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Entry version 153 (29 Sep 2021)
Sequence version 2 (10 Jan 2006)
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Protein

Methionine--tRNA ligase, mitochondrial

Gene

MARS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=18 µM for Met1 Publication
  2. KM=85 µM for ATP1 Publication
  3. KM=2.1 µM for tRNA-Met1 Publication

pH dependencei

Optimum pH is 7.8-8.2.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei350ATPBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q96GW9

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-379726, Mitochondrial tRNA aminoacylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methionine--tRNA ligase, mitochondrial (EC:6.1.1.10)
Alternative name(s):
Methionyl-tRNA synthetase 2
Mitochondrial methionyl-tRNA synthetase
Short name:
MtMetRS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MARS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25133, MARS2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609728, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96GW9

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000247626

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spastic ataxia 3, autosomal recessive (SPAX3)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA neurologic disorder characterized by cerebellar ataxia, ataxic gait, spasticity, and hyperreflexia. Other variable features include dysarthria, dysmetria, mild cognitive impairment, urinary urgency and dystonic positioning.
Related information in OMIM
Combined oxidative phosphorylation deficiency 25 (COXPD25)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA mitochondrial disorder resulting in developmental delay, growth failure, and sensorineural hearing loss.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073858142R → W in COXPD25. 1 PublicationCorresponds to variant dbSNP:rs794726870EnsemblClinVar.1

Keywords - Diseasei

Deafness, Disease variant, Neurodegeneration, Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...
DisGeNETi
92935

MalaCards human disease database

More...
MalaCardsi
MARS2
MIMi611390, phenotype
616430, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000247626

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
314603, Autosomal recessive spastic ataxia with leukoencephalopathy
447954, Combined oxidative phosphorylation defect type 25

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134863396

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96GW9, Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00134, Methionine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MARS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
85541638

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004549330 – 593Methionine--tRNA ligase, mitochondrialAdd BLAST564

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96GW9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96GW9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96GW9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96GW9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96GW9

PeptideAtlas

More...
PeptideAtlasi
Q96GW9

PRoteomics IDEntifications database

More...
PRIDEi
Q96GW9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
76673

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q96GW9, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96GW9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96GW9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000247626, Expressed in adrenal tissue and 149 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96GW9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000247626, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124988, 19 interactors

Protein interaction database and analysis system

More...
IntActi
Q96GW9, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000282276

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q96GW9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96GW9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi52 – 62'HIGH' regionAdd BLAST11
Motifi347 – 351'KMSKS' region5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0436, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000075136

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009710_9_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96GW9

Identification of Orthologs from Complete Genome Data

More...
OMAi
TYVWFDA

Database of Orthologous Groups

More...
OrthoDBi
788159at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96GW9

TreeFam database of animal gene trees

More...
TreeFami
TF105709

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07957, Anticodon_Ia_Met, 1 hit
cd00814, MetRS_core, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.620, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041872, Anticodon_Met
IPR014758, Met-tRNA_synth
IPR015413, Methionyl/Leucyl_tRNA_Synth
IPR033911, MetRS_core
IPR014729, Rossmann-like_a/b/a_fold
IPR009080, tRNAsynth_Ia_anticodon-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09334, tRNA-synt_1g, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01041, TRNASYNTHMET

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47323, SSF47323, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00398, metG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q96GW9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRTSVLRLL GRTGASRLSL LEDFGPRYYS SGSLSAGDDA CDVRAYFTTP
60 70 80 90 100
IFYVNAAPHI GHLYSALLAD ALCRHRRLRG PSTAATRFST GTDEHGLKIQ
110 120 130 140 150
QAAATAGLAP TELCDRVSEQ FQQLFQEAGI SCTDFIRTTE ARHRVAVQHF
160 170 180 190 200
WGVLKSRGLL YKGVYEGWYC ASDECFLPEA KVTQQPGPSG DSFPVSLESG
210 220 230 240 250
HPVSWTKEEN YIFRLSQFRK PLQRWLRGNP QAITPEPFHH VVLQWLDEEL
260 270 280 290 300
PDLSVSRRSS HLHWGIPVPG DDSQTIYVWL DALVNYLTVI GYPNAEFKSW
310 320 330 340 350
WPATSHIIGK DILKFHAIYW PAFLLGAGMS PPQRICVHSH WTVCGQKMSK
360 370 380 390 400
SLGNVVDPRT CLNRYTVDGF RYFLLRQGVP NWDCDYYDEK VVKLLNSELA
410 420 430 440 450
DALGGLLNRC TAKRINPSET YPAFCTTCFP SEPGLVGPSV RAQAEDYALV
460 470 480 490 500
SAVATLPKQV ADHYDNFRIY KALEAVSSCV RQTNGFVQRH APWKLNWESP
510 520 530 540 550
VDAPWLGTVL HVALECLRVF GTLLQPVTPS LADKLLSRLG VSASERSLGE
560 570 580 590
LYFLPRFYGH PCPFEGRRLG PETGLLFPRL DQSRTWLVKA HRT
Length:593
Mass (Da):66,591
Last modified:January 10, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA5076FD9F31F4B96
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH09115 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH40934 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti535 – 536LL → MM in BAC92749 (Ref. 1) Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073858142R → W in COXPD25. 1 PublicationCorresponds to variant dbSNP:rs794726870EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB107013 mRNA Translation: BAC92749.1
AK098121 mRNA Translation: BAC05238.1
AC073058 Genomic DNA Translation: AAX93244.1
BC009115 mRNA Translation: AAH09115.1 Different initiation.
BC040934 mRNA Translation: AAH40934.1 Different initiation.
BC126294 mRNA Translation: AAI26295.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33358.1

NCBI Reference Sequences

More...
RefSeqi
NP_612404.1, NM_138395.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000282276; ENSP00000282276; ENSG00000247626

Database of genes from NCBI RefSeq genomes

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GeneIDi
92935

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:92935

UCSC genome browser

More...
UCSCi
uc002uuq.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB107013 mRNA Translation: BAC92749.1
AK098121 mRNA Translation: BAC05238.1
AC073058 Genomic DNA Translation: AAX93244.1
BC009115 mRNA Translation: AAH09115.1 Different initiation.
BC040934 mRNA Translation: AAH40934.1 Different initiation.
BC126294 mRNA Translation: AAI26295.1
CCDSiCCDS33358.1
RefSeqiNP_612404.1, NM_138395.3

3D structure databases

SMRiQ96GW9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124988, 19 interactors
IntActiQ96GW9, 10 interactors
STRINGi9606.ENSP00000282276

Chemistry databases

DrugBankiDB00134, Methionine

PTM databases

GlyGeniQ96GW9, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ96GW9
PhosphoSitePlusiQ96GW9

Genetic variation databases

BioMutaiMARS2
DMDMi85541638

Proteomic databases

EPDiQ96GW9
jPOSTiQ96GW9
MassIVEiQ96GW9
MaxQBiQ96GW9
PaxDbiQ96GW9
PeptideAtlasiQ96GW9
PRIDEiQ96GW9
ProteomicsDBi76673

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
50280, 122 antibodies

The DNASU plasmid repository

More...
DNASUi
92935

Genome annotation databases

EnsembliENST00000282276; ENSP00000282276; ENSG00000247626
GeneIDi92935
KEGGihsa:92935
UCSCiuc002uuq.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
92935
DisGeNETi92935

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MARS2
HGNCiHGNC:25133, MARS2
HPAiENSG00000247626, Low tissue specificity
MalaCardsiMARS2
MIMi609728, gene
611390, phenotype
616430, phenotype
neXtProtiNX_Q96GW9
OpenTargetsiENSG00000247626
Orphaneti314603, Autosomal recessive spastic ataxia with leukoencephalopathy
447954, Combined oxidative phosphorylation defect type 25
PharmGKBiPA134863396
VEuPathDBiHostDB:ENSG00000247626

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0436, Eukaryota
GeneTreeiENSGT00550000075136
HOGENOMiCLU_009710_9_0_1
InParanoidiQ96GW9
OMAiTYVWFDA
OrthoDBi788159at2759
PhylomeDBiQ96GW9
TreeFamiTF105709

Enzyme and pathway databases

PathwayCommonsiQ96GW9
ReactomeiR-HSA-379726, Mitochondrial tRNA aminoacylation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
92935, 603 hits in 1025 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
92935
PharosiQ96GW9, Tbio

Protein Ontology

More...
PROi
PR:Q96GW9
RNActiQ96GW9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000247626, Expressed in adrenal tissue and 149 other tissues
GenevisibleiQ96GW9, HS

Family and domain databases

CDDicd07957, Anticodon_Ia_Met, 1 hit
cd00814, MetRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR041872, Anticodon_Met
IPR014758, Met-tRNA_synth
IPR015413, Methionyl/Leucyl_tRNA_Synth
IPR033911, MetRS_core
IPR014729, Rossmann-like_a/b/a_fold
IPR009080, tRNAsynth_Ia_anticodon-bd
PfamiView protein in Pfam
PF09334, tRNA-synt_1g, 1 hit
PRINTSiPR01041, TRNASYNTHMET
SUPFAMiSSF47323, SSF47323, 1 hit
TIGRFAMsiTIGR00398, metG, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYMM_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96GW9
Secondary accession number(s): A0AVC3
, Q76E79, Q8IW62, Q8N7N4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: September 29, 2021
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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