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UniProtKB - Q96GR2 (ACBG1_HUMAN)
Protein
Long-chain-fatty-acid--CoA ligase ACSBG1
Gene
ACSBG1
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:12975357, PubMed:24269233, PubMed:10954726).
Can activate diverse saturated, monosaturated and polyunsaturated fatty acids (PubMed:10954726).
3 PublicationsCatalytic activityi
- EC:6.2.1.32 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 550 | ATPBy similarity | 1 | |
Binding sitei | 565 | ATPBy similarity | 1 | |
Binding sitei | 701 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 282 – 290 | ATPBy similarity | 9 | |
Nucleotide bindingi | 472 – 477 | ATPBy similarity | 6 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- CoA-ligase activity Source: GO_Central
- long-chain fatty acid-CoA ligase activity Source: UniProtKB
- very long-chain fatty acid-CoA ligase activity Source: HGNC-UCL
GO - Biological processi
- long-chain fatty acid biosynthetic process Source: GO_Central
- long-chain fatty acid metabolic process Source: UniProtKB
- long-chain fatty-acyl-CoA biosynthetic process Source: Reactome
- myelination Source: HGNC-UCL
- ovarian follicle atresia Source: Ensembl
- response to glucocorticoid Source: Ensembl
- very long-chain fatty acid metabolic process Source: HGNC-UCL
Keywordsi
Molecular function | Ligase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q96GR2 |
Reactomei | R-HSA-75876, Synthesis of very long-chain fatty acyl-CoAs |
SignaLinki | Q96GR2 |
Chemistry databases
SwissLipidsi | SLP:000000450 |
Names & Taxonomyi
Protein namesi | Recommended name: Long-chain-fatty-acid--CoA ligase ACSBG1Curated (EC:6.2.1.32 Publications)Alternative name(s): Acyl-CoA synthetase bubblegum family member 1 Short name: hBG1 Short name: hsBG Short name: hsBGM Lipidosin |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29567, ACSBG1 |
MIMi | 614362, gene |
neXtProti | NX_Q96GR2 |
VEuPathDBi | HostDB:ENSG00000103740 |
Subcellular locationi
Endoplasmic reticulum
- Microsome By similarity
- Endoplasmic reticulum 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Plasma membrane
- Cell membrane 1 Publication
Other locations
- Cytoplasmic vesicle By similarity
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: HGNC-UCL
- cytoplasmic vesicle Source: UniProtKB-KW
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, MicrosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 23205 |
OpenTargetsi | ENSG00000103740 |
PharmGKBi | PA142672648 |
Miscellaneous databases
Pharosi | Q96GR2, Tbio |
Chemistry databases
DrugBanki | DB08326, 2-(6-HYDROXY-1,3-BENZOTHIAZOL-2-YL)-1,3-THIAZOL-4(5H)-ONE |
Genetic variation databases
BioMutai | ACSBG1 |
DMDMi | 296434385 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315808 | 1 – 724 | Long-chain-fatty-acid--CoA ligase ACSBG1Add BLAST | 724 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 53 | PhosphoserineBy similarity | 1 | |
Modified residuei | 56 | PhosphoserineBy similarity | 1 | |
Modified residuei | 658 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q96GR2 |
PaxDbi | Q96GR2 |
PeptideAtlasi | Q96GR2 |
PRIDEi | Q96GR2 |
ProteomicsDBi | 76656 |
PTM databases
iPTMneti | Q96GR2 |
PhosphoSitePlusi | Q96GR2 |
Expressioni
Tissue specificityi
Expressed primarily in brain. Expressed at lower level in testis and adrenal gland. Present in all regions of brain except pituitary.3 Publications
Gene expression databases
Bgeei | ENSG00000103740, Expressed in mammalian vulva and 159 other tissues |
ExpressionAtlasi | Q96GR2, baseline and differential |
Genevisiblei | Q96GR2, HS |
Organism-specific databases
HPAi | ENSG00000103740, Tissue enriched (brain) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 116813, 8 interactors |
IntActi | Q96GR2, 1 interactor |
MINTi | Q96GR2 |
STRINGi | 9606.ENSP00000258873 |
Miscellaneous databases
RNActi | Q96GR2, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 30 | DisorderedSequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1256, Eukaryota |
GeneTreei | ENSGT00940000160380 |
InParanoidi | Q96GR2 |
OMAi | RGMRKYD |
OrthoDBi | 806831at2759 |
PhylomeDBi | Q96GR2 |
TreeFami | TF354286 |
Family and domain databases
Gene3Di | 3.40.50.12780, 2 hits |
InterProi | View protein in InterPro IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q96GR2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRNSGAGYG CPHGDPSMLD SRETPQESRQ DMIVRTTQEK LKTSSLTDRQ
60 70 80 90 100
PLSKESLNHA LELSVPEKVN NAQWDAPEEA LWTTRADGRV RLRIDPSCPQ
110 120 130 140 150
LPYTVHRMFY EALDKYGDLI ALGFKRQDKW EHISYSQYYL LARRAAKGFL
160 170 180 190 200
KLGLKQAHSV AILGFNSPEW FFSAVGTVFA GGIVTGIYTT SSPEACQYIA
210 220 230 240 250
YDCCANVIMV DTQKQLEKIL KIWKQLPHLK AVVIYKEPPP NKMANVYTME
260 270 280 290 300
EFMELGNEVP EEALDAIIDT QQPNQCCVLV YTSGTTGNPK GVMLSQDNIT
310 320 330 340 350
WTARYGSQAG DIRPAEVQQE VVVSYLPLSH IAAQIYDLWT GIQWGAQVCF
360 370 380 390 400
AEPDALKGSL VNTLREVEPT SHMGVPRVWE KIMERIQEVA AQSGFIRRKM
410 420 430 440 450
LLWAMSVTLE QNLTCPGSDL KPFTTRLADY LVLAKVRQAL GFAKCQKNFY
460 470 480 490 500
GAAPMMAETQ HFFLGLNIRL YAGYGLSETS GPHFMSSPYN YRLYSSGKLV
510 520 530 540 550
PGCRVKLVNQ DAEGIGEICL WGRTIFMGYL NMEDKTCEAI DEEGWLHTGD
560 570 580 590 600
AGRLDADGFL YITGRLKELI ITAGGENVPP VPIEEAVKME LPIISNAMLI
610 620 630 640 650
GDQRKFLSML LTLKCTLDPD TSDQTDNLTE QAMEFCQRVG SRATTVSEII
660 670 680 690 700
EKKDEAVYQA IEEGIRRVNM NAAARPYHIQ KWAILERDFS ISGGELGPTM
710 720
KLKRLTVLEK YKGIIDSFYQ EQKM
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YM34 | H0YM34_HUMAN | Long-chain-fatty-acid--CoA ligase A... | ACSBG1 | 80 | Annotation score: | ||
H0YMZ0 | H0YMZ0_HUMAN | Long-chain-fatty-acid--CoA ligase A... | ACSBG1 | 181 | Annotation score: | ||
H0YMF5 | H0YMF5_HUMAN | Long-chain-fatty-acid--CoA ligase A... | ACSBG1 | 55 | Annotation score: | ||
H0YMH2 | H0YMH2_HUMAN | Long-chain-fatty-acid--CoA ligase A... | ACSBG1 | 51 | Annotation score: | ||
F5H4U6 | F5H4U6_HUMAN | Long-chain-fatty-acid--CoA ligase A... | ACSBG1 | 482 | Annotation score: | ||
H0YMC3 | H0YMC3_HUMAN | Long-chain-fatty-acid--CoA ligase A... | ACSBG1 | 243 | Annotation score: | ||
H0YNX0 | H0YNX0_HUMAN | Long-chain-fatty-acid--CoA ligase A... | ACSBG1 | 138 | Annotation score: |
Sequence cautioni
The sequence BAA31606 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038314 | 194 | E → V. Corresponds to variant dbSNP:rs12899901Ensembl. | 1 | |
Natural variantiVAR_038315 | 633 | M → V4 PublicationsCorresponds to variant dbSNP:rs2304824Ensembl. | 1 | |
Natural variantiVAR_038316 | 673 | A → V1 PublicationCorresponds to variant dbSNP:rs11072735Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF179481 mRNA Translation: AAG09404.1 AB014531 mRNA Translation: BAA31606.2 Different initiation. AK314508 mRNA Translation: BAG37108.1 AC090260 Genomic DNA No translation available. AC090607 Genomic DNA No translation available. CH471136 Genomic DNA Translation: EAW99180.1 BC009289 mRNA Translation: AAH09289.1 |
CCDSi | CCDS10298.1 |
RefSeqi | NP_001186306.1, NM_001199377.1 NP_055977.3, NM_015162.4 |
Genome annotation databases
Ensembli | ENST00000258873.9; ENSP00000258873.4; ENSG00000103740.10 |
GeneIDi | 23205 |
KEGGi | hsa:23205 |
MANE-Selecti | ENST00000258873.9; ENSP00000258873.4; NM_015162.5; NP_055977.3 |
UCSCi | uc002bdh.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF179481 mRNA Translation: AAG09404.1 AB014531 mRNA Translation: BAA31606.2 Different initiation. AK314508 mRNA Translation: BAG37108.1 AC090260 Genomic DNA No translation available. AC090607 Genomic DNA No translation available. CH471136 Genomic DNA Translation: EAW99180.1 BC009289 mRNA Translation: AAH09289.1 |
CCDSi | CCDS10298.1 |
RefSeqi | NP_001186306.1, NM_001199377.1 NP_055977.3, NM_015162.4 |
3D structure databases
AlphaFoldDBi | Q96GR2 |
SMRi | Q96GR2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116813, 8 interactors |
IntActi | Q96GR2, 1 interactor |
MINTi | Q96GR2 |
STRINGi | 9606.ENSP00000258873 |
Chemistry databases
DrugBanki | DB08326, 2-(6-HYDROXY-1,3-BENZOTHIAZOL-2-YL)-1,3-THIAZOL-4(5H)-ONE |
SwissLipidsi | SLP:000000450 |
PTM databases
iPTMneti | Q96GR2 |
PhosphoSitePlusi | Q96GR2 |
Genetic variation databases
BioMutai | ACSBG1 |
DMDMi | 296434385 |
Proteomic databases
MassIVEi | Q96GR2 |
PaxDbi | Q96GR2 |
PeptideAtlasi | Q96GR2 |
PRIDEi | Q96GR2 |
ProteomicsDBi | 76656 |
Protocols and materials databases
Antibodypediai | 27568, 162 antibodies from 22 providers |
DNASUi | 23205 |
Genome annotation databases
Ensembli | ENST00000258873.9; ENSP00000258873.4; ENSG00000103740.10 |
GeneIDi | 23205 |
KEGGi | hsa:23205 |
MANE-Selecti | ENST00000258873.9; ENSP00000258873.4; NM_015162.5; NP_055977.3 |
UCSCi | uc002bdh.4, human |
Organism-specific databases
CTDi | 23205 |
DisGeNETi | 23205 |
GeneCardsi | ACSBG1 |
HGNCi | HGNC:29567, ACSBG1 |
HPAi | ENSG00000103740, Tissue enriched (brain) |
MIMi | 614362, gene |
neXtProti | NX_Q96GR2 |
OpenTargetsi | ENSG00000103740 |
PharmGKBi | PA142672648 |
VEuPathDBi | HostDB:ENSG00000103740 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1256, Eukaryota |
GeneTreei | ENSGT00940000160380 |
InParanoidi | Q96GR2 |
OMAi | RGMRKYD |
OrthoDBi | 806831at2759 |
PhylomeDBi | Q96GR2 |
TreeFami | TF354286 |
Enzyme and pathway databases
PathwayCommonsi | Q96GR2 |
Reactomei | R-HSA-75876, Synthesis of very long-chain fatty acyl-CoAs |
SignaLinki | Q96GR2 |
Miscellaneous databases
BioGRID-ORCSi | 23205, 11 hits in 1071 CRISPR screens |
ChiTaRSi | ACSBG1, human |
GeneWikii | ACSBG1 |
GenomeRNAii | 23205 |
Pharosi | Q96GR2, Tbio |
PROi | PR:Q96GR2 |
RNActi | Q96GR2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000103740, Expressed in mammalian vulva and 159 other tissues |
ExpressionAtlasi | Q96GR2, baseline and differential |
Genevisiblei | Q96GR2, HS |
Family and domain databases
Gene3Di | 3.40.50.12780, 2 hits |
InterProi | View protein in InterPro IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACBG1_HUMAN | |
Accessioni | Q96GR2Primary (citable) accession number: Q96GR2 Secondary accession number(s): B2RB61 Q9HC26 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | May 18, 2010 | |
Last modified: | May 25, 2022 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families