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UniProtKB - Q96GQ5 (RUSF1_HUMAN)
Protein
RUS family member 1
Gene
RUSF1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: RUS family member 1Curated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25848, RUSF1 |
neXtProti | NX_Q96GQ5 |
VEuPathDBi | HostDB:ENSG00000140688 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 247 – 267 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 64755 |
OpenTargetsi | ENSG00000140688 |
PharmGKBi | PA143485395 |
Miscellaneous databases
Pharosi | Q96GQ5, Tdark |
Genetic variation databases
BioMutai | C16orf58 |
DMDMi | 143955305 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000282930 | 2 – 468 | RUS family member 1Add BLAST | 467 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 49 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q96GQ5 |
jPOSTi | Q96GQ5 |
MassIVEi | Q96GQ5 |
MaxQBi | Q96GQ5 |
PaxDbi | Q96GQ5 |
PeptideAtlasi | Q96GQ5 |
PRIDEi | Q96GQ5 |
ProteomicsDBi | 76653 [Q96GQ5-1] 76654 [Q96GQ5-2] |
PTM databases
iPTMneti | Q96GQ5 |
PhosphoSitePlusi | Q96GQ5 |
SwissPalmi | Q96GQ5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000140688, Expressed in left lobe of thyroid gland and 220 other tissues |
ExpressionAtlasi | Q96GQ5, baseline and differential |
Genevisiblei | Q96GQ5, HS |
Organism-specific databases
HPAi | ENSG00000140688, Low tissue specificity |
Interactioni
Binary interactionsi
Q96GQ5
Protein-protein interaction databases
BioGRIDi | 122269, 183 interactors |
IntActi | Q96GQ5, 86 interactors |
MINTi | Q96GQ5 |
STRINGi | 9606.ENSP00000317579 |
Miscellaneous databases
RNActi | Q96GQ5, protein |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the RUS1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4249, Eukaryota |
GeneTreei | ENSGT00390000000050 |
InParanoidi | Q96GQ5 |
OMAi | PFQIWDS |
PhylomeDBi | Q96GQ5 |
TreeFami | TF326424 |
Family and domain databases
InterProi | View protein in InterPro IPR006968, RUS_fam |
PANTHERi | PTHR12770, PTHR12770, 1 hit |
Pfami | View protein in Pfam PF04884, UVB_sens_prot, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q96GQ5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADDAGLETP LCSEQFGSGE ARGCRAAADG SLQWEVGGWR WWGLSRAFTV
60 70 80 90 100
KPEGRDAGEV GASGAPSPPL SGLQAVFLPQ GFPDSVSPDY LPYQLWDSVQ
110 120 130 140 150
AFASSLSGSL ATQAVLLGIG VGNAKATVSA ATATWLVKDS TGMLGRIVFA
160 170 180 190 200
WWKGSKLDCN AKQWRLFADI LNDVAMFLEI MAPVYPICFT MTVSTSNLAK
210 220 230 240 250
CIVSVAGGAT RAALTVHQAR RNNMADVSAK DSSQETLVNL AGLLVSLLML
260 270 280 290 300
PLVSGCPGFS LGCFFFLTAL HIYANYRAVR ALVMETLNEG RLRLVLKHYL
310 320 330 340 350
QRGEVLDPTA ANRMEPLWTG FWPAPSLSLG VPLHRLVSSV FELQQLVEGH
360 370 380 390 400
QESYLLCWDQ SQNQVQVVLN QKAGPKTILR AATHGLMLGA LQGDGPLPAE
410 420 430 440 450
LEELRNRVRA GPKKESWVVV KETHEVLDML FPKFLKGLQD AGWKTEKHQL
460
EVDEWRATWL LSPEKKVL
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BR29 | H3BR29_HUMAN | RUS family member 1 | RUSF1 | 423 | Annotation score: | ||
H3BSM7 | H3BSM7_HUMAN | RUS family member 1 | RUSF1 | 466 | Annotation score: | ||
I3L2V0 | I3L2V0_HUMAN | RUS family member 1 | RUSF1 | 82 | Annotation score: | ||
H3BS97 | H3BS97_HUMAN | RUS family member 1 | RUSF1 | 140 | Annotation score: | ||
H3BTA0 | H3BTA0_HUMAN | RUS family member 1 | RUSF1 | 135 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 449 | Q → R in BAC03918 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 453 | D → G in BAB14730 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036485 | 43 | G → E in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_031439 | 185 | Y → C1 PublicationCorresponds to variant dbSNP:rs17855405Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024255 | 1 – 262 | Missing in isoform 2. 1 PublicationAdd BLAST | 262 | |
Alternative sequenceiVSP_024256 | 263 – 338 | CFFFL…HRLVS → MCLMGEGRMGRWGSWMTGYR KKGWIWCVWVMAEGERKRGD LSEAWIISVHWVAVQWLVGH ACLCCPPPPLHCPLPH in isoform 2. 1 PublicationAdd BLAST | 76 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK023930 mRNA Translation: BAB14730.1 AK092580 mRNA Translation: BAC03918.1 AK222913 mRNA Translation: BAD96633.1 BC000822 mRNA Translation: AAH00822.1 BC009308 mRNA Translation: AAH09308.1 |
CCDSi | CCDS10715.1 [Q96GQ5-1] |
RefSeqi | NP_073581.2, NM_022744.3 [Q96GQ5-1] |
Genome annotation databases
Ensembli | ENST00000327237; ENSP00000317579; ENSG00000140688 ENST00000430477; ENSP00000398074; ENSG00000140688 |
GeneIDi | 64755 |
KEGGi | hsa:64755 |
MANE-Selecti | ENST00000327237.7; ENSP00000317579.2; NM_022744.4; NP_073581.2 |
UCSCi | uc002eci.4, human [Q96GQ5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK023930 mRNA Translation: BAB14730.1 AK092580 mRNA Translation: BAC03918.1 AK222913 mRNA Translation: BAD96633.1 BC000822 mRNA Translation: AAH00822.1 BC009308 mRNA Translation: AAH09308.1 |
CCDSi | CCDS10715.1 [Q96GQ5-1] |
RefSeqi | NP_073581.2, NM_022744.3 [Q96GQ5-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 122269, 183 interactors |
IntActi | Q96GQ5, 86 interactors |
MINTi | Q96GQ5 |
STRINGi | 9606.ENSP00000317579 |
PTM databases
iPTMneti | Q96GQ5 |
PhosphoSitePlusi | Q96GQ5 |
SwissPalmi | Q96GQ5 |
Genetic variation databases
BioMutai | C16orf58 |
DMDMi | 143955305 |
Proteomic databases
EPDi | Q96GQ5 |
jPOSTi | Q96GQ5 |
MassIVEi | Q96GQ5 |
MaxQBi | Q96GQ5 |
PaxDbi | Q96GQ5 |
PeptideAtlasi | Q96GQ5 |
PRIDEi | Q96GQ5 |
ProteomicsDBi | 76653 [Q96GQ5-1] 76654 [Q96GQ5-2] |
Protocols and materials databases
Antibodypediai | 14220, 32 antibodies from 15 providers |
DNASUi | 64755 |
Genome annotation databases
Ensembli | ENST00000327237; ENSP00000317579; ENSG00000140688 ENST00000430477; ENSP00000398074; ENSG00000140688 |
GeneIDi | 64755 |
KEGGi | hsa:64755 |
MANE-Selecti | ENST00000327237.7; ENSP00000317579.2; NM_022744.4; NP_073581.2 |
UCSCi | uc002eci.4, human [Q96GQ5-1] |
Organism-specific databases
CTDi | 64755 |
DisGeNETi | 64755 |
GeneCardsi | RUSF1 |
HGNCi | HGNC:25848, RUSF1 |
HPAi | ENSG00000140688, Low tissue specificity |
neXtProti | NX_Q96GQ5 |
OpenTargetsi | ENSG00000140688 |
PharmGKBi | PA143485395 |
VEuPathDBi | HostDB:ENSG00000140688 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4249, Eukaryota |
GeneTreei | ENSGT00390000000050 |
InParanoidi | Q96GQ5 |
OMAi | PFQIWDS |
PhylomeDBi | Q96GQ5 |
TreeFami | TF326424 |
Enzyme and pathway databases
PathwayCommonsi | Q96GQ5 |
SignaLinki | Q96GQ5 |
Miscellaneous databases
BioGRID-ORCSi | 64755, 7 hits in 1039 CRISPR screens |
ChiTaRSi | C16orf58, human |
GeneWikii | C16orf58 |
GenomeRNAii | 64755 |
Pharosi | Q96GQ5, Tdark |
PROi | PR:Q96GQ5 |
RNActi | Q96GQ5, protein |
Gene expression databases
Bgeei | ENSG00000140688, Expressed in left lobe of thyroid gland and 220 other tissues |
ExpressionAtlasi | Q96GQ5, baseline and differential |
Genevisiblei | Q96GQ5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006968, RUS_fam |
PANTHERi | PTHR12770, PTHR12770, 1 hit |
Pfami | View protein in Pfam PF04884, UVB_sens_prot, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RUSF1_HUMAN | |
Accessioni | Q96GQ5Primary (citable) accession number: Q96GQ5 Secondary accession number(s): Q53GL8 Q9H887 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2007 |
Last sequence update: | April 3, 2007 | |
Last modified: | February 23, 2022 | |
This is version 135 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families