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Protein

Protein lin-37 homolog

Gene

LIN37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-1538133 G0 and Early G1
R-HSA-156711 Polo-like kinase mediated events
R-HSA-539107 Activation of E2F1 target genes at G1/S
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
SignaLinkiQ96GY3

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-37 homolog
Alternative name(s):
Antolefinin
Gene namesi
Name:LIN37
ORF Names:MSTP064
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000267796.7
HGNCiHGNC:33234 LIN37
neXtProtiNX_Q96GY3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000267796
PharmGKBiPA162394016

Polymorphism and mutation databases

BioMutaiLIN37

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002384791 – 246Protein lin-37 homologAdd BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki7Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei135PhosphoserineBy similarity1
Modified residuei138PhosphoserineCombined sources1
Modified residuei167PhosphothreonineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei202PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96GY3
MaxQBiQ96GY3
PaxDbiQ96GY3
PeptideAtlasiQ96GY3
PRIDEiQ96GY3
ProteomicsDBi76683

PTM databases

iPTMnetiQ96GY3
PhosphoSitePlusiQ96GY3

Expressioni

Gene expression databases

BgeeiENSG00000267796 Expressed in 115 organ(s), highest expression level in right ovary
CleanExiHS_LIN37
ExpressionAtlasiQ96GY3 baseline and differential
GenevisibleiQ96GY3 HS

Organism-specific databases

HPAiHPA043253
HPA047809

Interactioni

Subunit structurei

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi121008, 32 interactors
CORUMiQ96GY3
IntActiQ96GY3, 40 interactors
MINTiQ96GY3
STRINGi9606.ENSP00000301159

Structurei

3D structure databases

ProteinModelPortaliQ96GY3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi136 – 203Pro-richAdd BLAST68

Phylogenomic databases

eggNOGiENOG410II8K Eukaryota
ENOG4111QJM LUCA
GeneTreeiENSGT00390000002748
HOGENOMiHOG000006536
HOVERGENiHBG054424
InParanoidiQ96GY3
KOiK21774
OMAiQKWKECS
OrthoDBiEOG091G0HEY
PhylomeDBiQ96GY3
TreeFamiTF329230

Family and domain databases

InterProiView protein in InterPro
IPR028226 LIN37
PANTHERiPTHR31336 PTHR31336, 1 hit
PfamiView protein in Pfam
PF15306 LIN37, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q96GY3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPVKVKVEK SELEMAKARN QLDAVLQCLL EKSHMDRERL DEEAGKTPSD
60 70 80 90 100
THNKDCSIAA TGKRPSARFP HQRRKKRREM DDGLAEGGPQ RSNTYVIKLF
110 120 130 140 150
DRSVDLAQFS ENTPLYPICR AWMRNSPSVR ERECSPSSPL PPLPEDEEGS
160 170 180 190 200
EVTNSKSRDV YKLPPPTPPG PPGDACRSRI PSPLQPEMQG TPDDEPSEPE
210 220 230 240
PSPSTLIYRN MQRWKRIRQR WKEASHRNQL RYSESMKILR EMYERQ
Length:246
Mass (Da):28,383
Last modified:December 1, 2001 - v1
Checksum:i8718E1C8FB13C446
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EMY4K7EMY4_HUMAN
Protein lin-37 homolog
LIN37
163Annotation score:
M0QYM3M0QYM3_HUMAN
Protein lin-37 homolog
LIN37
54Annotation score:
K7ELP2K7ELP2_HUMAN
Protein lin-37 homolog
LIN37
19Annotation score:

Sequence cautioni

The sequence AAB81199 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06167416A → V. Corresponds to variant dbSNP:rs170758Ensembl.1
Natural variantiVAR_051093172P → S. Corresponds to variant dbSNP:rs35617825Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293116 mRNA Translation: BAF85805.1
AC002398 Genomic DNA Translation: AAB81199.1 Sequence problems.
AD000671 Genomic DNA No translation available.
BC009071 mRNA Translation: AAH09071.1
AF162447 mRNA Translation: AAQ13584.1
CCDSiCCDS62642.1
PIRiT00702
RefSeqiNP_061977.1, NM_019104.2
UniGeneiHs.529100

Genome annotation databases

EnsembliENST00000301159; ENSP00000301159; ENSG00000267796
GeneIDi55957
KEGGihsa:55957
UCSCiuc021usw.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293116 mRNA Translation: BAF85805.1
AC002398 Genomic DNA Translation: AAB81199.1 Sequence problems.
AD000671 Genomic DNA No translation available.
BC009071 mRNA Translation: AAH09071.1
AF162447 mRNA Translation: AAQ13584.1
CCDSiCCDS62642.1
PIRiT00702
RefSeqiNP_061977.1, NM_019104.2
UniGeneiHs.529100

3D structure databases

ProteinModelPortaliQ96GY3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121008, 32 interactors
CORUMiQ96GY3
IntActiQ96GY3, 40 interactors
MINTiQ96GY3
STRINGi9606.ENSP00000301159

PTM databases

iPTMnetiQ96GY3
PhosphoSitePlusiQ96GY3

Polymorphism and mutation databases

BioMutaiLIN37

Proteomic databases

EPDiQ96GY3
MaxQBiQ96GY3
PaxDbiQ96GY3
PeptideAtlasiQ96GY3
PRIDEiQ96GY3
ProteomicsDBi76683

Protocols and materials databases

DNASUi55957
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301159; ENSP00000301159; ENSG00000267796
GeneIDi55957
KEGGihsa:55957
UCSCiuc021usw.1 human

Organism-specific databases

CTDi55957
EuPathDBiHostDB:ENSG00000267796.7
GeneCardsiLIN37
HGNCiHGNC:33234 LIN37
HPAiHPA043253
HPA047809
neXtProtiNX_Q96GY3
OpenTargetsiENSG00000267796
PharmGKBiPA162394016
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II8K Eukaryota
ENOG4111QJM LUCA
GeneTreeiENSGT00390000002748
HOGENOMiHOG000006536
HOVERGENiHBG054424
InParanoidiQ96GY3
KOiK21774
OMAiQKWKECS
OrthoDBiEOG091G0HEY
PhylomeDBiQ96GY3
TreeFamiTF329230

Enzyme and pathway databases

ReactomeiR-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-1538133 G0 and Early G1
R-HSA-156711 Polo-like kinase mediated events
R-HSA-539107 Activation of E2F1 target genes at G1/S
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
SignaLinkiQ96GY3

Miscellaneous databases

ChiTaRSiLIN37 human
GenomeRNAii55957
PROiPR:Q96GY3

Gene expression databases

BgeeiENSG00000267796 Expressed in 115 organ(s), highest expression level in right ovary
CleanExiHS_LIN37
ExpressionAtlasiQ96GY3 baseline and differential
GenevisibleiQ96GY3 HS

Family and domain databases

InterProiView protein in InterPro
IPR028226 LIN37
PANTHERiPTHR31336 PTHR31336, 1 hit
PfamiView protein in Pfam
PF15306 LIN37, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLIN37_HUMAN
AccessioniPrimary (citable) accession number: Q96GY3
Secondary accession number(s): A8KAQ1, O14557, Q7Z2T9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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