UniProtKB - Q96H12 (MSD3_HUMAN)
Protein
Myb/SANT-like DNA-binding domain-containing protein 3
Gene
MSANTD3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- identical protein binding Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q96H12 |
Names & Taxonomyi
Protein namesi | Recommended name: Myb/SANT-like DNA-binding domain-containing protein 3 |
Gene namesi | Name:MSANTD3 Synonyms:C9orf30 ORF Names:L8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23370, MSANTD3 |
neXtProti | NX_Q96H12 |
VEuPathDBi | HostDB:ENSG00000066697.14 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 91283 |
OpenTargetsi | ENSG00000066697 |
PharmGKBi | PA142672311 |
Miscellaneous databases
Pharosi | Q96H12, Tdark |
Genetic variation databases
BioMutai | MSANTD3 |
DMDMi | 74751897 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000292590 | 1 – 275 | Myb/SANT-like DNA-binding domain-containing protein 3Add BLAST | 275 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 96 | PhosphoserineCombined sources | 1 | |
Modified residuei | 98 | PhosphoserineCombined sources | 1 | |
Cross-linki | 154 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 274 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q96H12 |
jPOSTi | Q96H12 |
MassIVEi | Q96H12 |
MaxQBi | Q96H12 |
PaxDbi | Q96H12 |
PeptideAtlasi | Q96H12 |
PRIDEi | Q96H12 |
ProteomicsDBi | 76693 [Q96H12-1] |
PTM databases
iPTMneti | Q96H12 |
PhosphoSitePlusi | Q96H12 |
Expressioni
Tissue specificityi
Expressed in brain.1 Publication
Gene expression databases
Bgeei | ENSG00000066697, Expressed in female gonad and 211 other tissues |
ExpressionAtlasi | Q96H12, baseline and differential |
Genevisiblei | Q96H12, HS |
Organism-specific databases
HPAi | ENSG00000066697, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ96H12
GO - Molecular functioni
- identical protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 124810, 17 interactors |
IntActi | Q96H12, 24 interactors |
MINTi | Q96H12 |
STRINGi | 9606.ENSP00000480445 |
Miscellaneous databases
RNActi | Q96H12, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 78 | Myb-likeAdd BLAST | 66 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 211 – 247 | Sequence analysisAdd BLAST | 37 |
Sequence similaritiesi
Belongs to the MSANTD3 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502RFDD, Eukaryota |
GeneTreei | ENSGT00390000007901 |
HOGENOMi | CLU_065066_0_0_1 |
InParanoidi | Q96H12 |
OMAi | QIYFLQS |
PhylomeDBi | Q96H12 |
TreeFami | TF328595 |
Family and domain databases
InterProi | View protein in InterPro IPR026709, Msantd3 IPR028002, Myb_DNA-bind_5 |
PANTHERi | PTHR21632, PTHR21632, 1 hit |
Pfami | View protein in Pfam PF13873, Myb_DNA-bind_5, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96H12-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQNNEIIKPA KYFSELEKSI LLALVEKYKY VLECKKSDAR TIALKQRTWQ
60 70 80 90 100
ALAHEYNSQP SVSLRDFKQL KKCWENIKAR TKKIMAHERR EKVKRSVSPL
110 120 130 140 150
LSTHVLGKEK IASMLPEQLY FLQSPPEEEP EYHPDASAQE SFAVSNRELC
160 170 180 190 200
DDEKEFIHFP VCEGTSQPEP SCSAVRITAN KNYRSKTSQE GALKKMHEEE
210 220 230 240 250
HHQQMSILQL QLIQMNEVHV AKIQQIEREC EMAEEEHRIK MEVLNKKKMY
260 270
WERKLQTFTK EWPVSSFNRP FPNSP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketX6R907 | X6R907_HUMAN | Myb/SANT-like DNA-binding domain-co... | MSANTD3 | 181 | Annotation score: | ||
X6RL08 | X6RL08_HUMAN | Myb/SANT-like DNA-binding domain-co... | MSANTD3 | 134 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053346 | 140 – 159 | ESFAV…EFIHF → VFFQERKRSLELSIILSGTW in isoform 2. CuratedAdd BLAST | 20 | |
Alternative sequenceiVSP_053347 | 160 – 275 | Missing in isoform 2. CuratedAdd BLAST | 116 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY598327 mRNA Translation: AAT06738.1 AK314924 mRNA Translation: BAG37432.1 AL353805 Genomic DNA No translation available. BC008993 mRNA Translation: AAH08993.1 |
CCDSi | CCDS56579.1 [Q96H12-2] CCDS6749.1 [Q96H12-1] |
RefSeqi | NP_001185734.1, NM_001198805.1 [Q96H12-1] NP_001185735.1, NM_001198806.1 [Q96H12-1] NP_001185736.1, NM_001198807.1 [Q96H12-2] NP_542386.1, NM_080655.2 [Q96H12-1] |
Genome annotation databases
Ensembli | ENST00000374885; ENSP00000364020; ENSG00000066697 [Q96H12-2] ENST00000395067; ENSP00000378506; ENSG00000066697 [Q96H12-1] ENST00000613183; ENSP00000480445; ENSG00000066697 [Q96H12-1] ENST00000622639; ENSP00000480622; ENSG00000066697 [Q96H12-1] |
GeneIDi | 91283 |
KEGGi | hsa:91283 |
UCSCi | uc004baw.4, human [Q96H12-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY598327 mRNA Translation: AAT06738.1 AK314924 mRNA Translation: BAG37432.1 AL353805 Genomic DNA No translation available. BC008993 mRNA Translation: AAH08993.1 |
CCDSi | CCDS56579.1 [Q96H12-2] CCDS6749.1 [Q96H12-1] |
RefSeqi | NP_001185734.1, NM_001198805.1 [Q96H12-1] NP_001185735.1, NM_001198806.1 [Q96H12-1] NP_001185736.1, NM_001198807.1 [Q96H12-2] NP_542386.1, NM_080655.2 [Q96H12-1] |
3D structure databases
SMRi | Q96H12 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124810, 17 interactors |
IntActi | Q96H12, 24 interactors |
MINTi | Q96H12 |
STRINGi | 9606.ENSP00000480445 |
PTM databases
iPTMneti | Q96H12 |
PhosphoSitePlusi | Q96H12 |
Genetic variation databases
BioMutai | MSANTD3 |
DMDMi | 74751897 |
Proteomic databases
EPDi | Q96H12 |
jPOSTi | Q96H12 |
MassIVEi | Q96H12 |
MaxQBi | Q96H12 |
PaxDbi | Q96H12 |
PeptideAtlasi | Q96H12 |
PRIDEi | Q96H12 |
ProteomicsDBi | 76693 [Q96H12-1] |
Protocols and materials databases
Antibodypediai | 34901, 77 antibodies |
DNASUi | 91283 |
Genome annotation databases
Ensembli | ENST00000374885; ENSP00000364020; ENSG00000066697 [Q96H12-2] ENST00000395067; ENSP00000378506; ENSG00000066697 [Q96H12-1] ENST00000613183; ENSP00000480445; ENSG00000066697 [Q96H12-1] ENST00000622639; ENSP00000480622; ENSG00000066697 [Q96H12-1] |
GeneIDi | 91283 |
KEGGi | hsa:91283 |
UCSCi | uc004baw.4, human [Q96H12-1] |
Organism-specific databases
CTDi | 91283 |
DisGeNETi | 91283 |
GeneCardsi | MSANTD3 |
HGNCi | HGNC:23370, MSANTD3 |
HPAi | ENSG00000066697, Low tissue specificity |
neXtProti | NX_Q96H12 |
OpenTargetsi | ENSG00000066697 |
PharmGKBi | PA142672311 |
VEuPathDBi | HostDB:ENSG00000066697.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RFDD, Eukaryota |
GeneTreei | ENSGT00390000007901 |
HOGENOMi | CLU_065066_0_0_1 |
InParanoidi | Q96H12 |
OMAi | QIYFLQS |
PhylomeDBi | Q96H12 |
TreeFami | TF328595 |
Enzyme and pathway databases
PathwayCommonsi | Q96H12 |
Miscellaneous databases
BioGRID-ORCSi | 91283, 8 hits in 990 CRISPR screens |
ChiTaRSi | MSANTD3, human |
GenomeRNAii | 91283 |
Pharosi | Q96H12, Tdark |
PROi | PR:Q96H12 |
RNActi | Q96H12, protein |
Gene expression databases
Bgeei | ENSG00000066697, Expressed in female gonad and 211 other tissues |
ExpressionAtlasi | Q96H12, baseline and differential |
Genevisiblei | Q96H12, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026709, Msantd3 IPR028002, Myb_DNA-bind_5 |
PANTHERi | PTHR21632, PTHR21632, 1 hit |
Pfami | View protein in Pfam PF13873, Myb_DNA-bind_5, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MSD3_HUMAN | |
Accessioni | Q96H12Primary (citable) accession number: Q96H12 Secondary accession number(s): B2RC35 Q5T728 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2007 |
Last sequence update: | December 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families