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Protein

Myb/SANT-like DNA-binding domain-containing protein 3

Gene

MSANTD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • identical protein binding Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Myb/SANT-like DNA-binding domain-containing protein 3
Gene namesi
Name:MSANTD3
Synonyms:C9orf30
ORF Names:L8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000066697.14
HGNCiHGNC:23370 MSANTD3
neXtProtiNX_Q96H12

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000066697
PharmGKBiPA142672311

Polymorphism and mutation databases

BioMutaiMSANTD3
DMDMi74751897

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002925901 – 275Myb/SANT-like DNA-binding domain-containing protein 3Add BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei96PhosphoserineCombined sources1
Modified residuei98PhosphoserineCombined sources1
Cross-linki154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei274PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96H12
MaxQBiQ96H12
PaxDbiQ96H12
PeptideAtlasiQ96H12
PRIDEiQ96H12
ProteomicsDBi76693

PTM databases

iPTMnetiQ96H12
PhosphoSitePlusiQ96H12

Expressioni

Tissue specificityi

Expressed in brain.1 Publication

Gene expression databases

BgeeiENSG00000066697 Expressed in 196 organ(s), highest expression level in female gonad
CleanExiHS_C9orf30
ExpressionAtlasiQ96H12 baseline and differential
GenevisibleiQ96H12 HS

Organism-specific databases

HPAiHPA062662

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124810, 3 interactors
IntActiQ96H12, 15 interactors
MINTiQ96H12
STRINGi9606.ENSP00000378506

Structurei

3D structure databases

ProteinModelPortaliQ96H12
SMRiQ96H12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 78Myb-likeAdd BLAST66

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili211 – 247Sequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the MSANTD3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIVN Eukaryota
ENOG410XY2Z LUCA
GeneTreeiENSGT00390000007901
HOGENOMiHOG000111635
HOVERGENiHBG101140
InParanoidiQ96H12
OMAiCSDVRIA
OrthoDBiEOG091G18KL
PhylomeDBiQ96H12
TreeFamiTF328595

Family and domain databases

InterProiView protein in InterPro
IPR026709 Msantd3
IPR028002 Myb_DNA-bind_5
PANTHERiPTHR21632 PTHR21632, 1 hit
PfamiView protein in Pfam
PF13873 Myb_DNA-bind_5, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96H12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQNNEIIKPA KYFSELEKSI LLALVEKYKY VLECKKSDAR TIALKQRTWQ
60 70 80 90 100
ALAHEYNSQP SVSLRDFKQL KKCWENIKAR TKKIMAHERR EKVKRSVSPL
110 120 130 140 150
LSTHVLGKEK IASMLPEQLY FLQSPPEEEP EYHPDASAQE SFAVSNRELC
160 170 180 190 200
DDEKEFIHFP VCEGTSQPEP SCSAVRITAN KNYRSKTSQE GALKKMHEEE
210 220 230 240 250
HHQQMSILQL QLIQMNEVHV AKIQQIEREC EMAEEEHRIK MEVLNKKKMY
260 270
WERKLQTFTK EWPVSSFNRP FPNSP
Length:275
Mass (Da):32,363
Last modified:December 1, 2001 - v1
Checksum:i1CB06C2AD26FD135
GO
Isoform 2 (identifier: Q96H12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-159: ESFAVSNRELCDDEKEFIHF → VFFQERKRSLELSIILSGTW
     160-275: Missing.

Show »
Length:159
Mass (Da):18,665
Checksum:i2D0742D6201C1596
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R907X6R907_HUMAN
Myb/SANT-like DNA-binding domain-co...
MSANTD3
181Annotation score:
X6RL08X6RL08_HUMAN
Myb/SANT-like DNA-binding domain-co...
MSANTD3
134Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053346140 – 159ESFAV…EFIHF → VFFQERKRSLELSIILSGTW in isoform 2. CuratedAdd BLAST20
Alternative sequenceiVSP_053347160 – 275Missing in isoform 2. CuratedAdd BLAST116

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598327 mRNA Translation: AAT06738.1
AK314924 mRNA Translation: BAG37432.1
AL353805 Genomic DNA No translation available.
BC008993 mRNA Translation: AAH08993.1
CCDSiCCDS56579.1 [Q96H12-2]
CCDS6749.1 [Q96H12-1]
RefSeqiNP_001185734.1, NM_001198805.1 [Q96H12-1]
NP_001185735.1, NM_001198806.1 [Q96H12-1]
NP_001185736.1, NM_001198807.1 [Q96H12-2]
NP_542386.1, NM_080655.2 [Q96H12-1]
UniGeneiHs.530272
Hs.732964

Genome annotation databases

EnsembliENST00000374885; ENSP00000364020; ENSG00000066697 [Q96H12-2]
ENST00000395067; ENSP00000378506; ENSG00000066697 [Q96H12-1]
ENST00000613183; ENSP00000480445; ENSG00000066697 [Q96H12-1]
ENST00000622639; ENSP00000480622; ENSG00000066697 [Q96H12-1]
GeneIDi91283
KEGGihsa:91283
UCSCiuc004baw.4 human [Q96H12-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598327 mRNA Translation: AAT06738.1
AK314924 mRNA Translation: BAG37432.1
AL353805 Genomic DNA No translation available.
BC008993 mRNA Translation: AAH08993.1
CCDSiCCDS56579.1 [Q96H12-2]
CCDS6749.1 [Q96H12-1]
RefSeqiNP_001185734.1, NM_001198805.1 [Q96H12-1]
NP_001185735.1, NM_001198806.1 [Q96H12-1]
NP_001185736.1, NM_001198807.1 [Q96H12-2]
NP_542386.1, NM_080655.2 [Q96H12-1]
UniGeneiHs.530272
Hs.732964

3D structure databases

ProteinModelPortaliQ96H12
SMRiQ96H12
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124810, 3 interactors
IntActiQ96H12, 15 interactors
MINTiQ96H12
STRINGi9606.ENSP00000378506

PTM databases

iPTMnetiQ96H12
PhosphoSitePlusiQ96H12

Polymorphism and mutation databases

BioMutaiMSANTD3
DMDMi74751897

Proteomic databases

EPDiQ96H12
MaxQBiQ96H12
PaxDbiQ96H12
PeptideAtlasiQ96H12
PRIDEiQ96H12
ProteomicsDBi76693

Protocols and materials databases

DNASUi91283
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374885; ENSP00000364020; ENSG00000066697 [Q96H12-2]
ENST00000395067; ENSP00000378506; ENSG00000066697 [Q96H12-1]
ENST00000613183; ENSP00000480445; ENSG00000066697 [Q96H12-1]
ENST00000622639; ENSP00000480622; ENSG00000066697 [Q96H12-1]
GeneIDi91283
KEGGihsa:91283
UCSCiuc004baw.4 human [Q96H12-1]

Organism-specific databases

CTDi91283
EuPathDBiHostDB:ENSG00000066697.14
GeneCardsiMSANTD3
H-InvDBiHIX0008239
HGNCiHGNC:23370 MSANTD3
HPAiHPA062662
neXtProtiNX_Q96H12
OpenTargetsiENSG00000066697
PharmGKBiPA142672311
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIVN Eukaryota
ENOG410XY2Z LUCA
GeneTreeiENSGT00390000007901
HOGENOMiHOG000111635
HOVERGENiHBG101140
InParanoidiQ96H12
OMAiCSDVRIA
OrthoDBiEOG091G18KL
PhylomeDBiQ96H12
TreeFamiTF328595

Miscellaneous databases

ChiTaRSiMSANTD3 human
GenomeRNAii91283
PROiPR:Q96H12

Gene expression databases

BgeeiENSG00000066697 Expressed in 196 organ(s), highest expression level in female gonad
CleanExiHS_C9orf30
ExpressionAtlasiQ96H12 baseline and differential
GenevisibleiQ96H12 HS

Family and domain databases

InterProiView protein in InterPro
IPR026709 Msantd3
IPR028002 Myb_DNA-bind_5
PANTHERiPTHR21632 PTHR21632, 1 hit
PfamiView protein in Pfam
PF13873 Myb_DNA-bind_5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMSD3_HUMAN
AccessioniPrimary (citable) accession number: Q96H12
Secondary accession number(s): B2RC35
, Q5T726, Q5T727, Q5T728
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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