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Protein

Zinc finger C2HC domain-containing protein 1A

Gene

ZC2HC1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 39C2HC-typeAdd BLAST25

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger C2HC domain-containing protein 1A
Gene namesi
Name:ZC2HC1A
Synonyms:C8orf70, FAM164A
ORF Names:CGI-62
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104427.11
HGNCiHGNC:24277 ZC2HC1A
neXtProtiNX_Q96GY0

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104427
PharmGKBiPA162386952

Polymorphism and mutation databases

BioMutaiZC2HC1A
DMDMi296434498

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002802461 – 325Zinc finger C2HC domain-containing protein 1AAdd BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei223PhosphoserineCombined sources1
Modified residuei244PhosphothreonineCombined sources1
Modified residuei292PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96GY0
MaxQBiQ96GY0
PaxDbiQ96GY0
PeptideAtlasiQ96GY0
PRIDEiQ96GY0
ProteomicsDBi76682

PTM databases

iPTMnetiQ96GY0
PhosphoSitePlusiQ96GY0

Expressioni

Gene expression databases

BgeeiENSG00000104427
CleanExiHS_FAM164A
ExpressionAtlasiQ96GY0 baseline and differential
GenevisibleiQ96GY0 HS

Organism-specific databases

HPAiHPA024726

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119290, 17 interactors
IntActiQ96GY0, 22 interactors

Structurei

3D structure databases

ProteinModelPortaliQ96GY0
SMRiQ96GY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZC2HC1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 39C2HC-typeAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3940 Eukaryota
ENOG4111J7C LUCA
GeneTreeiENSGT00390000003459
HOGENOMiHOG000068024
HOVERGENiHBG107871
InParanoidiQ96GY0
OMAiCGIRRMV
OrthoDBiEOG091G0BFY
PhylomeDBiQ96GY0
TreeFamiTF319585

Family and domain databases

InterProiView protein in InterPro
IPR026319 ZC2HC1
PANTHERiPTHR13555 PTHR13555, 1 hit

Sequencei

Sequence statusi: Complete.

Q96GY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGLEENGGV VQVGELLPCK ICGRTFFPVA LKKHGPICQK TATKKRKTFD
60 70 80 90 100
SSRQRAEGTD IPTVKPLKPR PEPPKKPSNW RRKHEEFIAT IRAAKGLDQA
110 120 130 140 150
LKEGGKLPPP PPPSYDPDYI QCPYCQRRFN ENAADRHINF CKEQAARISN
160 170 180 190 200
KGKFSTDTKG KPTSRTQVYK PPALKKSNSP GTASSGSSRL PQPSGAGKTV
210 220 230 240 250
VGVPSGKVSS SSSSLGNKLQ TLSPSHKGIA APHAGANVKP RNSTPPSLAR
260 270 280 290 300
NPAPGVLTNK RKTYTESYIA RPDGDCASSL NGGNIKGIEG HSPGNLPKFC
310 320
HECGTKYPVE WAKFCCECGI RRMIL
Length:325
Mass (Da):35,092
Last modified:May 18, 2010 - v2
Checksum:i8ECAA1FB8B00A8BC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151K → E in AAD34057 (PubMed:10810093).Curated1
Sequence conflicti153K → E in AAD34057 (PubMed:10810093).Curated1
Sequence conflicti163T → S in AAD34057 (PubMed:10810093).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031102156T → A1 PublicationCorresponds to variant dbSNP:rs17850447Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151820 mRNA Translation: AAD34057.1
AC100854 Genomic DNA No translation available.
BC009074 mRNA Translation: AAH09074.1
CCDSiCCDS6223.1
RefSeqiNP_057094.2, NM_016010.2
UniGeneiHs.271876

Genome annotation databases

EnsembliENST00000263849; ENSP00000263849; ENSG00000104427
GeneIDi51101
KEGGihsa:51101
UCSCiuc003ybd.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZC21A_HUMAN
AccessioniPrimary (citable) accession number: Q96GY0
Secondary accession number(s): Q9Y372
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 18, 2010
Last modified: July 18, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

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