96H15, HS |
Organism-specific databases
HPAi | ENSG00000145850, Group enriched (liver, lymphoid tissue, testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124892, 3 interactors |
STRINGi | 9606.ENSP00000274532 |
Miscellaneous databases
RNActi | Q96H15, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q96H15 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 126 | Ig-like V-typeAdd BLAST | 102 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 136 – 214 | Thr-richAdd BLAST | 79 | |
Compositional biasi | 234 – 277 | Ser-richAdd BLAST | 44 |
Domaini
Recognizes phosphatidyl serine via its immunoglobulin domain.
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S1A2, Eukaryota |
GeneTreei | ENSGT00940000161609 |
HOGENOMi | CLU_047504_0_1_1 |
InParanoidi | Q96H15 |
OMAi | QSRNSMC |
OrthoDBi | 1147868at2759 |
PhylomeDBi | Q96H15 |
TreeFami | TF336163 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96H15-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSKEPLILWL MIEFWWLYLT PVTSETVVTE VLGHRVTLPC LYSSWSHNSN
60 70 80 90 100
SMCWGKDQCP YSGCKEALIR TDGMRVTSRK SAKYRLQGTI PRGDVSLTIL
110 120 130 140 150
NPSESDSGVY CCRIEVPGWF NDVKINVRLN LQRASTTTHR TATTTTRRTT
160 170 180 190 200
TTSPTTTRQM TTTPAALPTT VVTTPDLTTG TPLQMTTIAV FTTANTCLSL
210 220 230 240 250
TPSTLPEEAT GLLTPEPSKE GPILTAESET VLPSDSWSSV ESTSADTVLL
260 270 280 290 300
TSKESKVWDL PSTSHVSMWK TSDSVSSPQP GASDTAVPEQ NKTTKTGQMD
310 320 330 340 350
GIPMSMKNEM PISQLLMIIA PSLGFVLFAL FVAFLLRGKL METYCSQKHT
360 370
RLDYIGDSKN VLNDVQHGRE DEDGLFTL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB5MCV9 | B5MCV9_HUMAN | T-cell immunoglobulin and mucin dom... | TIMD4 | 80 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 67 | A → T in AK301337 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049946 | 240 | V → A2 PublicationsCorresponds to variant dbSNP:rs6873053Ensembl. | 1 | |
Natural variantiVAR_049947 | 365 | V → M. Corresponds to variant dbSNP:rs7731575EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045474 | 254 – 281 | Missing in isoform 2. 1 PublicationAdd BLAST | 28 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK301337 mRNA No translation available. AC008491 Genomic DNA No translation available. AC026777 Genomic DNA No translation available. BC008988 mRNA Translation: AAH08988.1 |
CCDSi | CCDS4332.1 [Q96H15-1] CCDS54943.1 [Q96H15-2] |
RefSeqi | NP_001140198.1, NM_001146726.1 [Q96H15-2] NP_612388.2, NM_138379.2 [Q96H15-1] |
Genome annotation databases
Ensembli | ENST00000274532; ENSP00000274532; ENSG00000145850 [Q96H15-1] ENST00000407087; ENSP00000385973; ENSG00000145850 [Q96H15-2] |
GeneIDi | 91937 |
KEGGi | hsa:91937 |
UCSCi | uc003lwh.2, human [Q96H15-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK301337 mRNA No translation available. AC008491 Genomic DNA No translation available. AC026777 Genomic DNA No translation available. BC008988 mRNA Translation: AAH08988.1 |
CCDSi | CCDS4332.1 [Q96H15-1] CCDS54943.1 [Q96H15-2] |
RefSeqi | NP_001140198.1, NM_001146726.1 [Q96H15-2] NP_612388.2, NM_138379.2 [Q96H15-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5DZN | X-ray | 2.30 | A/B/C/D/E/F/G/H | 22-134 | [»] | |
5F7F | X-ray | 1.50 | A/B | 24-134 | [»] | |
5F7H | X-ray | 2.50 | A/B/C/D/E/F | 24-134 | [»] | |
SMRi | Q96H15 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 124892, 3 interactors |
STRINGi | 9606.ENSP00000274532 |
PTM databases
GlyGeni | Q96H15, 1 site |
iPTMneti | Q96H15 |
PhosphoSitePlusi | Q96H15 |
Genetic variation databases
BioMutai | TIMD4 |
DMDMi | 296452930 |
Proteomic databases
PaxDbi | Q96H15 |
PeptideAtlasi | Q96H15 |
PRIDEi | Q96H15 |
ProteomicsDBi | 6068 76694 [Q96H15-1] |
Protocols and materials databases
Antibodypediai | 2737, 437 antibodies |
DNASUi | 91937 |
Genome annotation databases
Ensembli | ENST00000274532; ENSP00000274532; ENSG00000145850 [Q96H15-1] ENST00000407087; ENSP00000385973; ENSG00000145850 [Q96H15-2] |
GeneIDi | 91937 |
KEGGi | hsa:91937 |
UCSCi | uc003lwh.2, human [Q96H15-1] |
Organism-specific databases
CTDi | 91937 |
DisGeNETi | 91937 |
GeneCardsi | TIMD4 |
HGNCi | HGNC:25132, TIMD4 |
HPAi | ENSG00000145850, Group enriched (liver, lymphoid tissue, testis) |
MIMi | 610096, gene |
neXtProti | NX_Q96H15 |
OpenTargetsi | ENSG00000145850 |
PharmGKBi | PA134989118 |
VEuPathDBi | HostDB:ENSG00000145850.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S1A2, Eukaryota |
GeneTreei | ENSGT00940000161609 |
HOGENOMi | CLU_047504_0_1_1 |
InParanoidi | Q96H15 |
OMAi | QSRNSMC |
OrthoDBi | 1147868at2759 |
PhylomeDBi | Q96H15 |
TreeFami | TF336163 |
Enzyme and pathway databases
PathwayCommonsi | Q96H15 |
Miscellaneous databases
BioGRID-ORCSi | 91937, 5 hits in 978 CRISPR screens |
GeneWikii | TIMD4 |
GenomeRNAii | 91937 |
Pharosi | Q96H15, Tbio |
PROi | PR:Q96H15 |
RNActi | Q96H15, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000145850, Expressed in right testis and 116 other tissues |
ExpressionAtlasi | Q96H15, baseline and differential |
Genevisiblei | Q96H15, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TIMD4_HUMAN | |
Accessioni | Q96H15Primary (citable) accession number: Q96H15 Secondary accession number(s): B5MCL9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2005 |
Last sequence update: | May 18, 2010 | |
Last modified: | April 7, 2021 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families