Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 157 (13 Feb 2019)
Sequence version 2 (21 Jun 2005)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Brevican core protein

Gene

BCAN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandHyaluronic acid, Lectin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-2024101 CS/DS degradation
R-HSA-3000178 ECM proteoglycans
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3595172 Defective CHST3 causes SEDCJD
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177 Defective CHSY1 causes TPBS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Brevican core protein
Alternative name(s):
Brain-enriched hyaluronan-binding protein
Short name:
BEHAB
Chondroitin sulfate proteoglycan 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCAN
Synonyms:BEHAB, CSPG7
ORF Names:UNQ2525/PRO6018
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000132692.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23059 BCAN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600347 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96GW7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
63827

Open Targets

More...
OpenTargetsi
ENSG00000132692

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134868393

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BCAN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68067899

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001751123 – 911Brevican core proteinAdd BLAST889

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi57 ↔ 137By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi179 ↔ 250By similarity
Disulfide bondi203 ↔ 224By similarity
Disulfide bondi277 ↔ 352By similarity
Disulfide bondi301 ↔ 322By similarity
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei418PhosphoserineBy similarity1
Disulfide bondi650 ↔ 661By similarity
Disulfide bondi655 ↔ 670By similarity
Disulfide bondi672 ↔ 681By similarity
Disulfide bondi688 ↔ 699By similarity
Disulfide bondi716 ↔ 808By similarity
Disulfide bondi784 ↔ 800By similarity
Disulfide bondi815 ↔ 858By similarity
Disulfide bondi844 ↔ 871By similarity
Glycosylationi905O-linked (GalNAc...) serine1 Publication1
Glycosylationi906O-linked (GalNAc...) serine1 Publication1
Isoform 2 (identifier: Q96GW7-2)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi646GPI-anchor amidated alanineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Contains mostly chondroitin sulfate (By similarity). O-glycosylated with a core 1 or possibly core 8 glycan.By similarity1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96GW7

PeptideAtlas

More...
PeptideAtlasi
Q96GW7

PRoteomics IDEntifications database

More...
PRIDEi
Q96GW7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
76671
76672 [Q96GW7-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q96GW7-2 [Q96GW7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96GW7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96GW7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 1 is highly expressed from birth through 8 years of age and is down-regulated by 20 years of age to low levels that are maintained in the normal adult cortex. Isoform 2 is expressed at uniformly low levels throughout development.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132692 Expressed in 146 organ(s), highest expression level in amygdala

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96GW7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96GW7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025862
HPA007865

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TNR.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121964, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q96GW7, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000331210

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q96GW7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96GW7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 155Ig-like V-typeAdd BLAST120
Domaini157 – 252Link 1PROSITE-ProRule annotationAdd BLAST96
Domaini257 – 354Link 2PROSITE-ProRule annotationAdd BLAST98
Domaini646 – 682EGF-likePROSITE-ProRule annotationAdd BLAST37
Domaini695 – 809C-type lectinPROSITE-ProRule annotationAdd BLAST115
Domaini813 – 873SushiPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni520 – 530O-glycosylated at two sitesAdd BLAST11
Regioni540 – 545O-glycosylated at two sites6
Regioni569 – 575O-glycosylated at one site7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi385 – 477Glu-richAdd BLAST93

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IMD6 Eukaryota
ENOG410XW3U LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157343

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG008175

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96GW7

KEGG Orthology (KO)

More...
KOi
K06795

Identification of Orthologs from Complete Genome Data

More...
OMAi
NNRYREY

Database of Orthologous Groups

More...
OrthoDBi
174823at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96GW7

TreeFam database of animal gene trees

More...
TreeFami
TF332134

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.10.100.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 1 hit
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 1 hit
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01265 LINKMODULE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 1 hit
SM00034 CLECT, 1 hit
SM00181 EGF, 1 hit
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 3 hits
SSF57535 SSF57535, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 2 hits
PS50923 SUSHI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96GW7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQLFLPLLA ALVLAQAPAA LADVLEGDSS EDRAFRVRIA GDAPLQGVLG
60 70 80 90 100
GALTIPCHVH YLRPPPSRRA VLGSPRVKWT FLSRGREAEV LVARGVRVKV
110 120 130 140 150
NEAYRFRVAL PAYPASLTDV SLALSELRPN DSGIYRCEVQ HGIDDSSDAV
160 170 180 190 200
EVKVKGVVFL YREGSARYAF SFSGAQEACA RIGAHIATPE QLYAAYLGGY
210 220 230 240 250
EQCDAGWLSD QTVRYPIQTP REACYGDMDG FPGVRNYGVV DPDDLYDVYC
260 270 280 290 300
YAEDLNGELF LGDPPEKLTL EEARAYCQER GAEIATTGQL YAAWDGGLDH
310 320 330 340 350
CSPGWLADGS VRYPIVTPSQ RCGGGLPGVK TLFLFPNQTG FPNKHSRFNV
360 370 380 390 400
YCFRDSAQPS AIPEASNPAS NPASDGLEAI VTVTETLEEL QLPQEATESE
410 420 430 440 450
SRGAIYSIPI MEDGGGGSST PEDPAEAPRT LLEFETQSMV PPTGFSEEEG
460 470 480 490 500
KALEEEEKYE DEEEKEEEEE EEEVEDEALW AWPSELSSPG PEASLPTEPA
510 520 530 540 550
AQEESLSQAP ARAVLQPGAS PLPDGESEAS RPPRVHGPPT ETLPTPRERN
560 570 580 590 600
LASPSPSTLV EAREVGEATG GPELSGVPRG ESEETGSSEG APSLLPATRA
610 620 630 640 650
PEGTRELEAP SEDNSGRTAP AGTSVQAQPV LPTDSASRGG VAVVPASGDC
660 670 680 690 700
VPSPCHNGGT CLEEEEGVRC LCLPGYGGDL CDVGLRFCNP GWDAFQGACY
710 720 730 740 750
KHFSTRRSWE EAETQCRMYG AHLASISTPE EQDFINNRYR EYQWIGLNDR
760 770 780 790 800
TIEGDFLWSD GVPLLYENWN PGQPDSYFLS GENCVVMVWH DQGQWSDVPC
810 820 830 840 850
NYHLSYTCKM GLVSCGPPPE LPLAQVFGRP RLRYEVDTVL RYRCREGLAQ
860 870 880 890 900
RNLPLIRCQE NGRWEAPQIS CVPRRPARAL HPEEDPEGRQ GRLLGRWKAL
910
LIPPSSPMPG P
Length:911
Mass (Da):99,118
Last modified:June 21, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5268E796FA3938D2
GO
Isoform 2 (identifier: Q96GW7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     649-671: DCVPSPCHNGGTCLEEEEGVRCL → NSAQGSTALSILLLFFPLQLWVT
     672-911: Missing.

Show »
Length:671
Mass (Da):71,671
Checksum:iBAD0E1959546D4B9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T3I6Q5T3I6_HUMAN
Brevican core protein
BCAN
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T3I7Q5T3I7_HUMAN
Brevican core protein
BCAN
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GY88V9GY88_HUMAN
Brevican core protein
BCAN
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T3I8Q5T3I8_HUMAN
Brevican core protein
BCAN
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GXZ8V9GXZ8_HUMAN
Brevican core protein
BCAN
26Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti175A → T in AAH22938 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050123356S → L. Corresponds to variant dbSNP:rs12065791Ensembl.1
Natural variantiVAR_019551504E → K1 PublicationCorresponds to variant dbSNP:rs1056695Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011184649 – 671DCVPS…GVRCL → NSAQGSTALSILLLFFPLQL WVT in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_011185672 – 911Missing in isoform 2. 1 PublicationAdd BLAST240

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF228710 mRNA Translation: AAG23134.1
AF229053 mRNA Translation: AAG23135.1
AY358372 mRNA Translation: AAQ88738.1
AL365181 Genomic DNA No translation available.
AL590666 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52927.1
CH471121 Genomic DNA Translation: EAW52928.1
CH471121 Genomic DNA Translation: EAW52929.1
CH471121 Genomic DNA Translation: EAW52930.1
BC009117 mRNA Translation: AAH09117.1
BC022938 mRNA Translation: AAH22938.1
BC027971 mRNA Translation: AAH27971.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1149.1 [Q96GW7-1]
CCDS1150.1 [Q96GW7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_068767.3, NM_021948.4 [Q96GW7-1]
NP_940819.1, NM_198427.1 [Q96GW7-2]
XP_011508168.1, XM_011509866.1 [Q96GW7-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.516904

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000329117; ENSP00000331210; ENSG00000132692 [Q96GW7-1]
ENST00000361588; ENSP00000354925; ENSG00000132692 [Q96GW7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
63827

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:63827

UCSC genome browser

More...
UCSCi
uc001fpo.4 human [Q96GW7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Brevican

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228710 mRNA Translation: AAG23134.1
AF229053 mRNA Translation: AAG23135.1
AY358372 mRNA Translation: AAQ88738.1
AL365181 Genomic DNA No translation available.
AL590666 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52927.1
CH471121 Genomic DNA Translation: EAW52928.1
CH471121 Genomic DNA Translation: EAW52929.1
CH471121 Genomic DNA Translation: EAW52930.1
BC009117 mRNA Translation: AAH09117.1
BC022938 mRNA Translation: AAH22938.1
BC027971 mRNA Translation: AAH27971.1
CCDSiCCDS1149.1 [Q96GW7-1]
CCDS1150.1 [Q96GW7-2]
RefSeqiNP_068767.3, NM_021948.4 [Q96GW7-1]
NP_940819.1, NM_198427.1 [Q96GW7-2]
XP_011508168.1, XM_011509866.1 [Q96GW7-1]
UniGeneiHs.516904

3D structure databases

ProteinModelPortaliQ96GW7
SMRiQ96GW7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121964, 14 interactors
IntActiQ96GW7, 3 interactors
STRINGi9606.ENSP00000331210

PTM databases

iPTMnetiQ96GW7
PhosphoSitePlusiQ96GW7

Polymorphism and mutation databases

BioMutaiBCAN
DMDMi68067899

Proteomic databases

PaxDbiQ96GW7
PeptideAtlasiQ96GW7
PRIDEiQ96GW7
ProteomicsDBi76671
76672 [Q96GW7-2]
TopDownProteomicsiQ96GW7-2 [Q96GW7-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
63827
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329117; ENSP00000331210; ENSG00000132692 [Q96GW7-1]
ENST00000361588; ENSP00000354925; ENSG00000132692 [Q96GW7-2]
GeneIDi63827
KEGGihsa:63827
UCSCiuc001fpo.4 human [Q96GW7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
63827
DisGeNETi63827
EuPathDBiHostDB:ENSG00000132692.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BCAN
HGNCiHGNC:23059 BCAN
HPAiCAB025862
HPA007865
MIMi600347 gene
neXtProtiNX_Q96GW7
OpenTargetsiENSG00000132692
PharmGKBiPA134868393

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IMD6 Eukaryota
ENOG410XW3U LUCA
GeneTreeiENSGT00940000157343
HOVERGENiHBG008175
InParanoidiQ96GW7
KOiK06795
OMAiNNRYREY
OrthoDBi174823at2759
PhylomeDBiQ96GW7
TreeFamiTF332134

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-2024101 CS/DS degradation
R-HSA-3000178 ECM proteoglycans
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3595172 Defective CHST3 causes SEDCJD
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177 Defective CHSY1 causes TPBS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Brevican

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
63827

Protein Ontology

More...
PROi
PR:Q96GW7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132692 Expressed in 146 organ(s), highest expression level in amygdala
ExpressionAtlasiQ96GW7 baseline and differential
GenevisibleiQ96GW7 HS

Family and domain databases

CDDicd00033 CCP, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.100.10, 3 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 1 hit
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00032 CCP, 1 hit
SM00034 CLECT, 1 hit
SM00181 EGF, 1 hit
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 3 hits
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 2 hits
PS50923 SUSHI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPGCB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96GW7
Secondary accession number(s): D3DVC2
, Q5SZ10, Q5T3I5, Q8TBB9, Q9HBK1, Q9HBK4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 21, 2005
Last modified: February 13, 2019
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again