UniProtKB - Q96GV9 (MACIR_HUMAN)
Protein
Macrophage immunometabolism regulator
Gene
MACIR
Organism
Homo sapiens (Human)
Status
Functioni
Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages (PubMed:30659109). The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis (PubMed:30659109). May also play a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B (PubMed:22085962). May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells (PubMed:22085962).2 Publications
GO - Biological processi
- cilium assembly Source: UniProtKB
- inflammatory response Source: UniProtKB-KW
- negative regulation of cytokine production involved in inflammatory response Source: GO_Central
- negative regulation of fibroblast migration Source: GO_Central
- negative regulation of inflammatory response Source: UniProtKB
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | Cilium biogenesis/degradation, Inflammatory response, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q96GV9 |
Names & Taxonomyi
Protein namesi | Recommended name: Macrophage immunometabolism regulator |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000181751.9 |
HGNCi | HGNC:25052, MACIR |
MIMi | 616608, gene |
neXtProti | NX_Q96GV9 |
Subcellular locationi
Other locations
- ciliary transition zone Source: UniProtKB
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell projection, Cilium, CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 90355 |
OpenTargetsi | ENSG00000181751 |
PharmGKBi | PA162380017 |
Miscellaneous databases
Pharosi | Q96GV9, Tdark |
Polymorphism and mutation databases
BioMutai | C5orf30 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000316776 | 1 – 206 | Macrophage immunometabolism regulatorAdd BLAST | 206 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 25 | PhosphoserineCombined sources | 1 | |
Modified residuei | 140 | PhosphoserineCombined sources | 1 | |
Modified residuei | 167 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated.5 Publications
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q96GV9 |
jPOSTi | Q96GV9 |
MassIVEi | Q96GV9 |
MaxQBi | Q96GV9 |
PaxDbi | Q96GV9 |
PeptideAtlasi | Q96GV9 |
PRIDEi | Q96GV9 |
ProteomicsDBi | 76669 |
PTM databases
iPTMneti | Q96GV9 |
PhosphoSitePlusi | Q96GV9 |
Expressioni
Tissue specificityi
High expression in normal macrophages, monocytes, and cultured rheumatoid arthritis synovial fibroblasts (RASFs), with lower expression in B- and T-cells, and little to no expression in other tissues and cell lines.1 Publication
Inductioni
Up-regulated by hypoxia in cultured rheumatoid arthritis synovial fibroblasts (PubMed:26316022). Down-regulated by TNF in cultured rheumatoid arthritis synovial fibroblasts (PubMed:26316022). Down-regulated by the inflammatory mediators LPS and TNF in primary monocyte-derived macrophages via a c-Jun N-terminal kinase mediated mechanism (PubMed:30659109).2 Publications
Gene expression databases
Bgeei | ENSG00000181751, Expressed in brain and 234 other tissues |
Genevisiblei | Q96GV9, HS |
Organism-specific databases
HPAi | ENSG00000181751, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with UNC119 and UNC119B; interaction preferentially takes place when UNC119 and UNC119B are unliganded with myristoylated proteins.
1 PublicationBinary interactionsi
Hide detailsQ96GV9
With | #Exp. | IntAct |
---|---|---|
EXOSC8 [Q96B26] | 3 | EBI-2350695,EBI-371922 |
PNMA1 [Q8ND90] | 3 | EBI-2350695,EBI-302345 |
TRAF1 [Q13077] | 3 | EBI-2350695,EBI-359224 |
Protein-protein interaction databases
BioGRIDi | 124702, 16 interactors |
IntActi | Q96GV9, 18 interactors |
STRINGi | 9606.ENSP00000326110 |
Miscellaneous databases
RNActi | Q96GV9, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 125 – 129 | Poly-Arg | 5 |
Sequence similaritiesi
Belongs to the UNC119-binding protein family.Curated
Phylogenomic databases
eggNOGi | ENOG502QRGS, Eukaryota |
GeneTreei | ENSGT00390000005782 |
HOGENOMi | CLU_082309_0_0_1 |
InParanoidi | Q96GV9 |
OMAi | GDRMFAR |
OrthoDBi | 1190422at2759 |
PhylomeDBi | Q96GV9 |
TreeFami | TF331553 |
Family and domain databases
InterProi | View protein in InterPro IPR029219, UNC119-bd |
PANTHERi | PTHR31224, PTHR31224, 1 hit |
Pfami | View protein in Pfam PF15435, UNC119_bdg, 1 hit |
i Sequence
Sequence statusi: Complete.
Q96GV9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEVDINGESR STLTTLPFPG AEANSPGKAE AEKPRCSSTP CSPMRRTVSG
60 70 80 90 100
YQILHMDSNY LVGFTTGEEL LKLAQKCTGG EESKAEAMPS LRSKQLDAGL
110 120 130 140 150
ARSSRLYKTR SRYYQPYEIP AVNGRRRRRM PSSGDKCTKS LPYEPYKALH
160 170 180 190 200
GPLPLCLLKG KRAHSKSLDY LNLDKMIKEP ADTEVLQYQL QHLTLRGDRV
FARNNT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK090558 mRNA Translation: BAC03478.1 CH471086 Genomic DNA Translation: EAW49075.1 BC009203 mRNA Translation: AAH09203.1 |
CCDSi | CCDS4095.1 |
RefSeqi | NP_001303897.1, NM_001316968.1 NP_001303898.1, NM_001316969.1 NP_149988.1, NM_033211.3 |
Genome annotation databases
Ensembli | ENST00000319933; ENSP00000326110; ENSG00000181751 ENST00000510890; ENSP00000421270; ENSG00000181751 ENST00000515669; ENSP00000422836; ENSG00000181751 |
GeneIDi | 90355 |
KEGGi | hsa:90355 |
UCSCi | uc003kog.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK090558 mRNA Translation: BAC03478.1 CH471086 Genomic DNA Translation: EAW49075.1 BC009203 mRNA Translation: AAH09203.1 |
CCDSi | CCDS4095.1 |
RefSeqi | NP_001303897.1, NM_001316968.1 NP_001303898.1, NM_001316969.1 NP_149988.1, NM_033211.3 |
3D structure databases
SMRi | Q96GV9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124702, 16 interactors |
IntActi | Q96GV9, 18 interactors |
STRINGi | 9606.ENSP00000326110 |
PTM databases
iPTMneti | Q96GV9 |
PhosphoSitePlusi | Q96GV9 |
Polymorphism and mutation databases
BioMutai | C5orf30 |
Proteomic databases
EPDi | Q96GV9 |
jPOSTi | Q96GV9 |
MassIVEi | Q96GV9 |
MaxQBi | Q96GV9 |
PaxDbi | Q96GV9 |
PeptideAtlasi | Q96GV9 |
PRIDEi | Q96GV9 |
ProteomicsDBi | 76669 |
Protocols and materials databases
Antibodypediai | 52940, 8 antibodies |
DNASUi | 90355 |
Genome annotation databases
Ensembli | ENST00000319933; ENSP00000326110; ENSG00000181751 ENST00000510890; ENSP00000421270; ENSG00000181751 ENST00000515669; ENSP00000422836; ENSG00000181751 |
GeneIDi | 90355 |
KEGGi | hsa:90355 |
UCSCi | uc003kog.2, human |
Organism-specific databases
CTDi | 90355 |
DisGeNETi | 90355 |
EuPathDBi | HostDB:ENSG00000181751.9 |
GeneCardsi | MACIR |
HGNCi | HGNC:25052, MACIR |
HPAi | ENSG00000181751, Low tissue specificity |
MIMi | 616608, gene |
neXtProti | NX_Q96GV9 |
OpenTargetsi | ENSG00000181751 |
PharmGKBi | PA162380017 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRGS, Eukaryota |
GeneTreei | ENSGT00390000005782 |
HOGENOMi | CLU_082309_0_0_1 |
InParanoidi | Q96GV9 |
OMAi | GDRMFAR |
OrthoDBi | 1190422at2759 |
PhylomeDBi | Q96GV9 |
TreeFami | TF331553 |
Enzyme and pathway databases
PathwayCommonsi | Q96GV9 |
Miscellaneous databases
BioGRID-ORCSi | 90355, 14 hits in 836 CRISPR screens |
ChiTaRSi | C5orf30, human |
GenomeRNAii | 90355 |
Pharosi | Q96GV9, Tdark |
PROi | PR:Q96GV9 |
RNActi | Q96GV9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000181751, Expressed in brain and 234 other tissues |
Genevisiblei | Q96GV9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029219, UNC119-bd |
PANTHERi | PTHR31224, PTHR31224, 1 hit |
Pfami | View protein in Pfam PF15435, UNC119_bdg, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MACIR_HUMAN | |
Accessioni | Q96GV9Primary (citable) accession number: Q96GV9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families