UniProtKB - Q96H12 (MSD3_HUMAN)

BLAST

>sp|Q96H12|MSD3_HUMAN Myb/SANT-like DNA-binding domain-containing protein 3 OS=Homo sapiens OX=9606 GN=MSANTD3 PE=1 SV=1
MQNNEIIKPAKYFSELEKSILLALVEKYKYVLECKKSDARTIALKQRTWQALAHEYNSQP
SVSLRDFKQLKKCWENIKARTKKIMAHERREKVKRSVSPLLSTHVLGKEKIASMLPEQLY
FLQSPPEEEPEYHPDASAQESFAVSNRELCDDEKEFIHFPVCEGTSQPEPSCSAVRITAN
KNYRSKTSQEGALKKMHEEEHHQQMSILQLQLIQMNEVHVAKIQQIERECEMAEEEHRIK
MEVLNKKKMYWERKLQTFTKEWPVSSFNRPFPNSP

Align

Format
Add to basket Added to basket
History
Entry version 115 (07 Nov 2018)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Myb/SANT-like DNA-binding domain-containing protein 3

Gene

MSANTD3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

identical protein binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Myb/SANT-like DNA-binding domain-containing protein 3
Gene namesⁱ	Name:MSANTD3 Synonyms:C9orf30 ORF Names:L8
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000066697.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23370 MSANTD3
neXtProtⁱ	NX_Q96H12

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000066697
PharmGKBⁱ	PA142672311

Polymorphism and mutation databases

BioMutaⁱ	MSANTD3
DMDMⁱ	74751897

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000292590	1 – 275	Myb/SANT-like DNA-binding domain-containing protein 3Add BLAST		275

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	96	PhosphoserineCombined sources	1
Modified residueⁱ	98	PhosphoserineCombined sources	1
Cross-linkⁱ	154	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	274	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q96H12
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96H12
PaxDbⁱ	Q96H12
PeptideAtlas More...PeptideAtlasⁱ	Q96H12
PRIDEⁱ	Q96H12
ProteomicsDBⁱ	76693

PTM databases

iPTMnetⁱ	Q96H12
PhosphoSitePlusⁱ	Q96H12

Expressionⁱ

Tissue specificityⁱ

Expressed in brain.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000066697 Expressed in 196 organ(s), highest expression level in female gonad
CleanExⁱ	HS_C9orf30
ExpressionAtlasⁱ	Q96H12 baseline and differential
Genevisibleⁱ	Q96H12 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA062662

HPAⁱ

HPA062662

Interactionⁱ

GO - Molecular functionⁱ

identical protein binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	124810, 3 interactors
IntActⁱ	Q96H12, 15 interactors
Molecular INTeraction database More...MINTⁱ	Q96H12
STRINGⁱ	9606.ENSP00000378506

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96H12
SMRⁱ	Q96H12
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	13 – 78	Myb-likeAdd BLAST		66

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	211 – 247	Sequence analysisAdd BLAST		37

Sequence similaritiesⁱ

Belongs to the MSANTD3 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IIVN Eukaryota ENOG410XY2Z LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007901
HOGENOMⁱ	HOG000111635
HOVERGENⁱ	HBG101140
InParanoidⁱ	Q96H12
OMAⁱ	CSDVRIA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G18KL
PhylomeDBⁱ	Q96H12
TreeFamⁱ	TF328595

Family and domain databases

InterProⁱ	View protein in InterPro IPR026709 Msantd3 IPR028002 Myb_DNA-bind_5
PANTHERⁱ	PTHR21632 PTHR21632, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13873 Myb_DNA-bind_5, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96H12-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQNNEIIKPA KYFSELEKSI LLALVEKYKY VLECKKSDAR TIALKQRTWQ 
        60         70         80         90        100
ALAHEYNSQP SVSLRDFKQL KKCWENIKAR TKKIMAHERR EKVKRSVSPL 
       110        120        130        140        150
LSTHVLGKEK IASMLPEQLY FLQSPPEEEP EYHPDASAQE SFAVSNRELC 
       160        170        180        190        200
DDEKEFIHFP VCEGTSQPEP SCSAVRITAN KNYRSKTSQE GALKKMHEEE 
       210        220        230        240        250
HHQQMSILQL QLIQMNEVHV AKIQQIEREC EMAEEEHRIK MEVLNKKKMY 
       260        270 
WERKLQTFTK EWPVSSFNRP FPNSP

Length:275

Mass (Da):32,363

Last modified:December 1, 2001 - v1

Checksum:ⁱ1CB06C2AD26FD135

Isoform 2 (identifier: Q96H12-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
140-159: ESFAVSNRELCDDEKEFIHF → VFFQERKRSLELSIILSGTW
160-275: Missing.

« Hide

        10         20         30         40         50
MQNNEIIKPA KYFSELEKSI LLALVEKYKY VLECKKSDAR TIALKQRTWQ 
        60         70         80         90        100
ALAHEYNSQP SVSLRDFKQL KKCWENIKAR TKKIMAHERR EKVKRSVSPL 
       110        120        130        140        150
LSTHVLGKEK IASMLPEQLY FLQSPPEEEP EYHPDASAQV FFQERKRSLE 

LSIILSGTW

Show »

Length:159

Mass (Da):18,665

Checksum:ⁱ2D0742D6201C1596

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

X6R907	X6R907_HUMAN	Myb/SANT-like DNA-binding domain-co... Myb/SANT-like DNA-binding domain-containing protein 3	MSANTD3	181	Annotation score:
X6RL08	X6RL08_HUMAN	Myb/SANT-like DNA-binding domain-co... Myb/SANT-like DNA-binding domain-containing protein 3	MSANTD3	134	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_053346	140 – 159	ESFAV…EFIHF → VFFQERKRSLELSIILSGTW in isoform 2. CuratedAdd BLAST		20
Alternative sequenceⁱVSP_053347	160 – 275	Missing in isoform 2. CuratedAdd BLAST		116

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY598327 mRNA Translation: AAT06738.1 AK314924 mRNA Translation: BAG37432.1 AL353805 Genomic DNA No translation available. BC008993 mRNA Translation: AAH08993.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS56579.1 [Q96H12-2] CCDS6749.1 [Q96H12-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001185734.1, NM_001198805.1 [Q96H12-1] NP_001185735.1, NM_001198806.1 [Q96H12-1] NP_001185736.1, NM_001198807.1 [Q96H12-2] NP_542386.1, NM_080655.2 [Q96H12-1]
UniGeneⁱ	Hs.530272 Hs.732964

Genome annotation databases

Ensemblⁱ	ENST00000374885; ENSP00000364020; ENSG00000066697 [Q96H12-2] ENST00000395067; ENSP00000378506; ENSG00000066697 [Q96H12-1] ENST00000613183; ENSP00000480445; ENSG00000066697 [Q96H12-1] ENST00000622639; ENSP00000480622; ENSG00000066697 [Q96H12-1]
GeneIDⁱ	91283
KEGGⁱ	hsa:91283
UCSC genome browser More...UCSCⁱ	uc004baw.4 human [Q96H12-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q96H12	Chromosome 9 open reading frame 30, isoform CRA_a		HUMAN		275	UniRef100_Q96H12
Uncharacterized protein		MACMU		275
Chromosome 9 open reading frame 30		PANTR		275
MSANTD3-TMEFF1 readthrough		CERAT		275
MSANTD3-TMEFF1 readthrough		MACFA		275
+11
Q96H12-2	Uncharacterized protein		NOMLE		160	UniRef100_A0A2I3HYR7
MSANTD3 isoform 5		PANTR		159
Uncharacterized protein		PANPA		159

Protein	Similar proteins		Species	Score	Length	Source
Q96H12	Myb/SANT-like DNA-binding domain-containing protein 3		BOVIN		275	UniRef90_Q96H12
Myb/SANT-like DNA-binding domain-containing protein 3		MOUSE		275
Chromosome 9 open reading frame 30, isoform CRA_a		HUMAN		275
Uncharacterized protein		MACMU		275
Chromosome 9 open reading frame 30		PANTR		275
+86
Q96H12-2	myb/SANT-like DNA-binding domain-containing protein 3 isoform X2		Enhydra lutris kenyoni		149	UniRef90_A0A2Y9J734
Uncharacterized protein		PROCO		160
Uncharacterized protein		CALJA		160
Uncharacterized protein		COLAP		160
Uncharacterized protein		RHIRO		160
+17

Protein	Similar proteins		Species	Score	Length	Source
Q96H12	Myb/SANT-like DNA-binding domain-containing protein 3		MOUSE		275	UniRef50_Q96H12
Myb/SANT-like DNA-binding domain-containing protein 3		BOVIN		275
Chromosome 9 open reading frame 30, isoform CRA_a		HUMAN		275
Uncharacterized protein		MACMU		275
Chromosome 9 open reading frame 30		PANTR		275
+190
Q96H12-2	myb/SANT-like DNA-binding domain-containing protein 3 isoform X2		Enhydra lutris kenyoni		149	UniRef50_A0A2Y9J734
Uncharacterized protein		CERAT		160
Uncharacterized protein		MANLE		160
Uncharacterized protein		COLAP		160
Uncharacterized protein		RHIRO		160
+21

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY598327 mRNA Translation: AAT06738.1 AK314924 mRNA Translation: BAG37432.1 AL353805 Genomic DNA No translation available. BC008993 mRNA Translation: AAH08993.1
CCDSⁱ	CCDS56579.1 [Q96H12-2] CCDS6749.1 [Q96H12-1]
RefSeqⁱ	NP_001185734.1, NM_001198805.1 [Q96H12-1] NP_001185735.1, NM_001198806.1 [Q96H12-1] NP_001185736.1, NM_001198807.1 [Q96H12-2] NP_542386.1, NM_080655.2 [Q96H12-1]
UniGeneⁱ	Hs.530272 Hs.732964

3D structure databases

ProteinModelPortalⁱ	Q96H12
SMRⁱ	Q96H12
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124810, 3 interactors
IntActⁱ	Q96H12, 15 interactors
MINTⁱ	Q96H12
STRINGⁱ	9606.ENSP00000378506

PTM databases

iPTMnetⁱ	Q96H12
PhosphoSitePlusⁱ	Q96H12

Polymorphism and mutation databases

BioMutaⁱ	MSANTD3
DMDMⁱ	74751897

Proteomic databases

EPDⁱ	Q96H12
MaxQBⁱ	Q96H12
PaxDbⁱ	Q96H12
PeptideAtlasⁱ	Q96H12
PRIDEⁱ	Q96H12
ProteomicsDBⁱ	76693

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	91283
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000374885; ENSP00000364020; ENSG00000066697 [Q96H12-2] ENST00000395067; ENSP00000378506; ENSG00000066697 [Q96H12-1] ENST00000613183; ENSP00000480445; ENSG00000066697 [Q96H12-1] ENST00000622639; ENSP00000480622; ENSG00000066697 [Q96H12-1]
GeneIDⁱ	91283
KEGGⁱ	hsa:91283
UCSCⁱ	uc004baw.4 human [Q96H12-1]

Organism-specific databases

CTDⁱ	91283
EuPathDBⁱ	HostDB:ENSG00000066697.14
GeneCardsⁱ	MSANTD3
H-InvDBⁱ	HIX0008239
HGNCⁱ	HGNC:23370 MSANTD3
HPAⁱ	HPA062662
neXtProtⁱ	NX_Q96H12
OpenTargetsⁱ	ENSG00000066697
PharmGKBⁱ	PA142672311
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IIVN Eukaryota ENOG410XY2Z LUCA
GeneTreeⁱ	ENSGT00390000007901
HOGENOMⁱ	HOG000111635
HOVERGENⁱ	HBG101140
InParanoidⁱ	Q96H12
OMAⁱ	CSDVRIA
OrthoDBⁱ	EOG091G18KL
PhylomeDBⁱ	Q96H12
TreeFamⁱ	TF328595

Miscellaneous databases

ChiTaRSⁱ	MSANTD3 human
GenomeRNAiⁱ	91283
Protein Ontology More...PROⁱ	PR:Q96H12

Gene expression databases

Bgeeⁱ	ENSG00000066697 Expressed in 196 organ(s), highest expression level in female gonad
CleanExⁱ	HS_C9orf30
ExpressionAtlasⁱ	Q96H12 baseline and differential
Genevisibleⁱ	Q96H12 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR026709 Msantd3 IPR028002 Myb_DNA-bind_5
PANTHERⁱ	PTHR21632 PTHR21632, 1 hit
Pfamⁱ	View protein in Pfam PF13873 Myb_DNA-bind_5, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MSD3_HUMAN
Accessionⁱ	Q96H12Primary (citable) accession number: Q96H12 Secondary accession number(s): B2RC35 , Q5T726, Q5T727, Q5T728
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
	Last sequence update:	December 1, 2001
	Last modified:	November 7, 2018
	This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q96H12 (MSD3_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Myb/SANT-like DNA-binding domain-containing protein 3

MSANTD3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ