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Entry version 142 (18 Sep 2019)
Sequence version 2 (10 Jan 2006)
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Protein

Methionine--tRNA ligase, mitochondrial

Gene

MARS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=18 µM for Met1 Publication
  2. KM=85 µM for ATP1 Publication
  3. KM=2.1 µM for tRNA-Met1 Publication

    pH dependencei

    Optimum pH is 7.8-8.2.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei350ATPBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAminoacyl-tRNA synthetase, Ligase
    Biological processProtein biosynthesis
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-379726 Mitochondrial tRNA aminoacylation

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Methionine--tRNA ligase, mitochondrial (EC:6.1.1.10)
    Alternative name(s):
    Methionyl-tRNA synthetase 2
    Mitochondrial methionyl-tRNA synthetase
    Short name:
    MtMetRS
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:MARS2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:25133 MARS2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    609728 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q96GW9

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Mitochondrion

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Spastic ataxia 3, autosomal recessive (SPAX3)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA neurologic disorder characterized by cerebellar ataxia, ataxic gait, spasticity, and hyperreflexia. Other variable features include dysarthria, dysmetria, mild cognitive impairment, urinary urgency and dystonic positioning.
    Related information in OMIM
    Combined oxidative phosphorylation deficiency 25 (COXPD25)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA mitochondrial disorder resulting in developmental delay, growth failure, and sensorineural hearing loss.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073858142R → W in COXPD25. 1 PublicationCorresponds to variant dbSNP:rs794726870EnsemblClinVar.1

    Keywords - Diseasei

    Deafness, Disease mutation, Neurodegeneration, Primary mitochondrial disease

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    92935

    MalaCards human disease database

    More...
    MalaCardsi
    MARS2
    MIMi611390 phenotype
    616430 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000247626

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    314603 Autosomal recessive spastic ataxia with leukoencephalopathy
    447954 Combined oxidative phosphorylation defect type 25

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134863396

    Chemistry databases

    Drug and drug target database

    More...
    DrugBanki
    DB00134 Methionine

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    MARS2

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    85541638

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004549330 – 593Methionine--tRNA ligase, mitochondrialAdd BLAST564

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q96GW9

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q96GW9

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q96GW9

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q96GW9

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q96GW9

    PeptideAtlas

    More...
    PeptideAtlasi
    Q96GW9

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q96GW9

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    76673

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q96GW9

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q96GW9

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000247626 Expressed in 131 organ(s), highest expression level in adrenal tissue

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q96GW9 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA035589
    HPA035590

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    124988, 16 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q96GW9, 10 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000282276

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q96GW9

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi52 – 62"HIGH" regionAdd BLAST11
    Motifi347 – 351"KMSKS" region5

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0436 Eukaryota
    COG0143 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00550000075136

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000200401

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q96GW9

    KEGG Orthology (KO)

    More...
    KOi
    K01874

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    TYVWFDA

    Database of Orthologous Groups

    More...
    OrthoDBi
    788159at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q96GW9

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF105709

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd07957 Anticodon_Ia_Met, 1 hit
    cd00814 MetRS_core, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.50.620, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR041872 Anticodon_Met
    IPR014758 Met-tRNA_synth
    IPR015413 Methionyl/Leucyl_tRNA_Synth
    IPR033911 MetRS_core
    IPR014729 Rossmann-like_a/b/a_fold
    IPR009080 tRNAsynth_Ia_anticodon-bd

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF09334 tRNA-synt_1g, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR01041 TRNASYNTHMET

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF47323 SSF47323, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00398 metG, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96GW9-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MLRTSVLRLL GRTGASRLSL LEDFGPRYYS SGSLSAGDDA CDVRAYFTTP
    60 70 80 90 100
    IFYVNAAPHI GHLYSALLAD ALCRHRRLRG PSTAATRFST GTDEHGLKIQ
    110 120 130 140 150
    QAAATAGLAP TELCDRVSEQ FQQLFQEAGI SCTDFIRTTE ARHRVAVQHF
    160 170 180 190 200
    WGVLKSRGLL YKGVYEGWYC ASDECFLPEA KVTQQPGPSG DSFPVSLESG
    210 220 230 240 250
    HPVSWTKEEN YIFRLSQFRK PLQRWLRGNP QAITPEPFHH VVLQWLDEEL
    260 270 280 290 300
    PDLSVSRRSS HLHWGIPVPG DDSQTIYVWL DALVNYLTVI GYPNAEFKSW
    310 320 330 340 350
    WPATSHIIGK DILKFHAIYW PAFLLGAGMS PPQRICVHSH WTVCGQKMSK
    360 370 380 390 400
    SLGNVVDPRT CLNRYTVDGF RYFLLRQGVP NWDCDYYDEK VVKLLNSELA
    410 420 430 440 450
    DALGGLLNRC TAKRINPSET YPAFCTTCFP SEPGLVGPSV RAQAEDYALV
    460 470 480 490 500
    SAVATLPKQV ADHYDNFRIY KALEAVSSCV RQTNGFVQRH APWKLNWESP
    510 520 530 540 550
    VDAPWLGTVL HVALECLRVF GTLLQPVTPS LADKLLSRLG VSASERSLGE
    560 570 580 590
    LYFLPRFYGH PCPFEGRRLG PETGLLFPRL DQSRTWLVKA HRT
    Length:593
    Mass (Da):66,591
    Last modified:January 10, 2006 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA5076FD9F31F4B96
    GO

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAH09115 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
    The sequence AAH40934 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti535 – 536LL → MM in BAC92749 (Ref. 1) Curated2

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_073858142R → W in COXPD25. 1 PublicationCorresponds to variant dbSNP:rs794726870EnsemblClinVar.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB107013 mRNA Translation: BAC92749.1
    AK098121 mRNA Translation: BAC05238.1
    AC073058 Genomic DNA Translation: AAX93244.1
    BC009115 mRNA Translation: AAH09115.1 Different initiation.
    BC040934 mRNA Translation: AAH40934.1 Different initiation.
    BC126294 mRNA Translation: AAI26295.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS33358.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_612404.1, NM_138395.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000282276; ENSP00000282276; ENSG00000247626

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    92935

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:92935

    UCSC genome browser

    More...
    UCSCi
    uc002uuq.4 human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB107013 mRNA Translation: BAC92749.1
    AK098121 mRNA Translation: BAC05238.1
    AC073058 Genomic DNA Translation: AAX93244.1
    BC009115 mRNA Translation: AAH09115.1 Different initiation.
    BC040934 mRNA Translation: AAH40934.1 Different initiation.
    BC126294 mRNA Translation: AAI26295.1
    CCDSiCCDS33358.1
    RefSeqiNP_612404.1, NM_138395.3

    3D structure databases

    SMRiQ96GW9
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi124988, 16 interactors
    IntActiQ96GW9, 10 interactors
    STRINGi9606.ENSP00000282276

    Chemistry databases

    DrugBankiDB00134 Methionine

    PTM databases

    iPTMnetiQ96GW9
    PhosphoSitePlusiQ96GW9

    Polymorphism and mutation databases

    BioMutaiMARS2
    DMDMi85541638

    Proteomic databases

    EPDiQ96GW9
    jPOSTiQ96GW9
    MassIVEiQ96GW9
    MaxQBiQ96GW9
    PaxDbiQ96GW9
    PeptideAtlasiQ96GW9
    PRIDEiQ96GW9
    ProteomicsDBi76673

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    92935
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000282276; ENSP00000282276; ENSG00000247626
    GeneIDi92935
    KEGGihsa:92935
    UCSCiuc002uuq.4 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    92935
    DisGeNETi92935

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    MARS2
    HGNCiHGNC:25133 MARS2
    HPAiHPA035589
    HPA035590
    MalaCardsiMARS2
    MIMi609728 gene
    611390 phenotype
    616430 phenotype
    neXtProtiNX_Q96GW9
    OpenTargetsiENSG00000247626
    Orphaneti314603 Autosomal recessive spastic ataxia with leukoencephalopathy
    447954 Combined oxidative phosphorylation defect type 25
    PharmGKBiPA134863396

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0436 Eukaryota
    COG0143 LUCA
    GeneTreeiENSGT00550000075136
    HOGENOMiHOG000200401
    InParanoidiQ96GW9
    KOiK01874
    OMAiTYVWFDA
    OrthoDBi788159at2759
    PhylomeDBiQ96GW9
    TreeFamiTF105709

    Enzyme and pathway databases

    ReactomeiR-HSA-379726 Mitochondrial tRNA aminoacylation

    Miscellaneous databases

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    92935

    Pharos

    More...
    Pharosi
    Q96GW9

    Protein Ontology

    More...
    PROi
    PR:Q96GW9

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000247626 Expressed in 131 organ(s), highest expression level in adrenal tissue
    GenevisibleiQ96GW9 HS

    Family and domain databases

    CDDicd07957 Anticodon_Ia_Met, 1 hit
    cd00814 MetRS_core, 1 hit
    Gene3Di3.40.50.620, 1 hit
    InterProiView protein in InterPro
    IPR041872 Anticodon_Met
    IPR014758 Met-tRNA_synth
    IPR015413 Methionyl/Leucyl_tRNA_Synth
    IPR033911 MetRS_core
    IPR014729 Rossmann-like_a/b/a_fold
    IPR009080 tRNAsynth_Ia_anticodon-bd
    PfamiView protein in Pfam
    PF09334 tRNA-synt_1g, 1 hit
    PRINTSiPR01041 TRNASYNTHMET
    SUPFAMiSSF47323 SSF47323, 1 hit
    TIGRFAMsiTIGR00398 metG, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYMM_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96GW9
    Secondary accession number(s): A0AVC3
    , Q76E79, Q8IW62, Q8N7N4
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: January 10, 2006
    Last modified: September 18, 2019
    This is version 142 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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