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UniProtKB - Q96GQ5 (RUSF1_HUMAN)

Entry version 135 (23 Feb 2022)
Sequence version 2 (03 Apr 2007)
Previous versions | rss
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Protein

RUS family member 1

Gene

RUSF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q96GQ5

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q96GQ5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RUS family member 1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RUSF1Imported
Synonyms:C16orf58
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25848, RUSF1

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q96GQ5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000140688

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei247 – 267HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		64755

Open Targets

More...OpenTargetsi		ENSG00000140688

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA143485395

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q96GQ5, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C16orf58

Domain mapping of disease mutations (DMDM)

More...DMDMi		143955305

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002829302 – 468RUS family member 1Add BLAST467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei49PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q96GQ5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q96GQ5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q96GQ5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q96GQ5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q96GQ5

PeptideAtlas

More...PeptideAtlasi		Q96GQ5

PRoteomics IDEntifications database

More...PRIDEi		Q96GQ5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		76653 [Q96GQ5-1]
76654 [Q96GQ5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q96GQ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q96GQ5

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q96GQ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000140688, Expressed in left lobe of thyroid gland and 220 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q96GQ5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q96GQ5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000140688, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q96GQ5
With#Exp.IntAct
AQP6 [Q13520]3EBI-8636004,EBI-13059134
ARL6IP6 [Q8N6S5]3EBI-8636004,EBI-2808844
BDNF - isoform 2 [P23560-2]3EBI-8636004,EBI-12275524
BIK [Q13323]3EBI-8636004,EBI-700794
C5orf46 [Q6UWT4]3EBI-8636004,EBI-11986083
CISD2 [Q8N5K1]3EBI-8636004,EBI-1045797
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-8636004,EBI-11522780
CREB3L1 [Q96BA8]3EBI-8636004,EBI-6942903
CREB3L3 [Q68CJ9]3EBI-8636004,EBI-852194
DGAT2L6 [Q6ZPD8]3EBI-8636004,EBI-12831978
DHRSX [Q8N5I4]3EBI-8636004,EBI-3923585
EBP [Q15125]3EBI-8636004,EBI-3915253
EHHADH [Q08426]3EBI-8636004,EBI-2339219
ERGIC3 [Q9Y282]3EBI-8636004,EBI-781551
FAM209A [Q5JX71]3EBI-8636004,EBI-18304435
FFAR2 [O15552]3EBI-8636004,EBI-2833872
FKBP7 [Q9Y680]3EBI-8636004,EBI-3918971
GJA8 [P48165]3EBI-8636004,EBI-17458373
GPR42 [O15529]3EBI-8636004,EBI-18076404
HSD17B13 [Q7Z5P4]3EBI-8636004,EBI-18053395
HSD3B7 [Q9H2F3]3EBI-8636004,EBI-3918847
HTRA2 [O43464]3EBI-8636004,EBI-517086
HTT [P42858]3EBI-8636004,EBI-466029
IFNGR1 [P15260]4EBI-8636004,EBI-1030755
IL10RA [Q13651]3EBI-8636004,EBI-1031656
ITGAM [P11215]3EBI-8636004,EBI-2568251
LHFPL5 [Q8TAF8]3EBI-8636004,EBI-2820517
MMGT1 [Q8N4V1]3EBI-8636004,EBI-6163737
MS4A4A [Q96JQ5]3EBI-8636004,EBI-12820341
ODF4 [Q2M2E3]3EBI-8636004,EBI-12382569
PDCD1LG2 [Q9BQ51]3EBI-8636004,EBI-16427978
PGRMC2 [O15173]3EBI-8636004,EBI-1050125
PRPH [P41219]3EBI-8636004,EBI-752074
PVR [P15151]3EBI-8636004,EBI-3919694
RETREG3 [Q86VR2]3EBI-8636004,EBI-10192441
RNF5 [Q99942]3EBI-8636004,EBI-348482
SCN3B [Q9NY72]3EBI-8636004,EBI-17247926
SFXN3 [A0A1P0AYU5]3EBI-8636004,EBI-14193895
SLC10A1 [Q14973]3EBI-8636004,EBI-3923031
SLC10A6 [Q3KNW5]3EBI-8636004,EBI-18159983
SLC30A8 [Q8IWU4]3EBI-8636004,EBI-10262251
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-8636004,EBI-17295964
SLC35E3 [Q7Z769]3EBI-8636004,EBI-13389236
SPAG4 [Q9NPE6]3EBI-8636004,EBI-10819434
SSMEM1 [Q8WWF3]3EBI-8636004,EBI-17280858
TEX29 [Q8N6K0]3EBI-8636004,EBI-19027521
TMEM237 - isoform 2 [Q96Q45-2]3EBI-8636004,EBI-10982110
TMEM248 [Q9NWD8]3EBI-8636004,EBI-10314986
TMEM35A [Q53FP2]3EBI-8636004,EBI-11722971
TMX2 [Q9Y320]3EBI-8636004,EBI-6447886
UBE2I [Q7KZS0]3EBI-8636004,EBI-10180829
WFS1 [O76024]3EBI-8636004,EBI-720609
ZCCHC12 [Q6PEW1]3EBI-8636004,EBI-748373
ZDHHC15 [Q96MV8]3EBI-8636004,EBI-12837904

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122269, 183 interactors

Protein interaction database and analysis system

More...IntActi		Q96GQ5, 86 interactors

Molecular INTeraction database

More...MINTi		Q96GQ5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000317579

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q96GQ5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RUS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4249, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000050

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q96GQ5

Identification of Orthologs from Complete Genome Data

More...OMAi		PFQIWDS

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q96GQ5

TreeFam database of animal gene trees

More...TreeFami		TF326424

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006968, RUS_fam

The PANTHER Classification System

More...PANTHERi		PTHR12770, PTHR12770, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04884, UVB_sens_prot, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96GQ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADDAGLETP LCSEQFGSGE ARGCRAAADG SLQWEVGGWR WWGLSRAFTV 
        60         70         80         90        100
KPEGRDAGEV GASGAPSPPL SGLQAVFLPQ GFPDSVSPDY LPYQLWDSVQ 
       110        120        130        140        150
AFASSLSGSL ATQAVLLGIG VGNAKATVSA ATATWLVKDS TGMLGRIVFA 
       160        170        180        190        200
WWKGSKLDCN AKQWRLFADI LNDVAMFLEI MAPVYPICFT MTVSTSNLAK 
       210        220        230        240        250
CIVSVAGGAT RAALTVHQAR RNNMADVSAK DSSQETLVNL AGLLVSLLML 
       260        270        280        290        300
PLVSGCPGFS LGCFFFLTAL HIYANYRAVR ALVMETLNEG RLRLVLKHYL 
       310        320        330        340        350
QRGEVLDPTA ANRMEPLWTG FWPAPSLSLG VPLHRLVSSV FELQQLVEGH 
       360        370        380        390        400
QESYLLCWDQ SQNQVQVVLN QKAGPKTILR AATHGLMLGA LQGDGPLPAE 
       410        420        430        440        450
LEELRNRVRA GPKKESWVVV KETHEVLDML FPKFLKGLQD AGWKTEKHQL 
       460 
EVDEWRATWL LSPEKKVL
Length:468
Mass (Da):51,018
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA945866B56ED3B83
GO
Isoform 2 (identifier: Q96GQ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-262: Missing.
     263-338: CFFFLTALHI...LGVPLHRLVS → MCLMGEGRMG...PPPLHCPLPH

Show »
Length:206
Mass (Da):23,594
Checksum:iFC5C56E239D27651
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BR29H3BR29_HUMAN
RUS family member 1
RUSF1
423Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSM7H3BSM7_HUMAN
RUS family member 1
RUSF1
466Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2V0I3L2V0_HUMAN
RUS family member 1
RUSF1
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BS97H3BS97_HUMAN
RUS family member 1
RUSF1
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTA0H3BTA0_HUMAN
RUS family member 1
RUSF1
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti449Q → R in BAC03918 (PubMed:14702039).Curated1
Sequence conflicti453D → G in BAB14730 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03648543G → E in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_031439185Y → C1 PublicationCorresponds to variant dbSNP:rs17855405Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0242551 – 262Missing in isoform 2. 1 PublicationAdd BLAST262
Alternative sequenceiVSP_024256263 – 338CFFFL…HRLVS → MCLMGEGRMGRWGSWMTGYR KKGWIWCVWVMAEGERKRGD LSEAWIISVHWVAVQWLVGH ACLCCPPPPLHCPLPH in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK023930 mRNA Translation: BAB14730.1
AK092580 mRNA Translation: BAC03918.1
AK222913 mRNA Translation: BAD96633.1
BC000822 mRNA Translation: AAH00822.1
BC009308 mRNA Translation: AAH09308.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10715.1 [Q96GQ5-1]

NCBI Reference Sequences

More...RefSeqi		NP_073581.2, NM_022744.3 [Q96GQ5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000327237; ENSP00000317579; ENSG00000140688
ENST00000430477; ENSP00000398074; ENSG00000140688

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64755

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:64755

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000327237.7; ENSP00000317579.2; NM_022744.4; NP_073581.2

UCSC genome browser

More...UCSCi		uc002eci.4, human [Q96GQ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023930 mRNA Translation: BAB14730.1
AK092580 mRNA Translation: BAC03918.1
AK222913 mRNA Translation: BAD96633.1
BC000822 mRNA Translation: AAH00822.1
BC009308 mRNA Translation: AAH09308.1
CCDSiCCDS10715.1 [Q96GQ5-1]
RefSeqiNP_073581.2, NM_022744.3 [Q96GQ5-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi122269, 183 interactors
IntActiQ96GQ5, 86 interactors
MINTiQ96GQ5
STRINGi9606.ENSP00000317579

PTM databases

iPTMnetiQ96GQ5
PhosphoSitePlusiQ96GQ5
SwissPalmiQ96GQ5

Genetic variation databases

BioMutaiC16orf58
DMDMi143955305

Proteomic databases

EPDiQ96GQ5
jPOSTiQ96GQ5
MassIVEiQ96GQ5
MaxQBiQ96GQ5
PaxDbiQ96GQ5
PeptideAtlasiQ96GQ5
PRIDEiQ96GQ5
ProteomicsDBi76653 [Q96GQ5-1]
76654 [Q96GQ5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		14220, 32 antibodies from 15 providers

The DNASU plasmid repository

More...DNASUi		64755

Genome annotation databases

EnsembliENST00000327237; ENSP00000317579; ENSG00000140688
ENST00000430477; ENSP00000398074; ENSG00000140688
GeneIDi64755
KEGGihsa:64755
MANE-SelectiENST00000327237.7; ENSP00000317579.2; NM_022744.4; NP_073581.2
UCSCiuc002eci.4, human [Q96GQ5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64755
DisGeNETi64755

GeneCards: human genes, protein and diseases

More...GeneCardsi		RUSF1
HGNCiHGNC:25848, RUSF1
HPAiENSG00000140688, Low tissue specificity
neXtProtiNX_Q96GQ5
OpenTargetsiENSG00000140688
PharmGKBiPA143485395
VEuPathDBiHostDB:ENSG00000140688

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4249, Eukaryota
GeneTreeiENSGT00390000000050
InParanoidiQ96GQ5
OMAiPFQIWDS
PhylomeDBiQ96GQ5
TreeFamiTF326424

Enzyme and pathway databases

PathwayCommonsiQ96GQ5
SignaLinkiQ96GQ5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		64755, 7 hits in 1039 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		C16orf58, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		C16orf58

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		64755
PharosiQ96GQ5, Tdark

Protein Ontology

More...PROi		PR:Q96GQ5
RNActiQ96GQ5, protein

Gene expression databases

BgeeiENSG00000140688, Expressed in left lobe of thyroid gland and 220 other tissues
ExpressionAtlasiQ96GQ5, baseline and differential
GenevisibleiQ96GQ5, HS

Family and domain databases

InterProiView protein in InterPro
IPR006968, RUS_fam
PANTHERiPTHR12770, PTHR12770, 1 hit
PfamiView protein in Pfam
PF04884, UVB_sens_prot, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRUSF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96GQ5
Secondary accession number(s): Q53GL8
, Q8NAJ4, Q9BVY3, Q9H887
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: February 23, 2022
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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