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Protein

RUS1 family protein C16orf58

Gene

C16orf58

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RUS1 family protein C16orf58
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000140688.16
HGNCiHGNC:25848 C16orf58
neXtProtiNX_Q96GQ5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64755
OpenTargetsiENSG00000140688
PharmGKBiPA143485395

Polymorphism and mutation databases

DMDMi143955305

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002829302 – 468RUS1 family protein C16orf58Add BLAST467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei49PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96GQ5
MaxQBiQ96GQ5
PaxDbiQ96GQ5
PeptideAtlasiQ96GQ5
PRIDEiQ96GQ5
ProteomicsDBi76653
76654 [Q96GQ5-2]

PTM databases

iPTMnetiQ96GQ5
PhosphoSitePlusiQ96GQ5
SwissPalmiQ96GQ5

Expressioni

Gene expression databases

BgeeiENSG00000140688 Expressed in 205 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_C16orf58
ExpressionAtlasiQ96GQ5 baseline and differential
GenevisibleiQ96GQ5 HS

Organism-specific databases

HPAiHPA024406

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EBPQ151254EBI-8636004,EBI-3915253

Protein-protein interaction databases

BioGridi122269, 42 interactors
IntActiQ96GQ5, 47 interactors
MINTiQ96GQ5

Structurei

3D structure databases

ProteinModelPortaliQ96GQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RUS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4249 Eukaryota
ENOG410XU74 LUCA
GeneTreeiENSGT00390000000050
HOGENOMiHOG000030128
HOVERGENiHBG057219
InParanoidiQ96GQ5
OMAiHQEPYLL
OrthoDBiEOG091G0BBO
PhylomeDBiQ96GQ5
TreeFamiTF326424

Family and domain databases

InterProiView protein in InterPro
IPR006968 RUS_fam
PANTHERiPTHR12770 PTHR12770, 1 hit
PfamiView protein in Pfam
PF04884 DUF647, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96GQ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADDAGLETP LCSEQFGSGE ARGCRAAADG SLQWEVGGWR WWGLSRAFTV
60 70 80 90 100
KPEGRDAGEV GASGAPSPPL SGLQAVFLPQ GFPDSVSPDY LPYQLWDSVQ
110 120 130 140 150
AFASSLSGSL ATQAVLLGIG VGNAKATVSA ATATWLVKDS TGMLGRIVFA
160 170 180 190 200
WWKGSKLDCN AKQWRLFADI LNDVAMFLEI MAPVYPICFT MTVSTSNLAK
210 220 230 240 250
CIVSVAGGAT RAALTVHQAR RNNMADVSAK DSSQETLVNL AGLLVSLLML
260 270 280 290 300
PLVSGCPGFS LGCFFFLTAL HIYANYRAVR ALVMETLNEG RLRLVLKHYL
310 320 330 340 350
QRGEVLDPTA ANRMEPLWTG FWPAPSLSLG VPLHRLVSSV FELQQLVEGH
360 370 380 390 400
QESYLLCWDQ SQNQVQVVLN QKAGPKTILR AATHGLMLGA LQGDGPLPAE
410 420 430 440 450
LEELRNRVRA GPKKESWVVV KETHEVLDML FPKFLKGLQD AGWKTEKHQL
460
EVDEWRATWL LSPEKKVL
Length:468
Mass (Da):51,018
Last modified:April 3, 2007 - v2
Checksum:iA945866B56ED3B83
GO
Isoform 2 (identifier: Q96GQ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-262: Missing.
     263-338: CFFFLTALHI...LGVPLHRLVS → MCLMGEGRMG...PPPLHCPLPH

Show »
Length:206
Mass (Da):23,594
Checksum:iFC5C56E239D27651
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BSM7H3BSM7_HUMAN
RUS1 family protein C16orf58
C16orf58
466Annotation score:
H3BR29H3BR29_HUMAN
RUS1 family protein C16orf58
C16orf58
423Annotation score:
I3L2V0I3L2V0_HUMAN
RUS1 family protein C16orf58
C16orf58
82Annotation score:
H3BTA0H3BTA0_HUMAN
RUS1 family protein C16orf58
C16orf58
135Annotation score:
H3BS97H3BS97_HUMAN
RUS1 family protein C16orf58
C16orf58
140Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti449Q → R in BAC03918 (PubMed:14702039).Curated1
Sequence conflicti453D → G in BAB14730 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03648543G → E in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_031439185Y → C1 PublicationCorresponds to variant dbSNP:rs17855405Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0242551 – 262Missing in isoform 2. 1 PublicationAdd BLAST262
Alternative sequenceiVSP_024256263 – 338CFFFL…HRLVS → MCLMGEGRMGRWGSWMTGYR KKGWIWCVWVMAEGERKRGD LSEAWIISVHWVAVQWLVGH ACLCCPPPPLHCPLPH in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023930 mRNA Translation: BAB14730.1
AK092580 mRNA Translation: BAC03918.1
AK222913 mRNA Translation: BAD96633.1
BC000822 mRNA Translation: AAH00822.1
BC009308 mRNA Translation: AAH09308.1
CCDSiCCDS10715.1 [Q96GQ5-1]
RefSeqiNP_073581.2, NM_022744.3 [Q96GQ5-1]
UniGeneiHs.499102
Hs.9003

Genome annotation databases

EnsembliENST00000327237; ENSP00000317579; ENSG00000140688 [Q96GQ5-1]
ENST00000430477; ENSP00000398074; ENSG00000140688 [Q96GQ5-1]
GeneIDi64755
KEGGihsa:64755
UCSCiuc002eci.4 human [Q96GQ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023930 mRNA Translation: BAB14730.1
AK092580 mRNA Translation: BAC03918.1
AK222913 mRNA Translation: BAD96633.1
BC000822 mRNA Translation: AAH00822.1
BC009308 mRNA Translation: AAH09308.1
CCDSiCCDS10715.1 [Q96GQ5-1]
RefSeqiNP_073581.2, NM_022744.3 [Q96GQ5-1]
UniGeneiHs.499102
Hs.9003

3D structure databases

ProteinModelPortaliQ96GQ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122269, 42 interactors
IntActiQ96GQ5, 47 interactors
MINTiQ96GQ5

PTM databases

iPTMnetiQ96GQ5
PhosphoSitePlusiQ96GQ5
SwissPalmiQ96GQ5

Polymorphism and mutation databases

DMDMi143955305

Proteomic databases

EPDiQ96GQ5
MaxQBiQ96GQ5
PaxDbiQ96GQ5
PeptideAtlasiQ96GQ5
PRIDEiQ96GQ5
ProteomicsDBi76653
76654 [Q96GQ5-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327237; ENSP00000317579; ENSG00000140688 [Q96GQ5-1]
ENST00000430477; ENSP00000398074; ENSG00000140688 [Q96GQ5-1]
GeneIDi64755
KEGGihsa:64755
UCSCiuc002eci.4 human [Q96GQ5-1]

Organism-specific databases

CTDi64755
DisGeNETi64755
EuPathDBiHostDB:ENSG00000140688.16
GeneCardsiC16orf58
H-InvDBiHIX0012994
HGNCiHGNC:25848 C16orf58
HPAiHPA024406
neXtProtiNX_Q96GQ5
OpenTargetsiENSG00000140688
PharmGKBiPA143485395
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4249 Eukaryota
ENOG410XU74 LUCA
GeneTreeiENSGT00390000000050
HOGENOMiHOG000030128
HOVERGENiHBG057219
InParanoidiQ96GQ5
OMAiHQEPYLL
OrthoDBiEOG091G0BBO
PhylomeDBiQ96GQ5
TreeFamiTF326424

Miscellaneous databases

ChiTaRSiC16orf58 human
GeneWikiiC16orf58
GenomeRNAii64755
PROiPR:Q96GQ5

Gene expression databases

BgeeiENSG00000140688 Expressed in 205 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_C16orf58
ExpressionAtlasiQ96GQ5 baseline and differential
GenevisibleiQ96GQ5 HS

Family and domain databases

InterProiView protein in InterPro
IPR006968 RUS_fam
PANTHERiPTHR12770 PTHR12770, 1 hit
PfamiView protein in Pfam
PF04884 DUF647, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRUS1_HUMAN
AccessioniPrimary (citable) accession number: Q96GQ5
Secondary accession number(s): Q53GL8
, Q8NAJ4, Q9BVY3, Q9H887
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 12, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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