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Protein

Brevican core protein

Gene

BCAN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandHyaluronic acid, Lectin

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-2024101 CS/DS degradation
R-HSA-3000178 ECM proteoglycans
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3595172 Defective CHST3 causes SEDCJD
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177 Defective CHSY1 causes TPBS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1

Names & Taxonomyi

Protein namesi
Recommended name:
Brevican core protein
Alternative name(s):
Brain-enriched hyaluronan-binding protein
Short name:
BEHAB
Chondroitin sulfate proteoglycan 7
Gene namesi
Name:BCAN
Synonyms:BEHAB, CSPG7
ORF Names:UNQ2525/PRO6018
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000132692.18
HGNCiHGNC:23059 BCAN
MIMi600347 gene
neXtProtiNX_Q96GW7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi63827
OpenTargetsiENSG00000132692
PharmGKBiPA134868393

Polymorphism and mutation databases

BioMutaiBCAN
DMDMi68067899

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001751123 – 911Brevican core proteinAdd BLAST889

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 137By similarity
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi179 ↔ 250By similarity
Disulfide bondi203 ↔ 224By similarity
Disulfide bondi277 ↔ 352By similarity
Disulfide bondi301 ↔ 322By similarity
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei418PhosphoserineBy similarity1
Disulfide bondi650 ↔ 661By similarity
Disulfide bondi655 ↔ 670By similarity
Disulfide bondi672 ↔ 681By similarity
Disulfide bondi688 ↔ 699By similarity
Disulfide bondi716 ↔ 808By similarity
Disulfide bondi784 ↔ 800By similarity
Disulfide bondi815 ↔ 858By similarity
Disulfide bondi844 ↔ 871By similarity
Glycosylationi905O-linked (GalNAc...) serine1 Publication1
Glycosylationi906O-linked (GalNAc...) serine1 Publication1
Isoform 2 (identifier: Q96GW7-2)
Lipidationi646GPI-anchor amidated alanineSequence analysis1

Post-translational modificationi

Contains mostly chondroitin sulfate (By similarity). O-glycosylated with a core 1 or possibly core 8 glycan.By similarity1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiQ96GW7
PeptideAtlasiQ96GW7
PRIDEiQ96GW7
ProteomicsDBi76671
76672 [Q96GW7-2]
TopDownProteomicsiQ96GW7-2 [Q96GW7-2]

PTM databases

iPTMnetiQ96GW7
PhosphoSitePlusiQ96GW7

Expressioni

Developmental stagei

Isoform 1 is highly expressed from birth through 8 years of age and is down-regulated by 20 years of age to low levels that are maintained in the normal adult cortex. Isoform 2 is expressed at uniformly low levels throughout development.1 Publication

Gene expression databases

BgeeiENSG00000132692 Expressed in 146 organ(s), highest expression level in amygdala
CleanExiHS_BCAN
ExpressionAtlasiQ96GW7 baseline and differential
GenevisibleiQ96GW7 HS

Organism-specific databases

HPAiCAB025862
HPA007865

Interactioni

Subunit structurei

Interacts with TNR.By similarity

Protein-protein interaction databases

BioGridi121964, 14 interactors
IntActiQ96GW7, 3 interactors
STRINGi9606.ENSP00000331210

Structurei

3D structure databases

ProteinModelPortaliQ96GW7
SMRiQ96GW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 155Ig-like V-typeAdd BLAST120
Domaini157 – 252Link 1PROSITE-ProRule annotationAdd BLAST96
Domaini257 – 354Link 2PROSITE-ProRule annotationAdd BLAST98
Domaini646 – 682EGF-likePROSITE-ProRule annotationAdd BLAST37
Domaini695 – 809C-type lectinPROSITE-ProRule annotationAdd BLAST115
Domaini813 – 873SushiPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni520 – 530O-glycosylated at two sitesAdd BLAST11
Regioni540 – 545O-glycosylated at two sites6
Regioni569 – 575O-glycosylated at one site7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi385 – 477Glu-richAdd BLAST93

Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IMD6 Eukaryota
ENOG410XW3U LUCA
GeneTreeiENSGT00760000119025
HOVERGENiHBG008175
InParanoidiQ96GW7
KOiK06795
OMAiYAFSFAG
OrthoDBiEOG091G0KN3
PhylomeDBiQ96GW7
TreeFamiTF332134

Family and domain databases

CDDicd00033 CCP, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.100.10, 3 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 1 hit
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00032 CCP, 1 hit
SM00034 CLECT, 1 hit
SM00181 EGF, 1 hit
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 3 hits
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 2 hits
PS50923 SUSHI, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96GW7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQLFLPLLA ALVLAQAPAA LADVLEGDSS EDRAFRVRIA GDAPLQGVLG
60 70 80 90 100
GALTIPCHVH YLRPPPSRRA VLGSPRVKWT FLSRGREAEV LVARGVRVKV
110 120 130 140 150
NEAYRFRVAL PAYPASLTDV SLALSELRPN DSGIYRCEVQ HGIDDSSDAV
160 170 180 190 200
EVKVKGVVFL YREGSARYAF SFSGAQEACA RIGAHIATPE QLYAAYLGGY
210 220 230 240 250
EQCDAGWLSD QTVRYPIQTP REACYGDMDG FPGVRNYGVV DPDDLYDVYC
260 270 280 290 300
YAEDLNGELF LGDPPEKLTL EEARAYCQER GAEIATTGQL YAAWDGGLDH
310 320 330 340 350
CSPGWLADGS VRYPIVTPSQ RCGGGLPGVK TLFLFPNQTG FPNKHSRFNV
360 370 380 390 400
YCFRDSAQPS AIPEASNPAS NPASDGLEAI VTVTETLEEL QLPQEATESE
410 420 430 440 450
SRGAIYSIPI MEDGGGGSST PEDPAEAPRT LLEFETQSMV PPTGFSEEEG
460 470 480 490 500
KALEEEEKYE DEEEKEEEEE EEEVEDEALW AWPSELSSPG PEASLPTEPA
510 520 530 540 550
AQEESLSQAP ARAVLQPGAS PLPDGESEAS RPPRVHGPPT ETLPTPRERN
560 570 580 590 600
LASPSPSTLV EAREVGEATG GPELSGVPRG ESEETGSSEG APSLLPATRA
610 620 630 640 650
PEGTRELEAP SEDNSGRTAP AGTSVQAQPV LPTDSASRGG VAVVPASGDC
660 670 680 690 700
VPSPCHNGGT CLEEEEGVRC LCLPGYGGDL CDVGLRFCNP GWDAFQGACY
710 720 730 740 750
KHFSTRRSWE EAETQCRMYG AHLASISTPE EQDFINNRYR EYQWIGLNDR
760 770 780 790 800
TIEGDFLWSD GVPLLYENWN PGQPDSYFLS GENCVVMVWH DQGQWSDVPC
810 820 830 840 850
NYHLSYTCKM GLVSCGPPPE LPLAQVFGRP RLRYEVDTVL RYRCREGLAQ
860 870 880 890 900
RNLPLIRCQE NGRWEAPQIS CVPRRPARAL HPEEDPEGRQ GRLLGRWKAL
910
LIPPSSPMPG P
Length:911
Mass (Da):99,118
Last modified:June 21, 2005 - v2
Checksum:i5268E796FA3938D2
GO
Isoform 2 (identifier: Q96GW7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     649-671: DCVPSPCHNGGTCLEEEEGVRCL → NSAQGSTALSILLLFFPLQLWVT
     672-911: Missing.

Show »
Length:671
Mass (Da):71,671
Checksum:iBAD0E1959546D4B9
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T3I6Q5T3I6_HUMAN
Brevican core protein
BCAN
231Annotation score:
Q5T3I7Q5T3I7_HUMAN
Brevican core protein
BCAN
213Annotation score:
V9GY88V9GY88_HUMAN
Brevican core protein
BCAN
196Annotation score:
Q5T3I8Q5T3I8_HUMAN
Brevican core protein
BCAN
145Annotation score:
V9GXZ8V9GXZ8_HUMAN
Brevican core protein
BCAN
26Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti175A → T in AAH22938 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050123356S → L. Corresponds to variant dbSNP:rs12065791Ensembl.1
Natural variantiVAR_019551504E → K1 PublicationCorresponds to variant dbSNP:rs1056695Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011184649 – 671DCVPS…GVRCL → NSAQGSTALSILLLFFPLQL WVT in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_011185672 – 911Missing in isoform 2. 1 PublicationAdd BLAST240

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228710 mRNA Translation: AAG23134.1
AF229053 mRNA Translation: AAG23135.1
AY358372 mRNA Translation: AAQ88738.1
AL365181 Genomic DNA No translation available.
AL590666 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52927.1
CH471121 Genomic DNA Translation: EAW52928.1
CH471121 Genomic DNA Translation: EAW52929.1
CH471121 Genomic DNA Translation: EAW52930.1
BC009117 mRNA Translation: AAH09117.1
BC022938 mRNA Translation: AAH22938.1
BC027971 mRNA Translation: AAH27971.1
CCDSiCCDS1149.1 [Q96GW7-1]
CCDS1150.1 [Q96GW7-2]
RefSeqiNP_068767.3, NM_021948.4 [Q96GW7-1]
NP_940819.1, NM_198427.1 [Q96GW7-2]
XP_011508168.1, XM_011509866.1 [Q96GW7-1]
UniGeneiHs.516904

Genome annotation databases

EnsembliENST00000329117; ENSP00000331210; ENSG00000132692 [Q96GW7-1]
ENST00000361588; ENSP00000354925; ENSG00000132692 [Q96GW7-2]
GeneIDi63827
KEGGihsa:63827
UCSCiuc001fpo.4 human [Q96GW7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Brevican

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228710 mRNA Translation: AAG23134.1
AF229053 mRNA Translation: AAG23135.1
AY358372 mRNA Translation: AAQ88738.1
AL365181 Genomic DNA No translation available.
AL590666 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52927.1
CH471121 Genomic DNA Translation: EAW52928.1
CH471121 Genomic DNA Translation: EAW52929.1
CH471121 Genomic DNA Translation: EAW52930.1
BC009117 mRNA Translation: AAH09117.1
BC022938 mRNA Translation: AAH22938.1
BC027971 mRNA Translation: AAH27971.1
CCDSiCCDS1149.1 [Q96GW7-1]
CCDS1150.1 [Q96GW7-2]
RefSeqiNP_068767.3, NM_021948.4 [Q96GW7-1]
NP_940819.1, NM_198427.1 [Q96GW7-2]
XP_011508168.1, XM_011509866.1 [Q96GW7-1]
UniGeneiHs.516904

3D structure databases

ProteinModelPortaliQ96GW7
SMRiQ96GW7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121964, 14 interactors
IntActiQ96GW7, 3 interactors
STRINGi9606.ENSP00000331210

PTM databases

iPTMnetiQ96GW7
PhosphoSitePlusiQ96GW7

Polymorphism and mutation databases

BioMutaiBCAN
DMDMi68067899

Proteomic databases

PaxDbiQ96GW7
PeptideAtlasiQ96GW7
PRIDEiQ96GW7
ProteomicsDBi76671
76672 [Q96GW7-2]
TopDownProteomicsiQ96GW7-2 [Q96GW7-2]

Protocols and materials databases

DNASUi63827
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329117; ENSP00000331210; ENSG00000132692 [Q96GW7-1]
ENST00000361588; ENSP00000354925; ENSG00000132692 [Q96GW7-2]
GeneIDi63827
KEGGihsa:63827
UCSCiuc001fpo.4 human [Q96GW7-1]

Organism-specific databases

CTDi63827
DisGeNETi63827
EuPathDBiHostDB:ENSG00000132692.18
GeneCardsiBCAN
HGNCiHGNC:23059 BCAN
HPAiCAB025862
HPA007865
MIMi600347 gene
neXtProtiNX_Q96GW7
OpenTargetsiENSG00000132692
PharmGKBiPA134868393
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMD6 Eukaryota
ENOG410XW3U LUCA
GeneTreeiENSGT00760000119025
HOVERGENiHBG008175
InParanoidiQ96GW7
KOiK06795
OMAiYAFSFAG
OrthoDBiEOG091G0KN3
PhylomeDBiQ96GW7
TreeFamiTF332134

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-2024101 CS/DS degradation
R-HSA-3000178 ECM proteoglycans
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3595172 Defective CHST3 causes SEDCJD
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177 Defective CHSY1 causes TPBS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1

Miscellaneous databases

GeneWikiiBrevican
GenomeRNAii63827
PROiPR:Q96GW7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132692 Expressed in 146 organ(s), highest expression level in amygdala
CleanExiHS_BCAN
ExpressionAtlasiQ96GW7 baseline and differential
GenevisibleiQ96GW7 HS

Family and domain databases

CDDicd00033 CCP, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.100.10, 3 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 1 hit
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00032 CCP, 1 hit
SM00034 CLECT, 1 hit
SM00181 EGF, 1 hit
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 3 hits
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 2 hits
PS50923 SUSHI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPGCB_HUMAN
AccessioniPrimary (citable) accession number: Q96GW7
Secondary accession number(s): D3DVC2
, Q5SZ10, Q5T3I5, Q8TBB9, Q9HBK1, Q9HBK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 21, 2005
Last modified: October 10, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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