UniProtKB - Q96GQ5 (RUS1_HUMAN)

BLAST

>sp|Q96GQ5|RUS1_HUMAN RUS1 family protein C16orf58 OS=Homo sapiens OX=9606 GN=C16orf58 PE=1 SV=2
MADDAGLETPLCSEQFGSGEARGCRAAADGSLQWEVGGWRWWGLSRAFTVKPEGRDAGEV
GASGAPSPPLSGLQAVFLPQGFPDSVSPDYLPYQLWDSVQAFASSLSGSLATQAVLLGIG
VGNAKATVSAATATWLVKDSTGMLGRIVFAWWKGSKLDCNAKQWRLFADILNDVAMFLEI
MAPVYPICFTMTVSTSNLAKCIVSVAGGATRAALTVHQARRNNMADVSAKDSSQETLVNL
AGLLVSLLMLPLVSGCPGFSLGCFFFLTALHIYANYRAVRALVMETLNEGRLRLVLKHYL
QRGEVLDPTAANRMEPLWTGFWPAPSLSLGVPLHRLVSSVFELQQLVEGHQESYLLCWDQ
SQNQVQVVLNQKAGPKTILRAATHGLMLGALQGDGPLPAELEELRNRVRAGPKKESWVVV
KETHEVLDMLFPKFLKGLQDAGWKTEKHQLEVDEWRATWLLSPEKKVL

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History
Entry version 116 (12 Sep 2018)
Sequence version 2 (03 Apr 2007)
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Protein

RUS1 family protein C16orf58

Gene

C16orf58

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: RUS1 family protein C16orf58
Gene namesⁱ	Name:C16orf58
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000140688.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25848 C16orf58
neXtProtⁱ	NX_Q96GQ5

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	247 – 267	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	64755
Open Targets More...OpenTargetsⁱ	ENSG00000140688
PharmGKBⁱ	PA143485395

Polymorphism and mutation databases

DMDMⁱ	143955305

DMDMⁱ

143955305

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000282930	2 – 468	RUS1 family protein C16orf58Add BLAST		467

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1
Modified residueⁱ	49	PhosphothreonineCombined sources		1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q96GQ5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q96GQ5
PaxDbⁱ	Q96GQ5
PeptideAtlas More...PeptideAtlasⁱ	Q96GQ5
PRIDEⁱ	Q96GQ5
ProteomicsDBⁱ	76653 76654 [Q96GQ5-2]

PTM databases

iPTMnetⁱ	Q96GQ5
PhosphoSitePlusⁱ	Q96GQ5
SwissPalmⁱ	Q96GQ5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000140688 Expressed in 205 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_C16orf58
ExpressionAtlasⁱ	Q96GQ5 baseline and differential
Genevisibleⁱ	Q96GQ5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA024406

HPAⁱ

HPA024406

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
EBP	Q15125	4	EBI-8636004,EBI-3915253

With

Entry

#Exp.

IntAct

Notes

EBP

Q15125

EBI-8636004,EBI-3915253

Protein-protein interaction databases

BioGridⁱ	122269, 42 interactors
IntActⁱ	Q96GQ5, 47 interactors
Molecular INTeraction database More...MINTⁱ	Q96GQ5

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q96GQ5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the RUS1 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4249 Eukaryota ENOG410XU74 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000050
HOGENOMⁱ	HOG000030128
HOVERGENⁱ	HBG057219
InParanoidⁱ	Q96GQ5
OMAⁱ	HQEPYLL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BBO
PhylomeDBⁱ	Q96GQ5
TreeFamⁱ	TF326424

Family and domain databases

InterProⁱ	View protein in InterPro IPR006968 RUS_fam
PANTHERⁱ	PTHR12770 PTHR12770, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04884 DUF647, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q96GQ5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADDAGLETP LCSEQFGSGE ARGCRAAADG SLQWEVGGWR WWGLSRAFTV 
        60         70         80         90        100
KPEGRDAGEV GASGAPSPPL SGLQAVFLPQ GFPDSVSPDY LPYQLWDSVQ 
       110        120        130        140        150
AFASSLSGSL ATQAVLLGIG VGNAKATVSA ATATWLVKDS TGMLGRIVFA 
       160        170        180        190        200
WWKGSKLDCN AKQWRLFADI LNDVAMFLEI MAPVYPICFT MTVSTSNLAK 
       210        220        230        240        250
CIVSVAGGAT RAALTVHQAR RNNMADVSAK DSSQETLVNL AGLLVSLLML 
       260        270        280        290        300
PLVSGCPGFS LGCFFFLTAL HIYANYRAVR ALVMETLNEG RLRLVLKHYL 
       310        320        330        340        350
QRGEVLDPTA ANRMEPLWTG FWPAPSLSLG VPLHRLVSSV FELQQLVEGH 
       360        370        380        390        400
QESYLLCWDQ SQNQVQVVLN QKAGPKTILR AATHGLMLGA LQGDGPLPAE 
       410        420        430        440        450
LEELRNRVRA GPKKESWVVV KETHEVLDML FPKFLKGLQD AGWKTEKHQL 
       460 
EVDEWRATWL LSPEKKVL

Length:468

Mass (Da):51,018

Last modified:April 3, 2007 - v2

Checksum:ⁱA945866B56ED3B83

Isoform 2 (identifier: Q96GQ5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-262: Missing.
263-338: CFFFLTALHI...LGVPLHRLVS → MCLMGEGRMG...PPPLHCPLPH

« Hide

        10         20         30         40         50
MCLMGEGRMG RWGSWMTGYR KKGWIWCVWV MAEGERKRGD LSEAWIISVH 
        60         70         80         90        100
WVAVQWLVGH ACLCCPPPPL HCPLPHSVFE LQQLVEGHQE SYLLCWDQSQ 
       110        120        130        140        150
NQVQVVLNQK AGPKTILRAA THGLMLGALQ GDGPLPAELE ELRNRVRAGP 
       160        170        180        190        200
KKESWVVVKE THEVLDMLFP KFLKGLQDAG WKTEKHQLEV DEWRATWLLS 

PEKKVL

Show »

Length:206

Mass (Da):23,594

Checksum:ⁱFC5C56E239D27651

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H3BSM7	H3BSM7_HUMAN	RUS1 family protein C16orf58 RUS1 family protein C16orf58	C16orf58	466	Annotation score:
H3BR29	H3BR29_HUMAN	RUS1 family protein C16orf58 RUS1 family protein C16orf58	C16orf58	423	Annotation score:
I3L2V0	I3L2V0_HUMAN	RUS1 family protein C16orf58 RUS1 family protein C16orf58	C16orf58	82	Annotation score:
H3BTA0	H3BTA0_HUMAN	RUS1 family protein C16orf58 RUS1 family protein C16orf58	C16orf58	135	Annotation score:
H3BS97	H3BS97_HUMAN	RUS1 family protein C16orf58 RUS1 family protein C16orf58	C16orf58	140	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	449	Q → R in BAC03918 (PubMed:14702039).Curated		1
Sequence conflictⁱ	453	D → G in BAB14730 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_036485	43	G → E in a breast cancer sample; somatic mutation. 1 Publication		1
Natural variantⁱVAR_031439	185	Y → C1 PublicationCorresponds to variant dbSNP:rs17855405Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_024255	1 – 262	Missing in isoform 2. 1 PublicationAdd BLAST		262
Alternative sequenceⁱVSP_024256	263 – 338	CFFFL…HRLVS → MCLMGEGRMGRWGSWMTGYR KKGWIWCVWVMAEGERKRGD LSEAWIISVHWVAVQWLVGH ACLCCPPPPLHCPLPH in isoform 2. 1 PublicationAdd BLAST		76

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK023930 mRNA Translation: BAB14730.1 AK092580 mRNA Translation: BAC03918.1 AK222913 mRNA Translation: BAD96633.1 BC000822 mRNA Translation: AAH00822.1 BC009308 mRNA Translation: AAH09308.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10715.1 [Q96GQ5-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_073581.2, NM_022744.3 [Q96GQ5-1]
UniGeneⁱ	Hs.499102 Hs.9003

Genome annotation databases

Ensemblⁱ	ENST00000327237; ENSP00000317579; ENSG00000140688 [Q96GQ5-1] ENST00000430477; ENSP00000398074; ENSG00000140688 [Q96GQ5-1]
GeneIDⁱ	64755
KEGGⁱ	hsa:64755
UCSC genome browser More...UCSCⁱ	uc002eci.4 human [Q96GQ5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q96GQ5	Chromosome 16 open reading frame 58, isoform CRA_a		HUMAN		468	UniRef100_Q96GQ5
UPI00003D68B0		HUMAN		245

Protein	Similar proteins		Species	Score	Length	Source
Q96GQ5	RUS1 family protein C16orf58 homolog		PONAB		468	UniRef90_Q96GQ5
Chromosome 16 open reading frame 58, isoform CRA_a		HUMAN		468
Chromosome 16 open reading frame 58		CHLSB		488
C16orf58 isoform 12 (Fragment)		PANTR		82
Uncharacterized protein		MACMU		469
+64

Protein	Similar proteins		Species	Score	Length	Source
Q96GQ5	RUS1 family protein C16orf58 homolog		PONAB		468	UniRef50_Q96GQ5
RUS1 family protein C16orf58 homolog		RAT		466
RUS1 family protein C16orf58 homolog		MOUSE		466
Chromosome 16 open reading frame 58, isoform CRA_a		HUMAN		468
Chromosome 16 open reading frame 58		CHLSB		488
+152
Q96GQ5-2	RUS1 family protein C16orf58 (Fragment)		ESCRO		252	UniRef50_Q96GQ5-2
UPI00053F625E		FUKDA		242

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK023930 mRNA Translation: BAB14730.1 AK092580 mRNA Translation: BAC03918.1 AK222913 mRNA Translation: BAD96633.1 BC000822 mRNA Translation: AAH00822.1 BC009308 mRNA Translation: AAH09308.1
CCDSⁱ	CCDS10715.1 [Q96GQ5-1]
RefSeqⁱ	NP_073581.2, NM_022744.3 [Q96GQ5-1]
UniGeneⁱ	Hs.499102 Hs.9003

3D structure databases

ProteinModelPortalⁱ	Q96GQ5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122269, 42 interactors
IntActⁱ	Q96GQ5, 47 interactors
MINTⁱ	Q96GQ5

PTM databases

iPTMnetⁱ	Q96GQ5
PhosphoSitePlusⁱ	Q96GQ5
SwissPalmⁱ	Q96GQ5

Polymorphism and mutation databases

DMDMⁱ	143955305

DMDMⁱ

143955305

Proteomic databases

EPDⁱ	Q96GQ5
MaxQBⁱ	Q96GQ5
PaxDbⁱ	Q96GQ5
PeptideAtlasⁱ	Q96GQ5
PRIDEⁱ	Q96GQ5
ProteomicsDBⁱ	76653 76654 [Q96GQ5-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000327237; ENSP00000317579; ENSG00000140688 [Q96GQ5-1] ENST00000430477; ENSP00000398074; ENSG00000140688 [Q96GQ5-1]
GeneIDⁱ	64755
KEGGⁱ	hsa:64755
UCSCⁱ	uc002eci.4 human [Q96GQ5-1]

Organism-specific databases

CTDⁱ	64755
DisGeNETⁱ	64755
EuPathDBⁱ	HostDB:ENSG00000140688.16
GeneCardsⁱ	C16orf58
H-InvDBⁱ	HIX0012994
HGNCⁱ	HGNC:25848 C16orf58
HPAⁱ	HPA024406
neXtProtⁱ	NX_Q96GQ5
OpenTargetsⁱ	ENSG00000140688
PharmGKBⁱ	PA143485395
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4249 Eukaryota ENOG410XU74 LUCA
GeneTreeⁱ	ENSGT00390000000050
HOGENOMⁱ	HOG000030128
HOVERGENⁱ	HBG057219
InParanoidⁱ	Q96GQ5
OMAⁱ	HQEPYLL
OrthoDBⁱ	EOG091G0BBO
PhylomeDBⁱ	Q96GQ5
TreeFamⁱ	TF326424

Miscellaneous databases

ChiTaRSⁱ	C16orf58 human
GeneWikiⁱ	C16orf58
GenomeRNAiⁱ	64755
Protein Ontology More...PROⁱ	PR:Q96GQ5

Gene expression databases

Bgeeⁱ	ENSG00000140688 Expressed in 205 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_C16orf58
ExpressionAtlasⁱ	Q96GQ5 baseline and differential
Genevisibleⁱ	Q96GQ5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR006968 RUS_fam
PANTHERⁱ	PTHR12770 PTHR12770, 1 hit
Pfamⁱ	View protein in Pfam PF04884 DUF647, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RUS1_HUMAN
Accessionⁱ	Q96GQ5Primary (citable) accession number: Q96GQ5 Secondary accession number(s): Q53GL8 , Q8NAJ4, Q9BVY3, Q9H887
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
	Last sequence update:	April 3, 2007
	Last modified:	September 12, 2018
	This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q96GQ5 (RUS1_HUMAN)

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RUS1 family protein C16orf58

C16orf58

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ