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Protein

Long-chain-fatty-acid--CoA ligase ACSBG1

Gene

ACSBG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.2 Publications

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei550ATPBy similarity1
Binding sitei565ATPBy similarity1
Binding sitei701ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi282 – 290ATPBy similarity9
Nucleotide bindingi472 – 477ATPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS02532-MONOMER
ReactomeiR-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs

Chemistry databases

SwissLipidsiSLP:000000450

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase ACSBG1 (EC:6.2.1.3)
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 1
Short name:
hBG1
Short name:
hsBG
Short name:
hsBGM
Lipidosin
Gene namesi
Name:ACSBG1
Synonyms:BGM, KIAA0631, LPD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000103740.9
HGNCiHGNC:29567 ACSBG1
MIMi614362 gene
neXtProtiNX_Q96GR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi23205
OpenTargetsiENSG00000103740
PharmGKBiPA142672648

Polymorphism and mutation databases

BioMutaiACSBG1
DMDMi296434385

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003158081 – 724Long-chain-fatty-acid--CoA ligase ACSBG1Add BLAST724

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53PhosphoserineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei658PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96GR2
PeptideAtlasiQ96GR2
PRIDEiQ96GR2
ProteomicsDBi76656

PTM databases

iPTMnetiQ96GR2
PhosphoSitePlusiQ96GR2

Expressioni

Tissue specificityi

Expressed primarily in brain. Expressed at lower level in testis and adrenal gland. Present in all regions of brain except pituitary.2 Publications

Gene expression databases

BgeeiENSG00000103740 Expressed in 138 organ(s), highest expression level in mammalian vulva
CleanExiHS_ACSBG1
ExpressionAtlasiQ96GR2 baseline and differential
GenevisibleiQ96GR2 HS

Organism-specific databases

HPAiCAB045955
HPA041642
HPA058869

Interactioni

Protein-protein interaction databases

BioGridi116813, 3 interactors
IntActiQ96GR2, 2 interactors
MINTiQ96GR2
STRINGi9606.ENSP00000258873

Structurei

3D structure databases

ProteinModelPortaliQ96GR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1256 Eukaryota
COG1022 LUCA
GeneTreeiENSGT00690000101725
HOGENOMiHOG000230004
HOVERGENiHBG054660
InParanoidiQ96GR2
KOiK15013
OMAiEIGPTYY
OrthoDBiEOG091G03FO
PhylomeDBiQ96GR2
TreeFamiTF354286

Family and domain databases

InterProiView protein in InterPro
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q96GR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRNSGAGYG CPHGDPSMLD SRETPQESRQ DMIVRTTQEK LKTSSLTDRQ
60 70 80 90 100
PLSKESLNHA LELSVPEKVN NAQWDAPEEA LWTTRADGRV RLRIDPSCPQ
110 120 130 140 150
LPYTVHRMFY EALDKYGDLI ALGFKRQDKW EHISYSQYYL LARRAAKGFL
160 170 180 190 200
KLGLKQAHSV AILGFNSPEW FFSAVGTVFA GGIVTGIYTT SSPEACQYIA
210 220 230 240 250
YDCCANVIMV DTQKQLEKIL KIWKQLPHLK AVVIYKEPPP NKMANVYTME
260 270 280 290 300
EFMELGNEVP EEALDAIIDT QQPNQCCVLV YTSGTTGNPK GVMLSQDNIT
310 320 330 340 350
WTARYGSQAG DIRPAEVQQE VVVSYLPLSH IAAQIYDLWT GIQWGAQVCF
360 370 380 390 400
AEPDALKGSL VNTLREVEPT SHMGVPRVWE KIMERIQEVA AQSGFIRRKM
410 420 430 440 450
LLWAMSVTLE QNLTCPGSDL KPFTTRLADY LVLAKVRQAL GFAKCQKNFY
460 470 480 490 500
GAAPMMAETQ HFFLGLNIRL YAGYGLSETS GPHFMSSPYN YRLYSSGKLV
510 520 530 540 550
PGCRVKLVNQ DAEGIGEICL WGRTIFMGYL NMEDKTCEAI DEEGWLHTGD
560 570 580 590 600
AGRLDADGFL YITGRLKELI ITAGGENVPP VPIEEAVKME LPIISNAMLI
610 620 630 640 650
GDQRKFLSML LTLKCTLDPD TSDQTDNLTE QAMEFCQRVG SRATTVSEII
660 670 680 690 700
EKKDEAVYQA IEEGIRRVNM NAAARPYHIQ KWAILERDFS ISGGELGPTM
710 720
KLKRLTVLEK YKGIIDSFYQ EQKM
Length:724
Mass (Da):81,290
Last modified:May 18, 2010 - v2
Checksum:i2C27BA65CE95CE17
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YMC3H0YMC3_HUMAN
Long-chain-fatty-acid--CoA ligase A...
ACSBG1
243Annotation score:
F5H4U6F5H4U6_HUMAN
Long-chain-fatty-acid--CoA ligase A...
ACSBG1
482Annotation score:
H0YMZ0H0YMZ0_HUMAN
Long-chain-fatty-acid--CoA ligase A...
ACSBG1
181Annotation score:
H0YNX0H0YNX0_HUMAN
Long-chain-fatty-acid--CoA ligase A...
ACSBG1
138Annotation score:
H0YM34H0YM34_HUMAN
Long-chain-fatty-acid--CoA ligase A...
ACSBG1
80Annotation score:
H0YMF5H0YMF5_HUMAN
Long-chain-fatty-acid--CoA ligase A...
ACSBG1
55Annotation score:
H0YMH2H0YMH2_HUMAN
Long-chain-fatty-acid--CoA ligase A...
ACSBG1
51Annotation score:

Sequence cautioni

The sequence BAA31606 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038314194E → V. Corresponds to variant dbSNP:rs12899901Ensembl.1
Natural variantiVAR_038315633M → V4 PublicationsCorresponds to variant dbSNP:rs2304824Ensembl.1
Natural variantiVAR_038316673A → V1 PublicationCorresponds to variant dbSNP:rs11072735Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179481 mRNA Translation: AAG09404.1
AB014531 mRNA Translation: BAA31606.2 Different initiation.
AK314508 mRNA Translation: BAG37108.1
AC090260 Genomic DNA No translation available.
AC090607 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99180.1
BC009289 mRNA Translation: AAH09289.1
CCDSiCCDS10298.1
RefSeqiNP_001186306.1, NM_001199377.1
NP_055977.3, NM_015162.4
UniGeneiHs.655760

Genome annotation databases

EnsembliENST00000258873; ENSP00000258873; ENSG00000103740
GeneIDi23205
KEGGihsa:23205
UCSCiuc002bdh.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179481 mRNA Translation: AAG09404.1
AB014531 mRNA Translation: BAA31606.2 Different initiation.
AK314508 mRNA Translation: BAG37108.1
AC090260 Genomic DNA No translation available.
AC090607 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99180.1
BC009289 mRNA Translation: AAH09289.1
CCDSiCCDS10298.1
RefSeqiNP_001186306.1, NM_001199377.1
NP_055977.3, NM_015162.4
UniGeneiHs.655760

3D structure databases

ProteinModelPortaliQ96GR2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116813, 3 interactors
IntActiQ96GR2, 2 interactors
MINTiQ96GR2
STRINGi9606.ENSP00000258873

Chemistry databases

SwissLipidsiSLP:000000450

PTM databases

iPTMnetiQ96GR2
PhosphoSitePlusiQ96GR2

Polymorphism and mutation databases

BioMutaiACSBG1
DMDMi296434385

Proteomic databases

PaxDbiQ96GR2
PeptideAtlasiQ96GR2
PRIDEiQ96GR2
ProteomicsDBi76656

Protocols and materials databases

DNASUi23205
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258873; ENSP00000258873; ENSG00000103740
GeneIDi23205
KEGGihsa:23205
UCSCiuc002bdh.4 human

Organism-specific databases

CTDi23205
DisGeNETi23205
EuPathDBiHostDB:ENSG00000103740.9
GeneCardsiACSBG1
HGNCiHGNC:29567 ACSBG1
HPAiCAB045955
HPA041642
HPA058869
MIMi614362 gene
neXtProtiNX_Q96GR2
OpenTargetsiENSG00000103740
PharmGKBiPA142672648
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1256 Eukaryota
COG1022 LUCA
GeneTreeiENSGT00690000101725
HOGENOMiHOG000230004
HOVERGENiHBG054660
InParanoidiQ96GR2
KOiK15013
OMAiEIGPTYY
OrthoDBiEOG091G03FO
PhylomeDBiQ96GR2
TreeFamiTF354286

Enzyme and pathway databases

BioCyciMetaCyc:HS02532-MONOMER
ReactomeiR-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs

Miscellaneous databases

ChiTaRSiACSBG1 human
GeneWikiiACSBG1
GenomeRNAii23205
PROiPR:Q96GR2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103740 Expressed in 138 organ(s), highest expression level in mammalian vulva
CleanExiHS_ACSBG1
ExpressionAtlasiQ96GR2 baseline and differential
GenevisibleiQ96GR2 HS

Family and domain databases

InterProiView protein in InterPro
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACBG1_HUMAN
AccessioniPrimary (citable) accession number: Q96GR2
Secondary accession number(s): B2RB61
, O75126, Q76N27, Q9HC26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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