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Protein

UNC119-binding protein C5orf30

Gene

C5orf30

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably plays a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B (PubMed:22085962). May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells (PubMed:22085962).1 Publication

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
UNC119-binding protein C5orf30
Gene namesi
Name:C5orf30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000181751.9
HGNCiHGNC:25052 C5orf30
MIMi616608 gene
neXtProtiNX_Q96GV9

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi90355
OpenTargetsiENSG00000181751
PharmGKBiPA162380017

Polymorphism and mutation databases

BioMutaiC5orf30

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003167761 – 206UNC119-binding protein C5orf30Add BLAST206

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96GV9
MaxQBiQ96GV9
PaxDbiQ96GV9
PeptideAtlasiQ96GV9
PRIDEiQ96GV9
ProteomicsDBi76669

PTM databases

iPTMnetiQ96GV9
PhosphoSitePlusiQ96GV9

Expressioni

Tissue specificityi

High expression in normal macrophages, monocytes, and cultured rheumatoid arthritis synovial fibroblasts (RASFs), with lower expression in B- and T-cells, and little to no expression in other tissues and cell lines (PubMed:26316022).1 Publication

Inductioni

Up-regulated by hypoxia (PubMed:26316022). Down-regulated by TNF (PubMed:26316022).1 Publication

Gene expression databases

BgeeiENSG00000181751 Expressed in 220 organ(s), highest expression level in brain
CleanExiHS_C5orf30
GenevisibleiQ96GV9 HS

Organism-specific databases

HPAiHPA043434

Interactioni

Subunit structurei

Interacts with UNC119 and UNC119B; interaction preferentially takes place when UNC119 and UNC119B are unliganded with myristoylated proteins.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi124702, 15 interactors
IntActiQ96GV9, 7 interactors
STRINGi9606.ENSP00000326110

Structurei

3D structure databases

ProteinModelPortaliQ96GV9
SMRiQ96GV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi125 – 129Poly-Arg5

Sequence similaritiesi

Belongs to the UNC119-binding protein family.Curated

Phylogenomic databases

eggNOGiENOG410IE29 Eukaryota
ENOG4111FA7 LUCA
GeneTreeiENSGT00390000005782
HOGENOMiHOG000111511
HOVERGENiHBG097534
InParanoidiQ96GV9
OMAiMSIKEPA
OrthoDBiEOG091G0J9D
PhylomeDBiQ96GV9
TreeFamiTF331553

Family and domain databases

InterProiView protein in InterPro
IPR029219 UNC119-bd
PANTHERiPTHR31224 PTHR31224, 1 hit
PfamiView protein in Pfam
PF15435 UNC119_bdg, 1 hit

Sequencei

Sequence statusi: Complete.

Q96GV9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVDINGESR STLTTLPFPG AEANSPGKAE AEKPRCSSTP CSPMRRTVSG
60 70 80 90 100
YQILHMDSNY LVGFTTGEEL LKLAQKCTGG EESKAEAMPS LRSKQLDAGL
110 120 130 140 150
ARSSRLYKTR SRYYQPYEIP AVNGRRRRRM PSSGDKCTKS LPYEPYKALH
160 170 180 190 200
GPLPLCLLKG KRAHSKSLDY LNLDKMIKEP ADTEVLQYQL QHLTLRGDRV

FARNNT
Length:206
Mass (Da):23,083
Last modified:December 1, 2001 - v1
Checksum:i5D52D27AC5CA7A85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090558 mRNA Translation: BAC03478.1
CH471086 Genomic DNA Translation: EAW49075.1
BC009203 mRNA Translation: AAH09203.1
CCDSiCCDS4095.1
RefSeqiNP_001303897.1, NM_001316968.1
NP_001303898.1, NM_001316969.1
NP_149988.1, NM_033211.3
UniGeneiHs.482976

Genome annotation databases

EnsembliENST00000319933; ENSP00000326110; ENSG00000181751
ENST00000510890; ENSP00000421270; ENSG00000181751
ENST00000515669; ENSP00000422836; ENSG00000181751
GeneIDi90355
KEGGihsa:90355
UCSCiuc003kog.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090558 mRNA Translation: BAC03478.1
CH471086 Genomic DNA Translation: EAW49075.1
BC009203 mRNA Translation: AAH09203.1
CCDSiCCDS4095.1
RefSeqiNP_001303897.1, NM_001316968.1
NP_001303898.1, NM_001316969.1
NP_149988.1, NM_033211.3
UniGeneiHs.482976

3D structure databases

ProteinModelPortaliQ96GV9
SMRiQ96GV9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124702, 15 interactors
IntActiQ96GV9, 7 interactors
STRINGi9606.ENSP00000326110

PTM databases

iPTMnetiQ96GV9
PhosphoSitePlusiQ96GV9

Polymorphism and mutation databases

BioMutaiC5orf30

Proteomic databases

EPDiQ96GV9
MaxQBiQ96GV9
PaxDbiQ96GV9
PeptideAtlasiQ96GV9
PRIDEiQ96GV9
ProteomicsDBi76669

Protocols and materials databases

DNASUi90355
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319933; ENSP00000326110; ENSG00000181751
ENST00000510890; ENSP00000421270; ENSG00000181751
ENST00000515669; ENSP00000422836; ENSG00000181751
GeneIDi90355
KEGGihsa:90355
UCSCiuc003kog.2 human

Organism-specific databases

CTDi90355
DisGeNETi90355
EuPathDBiHostDB:ENSG00000181751.9
GeneCardsiC5orf30
H-InvDBiHIX0005069
HGNCiHGNC:25052 C5orf30
HPAiHPA043434
MIMi616608 gene
neXtProtiNX_Q96GV9
OpenTargetsiENSG00000181751
PharmGKBiPA162380017
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE29 Eukaryota
ENOG4111FA7 LUCA
GeneTreeiENSGT00390000005782
HOGENOMiHOG000111511
HOVERGENiHBG097534
InParanoidiQ96GV9
OMAiMSIKEPA
OrthoDBiEOG091G0J9D
PhylomeDBiQ96GV9
TreeFamiTF331553

Miscellaneous databases

ChiTaRSiC5orf30 human
GenomeRNAii90355
PROiPR:Q96GV9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181751 Expressed in 220 organ(s), highest expression level in brain
CleanExiHS_C5orf30
GenevisibleiQ96GV9 HS

Family and domain databases

InterProiView protein in InterPro
IPR029219 UNC119-bd
PANTHERiPTHR31224 PTHR31224, 1 hit
PfamiView protein in Pfam
PF15435 UNC119_bdg, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCE030_HUMAN
AccessioniPrimary (citable) accession number: Q96GV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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