C5orf30

Functionⁱ

Probably plays a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B (PubMed:22085962). May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells (PubMed:22085962).1 Publication

GO - Biological processⁱ

cilium assembly Source: UniProtKB
negative regulation of cytokine production involved in inflammatory response Source: Ensembl
negative regulation of fibroblast migration Source: Ensembl
protein transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cilium biogenesis/degradation, Protein transport, Transport

Biological process

Cilium biogenesis/degradation, Protein transport, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: UNC119-binding protein C5orf30
Gene namesⁱ	Name:C5orf30
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000181751.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25052 C5orf30
MIMⁱ	616608 gene
neXtProtⁱ	NX_Q96GV9

Keywords - Cellular componentⁱ

Cell projection, Cilium, Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	90355
Open Targets More...OpenTargetsⁱ	ENSG00000181751
PharmGKBⁱ	PA162380017

Polymorphism and mutation databases

BioMutaⁱ	C5orf30

BioMutaⁱ

C5orf30

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000316776	1 – 206	UNC119-binding protein C5orf30Add BLAST		206

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	25	PhosphoserineCombined sources	1
Modified residueⁱ	140	PhosphoserineCombined sources	1
Modified residueⁱ	167	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q96GV9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96GV9
PaxDbⁱ	Q96GV9
PeptideAtlas More...PeptideAtlasⁱ	Q96GV9
PRIDEⁱ	Q96GV9
ProteomicsDBⁱ	76669

PTM databases

iPTMnetⁱ	Q96GV9
PhosphoSitePlusⁱ	Q96GV9

Expressionⁱ

Tissue specificityⁱ

High expression in normal macrophages, monocytes, and cultured rheumatoid arthritis synovial fibroblasts (RASFs), with lower expression in B- and T-cells, and little to no expression in other tissues and cell lines (PubMed:26316022).1 Publication

Inductionⁱ

Up-regulated by hypoxia (PubMed:26316022). Down-regulated by TNF (PubMed:26316022).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000181751 Expressed in 220 organ(s), highest expression level in brain
CleanExⁱ	HS_C5orf30
Genevisibleⁱ	Q96GV9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043434

HPAⁱ

HPA043434

Interactionⁱ

Subunit structureⁱ

Interacts with UNC119 and UNC119B; interaction preferentially takes place when UNC119 and UNC119B are unliganded with myristoylated proteins.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PNMA1	Q8ND90	3	EBI-2350695,EBI-302345
TRAF1	Q13077	3	EBI-2350695,EBI-359224

Protein-protein interaction databases

BioGridⁱ	124702, 15 interactors
IntActⁱ	Q96GV9, 7 interactors
STRINGⁱ	9606.ENSP00000326110

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96GV9
SMRⁱ	Q96GV9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	125 – 129	Poly-Arg		5

Sequence similaritiesⁱ

Belongs to the UNC119-binding protein family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IE29 Eukaryota ENOG4111FA7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005782
HOGENOMⁱ	HOG000111511
HOVERGENⁱ	HBG097534
InParanoidⁱ	Q96GV9
OMAⁱ	MSIKEPA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0J9D
PhylomeDBⁱ	Q96GV9
TreeFamⁱ	TF331553

Family and domain databases

InterProⁱ	View protein in InterPro IPR029219 UNC119-bd
PANTHERⁱ	PTHR31224 PTHR31224, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15435 UNC119_bdg, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q96GV9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEVDINGESR STLTTLPFPG AEANSPGKAE AEKPRCSSTP CSPMRRTVSG 
        60         70         80         90        100
YQILHMDSNY LVGFTTGEEL LKLAQKCTGG EESKAEAMPS LRSKQLDAGL 
       110        120        130        140        150
ARSSRLYKTR SRYYQPYEIP AVNGRRRRRM PSSGDKCTKS LPYEPYKALH 
       160        170        180        190        200
GPLPLCLLKG KRAHSKSLDY LNLDKMIKEP ADTEVLQYQL QHLTLRGDRV 

FARNNT

Length:206

Mass (Da):23,083

Last modified:December 1, 2001 - v1

Checksum:ⁱ5D52D27AC5CA7A85

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK090558 mRNA Translation: BAC03478.1 CH471086 Genomic DNA Translation: EAW49075.1 BC009203 mRNA Translation: AAH09203.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4095.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001303897.1, NM_001316968.1 NP_001303898.1, NM_001316969.1 NP_149988.1, NM_033211.3
UniGeneⁱ	Hs.482976

Genome annotation databases

Ensemblⁱ	ENST00000319933; ENSP00000326110; ENSG00000181751 ENST00000510890; ENSP00000421270; ENSG00000181751 ENST00000515669; ENSP00000422836; ENSG00000181751
GeneIDⁱ	90355
KEGGⁱ	hsa:90355
UCSC genome browser More...UCSCⁱ	uc003kog.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96GV9	Chromosome 5 open reading frame 30		MACMU		206	UniRef100_Q96GV9
Chromosome 5 open reading frame 30		MACFA		206
Uncharacterized protein		COLAP		206
Uncharacterized protein		PONAB		206
Uncharacterized protein		CERAT		206
+8

Protein	Similar proteins		Species	Score	Length	Source
Q96GV9	UNC119-binding protein C5orf30 homolog		BOVIN		207	UniRef90_Q96GV9
UNC119-binding protein C5orf30 homolog		MOUSE		207
UNC119-binding protein C5orf30 homolog		PONAB		206
Chromosome 5 open reading frame 30		MACMU		206
Chromosome 5 open reading frame 30		MACFA		206
+98

Protein	Similar proteins		Species	Score	Length	Source
Q96GV9	UNC119-binding protein C5orf30 homolog		BOVIN		207	UniRef50_Q96GV9
UNC119-binding protein C5orf30 homolog		MOUSE		207
UNC119-binding protein C5orf30 homolog		PONAB		206
Chromosome 5 open reading frame 30		MACMU		206
Chromosome 5 open reading frame 30		MACFA		206
+174

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK090558 mRNA Translation: BAC03478.1 CH471086 Genomic DNA Translation: EAW49075.1 BC009203 mRNA Translation: AAH09203.1
CCDSⁱ	CCDS4095.1
RefSeqⁱ	NP_001303897.1, NM_001316968.1 NP_001303898.1, NM_001316969.1 NP_149988.1, NM_033211.3
UniGeneⁱ	Hs.482976

3D structure databases

ProteinModelPortalⁱ	Q96GV9
SMRⁱ	Q96GV9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124702, 15 interactors
IntActⁱ	Q96GV9, 7 interactors
STRINGⁱ	9606.ENSP00000326110

PTM databases

iPTMnetⁱ	Q96GV9
PhosphoSitePlusⁱ	Q96GV9

Polymorphism and mutation databases

BioMutaⁱ	C5orf30

BioMutaⁱ

C5orf30

Proteomic databases

EPDⁱ	Q96GV9
MaxQBⁱ	Q96GV9
PaxDbⁱ	Q96GV9
PeptideAtlasⁱ	Q96GV9
PRIDEⁱ	Q96GV9
ProteomicsDBⁱ	76669

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	90355
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000319933; ENSP00000326110; ENSG00000181751 ENST00000510890; ENSP00000421270; ENSG00000181751 ENST00000515669; ENSP00000422836; ENSG00000181751
GeneIDⁱ	90355
KEGGⁱ	hsa:90355
UCSCⁱ	uc003kog.2 human

Organism-specific databases

CTDⁱ	90355
DisGeNETⁱ	90355
EuPathDBⁱ	HostDB:ENSG00000181751.9
GeneCardsⁱ	C5orf30
H-InvDBⁱ	HIX0005069
HGNCⁱ	HGNC:25052 C5orf30
HPAⁱ	HPA043434
MIMⁱ	616608 gene
neXtProtⁱ	NX_Q96GV9
OpenTargetsⁱ	ENSG00000181751
PharmGKBⁱ	PA162380017
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IE29 Eukaryota ENOG4111FA7 LUCA
GeneTreeⁱ	ENSGT00390000005782
HOGENOMⁱ	HOG000111511
HOVERGENⁱ	HBG097534
InParanoidⁱ	Q96GV9
OMAⁱ	MSIKEPA
OrthoDBⁱ	EOG091G0J9D
PhylomeDBⁱ	Q96GV9
TreeFamⁱ	TF331553

Miscellaneous databases

ChiTaRSⁱ	C5orf30 human
GenomeRNAiⁱ	90355
Protein Ontology More...PROⁱ	PR:Q96GV9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000181751 Expressed in 220 organ(s), highest expression level in brain
CleanExⁱ	HS_C5orf30
Genevisibleⁱ	Q96GV9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR029219 UNC119-bd
PANTHERⁱ	PTHR31224 PTHR31224, 1 hit
Pfamⁱ	View protein in Pfam PF15435 UNC119_bdg, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CE030_HUMAN
Accessionⁱ	Q96GV9Primary (citable) accession number: Q96GV9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
	Last sequence update:	December 1, 2001
	Last modified:	September 12, 2018
	This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

UniProtKB

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Supporting data

UniProtKB - Q96GV9 (CE030_HUMAN)

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UNC119-binding protein C5orf30

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ